{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:54:57Z","timestamp":1777866897118,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.exger.2026.113120","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:08:45Z","timestamp":1775059725000},"page":"113120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Discovery of frailty-linked proteins through multi-omics integration of brain and plasma proteomes with GWAS datasets"],"prefix":"10.1016","volume":"218","author":[{"given":"JiaYu","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MingHao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"En","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2026.113120_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009224","article-title":"Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome","volume":"17","author":"Baird","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.exger.2026.113120_bb0010","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/neup.12189","article-title":"Arizona study of aging and neurodegenerative disorders and brain and body donation program","volume":"35","author":"Beach","year":"2015","journal-title":"Neuropathology"},{"key":"10.1016\/j.exger.2026.113120_bb0015","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.3233\/JAD-179939","article-title":"Religious orders study and rush memory and aging project","volume":"64","author":"Bennett","year":"2018","journal-title":"J. Alzheimer\u2019s Dis"},{"key":"10.1016\/j.exger.2026.113120_bb0020","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.exger.2026.113120_bb0025","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/EDE.0000000000000559","article-title":"Sensitivity analyses for robust causal inference from Mendelian randomization analyses with multiple genetic variants","volume":"28","author":"Burgess","year":"2017","journal-title":"Epidemiology"},{"key":"10.1016\/j.exger.2026.113120_bb0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.exger.2026.113120_bb0035","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1001\/jamapsychiatry.2021.0005","article-title":"Association of antihypertensive drug target genes with psychiatric disorders: a Mendelian randomization study","volume":"78","author":"Chauquet","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.exger.2026.113120_bb0040","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1532-5415.2009.02225.x","article-title":"Comparing models of frailty: the Health and Retirement Study","volume":"57","author":"Cigolle","year":"2009","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.exger.2026.113120_bb0045","doi-asserted-by":"crossref","first-page":"252","DOI":"10.5582\/bst.2023.01204","article-title":"Healthy aging, early screening, and interventions for frailty in the elderly","volume":"17","author":"Deng","year":"2023","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.exger.2026.113120_bb0050","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000435853","article-title":"In search of \u2018omics\u2019-based biomarkers to predict risk of frailty and its consequences in older individuals: the FRAILOMIC initiative","volume":"62","author":"Erusalimsky","year":"2016","journal-title":"Gerontology"},{"key":"10.1016\/j.exger.2026.113120_bb0055","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","article-title":"Large-scale integration of the plasma proteome with genetics and disease","volume":"53","author":"Ferkingstad","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exger.2026.113120_bb0060","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.exger.2026.113120_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.exger.2026.113120_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27850-z","article-title":"A genome-wide association study of serum proteins reveals shared loci with common diseases","volume":"13","author":"Gudjonsson","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2026.113120_bb0075","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2468-2667(18)30091-4","article-title":"Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493737 UK Biobank participants","volume":"3","author":"Hanlon","year":"2018","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.exger.2026.113120_bb0080","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0140-6736(19)31786-6","article-title":"Frailty: implications for clinical practice and public health","volume":"394","author":"Hoogendijk","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2026.113120_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008164","article-title":"Genome-wide association study of multisite chronic pain in UK Biobank","volume":"15","author":"Johnston","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.exger.2026.113120_bb0090","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1001\/jamaneurol.2020.5257","article-title":"Identification of candidate Parkinson disease genes by integrating genome-wide association study, expression, and epigenetic data sets","volume":"78","author":"Kia","year":"2021","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.exger.2026.113120_bb0095","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14171","article-title":"Identification of prospective aging drug targets via Mendelian randomization analysis","volume":"23","author":"Mao","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2026.113120_bb0105","doi-asserted-by":"crossref","DOI":"10.1126\/science.abj1541","article-title":"Mapping the proteo-genomic convergence of human diseases","volume":"374","author":"Pietzner","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.exger.2026.113120_bb0110","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ajhg.2021.01.012","article-title":"Genetic control of the human brain proteome","volume":"108","author":"Robins","year":"2021","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.exger.2026.113120_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102044","article-title":"Biomarkers of aging in frailty and age-associated disorders: state of the art and future perspective","volume":"91","author":"Salvioli","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.exger.2026.113120_bb0120","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s13105-022-00904-6","article-title":"Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases","volume":"78","author":"Shang","year":"2022","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.exger.2026.113120_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124296","article-title":"MST1: a future novel target for cardiac diseases","volume":"239","author":"Shao","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.exger.2026.113120_bb0130","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1016\/j.celrep.2017.10.099","article-title":"CISD2 haploinsufficiency disrupts calcium homeostasis, causes nonalcoholic fatty liver disease, and promotes hepatocellular carcinoma","volume":"21","author":"Shen","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.exger.2026.113120_bb0135","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1001\/jama.2021.18236","article-title":"Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement","volume":"326","author":"Skrivankova","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.exger.2026.113120_bb0140","article-title":"Finding genetically-supported drug targets for Parkinson's disease using Mendelian randomization of the druggable genome","volume":"12","author":"Storm","year":"2021"},{"key":"10.1016\/j.exger.2026.113120_bb0145","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/bioinformatics\/btn209","article-title":"fdrtool: a versatile R package for estimating local and tail area-based false discovery rates","volume":"24","author":"Strimmer","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exger.2026.113120_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med."},{"key":"10.1016\/j.exger.2026.113120_bb0155","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41588-020-00773-z","article-title":"Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer\u2019s disease pathogenesis","volume":"53","author":"Wingo","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exger.2026.113120_bb0160","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/s41386-024-01807-4","article-title":"Identifying novel proteins for suicide attempt by integrating proteomes from brain and blood with genome-wide association data","volume":"49","author":"Zhao","year":"2024","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.exger.2026.113120_bb0165","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat. Genet."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526000999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526000999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:33:17Z","timestamp":1777541597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556526000999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":32,"alternative-id":["S0531556526000999"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2026.113120","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of frailty-linked proteins through multi-omics integration of brain and plasma proteomes with GWAS datasets","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2026.113120","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113120"}}