{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:20:39Z","timestamp":1790961639877,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2022-KH130590"],"award-info":[{"award-number":["RS-2022-KH130590"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.exger.2026.113059","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:39:10Z","timestamp":1770449950000},"page":"113059","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Cumulative diabetes-related metabolic burden and the risk of hearing loss: A population-based study"],"prefix":"10.1016","volume":"215","author":[{"given":"Youngji","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Yup","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Incheol","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da Jung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2026.113059_bb0005","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/S0140-6736(22)01655-5","article-title":"Type 2 diabetes","volume":"400","author":"Ahmad","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2026.113059_bb0010","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.17305\/bb.2024.10426","article-title":"Serum C-reactive protein to albumin ratio as a reliable marker of diabetic neuropathy in type 2 diabetes mellitus","volume":"24","author":"Aktas","year":"2024","journal-title":"Biomol. Biomed."},{"key":"10.1016\/j.exger.2026.113059_bb0015","doi-asserted-by":"crossref","DOI":"10.4239\/wjd.v16.i7.105233","article-title":"Exploring the link: Hemogram-derived markers in type 2 diabetes mellitus and its complications","volume":"16","author":"Aktas","year":"2025","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.exger.2026.113059_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-149-1-200807010-00231","article-title":"Diabetes and hearing impairment in the United States: audiometric evidence from the National Health and Nutrition Examination Survey, 1999 to 2004","volume":"149","author":"Bainbridge","year":"2008","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.exger.2026.113059_bb0025","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2337\/dc09-1193","article-title":"Potential mediators of diabetes-related hearing impairment in the U.S. population: National Health and Nutrition Examination Survey 1999\u20132004","volume":"33","author":"Bainbridge","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.exger.2026.113059_bb0030","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.4158\/EP-2019-0193","article-title":"Risk factors for hearing impairment in type 1 diabetes","volume":"25","author":"Braffett","year":"2019","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.exger.2026.113059_bb0035","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/ohn.1346","article-title":"Type 2 diabetes mellitus and hearing loss: a prisma systematic review and meta-analysis","volume":"173","author":"Caballero-Borrego","year":"2025","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.exger.2026.113059_bb0040","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000003423","article-title":"Glomerular filtration rate and urine albumin to creatinine ratio associated with hearing impairment among Korean adults with diabetes: a nationwide population-based study","volume":"95","author":"Cho","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.exger.2026.113059_bb0045","article-title":"Systemic inflammatory markers and epicardial fat volume as predictors of cardiometabolic risk in type 2 diabetes","author":"Cosgun","year":"2025","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.exger.2026.113059_bb5000","doi-asserted-by":"crossref","first-page":"646","DOI":"10.2471\/BLT.19.224683","article-title":"Hearing loss: rising prevalence and impact","volume":"97","author":"Davis","year":"2019","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.exger.2026.113059_bb0050","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s10020-023-00737-z","article-title":"Diabetes mellitus and hearing loss","volume":"29","author":"Deng","year":"2023","journal-title":"Mol. Med."},{"key":"10.1016\/j.exger.2026.113059_bb0055","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s00125-019-4959-1","article-title":"New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism","volume":"62","author":"Eid","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.exger.2026.113059_bb0060","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S1474-4422(22)00188-0","article-title":"Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments","volume":"21","author":"Elafros","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.exger.2026.113059_bb0065","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1038\/s41598-025-32154-z","article-title":"Adriamycin nephropathy induces sensorineural hearing loss via blood\u2013labyrinth barrier breakdown in BALB\/c mice","volume":"16","author":"Gajbhiye","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2026.113059_bb0070","doi-asserted-by":"crossref","first-page":"15356","DOI":"10.1038\/s41598-021-94807-z","article-title":"Trends in type 2 diabetes mellitus disease burden in European Union countries between 1990 and 2019","volume":"11","author":"Goodall","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2026.113059_bb0075","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.2105\/AJPH.2007.133215","article-title":"Socioeconomic inequalities in hearing loss in a healthy population sample: the HUNT Study","volume":"99","author":"Helvik","year":"2009","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.exger.2026.113059_bb0080","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/00129492-200305000-00006","article-title":"The effect of diabetes on sensorineural hearing loss","volume":"24","author":"Kakarlapudi","year":"2003","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.exger.2026.113059_bb0085","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/03007995.2025.2463952","article-title":"The systemic immune inflammation index is a reliable and novel risk factor for metabolic dysfunction-associated fatty liver disease","volume":"41","author":"Kosekli","year":"2025","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.exger.2026.113059_bb0090","doi-asserted-by":"crossref","DOI":"10.4103\/0971-7749.146930","article-title":"A clinical study of age related hearing loss among diabetes patients","volume":"20","author":"Krishnappa","year":"2014","journal-title":"Indian J. Otol."},{"key":"10.1016\/j.exger.2026.113059_bb0095","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jclinepi.2017.10.006","article-title":"Kaplan\u2013meier survival analysis overestimates cumulative incidence of health-related events in competing risk settings: a meta-analysis","volume":"93","author":"Lacny","year":"2018","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.exger.2026.113059_bb0100","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3342\/ceo.2008.1.4.211","article-title":"Early sensorineural hearing loss in ob\/ob mouse, an animal model of type 2 diabetes","volume":"1","author":"Lee","year":"2008","journal-title":"Clin. Experim. Otorhinolaryngol."},{"key":"10.1016\/j.exger.2026.113059_bb0105","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5683287","article-title":"Diabetic microvascular complications","volume":"2018","author":"Migdalis","year":"2018","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.exger.2026.113059_bb0110","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1464-5491.2009.02710.x","article-title":"Relationship of Type 2 diabetes to the prevalence, incidence and progression of age-related hearing loss","volume":"26","author":"Mitchell","year":"2009","journal-title":"Diabet. Med."},{"key":"10.1016\/j.exger.2026.113059_bb5010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210674","article-title":"Which clinical and biochemical predictors should be used to screen for diabetes in patients with serious mental illness receiving antipsychotic medication? A large observational study","volume":"14","author":"Mitchell","year":"2019","journal-title":"PLOS ONE"},{"key":"10.1016\/j.exger.2026.113059_bb0115","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","article-title":"Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021","volume":"402","author":"Ong","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2026.113059_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101423","article-title":"Diabetes mellitus and hearing loss: a review","volume":"71","author":"Samocha-Bonet","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exger.2026.113059_bb0125","doi-asserted-by":"crossref","first-page":"1497449","DOI":"10.1155\/2021\/1497449","article-title":"Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment","volume":"2021","author":"Samsu","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.exger.2026.113059_bb0130","doi-asserted-by":"crossref","DOI":"10.1186\/s12882-015-0151-0","article-title":"Association of hearing impairment with chronic kidney disease: a cross-sectional study of the Korean general population","volume":"16","author":"Seo","year":"2015","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.exger.2026.113059_bb0135","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s40273-019-00775-8","article-title":"Estimating quality of life decrements due to diabetes complications in the United States: the health utility index (HUI) diabetes complication equation","volume":"37","author":"Shao","year":"2019","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.exger.2026.113059_bb0140","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/jdi.12196","article-title":"Severity of hearing impairment is positively associated with urine albumin excretion rate in patients with type 2 diabetes","volume":"5","author":"Shen","year":"2014","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.exger.2026.113059_bb0145","first-page":"1","article-title":"The role of chronic inflammation duration in age-related hearing loss: a cross-sectional study","author":"Tekta\u015f","year":"2025","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.exger.2026.113059_bb0150","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Vos","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2026.113059_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2024.109072","article-title":"Associations between diabetes mellitus and sensorineural hearing loss from humans and animal studies","volume":"450","author":"Williams","year":"2024","journal-title":"Hear. Res."},{"key":"10.1016\/j.exger.2026.113059_bb5005","series-title":"World Report on Hearing","year":"2021"},{"key":"10.1016\/j.exger.2026.113059_bb0160","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S1672-2930(13)50017-1","article-title":"Effects of diabetes on hearing and cochlear structures","volume":"8","author":"Xipeng","year":"2013","journal-title":"J. Otol."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526000379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526000379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:57:14Z","timestamp":1777571834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556526000379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":35,"alternative-id":["S0531556526000379"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2026.113059","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cumulative diabetes-related metabolic burden and the risk of hearing loss: A population-based study","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2026.113059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113059"}}