{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T14:04:09Z","timestamp":1785074649321,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.exger.2026.113230","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:28:55Z","timestamp":1783380535000},"page":"113230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Astragalus membranaceus and Salvia miltiorrhiza injections confer cardioprotection via SERCA\/SIRT1\u2013mediated Ca2+ regulation"],"prefix":"10.1016","volume":"222","author":[{"given":"Shengyao","family":"Xiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingkun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2026.113230_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122846","article-title":"Altered dynamics of calcium fluxes and mitochondrial metabolism in platelet activation-related disease and aging","volume":"351","author":"Arauna","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.exger.2026.113230_bb0010","article-title":"SIRT1 and thrombosis","volume":"10","author":"Bettiol","year":"2023","journal-title":"Front. Mol. Biosci."},{"issue":"12","key":"10.1016\/j.exger.2026.113230_bb0015","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1177\/2047487315600169","article-title":"Impaired vascular function and repair in patients with premature coronary artery disease","volume":"22","author":"Brittan","year":"2015","journal-title":"Eur. J. Prev. Cardiol."},{"issue":"1","key":"10.1016\/j.exger.2026.113230_bb0020","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1038\/s41598-021-82531-7","article-title":"Macrophages enhance lipopolysaccharide induced apoptosis via Ang1 and NF-\u03baB pathways in human umbilical vein endothelial cells","volume":"11","author":"Cai","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2026.113230_bb0025","article-title":"Protocatechualdehyde rescues oxygen-glucose deprivation\/Reoxygenation-induced endothelial cells injury by inducing autophagy and inhibiting apoptosis via regulation of SIRT1","volume":"13","author":"Cao","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.exger.2026.113230_bb0030","first-page":"53","article-title":"Study on immunomodulatory effect of Belamcandae Rhizoma and Ephedrae Herba on bronchitis based on network pharmacology and experimental verification","volume":"10","author":"Chen","year":"2022","journal-title":"Hans J. Med. Chem."},{"key":"10.1016\/j.exger.2026.113230_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104755","article-title":"A review of pharmacological and pharmacokinetic properties of stachydrine","volume":"155","author":"Cheng","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.exger.2026.113230_bb0040","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.atherosclerosis.2020.12.017","article-title":"The multifaceted contribution of platelets in the emergence and aftermath of acute cardiovascular events","volume":"319","author":"Coenen","year":"2021","journal-title":"Atherosclerosis"},{"issue":"14","key":"10.1016\/j.exger.2026.113230_bb0045","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/eurheartj\/ehaa575","article-title":"2020 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"42","author":"Collet","year":"2021","journal-title":"Eur. Heart J."},{"issue":"6","key":"10.1016\/j.exger.2026.113230_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/biom15060892","article-title":"Calcium signaling dynamics in vascular cells and their dysregulation in vascular disease","volume":"15","author":"Dai","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.exger.2026.113230_bb0055","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbrc.2021.01.086","article-title":"Rosmarinic acid ameliorated cardiac dysfunction and mitochondrial injury in diabetic cardiomyopathy mice via activation of the SIRT1\/PGC-1\u03b1 pathway","volume":"546","author":"Diao","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.exger.2026.113230_bb0060","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1038\/s41598-017-02360-5","article-title":"Astragaloside IV alleviates heart failure via activating PPAR\u03b1 to switch glycolysis to fatty acid \u03b2-oxidation","volume":"7","author":"Dong","year":"2017","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.exger.2026.113230_bb0065","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1182\/blood-2015-10-678383","article-title":"Full activation of mouse platelets requires ADP secretion regulated by SERCA3 ATPase-dependent calcium stores","volume":"128","author":"Ela\u00efb","year":"2016","journal-title":"Blood"},{"issue":"Pt 1","key":"10.1016\/j.exger.2026.113230_bb0070","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/bj2860135","article-title":"Human platelets express the SERCA2-b isoform of Ca(2+)-transport ATPase","volume":"286","author":"Enouf","year":"1992","journal-title":"Biochem. J."},{"issue":"18","key":"10.1016\/j.exger.2026.113230_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184525","article-title":"Calcium mobilization in endothelial cell functions","volume":"20","author":"Filippini","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2026.113230_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.01260","article-title":"Comparative efficacy of Danshen class injections for treating acute coronary syndrome: a multidimensional Bayesian network meta-analysis of randomized controlled trials","volume":"11","author":"Guo","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exger.2026.113230_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114929","article-title":"Buyang Huanwu decoction promotes angiogenesis in myocardial infarction through suppression of PTEN and activation of the PI3K\/Akt signalling pathway","volume":"287","author":"Han","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.exger.2026.113230_bb0090","doi-asserted-by":"crossref","first-page":"C104","DOI":"10.1152\/ajpcell.00313.2018","article-title":"Blocking the REDD1\/TXNIP axis ameliorates LPS-induced vascular endothelial cell injury through repressing oxidative stress and apoptosis","volume":"316","author":"Hou","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.exger.2026.113230_bb0095","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6685307","article-title":"Exosomes from LPS-stimulated hDPSCs activated the angiogenic potential of HUVECs in vitro","volume":"2021","author":"Huang","year":"2021","journal-title":"Stem Cells Int."},{"issue":"9","key":"10.1016\/j.exger.2026.113230_bb0100","doi-asserted-by":"crossref","first-page":"970","DOI":"10.5551\/jat.4333","article-title":"Resveratrol protects human endothelium from H(2)O(2)-induced oxidative stress and senescence via SirT1 activation","volume":"17","author":"Kao","year":"2010","journal-title":"J. Atheroscler. Thromb."},{"issue":"3","key":"10.1016\/j.exger.2026.113230_bb0105","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur. Heart J."},{"issue":"1\u20133","key":"10.1016\/j.exger.2026.113230_bb0110","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ejphar.2006.09.030","article-title":"Salvianolic acid B, an aqueous component of danshen (Salvia miltiorrhiza), relaxes rat coronary artery by inhibition of calcium channels","volume":"553","author":"Lam","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.exger.2026.113230_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101659","article-title":"SERCA overexpression reduces reperfusion-mediated cardiac microvascular damage through inhibition of the calcium\/MCU\/mPTP\/necroptosis signaling pathways","volume":"36","author":"Li","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.exger.2026.113230_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114062","article-title":"Integrating network pharmacology and experimental evidence to decipher the cardioprotective mechanism of Yiqihuoxue decoction in rats after myocardial infarction","volume":"279","author":"Li","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.exger.2026.113230_bb0125","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jare.2021.01.009","article-title":"Naringenin ameliorates homocysteine induced endothelial damage via the AMPK\u03b1\/Sirt1 pathway","volume":"34","author":"Li","year":"2021","journal-title":"J. Adv. Res."},{"issue":"9","key":"10.1016\/j.exger.2026.113230_bb0130","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/s12012-022-09760-8","article-title":"Salvianolic acid B alleviates myocardial ischemia injury by suppressing NLRP3 Inflammasome activation via SIRT1-AMPK-PGC-1\u03b1 signaling pathway","volume":"22","author":"Li","year":"2022","journal-title":"Cardiovasc. Toxicol."},{"issue":"10","key":"10.1016\/j.exger.2026.113230_bb0135","first-page":"2062","article-title":"Salvianolic acid B promotes mitochondrial homeostasis and improves cardiac function in mice with ischemia-reperfusion injury by inhibiting Sirt1 protein degradation","volume":"45","author":"Li","year":"2025","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"issue":"21","key":"10.1016\/j.exger.2026.113230_bb0140","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1056\/NEJMra1216063","article-title":"Mechanisms of acute coronary syndromes and their implications for therapy","volume":"368","author":"Libby","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"20","key":"10.1016\/j.exger.2026.113230_bb0145","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1182\/blood-2010-01-261206","article-title":"Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis","volume":"116","author":"Lievens","year":"2010","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.exger.2026.113230_bb0150","first-page":"429","article-title":"Angiotensin II inhibits the protein expression of ZO-1 in vascular endothelial cells by downregulating VE-cadherin","volume":"18","author":"Liu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.exger.2026.113230_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119607","article-title":"Astragalus injection inhibits the growth of osteosarcoma by activating cytotoxic T lymphocyte and targeting CTSL","volume":"345","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.exger.2026.113230_bb0160","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jep.2013.07.036","article-title":"Extracts from Astragalus membranaceus limit myocardial cell death and improve cardiac function in a rat model of myocardial ischemia","volume":"149","author":"Ma","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.exger.2026.113230_bb0165","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ceca.2010.11.010","article-title":"The mechanism of agonist induced Ca2+ signalling in intact endothelial cells studied confocally in in situ arteries","volume":"49","author":"Mumtaz","year":"2011","journal-title":"Cell Calcium"},{"issue":"1","key":"10.1016\/j.exger.2026.113230_bb0170","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12272-008-1119-4","article-title":"15,16-dihydrotanshinone I, a major component from Salvia miltiorrhiza Bunge (Dansham), inhibits rabbit platelet aggregation by suppressing intracellular calcium mobilization","volume":"31","author":"Park","year":"2008","journal-title":"Arch. Pharm. Res."},{"issue":"05","key":"10.1016\/j.exger.2026.113230_bb0175","first-page":"780","article-title":"Study on 1H NMR fingerprint of Astragalus injection","volume":"51","author":"Qu","year":"2016","journal-title":"Acta Pharm. Sin."},{"issue":"6","key":"10.1016\/j.exger.2026.113230_bb0180","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1039\/D3LC00824J","article-title":"Immune cells and inflammatory mediators cause endothelial dysfunction in a vascular microphysiological system","volume":"24","author":"Rengarajan","year":"2024","journal-title":"Lab Chip"},{"key":"10.1016\/j.exger.2026.113230_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2012.00040","article-title":"Interactomic and pharmacological insights on human sirt-1","volume":"3","author":"Sharma","year":"2012","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.exger.2026.113230_bb0190","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1055\/s-2007-969025","article-title":"Platelets and endothelial cells","volume":"33","author":"Siegel-Axel","year":"2007","journal-title":"Semin. Thromb. Hemost."},{"issue":"4","key":"10.1016\/j.exger.2026.113230_bb0195","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s11655-019-3165-9","article-title":"Danshensu ameliorates cardiac Ischaemia reperfusion injury through activating Sirt1\/FoxO1\/Rab7 signal pathway","volume":"26","author":"Sun","year":"2020","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.exger.2026.113230_bb0200","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bios.2015.04.004","article-title":"Novel S-MSPQC cell sensor for real time monitoring the injury of endothelial cell by LPS and assessing the drug effect on this injury","volume":"71","author":"Tong","year":"2015","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.exger.2026.113230_bb0205","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0008-6363(00)00172-3","article-title":"Calcium signalling in endothelial cells","volume":"48","author":"Tran","year":"2000","journal-title":"Cardiovasc. Res."},{"issue":"7","key":"10.1016\/j.exger.2026.113230_bb0210","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1538-7836.2009.03455.x","article-title":"Calcium signaling in platelets","volume":"7","author":"Varga-Szabo","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.exger.2026.113230_bb0215","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jep.2017.04.027","article-title":"Danshen injection prevents heart failure by attenuating post-infarct remodeling","volume":"205","author":"Wang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.exger.2026.113230_bb0220","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ctim.2019.01.019","article-title":"Comparative efficacy of Chinese herbal injections for angina pectoris: a Bayesian network meta-analysis of randomized controlled trials","volume":"43","author":"Wang","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"10.1016\/j.exger.2026.113230_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116994","article-title":"SGLT2 inhibitor Dapagliflozin alleviates cardiac dysfunction and fibrosis after myocardial infarction by activating PXR and promoting angiogenesis","volume":"177","author":"Wang","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.exger.2026.113230_bb0230","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000121335","article-title":"Astragaloside IV improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum Ca-ATPase","volume":"81","author":"Xu","year":"2008","journal-title":"Pharmacology"},{"key":"10.1016\/j.exger.2026.113230_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154271","article-title":"Danshensu prevents thrombosis by inhibiting platelet activation via SIRT1\/ROS\/mtDNA pathways without increasing bleeding risk","volume":"104","author":"Xue","year":"2022","journal-title":"Phytomedicine"},{"issue":"12","key":"10.1016\/j.exger.2026.113230_bb0245","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.1111\/jcmm.15327","article-title":"The effect of Sirt1 deficiency on Ca(2+) and Na(+) regulation in mouse ventricular myocytes","volume":"24","author":"Yang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"7","key":"10.1016\/j.exger.2026.113230_bb0250","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jcmg.2015.08.019","article-title":"Relationship between platelet reactivity and culprit lesion morphology: an assessment from the ADAPT-DES intravascular ultrasound substudy","volume":"9","author":"Yun","year":"2016","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"7","key":"10.1016\/j.exger.2026.113230_bb0255","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1056\/NEJMoa010746","article-title":"Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation","volume":"345","author":"Yusuf","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exger.2026.113230_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155034","article-title":"Protective effect of Xinmai\u2019an tablets via mediation of the AMPK\/SIRT1\/PGC-1\u03b1 signaling pathway on myocardial ischemia-reperfusion injury in rats","volume":"120","author":"Zhang","year":"2023","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.exger.2026.113230_bb0275","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3233\/CH-190706","article-title":"Chronic intermittent hypoxia vs chronic continuous hypoxia: effects on vascular endothelial function and myocardial contractility","volume":"74","author":"Zhu","year":"2020","journal-title":"Clin. Hemorheol. Microcirc."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:52:03Z","timestamp":1785073923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556526002093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":52,"alternative-id":["S0531556526002093"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2026.113230","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astragalus membranaceus and Salvia miltiorrhiza injections confer cardioprotection via SERCA\/SIRT1\u2013mediated Ca2+ regulation","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2026.113230","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113230"}}