{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:39:38Z","timestamp":1792431578514,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.exger.2026.113273","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T15:07:34Z","timestamp":1786201654000},"page":"113273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Sex-specific associations of serum estradiol and the testosterone-to-estradiol ratio with handgrip strength and appendicular lean soft tissue in US adults aged 40\u201359\u00a0years"],"prefix":"10.1016","volume":"224","author":[{"given":"Konstantinos","family":"Prokopidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Boccardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cacciatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"McLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Piaggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Tange","family":"Kristensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Schl\u00f6gl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2026.113273_bb0005","doi-asserted-by":"crossref","DOI":"10.5014\/ajot.2019.029538","article-title":"Handgrip strength: a comparison of values obtained from the NHANES and NIH toolbox studies","volume":"73","author":"Bohannon","year":"2019","journal-title":"Am. J. Occup. Ther."},{"key":"10.1016\/j.exger.2026.113273_bb0010","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1097\/GME.0000000000001137","article-title":"Physical performance in relation to menopause status and physical activity","volume":"25","author":"Bondarev","year":"2018","journal-title":"Menopause"},{"key":"10.1016\/j.exger.2026.113273_bb0015","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1093\/gerona\/glaa292","article-title":"Physical performance during the menopausal transition and the role of physical activity","volume":"76","author":"Bondarev","year":"2021","journal-title":"J. Gerontol. Ser. A."},{"key":"10.1016\/j.exger.2026.113273_bb0020","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1113\/JP277270","article-title":"Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance","volume":"597","author":"Camporez","year":"2019","journal-title":"J. Physiol."},{"key":"10.1016\/j.exger.2026.113273_bb0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1530\/JOE-14-0008","article-title":"Estradiol stimulates mitochondrial biogenesis and adiponectin expression in skeletal muscle","volume":"221","author":"Capllonch-Amer","year":"2014","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.exger.2026.113273_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2014.00192","article-title":"Sarcopenia and physical frailty: two sides of the same coin","volume":"6","author":"Cesari","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.exger.2026.113273_bb0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bone.2019.03.033","article-title":"Aging of the musculoskeletal system: how the loss of estrogen impacts muscle strength","volume":"123","author":"Collins","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.exger.2026.113273_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.13786","article-title":"Associations between female sex hormones and skeletal muscle ageing: the Baltimore longitudinal study of aging","volume":"16","author":"Critchlow","year":"2025","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.exger.2026.113273_bb0045","article-title":"Profiling muscle mass, function and molecular signalling in females aged 18\u201380 years and their associations with sex hormones","author":"Critchlow","year":"2025","journal-title":"J. Physiol."},{"key":"10.1016\/j.exger.2026.113273_bb0050","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"key":"10.1016\/j.exger.2026.113273_bb0055","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/japplphysiol.00404.2009","article-title":"Hormone therapy attenuates exercise-induced skeletal muscle damage in postmenopausal women","volume":"107","author":"Dieli-Conwright","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.exger.2026.113273_bb0060","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jsbmb.2009.10.015","article-title":"Aromatase and regulating the estrogen: androgen ratio in the prostate gland","volume":"118","author":"Ellem","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.exger.2026.113273_bb0065","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.exger.2026.113273_bb0070","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1210\/jc.2012-2582","article-title":"Sex steroid hormone levels and body composition in men","volume":"98","author":"Gates","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.exger.2026.113273_bb0075","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1080\/13697137.2024.2310521","article-title":"Resistance training effects on healthy postmenopausal women: a systematic review with meta-analysis","volume":"27","author":"Gonz\u00e1lez-G\u00e1lvez","year":"2024","journal-title":"Climacteric"},{"key":"10.1016\/j.exger.2026.113273_bb0080","doi-asserted-by":"crossref","DOI":"10.5694\/mja2.50466","article-title":"Differences in frailty in older men and women","volume":"212","author":"Gordon","year":"2020","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.exger.2026.113273_bb0085","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1042\/CS20230319","article-title":"Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men","volume":"137","author":"Granic","year":"2023","journal-title":"Clin. Sci."},{"key":"10.1016\/j.exger.2026.113273_bb0090","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1249\/JES.0000000000000026","article-title":"Influence of sex and estrogen on musculotendinous protein turnover at rest and after exercise","volume":"42","author":"Hansen","year":"2014","journal-title":"Exerc. Sport Sci. Rev."},{"key":"10.1016\/j.exger.2026.113273_bb0095","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.afos.2016.06.002","article-title":"The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia","volume":"2","author":"Kim","year":"2016","journal-title":"Osteoporos. Sarcopenia."},{"key":"10.1016\/j.exger.2026.113273_bb0100","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1113\/EP088827","article-title":"Oestradiol affects skeletal muscle mass, strength and satellite cells following repeated injuries","volume":"105","author":"Larson","year":"2020","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.exger.2026.113273_bb0105","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.maturitas.2011.01.014","article-title":"Menopause and sarcopenia: a potential role for sex hormones","volume":"68","author":"Messier","year":"2011","journal-title":"Maturitas"},{"key":"10.1016\/j.exger.2026.113273_bb0110","article-title":"The contribution of age and sex hormones to female neuromuscular function across the adult lifespan","author":"O\u2019Bryan","year":"2025","journal-title":"J. Physiol."},{"key":"10.1016\/j.exger.2026.113273_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.maturitas.2025.108609","article-title":"Systematic review on the relationship between menopausal hormone replacement therapy, sarcopenia, and sarcopenia-related parameters","volume":"199","author":"\u00d6sterdahl","year":"2025","journal-title":"Maturitas"},{"key":"10.1016\/j.exger.2026.113273_bb0120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41586-018-0457-8","article-title":"Facing up to the global challenges of ageing","volume":"561","author":"Partridge","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.exger.2026.113273_bb0125","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1007\/s40279-022-01733-9","article-title":"Mechanisms of estrogen influence on skeletal muscle: mass, regeneration, and mitochondrial function","volume":"52","author":"Pellegrino","year":"2022","journal-title":"Sports Med."},{"key":"10.1016\/j.exger.2026.113273_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajcnut.2025.05.022","article-title":"Methodological standards for body composition\u2014an expert-endorsed guide for research and clinical applications: levels, models, and terminology","author":"Prado","year":"2025","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.exger.2026.113273_bb0135","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/gerona\/62.3.330","article-title":"Loss of appendicular muscle mass and loss of muscle strength in young postmenopausal women","volume":"62","author":"Rolland","year":"2007","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.exger.2026.113273_bb0140","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.tem.2015.05.001","article-title":"Novel insights in SHBG regulation and clinical implications","volume":"26","author":"Sim\u00f3","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.exger.2026.113273_bb0145","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/jcsm.12547","article-title":"Muscle and bone mass in middle-aged women: role of menopausal status and physical activity","volume":"11","author":"Sipil\u00e4","year":"2020","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.exger.2026.113273_bb0150","series-title":"National Health and Nutrition Examination Survey, 2013\u20132014. Hyattsville: Centers for Disease Control and Prevention, US Department of Health and Human Services","author":"Statistics, N.C.f.H","year":"2013"},{"key":"10.1016\/j.exger.2026.113273_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.889923","article-title":"The regulation of adipose tissue health by estrogens","volume":"13","author":"Steiner","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.exger.2026.113273_bb0160","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S2213-8587(18)30026-3","article-title":"The physiology of endocrine systems with ageing","volume":"6","author":"van den Beld","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.exger.2026.113273_bb0165","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1530\/EJE-09-0696","article-title":"Serum estradiol is associated with lean mass in elderly Swedish men","volume":"162","author":"Vandenput","year":"2010","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.exger.2026.113273_bb0170","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1373\/clinchem.2015.245969","article-title":"Serum total testosterone concentrations in the US household population from the NHANES 2011\u20132012 study population","volume":"61","author":"Vesper","year":"2015","journal-title":"Clin. Chem."},{"key":"10.1016\/j.exger.2026.113273_bb0175","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jsbmb.2017.06.007","article-title":"Metabolism of sex steroids is influenced by acquired adiposity\u2014a study of young adult male monozygotic twin pairs","volume":"172","author":"Vihma","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.exger.2026.113273_bb0180","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"Von Elm","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2026.113273_bb0185","article-title":"Age-related changes in estradiol and longitudinal associations with fat mass in men","volume":"13","author":"Wu","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.exger.2026.113273_bb0190","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1136\/jech-2018-211258","article-title":"Gender-specific risk factors for incident sarcopenia: 8-year follow-up of the English longitudinal study of ageing","volume":"73","author":"Yang","year":"2019","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.exger.2026.113273_bb0195","first-page":"208","article-title":"The impact of lifestyle factors across the life course on sarcopenia and physical frailty","volume":"28","author":"Yang","year":"2025","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:44:09Z","timestamp":1792428249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556526002524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":39,"alternative-id":["S0531556526002524"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2026.113273","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-specific associations of serum estradiol and the testosterone-to-estradiol ratio with handgrip strength and appendicular lean soft tissue in US adults aged 40\u201359\u00a0years","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2026.113273","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113273"}}