{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:47:46Z","timestamp":1784609266550,"version":"3.55.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017949","name":"Health Commission of Shanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.exger.2026.113124","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:37:47Z","timestamp":1775666267000},"page":"113124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["ZDHHC14 Attenuates Osteoarthritis Progression through Metabolic Pathways: Multi-omics Fusion and Functional Validation"],"prefix":"10.1016","volume":"218","author":[{"given":"Jingkai","family":"Di","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingda","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feida","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2026.113124_bb0005","doi-asserted-by":"crossref","first-page":"277","DOI":"10.7762\/cnr.2022.11.4.277","article-title":"The association between dietary acidity and clinical symptoms in patients with rheumatoid arthritis","volume":"11","author":"Amjadi","year":"2022","journal-title":"Clin. Nutr. Res."},{"key":"10.1016\/j.exger.2026.113124_bb0010","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk8402","article-title":"PTH treatment before cyclic joint loading improves cartilage health and attenuates load-induced osteoarthritis development in mice","volume":"10","author":"Antoinette","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.exger.2026.113124_bb0015","doi-asserted-by":"crossref","DOI":"10.12688\/wellcomeopenres.15555.1","article-title":"Guidelines for performing Mendelian randomization investigations: update for summer 2023","volume":"4","author":"Burgess","year":"2019","journal-title":"Wellcome Open Res."},{"key":"10.1016\/j.exger.2026.113124_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2022.100316","article-title":"Differential gene co-expression network analyses reveal novel molecules associated with transcriptional dysregulation of key biological processes in osteoarthritis knee cartilage","volume":"4","author":"Buzzatto-Leite","year":"2022","journal-title":"Osteoarthr. Cartil. Open"},{"key":"10.1016\/j.exger.2026.113124_bb0025","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1152\/physrev.00032.2014","article-title":"The physiology of protein S-acylation","volume":"95","author":"Chamberlain","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exger.2026.113124_bb0030","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41588-022-01270-1","article-title":"Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases","volume":"55","author":"Chen","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exger.2026.113124_bb0035","doi-asserted-by":"crossref","first-page":"1337478","DOI":"10.3389\/fimmu.2024.1337478","article-title":"Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exger.2026.113124_bb0040","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3390\/nu12030788","article-title":"Modulation of cellular biochemistry, epigenetics and metabolomics by ketone bodies. Implications of the ketogenic diet in the physiology of the organism and pathological states","volume":"12","author":"D\u0105bek","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.exger.2026.113124_bb0045","doi-asserted-by":"crossref","first-page":"1401626","DOI":"10.3389\/fimmu.2024.1401626","article-title":"The anti-inflammatory role of zDHHC23 through the promotion of macrophage M2 polarization and macrophage necroptosis in large yellow croaker (Larimichthys crocea)","volume":"15","author":"Dai","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exger.2026.113124_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115107","article-title":"Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation","volume":"202","author":"Ding","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.exger.2026.113124_bb0055","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1186\/s13018-025-05804-1","article-title":"Obacunone acts as a histone deacetylase 1 inhibitor to limit p38MAPK signaling and alleviate osteoarthritis progression","volume":"20","author":"Gao","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.exger.2026.113124_bb0060","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbrc.2022.08.074","article-title":"Sphingomyelin: what is it good for","volume":"633","author":"Go\u00f1i","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exger.2026.113124_bb0065","article-title":"Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2026.113124_bb0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1423-0127-19-77","article-title":"Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis","volume":"19","author":"Izumi","year":"2012","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.exger.2026.113124_bb0075","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1136\/annrheumdis-2020-217050","article-title":"Incidence trend of five common musculoskeletal disorders from 1990 to 2017 at the global, regional and national level: results from the global burden of disease study 2017","volume":"79","author":"Jin","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.exger.2026.113124_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091769","article-title":"Sphingolipids in human synovial fluid\u2014a lipidomic study","volume":"9","author":"Kosinska","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2026.113124_bb0085","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/bs.acc.2020.04.002","article-title":"Pathophysiological landscape of osteoarthritis","volume":"100","author":"Kulkarni","year":"2021","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.exger.2026.113124_bb0090","doi-asserted-by":"crossref","first-page":"1476853","DOI":"10.3389\/fmed.2024.1476853","article-title":"Global, regional, and national burdens of osteoarthritis from 1990 to 2021: findings from the 2021 global burden of disease study","volume":"11","author":"Li","year":"2024","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.exger.2026.113124_bb0095","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s13018-025-05719-x","article-title":"MiR-103-3p regulates chondrocyte autophagy, apoptosis, and ECM degradation through the PI3K\/Akt\/mTOR pathway by targeting CPEB3","volume":"20","author":"Li","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.exger.2026.113124_bb0100","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.3390\/cells12182209","article-title":"Diverse roles of protein palmitoylation in cancer progression, immunity, stemness, and beyond","volume":"12","author":"Li","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.exger.2026.113124_bb0105","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13578-023-01189-y","article-title":"Abnormal protein post-translational modifications induces aggregation and abnormal deposition of protein, mediating neurodegenerative diseases","volume":"14","author":"Li","year":"2024","journal-title":"Cell Biosci."},{"key":"10.1016\/j.exger.2026.113124_bb0110","doi-asserted-by":"crossref","first-page":"24858","DOI":"10.1038\/s41598-025-09441-w","article-title":"KIAA1429 promotes non-small-cell lung cancer cell proliferation through the TRERNA1\/HOXA6 axis","volume":"15","author":"Li","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2026.113124_bb0115","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrm2084","article-title":"Palmitoylation: policing protein stability and traffic","volume":"8","author":"Linder","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.exger.2026.113124_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/cells11213430","article-title":"Identification of SLC3A2 as a potential therapeutic target of osteoarthritis involved in ferroptosis by integrating bioinformatics, clinical factors and experiments","volume":"11","author":"Liu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.exger.2026.113124_bb0125","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/art.43164","article-title":"Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation","volume":"77","author":"Liu","year":"2025","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.exger.2026.113124_bb0130","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.7150\/ijbs.72244","article-title":"Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy","volume":"18","author":"Liu","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.exger.2026.113124_bb0135","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000041335","article-title":"Recent advances in osteoarthritis research: a review of treatment strategies, mechanistic insights, and acupuncture","volume":"104","author":"Lou","year":"2025","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.exger.2026.113124_bb0140","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1186\/s13018-025-05785-1","article-title":"Quercetin-primed MSC exosomes synergistically attenuate osteoarthritis progression","volume":"20","author":"Lu","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.exger.2026.113124_bb0145","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/00002826-198503000-00009","article-title":"Qualitative assessment of Parkinson\u2019s disease: study of reliability and data reduction with an abbreviated Columbia Scale","volume":"8","author":"Montgomery","year":"1985","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.exger.2026.113124_bb0150","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2402604121","article-title":"Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits in an experimental model of Alzheimer\u2019s disease","volume":"121","author":"Natale","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.exger.2026.113124_bb0155","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1186\/s12885-025-13690-3","article-title":"Causality of blood metabolites on hepatocellular carcinoma and cholangiocarcinoma: a metabolome-wide Mendelian randomization study","volume":"25","author":"Ning","year":"2025","journal-title":"BMC Cancer"},{"key":"10.1016\/j.exger.2026.113124_bb0160","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1097\/j.pain.0000000000002163","article-title":"Sphingomyelin is involved in multisite musculoskeletal pain: evidence from metabolomic analysis in 2 independent cohorts","volume":"162","author":"Pan","year":"2021","journal-title":"Pain"},{"key":"10.1016\/j.exger.2026.113124_bb0165","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s11427-021-2048-2","article-title":"Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth","volume":"65","author":"Pei","year":"2022","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.exger.2026.113124_bb0170","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jare.2025.01.053","article-title":"Advances in the pathology and treatment of osteoarthritis","volume":"78","author":"Peng","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.exger.2026.113124_bb0175","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s11306-020-01652-8","article-title":"Lipidomic identification of plasma lipids associated with pain behaviour and pathology in a mouse model of osteoarthritis","volume":"16","author":"Pousinis","year":"2020","journal-title":"Metabolomics"},{"issue":"2020","key":"10.1016\/j.exger.2026.113124_bb0180","article-title":"Protein palmitoylation: biological functions, disease, and therapeutic targets","volume":"6","author":"Qian","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.exger.2026.113124_bb0185","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.7150\/ijbs.64046","article-title":"Lipid-induced S-palmitoylation as a vital regulator of cell signaling and disease development","volume":"17","author":"Qu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.exger.2026.113124_bb0190","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1042\/BST20160233","article-title":"Palmitoylation of proteins in cancer","volume":"45","author":"Resh","year":"2017","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.exger.2026.113124_bb0195","article-title":"Role of s-palmitoylation by ZDHHC13 in mitochondrial function and metabolism in liver","volume":"7","author":"Shen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2026.113124_bb0200","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1007\/s43032-021-00776-z","article-title":"Mendelian randomization analysis identified potential genes pleiotropically associated with polycystic ovary syndrome","volume":"29","author":"Sun","year":"2022","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.exger.2026.113124_bb0205","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s10194-024-01828-w","article-title":"Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine","volume":"25","author":"Sun","year":"2024","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.exger.2026.113124_bb0210","doi-asserted-by":"crossref","first-page":"10047","DOI":"10.1074\/jbc.M611249200","article-title":"Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization","volume":"282","author":"Tani","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2026.113124_bb0215","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3390\/metabo10080323","article-title":"Metabolomic signature of amino acids, biogenic amines and lipids in blood serum of patients with severe osteoarthritis","volume":"10","author":"Tootsi","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.exger.2026.113124_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115695","article-title":"Palmitoylation of solute carriers","volume":"215","author":"Villanueva","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.exger.2026.113124_bb0225","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"V\u00f5sa","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.exger.2026.113124_bb0230","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.molcel.2022.12.002","article-title":"Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy","volume":"83","author":"Wang","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.exger.2026.113124_bb0235","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.joca.2019.12.007","article-title":"The role of macrophages in osteoarthritis and cartilage repair","volume":"28","author":"Wu","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.exger.2026.113124_bb0240","doi-asserted-by":"crossref","first-page":"8305","DOI":"10.1038\/s41598-025-93124-z","article-title":"Osteoarthritis burden and inequality from 1990 to 2021: a systematic analysis for the global burden of disease study 2021","volume":"15","author":"Wu","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2026.113124_bb0245","doi-asserted-by":"crossref","first-page":"eade5584","DOI":"10.1126\/sciadv.ade5584","article-title":"Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis","volume":"9","author":"Wu","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.exger.2026.113124_bb0250","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41398-021-01348-0","article-title":"Mendelian randomization integrating GWAS and eQTL data revealed genes pleiotropically associated with major depressive disorder","volume":"11","author":"Yang","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.exger.2026.113124_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114070","article-title":"NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation","volume":"43","author":"Yu","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.exger.2026.113124_bb0260","article-title":"Pathophysiological perspective of osteoarthritis","volume":"56","author":"Yunus","year":"2020","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.exger.2026.113124_bb0265","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1186\/s12951-024-02965-9","article-title":"Targeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration","volume":"22","author":"Zhao","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.exger.2026.113124_bb0270","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1038\/s42255-024-01085-w","article-title":"S-acylation of ATGL is required for lipid droplet homoeostasis in hepatocytes","volume":"6","author":"Zheng","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.exger.2026.113124_bb0275","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/1878-0261.13308","article-title":"Protein palmitoylation in cancer: molecular functions and therapeutic potential","volume":"17","author":"Zhou","year":"2023","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.exger.2026.113124_bb0280","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13018-025-05525-5","article-title":"Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-\u03baB and MAPK signaling pathways","volume":"20","author":"Zhu","year":"2025","journal-title":"J. Orthop. Surg. Res."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526001038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526001038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:34:41Z","timestamp":1777541681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556526001038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":56,"alternative-id":["S0531556526001038"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2026.113124","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ZDHHC14 Attenuates Osteoarthritis Progression through Metabolic Pathways: Multi-omics Fusion and Functional Validation","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2026.113124","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113124"}}