{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:33:11Z","timestamp":1782441191284,"version":"3.54.5"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202403AC100003"],"award-info":[{"award-number":["202403AC100003"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172442"],"award-info":[{"award-number":["82172442"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.exger.2026.113033","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T16:59:22Z","timestamp":1768237162000},"page":"113033","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Exploring the molecular intersections of osteoporosis and sarcopenia: An integrated bioinformatics and experimental validation"],"prefix":"10.1016","volume":"214","author":[{"given":"Yan","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoquan","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2026.113033_bb0005","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jocd.2009.06.004","article-title":"Beyond FRAX: it\u2019s time to consider \u201csarco-osteopenia\u201d","volume":"12","author":"Binkley","year":"2009","journal-title":"J. Clin. Densitom."},{"key":"10.1016\/j.exger.2026.113033_bb0010","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJMcp1513724","article-title":"Clinical practice. Postmenopausal osteoporosis","volume":"374","author":"Black","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exger.2026.113033_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105427","article-title":"The muscle to bone axis (and viceversa): an encrypted language affecting tissues and organs and yet to be codified?","volume":"165","author":"Bosco","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.exger.2026.113033_bb0020","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bone.2015.02.010","article-title":"Bone and muscle: interactions beyond mechanical","volume":"80","author":"Brotto","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.exger.2026.113033_bb0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/jcsm.13392","article-title":"Global epidemiological features and impact of osteosarcopenia: a comprehensive meta-analysis and systematic review","volume":"15","author":"Chen","year":"2024","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.exger.2026.113033_bb0030","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/jcsm.13447","article-title":"Frailty phenotype as mediator between systemic inflammation and osteoporosis and fracture risks: a prospective study","volume":"15","author":"Di","year":"2024","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.exger.2026.113033_bb0035","doi-asserted-by":"crossref","DOI":"10.7326\/AITC201708010","article-title":"Osteoporosis","volume":"167","author":"Ensrud","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.exger.2026.113033_bb0040","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/jcsm.13421","article-title":"Plasma microRNA signature associated with skeletal muscle wasting in post-menopausal osteoporotic women","volume":"15","author":"Faraldi","year":"2024","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.exger.2026.113033_bb0045","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1080\/14728222.2019.1702973","article-title":"Targeting fundamental aging mechanisms to treat osteoporosis","volume":"23","author":"Feehan","year":"2019","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.exger.2026.113033_bb0050","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.lfs.2018.10.032","article-title":"Strength training reverses ovariectomy-induced bone loss and improve metabolic parameters in female Wistar rats","volume":"213","author":"Gomes","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.exger.2026.113033_bb0055","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-006092","article-title":"Profiling specific cell populations within the inflammatory tumor microenvironment by oscillating-gradient diffusion-weighted MRI","volume":"11","author":"Hoffmann","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.exger.2026.113033_bb0060","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jare.2023.09.001","article-title":"Irisin as an agent for protecting against osteoporosis: a review of the current mechanisms and pathways","volume":"62","author":"Hu","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.exger.2026.113033_bb0065","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s12603-014-0543-z","article-title":"Comprehensive nutritional status in sarco-osteoporotic older fallers","volume":"19","author":"Huo","year":"2015","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.exger.2026.113033_bb0070","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2147\/IJWH.S106107","article-title":"Osteosarcopenic obesity in women: impact, prevalence, and management challenges","volume":"9","author":"JafariNasabian","year":"2017","journal-title":"Int. J. Womens Health"},{"key":"10.1016\/j.exger.2026.113033_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/cells11152359","article-title":"Molecular mechanisms of inflammation in sarcopenia: diagnosis and therapeutic update","volume":"11","author":"Jimenez-Gutierrez","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.exger.2026.113033_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002730","article-title":"Predicting survival from colorectal cancer histology slides using deep learning: a retrospective multicenter study","volume":"16","author":"Kather","year":"2019","journal-title":"PLoS Med."},{"key":"10.1016\/j.exger.2026.113033_bb0085","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1249\/MSS.0000000000000980","article-title":"Neutrophil depletion attenuates muscle injury after exhaustive exercise","volume":"48","author":"Kawanishi","year":"2016","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.exger.2026.113033_bb0090","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/jbmr.4027","article-title":"Effects of high-intensity resistance training on osteopenia and sarcopenia parameters in older men with osteosarcopenia-one-year results of the randomized controlled Franconian osteopenia and sarcopenia trial (FrOST)","volume":"35","author":"Kemmler","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.exger.2026.113033_bb0095","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/jcsm.12567","article-title":"Osteosarcopenia: epidemiology, diagnosis, and treatment-facts and numbers","volume":"11","author":"Kirk","year":"2020","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.exger.2026.113033_bb0100","article-title":"PGRMC1 and PAQR4 are promising molecular targets for a rare subtype of ovarian cancer","volume":"19","author":"Koz\u0142owska-Tomczyk","year":"2024","journal-title":"Open Life Sci."},{"key":"10.1016\/j.exger.2026.113033_bb0105","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1021\/acs.analchem.7b04531","article-title":"Sensitive Western-blot analysis of Azide-tagged protein post translational modifications using thermoresponsive polymer self-assembly","volume":"90","author":"Liu","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.exger.2026.113033_bb0110","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1080\/22221751.2020.1772679","article-title":"Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer\/probe sets","volume":"9","author":"Liu","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.exger.2026.113033_bb0115","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1302\/2046-3758.138.BJR-2023-0351.R2","article-title":"Identification of the molecular link: STAT3 is a shared key gene linking postmenopausal osteoporosis and sarcopenia","volume":"13","author":"Liu","year":"2024","journal-title":"Bone Joint Res."},{"key":"10.1016\/j.exger.2026.113033_bb0120","article-title":"The creation of a rat model for osteosarcopenia via ovariectomy","volume":"216","author":"Ma","year":"2025","journal-title":"J. Vis."},{"key":"10.1016\/j.exger.2026.113033_bb0125","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.1021\/acs.est.1c07440","article-title":"PyLEnM: a machine learning framework for long-term groundwater contamination monitoring strategies","volume":"56","author":"Meray","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.exger.2026.113033_bb0130","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1007\/s11547-024-01843-6","article-title":"DXA beyond bone mineral density and the REMS technique: new insights for current radiologists practice","volume":"129","author":"Messina","year":"2024","journal-title":"Radiol. Med."},{"key":"10.1016\/j.exger.2026.113033_bb0135","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/s12877-022-03225-x","article-title":"Osteosarcopenic obesity and its components-osteoporosis, sarcopenia, and obesity-are associated with blood cell count-derived inflammation indices in older Chinese people","volume":"22","author":"Nie","year":"2022","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.exger.2026.113033_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031426","article-title":"Ten approaches that improve immunostaining: a review of the latest advances for the optimization of immunofluorescence","volume":"23","author":"Pi\u00f1a","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2026.113033_bb0145","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1210\/clinem\/dgad496","article-title":"Sequential therapy for the long-term treatment of postmenopausal osteoporosis","volume":"109","author":"Ramchand","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.exger.2026.113033_bb0150","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exger.2026.113033_bb0155","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.jamda.2020.07.032","article-title":"Osteosarcopenia predicts falls, fractures, and mortality in Chilean community-dwelling older adults","volume":"22","author":"Salech","year":"2021","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"10.1016\/j.exger.2026.113033_bb0160","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/gerona\/gly162","article-title":"Does combined osteopenia\/osteoporosis and sarcopenia confer greater risk of falls and fracture than either condition alone in older men? The Concord health and ageing in men project","volume":"74","author":"Scott","year":"2019","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.exger.2026.113033_bb0165","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jot.2023.09.007","article-title":"Muscle-bone crosstalk via endocrine signals and potential targets for osteosarcopenia-related fracture","volume":"43","author":"Sheng","year":"2023","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.exger.2026.113033_bb0170","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/jamacardio.2024.0911","article-title":"Osteosarcopenia and mortality in older adults undergoing transcatheter aortic valve replacement","volume":"9","author":"Solla-Suarez","year":"2024","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.exger.2026.113033_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101259","article-title":"Aging adipose: depot location dictates age-associated expansion and dysfunction","volume":"67","author":"Von Bank","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exger.2026.113033_bb0180","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/jmcb\/mjx028","article-title":"The steady-state level of CDK4 protein is regulated by antagonistic actions between PAQR4 and SKP2 and involved in tumorigenesis","volume":"9","author":"Wang","year":"2017","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.exger.2026.113033_bb0185","article-title":"A multifunctional therapeutic strategy using P7C3 as a countermeasure against bone loss and fragility in an ovariectomized rat model of postmenopausal osteoporosis","volume":"11","author":"Wei","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.exger.2026.113033_bb0190","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/jcsm.12709","article-title":"Mouse models of sarcopenia: classification and evaluation","volume":"12","author":"Xie","year":"2021","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.exger.2026.113033_bb0195","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.7150\/thno.43142","article-title":"PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation","volume":"10","author":"Xu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.exger.2026.113033_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110223","article-title":"Breviscapine suppresses the growth and metastasis of prostate cancer through regulating PAQR4-mediated PI3K\/Akt pathway","volume":"127","author":"Ye","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exger.2026.113033_bb0205","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.7150\/thno.33000","article-title":"New insights into the pathogenesis and treatment of sarcopenia in chronic heart failure","volume":"9","author":"Yin","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.exger.2026.113033_bb0210","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2018.33.e27","article-title":"Osteosarcopenia in patients with hip fracture is related with high mortality","volume":"33","author":"Yoo","year":"2018","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.exger.2026.113033_bb0215","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jamda.2014.02.005","article-title":"Incremental predictive value of sarcopenia for incident fracture in an elderly Chinese cohort: results from the osteoporotic fractures in men (MrOs) study","volume":"15","author":"Yu","year":"2014","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"10.1016\/j.exger.2026.113033_bb0220","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41597-021-00913-y","article-title":"Micro-CT data of early physiological cancellous bone formation in the lumbar spine of female C57BL\/6 mice","volume":"8","author":"Zenzes","year":"2021","journal-title":"Sci. Data"},{"key":"10.1016\/j.exger.2026.113033_bb0225","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/abbs\/gmab143","article-title":"PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K\/AKT pathway","volume":"53","author":"Zhao","year":"2021","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"key":"10.1016\/j.exger.2026.113033_bb0230","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1245514","article-title":"Single-cell and bulk RNA sequencing analysis of B cell marker genes in TNBC TME landscape and immunotherapy","volume":"14","author":"Zhao","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exger.2026.113033_bb0235","article-title":"Clinical significance and immunometabolism landscapes of a novel recurrence-associated lipid metabolism signature in early-stage lung adenocarcinoma: a comprehensive analysis","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exger.2026.113033_bb0240","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/s42255-024-01078-9","article-title":"PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels","volume":"6","author":"Zhu","year":"2024","journal-title":"Nat. Metab."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526000112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526000112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:57:44Z","timestamp":1777571864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556526000112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":48,"alternative-id":["S0531556526000112"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2026.113033","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the molecular intersections of osteoporosis and sarcopenia: An integrated bioinformatics and experimental validation","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2026.113033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113033"}}