{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:31:20Z","timestamp":1793115080058,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFC2703405"],"award-info":[{"award-number":["2022YFC2703405"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371353"],"award-info":[{"award-number":["82371353"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.exger.2026.113027","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:02:08Z","timestamp":1767916928000},"page":"113027","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Quercetin rejuvenates aged adipose progenitor cells by attenuating inflammatory pathways"],"prefix":"10.1016","volume":"214","author":[{"given":"Junwan","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2026.113027_bb0005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cmet.2013.10.003","article-title":"Weighing in on adipocyte precursors","volume":"19","author":"Berry","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.exger.2026.113027_bb0010","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cmet.2018.05.025","article-title":"Deconstructing adipogenesis induced by \u03b23-adrenergic receptor activation with single-cell expression profiling","volume":"28","author":"Burl","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.exger.2026.113027_bb0015","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.cmet.2019.10.006","article-title":"Aging induces an Nlrp3 inflammasome-dependent expansion of adipose B cells that impairs metabolic homeostasis","volume":"30","author":"Camell","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.exger.2026.113027_bb0020","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jnutbio.2016.03.005","article-title":"Effects of quercetin, a natural phenolic compound, in the differentiation of human mesenchymal stem cells (MSC) into adipocytes and osteoblasts","volume":"32","author":"Casado-D\u00edaz","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.exger.2026.113027_bb0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0784-9","article-title":"L1 drives IFN in senescent cells and promotes age-associated inflammation","volume":"566","author":"De Cecco","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.exger.2026.113027_bb0030","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.3390\/molecules27082498","article-title":"Health benefits of quercetin in age-related diseases","volume":"27","author":"Deepika","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.exger.2026.113027_bb0035","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41586-022-04518-2","article-title":"A single-cell atlas of human and mouse white adipose tissue","volume":"603","author":"Emont","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.exger.2026.113027_bb0040","doi-asserted-by":"crossref","first-page":"E1041","DOI":"10.1152\/ajpendo.00557.2006","article-title":"Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity","volume":"292","author":"Guo","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.exger.2026.113027_bb0045","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.exger.2026.113027_bb0050","doi-asserted-by":"crossref","first-page":"444","DOI":"10.4162\/nrp.2021.15.4.444","article-title":"Effects of quercetin on cell differentiation and adipogenesis in 3T3-L1 adipocytes","volume":"15","author":"Hong","year":"2021","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.exger.2026.113027_bb0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1467-789X.2009.00623.x","article-title":"Subcutaneous and visceral adipose tissue: structural and functional differences","volume":"11","author":"Ibrahim","year":"2010","journal-title":"Obes. Rev."},{"key":"10.1016\/j.exger.2026.113027_bb0060","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13767","article-title":"Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age","volume":"22","author":"Islam","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2026.113027_bb0065","doi-asserted-by":"crossref","first-page":"23025","DOI":"10.1074\/jbc.M513187200","article-title":"Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging","volume":"281","author":"Karagiannides","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2026.113027_bb0070","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/joim.13141","article-title":"Senolytic drugs: from discovery to translation","volume":"288","author":"Kirkland","year":"2020","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.exger.2026.113027_bb0075","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.arr.2009.06.001","article-title":"Age-related changes in total and regional fat distribution","volume":"8","author":"Kuk","year":"2009","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exger.2026.113027_bb0080","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13282","article-title":"SPATA4 improves aging-induced metabolic dysfunction through promotion of preadipocyte differentiation and adipose tissue expansion","volume":"20","author":"Li","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2026.113027_bb0085","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.cmet.2023.02.002","article-title":"Adipose tissue at single-cell resolution","volume":"35","author":"Maniyadath","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.exger.2026.113027_bb0090","doi-asserted-by":"crossref","first-page":"126","DOI":"10.12688\/f1000research.143511.2","article-title":"Life of Pi: exploring functions of Pi16+ fibroblasts","volume":"13","author":"McCartney","year":"2024","journal-title":"F1000Res"},{"key":"10.1016\/j.exger.2026.113027_bb0095","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav2501","article-title":"Identification of a mesenchymal progenitor cell hierarchy in adipose tissue","volume":"364","author":"Merrick","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.exger.2026.113027_bb0100","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.devcel.2021.03.026","article-title":"Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis","volume":"56","author":"Nguyen","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.exger.2026.113027_bb0105","doi-asserted-by":"crossref","first-page":"8044","DOI":"10.3390\/ijms21218044","article-title":"Effect of quercetin 3-O-\u03b2-D-galactopyranoside on the adipogenic and osteoblastogenic differentiation of human bone marrow-derived mesenchymal stromal cells","volume":"21","author":"Oh","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2026.113027_bb0110","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12950","article-title":"Targeting senescent cells alleviates obesity-induced metabolic dysfunction","volume":"18","author":"Palmer","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2026.113027_bb0115","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cell.2008.09.036","article-title":"Identification of white adipocyte progenitor cells in vivo","volume":"135","author":"Rodeheffer","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.exger.2026.113027_bb0120","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cell.2021.12.016","article-title":"Adipose-tissue plasticity in health and disease","volume":"185","author":"Sakers","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.exger.2026.113027_bb0125","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3390\/ijms21010282","article-title":"Age-dependent and -independent effects of perivascular adipose tissue and its paracrine activities during neointima formation","volume":"21","author":"Sch\u00fctz","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2026.113027_bb0130","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41366-021-00757-x","article-title":"Cellular senescence and its role in white adipose tissue","volume":"45","author":"Smith","year":"2021","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.exger.2026.113027_bb0135","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4162\/nrp.2023.17.3.438","article-title":"Quercetin inhibits body weight gain and adipogenesis via matrix metalloproteinases in mice fed a high-fat diet","volume":"17","author":"Song","year":"2023","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.exger.2026.113027_bb0140","doi-asserted-by":"crossref","first-page":"E1810","DOI":"10.1152\/ajpendo.00295.2007","article-title":"Increased TNFalpha and CCAAT\/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis","volume":"293","author":"Tchkonia","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.exger.2026.113027_bb0145","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1474-9726.2010.00608.x","article-title":"Fat tissue, aging, and cellular senescence","volume":"9","author":"Tchkonia","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2026.113027_bb0150","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/nm.3324","article-title":"Tracking adipogenesis during white adipose tissue development, expansion and regeneration","volume":"19","author":"Wang","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.exger.2026.113027_bb0155","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.cellsig.2016.06.004","article-title":"AMPK promotes osteogenesis and inhibits adipogenesis through AMPK-Gfi1-OPN axis","volume":"28","author":"Wang","year":"2016","journal-title":"Cell. Signal."},{"key":"10.1016\/j.exger.2026.113027_bb0160","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1002\/ptr.7010","article-title":"Quercetin promotes osteogenic differentiation and antioxidant responses of mouse bone mesenchymal stem cells through activation of the AMPK\/SIRT1 signaling pathway","volume":"35","author":"Wang","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.exger.2026.113027_bb0165","doi-asserted-by":"crossref","DOI":"10.1126\/science.adj0430","article-title":"Distinct adipose progenitor cells emerging with age drive active adipogenesis","volume":"388","author":"Wang","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.exger.2026.113027_bb0170","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41574-025-01142-8","article-title":"Adipose tissue ageing: implications for metabolic health and lifespan","volume":"21","author":"Wang","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.exger.2026.113027_bb0175","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA stress primes the antiviral innate immune response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.exger.2026.113027_bb0180","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12997","article-title":"Targeting senescent cells enhances adipogenesis and metabolic function in old age","volume":"4","author":"Xu","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.exger.2026.113027_bb0185","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41586-018-0049-7","article-title":"Genetic identification of leptin neural circuits in energy and glucose homeostases","volume":"556","author":"Xu","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.exger.2026.113027_bb0190","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age","volume":"24","author":"Xu","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.exger.2026.113027_bb0195","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10522-023-10067-6","article-title":"Aging adipose tissue, insulin resistance, and type 2 diabetes","volume":"25","author":"Zhao","year":"2024","journal-title":"Biogerontology"},{"key":"10.1016\/j.exger.2026.113027_bb0200","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-02544-0","article-title":"Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence","volume":"11","author":"Zoico","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2026.113027_bb0205","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cmet.2017.12.002","article-title":"Anatomical, physiological, and functional diversity of adipose tissue","volume":"27","author":"Zwick","year":"2018","journal-title":"Cell Metab."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526000057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526000057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:57:49Z","timestamp":1777571869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556526000057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":41,"alternative-id":["S0531556526000057"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2026.113027","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quercetin rejuvenates aged adipose progenitor cells by attenuating inflammatory pathways","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2026.113027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113027"}}