{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:03:53Z","timestamp":1789549433584,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.exger.2026.113278","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:11:25Z","timestamp":1786547485000},"page":"113278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["PRMT6 drives hearing loss by promoting asymmetric arginine dimethylation-mediated FOXG1 degradation and suppressing mitophagy"],"prefix":"10.1016","volume":"223","author":[{"given":"Jin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2492-9537","authenticated-orcid":false,"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.exger.2026.113278_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/biology12091257","article-title":"Functional implications of protein arginine methyltransferases (PRMTs) in neurodegenerative diseases","volume":"12","author":"Angelopoulou","year":"2023","journal-title":"Biology"},{"issue":"8","key":"10.1016\/j.exger.2026.113278_bb0010","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a033217","article-title":"Age-related hearing loss","volume":"9","author":"Bowl","year":"2019","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"1","key":"10.1016\/j.exger.2026.113278_bb0015","article-title":"Urolithin A attenuates auditory cell senescence by activating mitophagy","volume":"12","author":"Cho","year":"2022","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.exger.2026.113278_bb0020","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1007\/s12035-019-01850-z","article-title":"Protein arginine methyltransferases in cardiovascular and neuronal function","volume":"57","author":"Couto","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.exger.2026.113278_bb0025","doi-asserted-by":"crossref","first-page":"9902","DOI":"10.1007\/s12035-025-04880-y","article-title":"Melatonin ameliorates senescence of mouse auditory cell line HEI-OC1 cells by suppressing NLRP3 inflammasome-mediated pyroptosis","volume":"62","author":"Ding","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.exger.2026.113278_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2025.105847","article-title":"Global trends and burden of age-related hearing loss: 32-year study","volume":"134","author":"Dong","year":"2025","journal-title":"Arch. Gerontol. Geriatr."},{"issue":"17","key":"10.1016\/j.exger.2026.113278_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179705","article-title":"The role of molecular and cellular aging pathways on age-related hearing loss","volume":"25","author":"Ege","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2026.113278_bb0040","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-1-4939-7698-0_9","article-title":"A method for in vivo induction and ultrastructural detection of mitophagy in sertoli cells","volume":"1748","author":"Eid","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"3","key":"10.1016\/j.exger.2026.113278_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/cells8030283","article-title":"Ethanol-induced mitochondrial damage in Sertoli cells is associated with Parkin overexpression and activation of mitophagy","volume":"8","author":"Eid","year":"2019","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.exger.2026.113278_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/biom13101537","article-title":"Comprehensive transcriptomic profiling of m6A modification in age-related hearing loss","volume":"13","author":"Feng","year":"2023","journal-title":"Biomolecules"},{"issue":"5","key":"10.1016\/j.exger.2026.113278_bb0055","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1074\/jbc.M108786200","article-title":"The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity","volume":"277","author":"Frankel","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.exger.2026.113278_bb0060","doi-asserted-by":"crossref","first-page":"133","DOI":"10.7150\/thno.37362","article-title":"Inhibition of protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death","volume":"10","author":"He","year":"2020","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.exger.2026.113278_bb0065","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.apsb.2021.11.002","article-title":"Inhibiting DNA methylation alleviates cisplatin-induced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis via the LRP1-PI3K\/AKT pathway","volume":"12","author":"He","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"12","key":"10.1016\/j.exger.2026.113278_bb0070","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1080\/15548627.2021.1916194","article-title":"FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway","volume":"17","author":"He","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.exger.2026.113278_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116916","article-title":"Vascular cellular senescence in human atherosclerosis: the critical modulating roles of CDKN2A and CDK4\/6 signaling pathways","volume":"237","author":"Hu","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.exger.2026.113278_bb0080","doi-asserted-by":"crossref","DOI":"10.1186\/s42649-019-0012-6","article-title":"The autophagy research in electron microscopy","volume":"49","author":"Jung","year":"2019","journal-title":"Appl. Microsc."},{"key":"10.1016\/j.exger.2026.113278_bb0085","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.heares.2016.02.019","article-title":"HEI-OC1 cells as a model for investigating drug cytotoxicity","volume":"335","author":"Kalinec","year":"2016","journal-title":"Hear. Res."},{"issue":"9","key":"10.1016\/j.exger.2026.113278_bb0090","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1002\/jnr.24439","article-title":"Pathology and mechanisms of cochlear aging","volume":"98","author":"Keithley","year":"2020","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.exger.2026.113278_bb0095","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-024-00740-w","article-title":"Astrocytic autophagy plasticity modulates Abeta clearance and cognitive function in Alzheimer\u2019s disease","volume":"19","author":"Kim","year":"2024","journal-title":"Mol. Neurodegener."},{"issue":"5","key":"10.1016\/j.exger.2026.113278_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-04906-6","article-title":"Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.exger.2026.113278_bb0105","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1016\/j.ymthe.2025.03.046","article-title":"TNFAIP8L2 maintains hair cell function and regulates age-related hearing loss via mTORC1 signaling","volume":"33","author":"Li","year":"2025","journal-title":"Mol. Ther."},{"issue":"3","key":"10.1016\/j.exger.2026.113278_bb0110","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00011-022-01541-x","article-title":"Inhibition of PRMT6 reduces neomycin-induced inner ear hair cell injury through the restraint of FoxG1 arginine methylation","volume":"71","author":"Li","year":"2022","journal-title":"Inflamm. Res."},{"issue":"4","key":"10.1016\/j.exger.2026.113278_bb0115","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"4","key":"10.1016\/j.exger.2026.113278_bb0120","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1097\/MAO.0000000000001716","article-title":"Serum methylarginines and hearing loss in a population-based cohort of older adults","volume":"39","author":"McEvoy","year":"2018","journal-title":"Otol. Neurotol."},{"issue":"1","key":"10.1016\/j.exger.2026.113278_bb0125","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2025.2458942","article-title":"Oxidative stress and reactive oxygen species in otorhinolaryngological diseases: insights from pathophysiology to targeted antioxidant therapies","volume":"30","author":"Meng","year":"2025","journal-title":"Redox Rep."},{"issue":"13","key":"10.1016\/j.exger.2026.113278_bb0130","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158447","article-title":"Mitochondrial dysfunction in cell senescence and aging","volume":"132","author":"Miwa","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exger.2026.113278_bb0135","article-title":"Whole mount dissection and immunofluorescence of the adult mouse cochlea","volume":"107","author":"Montgomery","year":"2016","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.exger.2026.113278_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1064579","article-title":"Role and mechanism of FOXG1-related epigenetic modifications in cisplatin-induced hair cell damage","volume":"16","author":"Mu","year":"2023","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.exger.2026.113278_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.110946","article-title":"Reduced mitophagy in the cochlea of aged C57BL\/6J mice","volume":"137","author":"Oh","year":"2020","journal-title":"Exp. Gerontol."},{"issue":"8","key":"10.1016\/j.exger.2026.113278_bb0150","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1111\/cas.16242","article-title":"FoxG1\/BNIP3 axis promotes mitophagy and blunts cisplatin resistance in osteosarcoma","volume":"115","author":"Pan","year":"2024","journal-title":"Cancer Sci."},{"key":"10.1016\/j.exger.2026.113278_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.680856","article-title":"Age-related changes in the cochlea and vestibule: shared patterns and processes","volume":"15","author":"Paplou","year":"2021","journal-title":"Front. Neurosci."},{"issue":"5","key":"10.1016\/j.exger.2026.113278_bb0160","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.molcel.2019.09.009","article-title":"AUTACs: cargo-specific degraders using selective autophagy","volume":"76","author":"Takahashi","year":"2019","journal-title":"Mol. Cell"},{"issue":"8","key":"10.1016\/j.exger.2026.113278_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25084146","article-title":"Role of oxidative stress in sensorineural hearing loss","volume":"25","author":"Teraoka","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"17","key":"10.1016\/j.exger.2026.113278_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/cells13171433","article-title":"Metformin alleviates inflammation and induces mitophagy in human retinal pigment epithelium cells suffering from mitochondrial damage","volume":"13","author":"Toppila","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.exger.2026.113278_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1345536","article-title":"Ototoxicity of polystyrene nanoplastics in mice, HEI-OC1 cells and zebrafish","volume":"17","author":"Wu","year":"2024","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.exger.2026.113278_bb0180","doi-asserted-by":"crossref","DOI":"10.1007\/s10571-025-01546-0","article-title":"Protein arginine methyltransferases from regulatory function to clinical implication in central nervous system","volume":"45","author":"Xie","year":"2025","journal-title":"Cell. Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.exger.2026.113278_bb0185","doi-asserted-by":"crossref","first-page":"6913","DOI":"10.1007\/s12035-024-04470-4","article-title":"The role and research progress of mitochondria in sensorineural hearing loss","volume":"62","author":"Xu","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.exger.2026.113278_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1253574","article-title":"Progress on mechanisms of age-related hearing loss","volume":"17","author":"Yang","year":"2023","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.exger.2026.113278_bb0195","doi-asserted-by":"crossref","DOI":"10.1007\/s10571-024-01467-4","article-title":"FoxG1 as a potential therapeutic target for Alzheimer\u2019s disease: modulating NLRP3 inflammasome via AMPK\/mTOR autophagy pathway","volume":"44","author":"Yun","year":"2024","journal-title":"Cell. Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.exger.2026.113278_bb0200","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14091","article-title":"Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics","volume":"23","author":"Zhang","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2026.113278_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2024.111964","article-title":"Sestrin2 plays a protective role in age-related hearing loss by inhibiting NLRP3-inflammasome activity","volume":"221","author":"Zheng","year":"2024","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.exger.2026.113278_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.1001760","article-title":"Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss","volume":"10","author":"Zou","year":"2022","journal-title":"Front. Public Health"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:10:25Z","timestamp":1789546225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556526002573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":42,"alternative-id":["S0531556526002573"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2026.113278","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PRMT6 drives hearing loss by promoting asymmetric arginine dimethylation-mediated FOXG1 degradation and suppressing mitophagy","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2026.113278","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113278"}}