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(Camb.)"},{"key":"10.1016\/j.exger.2026.113177_bb2530","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41467-017-02533-w","article-title":"Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures","volume":"9","author":"Miranda","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2026.113177_bb0535","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuron.2014.12.032","article-title":"Blood-brain barrier breakdown in the aging human hippocampus","volume":"85","author":"Montagne","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.exger.2026.113177_bb0540","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1084\/jem.20171406","article-title":"Alzheimer\u2019s disease: a matter of blood\u2013brain barrier dysfunction?","volume":"214","author":"Montagne","year":"2017","journal-title":"J. Exp. 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Lett."},{"key":"10.1016\/j.exger.2026.113177_bb2725","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3390\/cells8020194","article-title":"Anti-inflammatory effect of sulforaphane on LPS-activated microglia potentially through JNK\/AP-1\/NF-\u03baB inhibition and Nrf2\/HO-1 activation","volume":"8","author":"Subedi","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.exger.2026.113177_bb0730","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbih.2020.100111","article-title":"Stress and brain immunity: Microglial homeostasis through hypothalamus-pituitary-adrenal gland axis and sympathetic nervous system","volume":"7","author":"Sugama","year":"2020","journal-title":"Brain, Behavior, & Immunity - Health"},{"key":"10.1016\/j.exger.2026.113177_bb0735","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s41580-024-00738-8","article-title":"SenNet recommendations for detecting senescent cells in different tissues","volume":"25","author":"Suryadevara","year":"2024","journal-title":"Nat. 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Rep."},{"key":"10.1016\/j.exger.2026.113177_bb0765","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.nlm.2017.05.005","article-title":"Inactivation of basolateral amygdala prevents chronic immobilization stress-induced memory impairment and associated changes in corticosterone levels","volume":"142","author":"Tripathi","year":"2017","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.exger.2026.113177_bb0770","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.pnpbp.2018.07.016","article-title":"Basolateral amygdalar inactivation blocks chronic stress-induced lamina-specific reduction in prefrontal cortex volume and associated anxiety-like behavior","volume":"88","author":"Tripathi","year":"2019","journal-title":"Prog. Neuro-Psychopharmacol. Biol. 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