{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:05:15Z","timestamp":1789549515269,"version":"build-2803163510"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030098"],"award-info":[{"award-number":["82030098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.exger.2026.113279","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:31:36Z","timestamp":1786548696000},"page":"113279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Age-associated inflammation is accompanied by JAK1\u2013STAT1 signaling activation, megakaryocyte apoptosis, and enhanced thrombopoiesis in naturally aged mice"],"prefix":"10.1016","volume":"223","author":[{"given":"Yixuan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangfeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Heng","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyu","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.exger.2026.113279_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12030548","article-title":"Oxidative stress and inflammation in acute and chronic lung injuries","volume":"12","author":"Bezerra","year":"2023","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s42003-018-0259-4","article-title":"Robustness and information transfer within IL-6-induced JAK\/STAT signalling","volume":"2","author":"Billing","year":"2019","journal-title":"Commun. Biol."},{"issue":"4","key":"10.1016\/j.exger.2026.113279_bb0015","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1182\/blood.2023023105","article-title":"IL-1 in aging and pathologies of hematopoietic stem cells","volume":"144","author":"Caiado","year":"2024","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.exger.2026.113279_bb0020","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.cellsig.2005.09.010","article-title":"Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes","volume":"18","author":"Chanprasert","year":"2006","journal-title":"Cell. Signal."},{"issue":"11","key":"10.1016\/j.exger.2026.113279_bb0025","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.15252\/embr.201439245","article-title":"Senescence and apoptosis: dueling or complementary cell fates?","volume":"15","author":"Childs","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.exger.2026.113279_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molmet.2018.06.011","article-title":"An integrated view of sex differences in metabolic physiology and disease","volume":"15","author":"Clegg","year":"2018","journal-title":"Mol. Metab."},{"key":"10.1016\/j.exger.2026.113279_bb0035","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.thromres.2019.05.008","article-title":"Modulation of megakaryopoiesis and platelet production during inflammation","volume":"179","author":"Couldwell","year":"2019","journal-title":"Thromb. Res."},{"issue":"9","key":"10.1016\/j.exger.2026.113279_bb0040","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1182\/blood.2019000200","article-title":"TNF-\u03b1-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging","volume":"134","author":"Davizon-Castillo","year":"2019","journal-title":"Blood"},{"issue":"25","key":"10.1016\/j.exger.2026.113279_bb0045","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1182\/blood-2013-07-514208","article-title":"Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F\u2013driven mouse model of MPNs","volume":"123","author":"Duek","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.exger.2026.113279_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.959806","article-title":"Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice","volume":"12","author":"Eaton","year":"2022","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0055","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/cdd.2017.172","article-title":"Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM","volume":"25","author":"Engeland","year":"2017","journal-title":"Cell Death Differ."},{"issue":"6","key":"10.1016\/j.exger.2026.113279_bb0060","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ejcb.2011.09.010","article-title":"Interleukin-6 signalling: more than Jaks and STATs","volume":"91","author":"Eulenfeld","year":"2012","journal-title":"Eur. J. Cell Biol."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0065","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1186\/s12967-024-05990-2","article-title":"Sex differences in disease: sex chromosome and immunity","volume":"22","author":"Feng","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.exger.2026.113279_bb0070","series-title":"The mouse in biomedical research","author":"Fox","year":"2007"},{"key":"10.1016\/j.exger.2026.113279_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1083339","article-title":"Megakaryocytes respond during sepsis and display innate immune cell behaviors","volume":"14","author":"Frydman","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0080","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41392-025-02371-z","article-title":"Immunosenescence: signaling pathways, diseases and therapeutic targets","volume":"10","author":"Fu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0085","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41419-025-08205-8","article-title":"Platelet aging and desialylation increase apoptotic priming and BCL-X(L) dependence","volume":"17","author":"Grozovsky","year":"2026","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0090","article-title":"Aging and aging-related diseases: from molecular mechanisms to interventions and treatments","volume":"7","author":"Guo","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-37780-7","article-title":"High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production","volume":"14","author":"Heazlewood","year":"2023","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.exger.2026.113279_bb0100","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1080\/09537104.2021.1925102","article-title":"The thrombopoietin receptor: revisiting the master regulator of platelet production","volume":"32","author":"Hitchcock","year":"2021","journal-title":"Platelets"},{"issue":"21","key":"10.1016\/j.exger.2026.113279_bb0105","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V124.21.SCI-52.SCI-52","article-title":"Platelets regulate thrombopoietin production: the missing link","volume":"124","author":"Hoffmeister","year":"2014","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.exger.2026.113279_bb0110","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1172\/JCI33010","article-title":"STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice","volume":"117","author":"Huang","year":"2007","journal-title":"J. Clin. Investig."},{"issue":"17","key":"10.1016\/j.exger.2026.113279_bb0115","doi-asserted-by":"crossref","first-page":"8356","DOI":"10.1158\/0008-5472.CAN-06-1752","article-title":"p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts","volume":"66","author":"Jackson","year":"2006","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.exger.2026.113279_bb0120","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/CIRCRESAHA.121.319902","article-title":"Sex differences in myocardial and vascular aging","volume":"130","author":"Ji","year":"2022","journal-title":"Circ. Res."},{"issue":"19","key":"10.1016\/j.exger.2026.113279_bb0125","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1038\/onc.2016.418","article-title":"The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1\/STAT1\/IFIT2 network","volume":"36","author":"Jia","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.exger.2026.113279_bb0130","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.dnarep.2016.04.008","article-title":"Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage","volume":"42","author":"Karimian","year":"2016","journal-title":"DNA Repair"},{"issue":"10","key":"10.1016\/j.exger.2026.113279_bb0135","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.exger.2026.113279_bb0140","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.stem.2017.08.011","article-title":"Jak1 integrates cytokine sensing to regulate hematopoietic stem cell function and stress hematopoiesis","volume":"21","author":"Kleppe","year":"2017","journal-title":"Cell Stem Cell"},{"issue":"20","key":"10.1016\/j.exger.2026.113279_bb0145","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1080\/15384101.2023.2287929","article-title":"Understanding cellular senescence: pathways involved, therapeutics and longevity aiding","volume":"22","author":"Kumar","year":"2023","journal-title":"Cell Cycle"},{"key":"10.1016\/j.exger.2026.113279_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.645593","article-title":"Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype","volume":"9","author":"Kumari","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0155","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-21661-x","article-title":"Elements of the complete blood count associated with cardiovascular disease incidence: findings from the EPIC-NL cohort study","volume":"8","author":"Lassale","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.exger.2026.113279_bb0160","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.stemcr.2023.12.004","article-title":"Deciphering the differential impact of thrombopoietin\/MPL signaling on hematopoietic stem\/progenitor cell function in bone marrow and spleen","volume":"19","author":"Lee","year":"2024","journal-title":"Stem Cell Rep."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0165","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41392-024-01953-7","article-title":"Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy","volume":"9","author":"Li","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0170","article-title":"Inflammation and aging: signaling pathways and intervention therapies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0175","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-024-01663-1","article-title":"Molecular mechanisms of aging and anti-aging strategies","volume":"22","author":"Li","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"7","key":"10.1016\/j.exger.2026.113279_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70268","article-title":"Oxidative stress: signaling pathways, biological functions, and disease","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0185","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41392-023-01451-2","article-title":"Immunosenescence: molecular mechanisms and diseases","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0190","doi-asserted-by":"crossref","DOI":"10.1186\/s12979-023-00403-2","article-title":"An aging-related immune landscape in the hematopoietic immune system","volume":"21","author":"Lv","year":"2024","journal-title":"Immun. Ageing"},{"issue":"6","key":"10.1016\/j.exger.2026.113279_bb0195","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1083\/jcb.201304054","article-title":"The incredible journey: from megakaryocyte development to platelet formation","volume":"201","author":"Machlus","year":"2013","journal-title":"J. Cell Biol."},{"issue":"11","key":"10.1016\/j.exger.2026.113279_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/jpm11111073","article-title":"The IL6-like cytokine family: role and biomarker potential in breast cancer","volume":"11","author":"Mart\u00ednez-P\u00e9rez","year":"2021","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.exger.2026.113279_bb0205","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3389\/fphys.2019.00500","article-title":"The JAK\/STAT pathway in skeletal muscle pathophysiology","volume":"10","author":"Moresi","year":"2019","journal-title":"Front. Physiol."},{"issue":"12","key":"10.1016\/j.exger.2026.113279_bb0210","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1182\/blood-2006-11-059378","article-title":"Cyclin D\u2013Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization","volume":"109","author":"Muntean","year":"2007","journal-title":"Blood"},{"issue":"22","key":"10.1016\/j.exger.2026.113279_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/cells13221838","article-title":"Apoptosis: a comprehensive overview of signaling pathways, morphological changes, and physiological significance and therapeutic implications","volume":"13","author":"Mustafa","year":"2024","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.exger.2026.113279_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/cells14070488","article-title":"The role of inflammation in cancer: mechanisms of tumor initiation, progression, and metastasis","volume":"14","author":"Nishida","year":"2025","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.exger.2026.113279_bb0225","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1161\/ATVBAHA.119.312129","article-title":"New insights into the differentiation of megakaryocytes from hematopoietic progenitors","volume":"39","author":"Noetzli","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"12","key":"10.1016\/j.exger.2026.113279_bb0230","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1172\/JCI26891","article-title":"The biogenesis of platelets from megakaryocyte proplatelets","volume":"115","author":"Patel","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"15","key":"10.1016\/j.exger.2026.113279_bb0235","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1182\/blood-2017-06-780882","article-title":"Inflammation: a key regulator of hematopoietic stem cell fate in health and disease","volume":"130","author":"Pietras","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.exger.2026.113279_bb0240","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2017.00234","article-title":"Genetic alterations of the thrombopoietin\/MPL\/JAK2 axis impacting megakaryopoiesis","volume":"8","author":"Plo","year":"2017","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"6","key":"10.1016\/j.exger.2026.113279_bb0245","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.stemcr.2021.04.016","article-title":"Megakaryocyte progenitor cell function is enhanced upon aging despite the functional decline of aged hematopoietic stem cells","volume":"16","author":"Poscablo","year":"2021","journal-title":"Stem Cell Rep."},{"issue":"12","key":"10.1016\/j.exger.2026.113279_bb0250","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1016\/j.cell.2024.04.018","article-title":"An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis","volume":"187","author":"Poscablo","year":"2024","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.exger.2026.113279_bb0255","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1161\/ATVBAHA.123.318782","article-title":"Diversity of megakaryocytes","volume":"43","author":"Puhm","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"0 1","key":"10.1016\/j.exger.2026.113279_bb0260","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1111\/jth.12965","article-title":"Regulation of the genetic code in megakaryocytes and platelets","volume":"13 Suppl 1","author":"Rondina","year":"2015","journal-title":"J. Thromb. Haemost."},{"issue":"9","key":"10.1016\/j.exger.2026.113279_bb0265","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1200\/JCO.2010.31.8907","article-title":"Targeting the interleukin-6\/Jak\/stat pathway in human malignancies","volume":"30","author":"Sansone","year":"2012","journal-title":"J. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.exger.2026.113279_bb0270","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/febs.16325","article-title":"p53 in senescence - it\u2019s a marathon, not a sprint","volume":"290","author":"Sheekey","year":"2023","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0275","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-026-07998-2","article-title":"The PI3K-AKT pathway mediates the imbalance of bone marrow macrophage polarization in patients with immune thrombocytopenia","volume":"24","author":"Shen","year":"2026","journal-title":"J. Transl. Med."},{"issue":"15","key":"10.1016\/j.exger.2026.113279_bb0280","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1016\/j.jmb.2019.05.036","article-title":"Regulation of survival networks in senescent cells: from mechanisms to interventions","volume":"431","author":"Soto-Gamez","year":"2019","journal-title":"J. Mol. Biol."},{"issue":"4","key":"10.1016\/j.exger.2026.113279_bb0285","first-page":"3111","article-title":"IFN-gamma induces apoptosis in human melanocytes by activating the JAK1\/STAT1 signaling pathway","volume":"22","author":"Su","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0290","doi-asserted-by":"crossref","first-page":"7966","DOI":"10.1038\/s41467-024-52318-1","article-title":"Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets","volume":"15","author":"Su","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2026.113279_bb0295","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00909","article-title":"Anti-inflammatory mechanisms triggered by apoptotic cells during their clearance","volume":"8","author":"Szondy","year":"2017","journal-title":"Front. Immunol."},{"issue":"19","key":"10.1016\/j.exger.2026.113279_bb0300","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914914","article-title":"Platelets as potential non-traditional cardiovascular risk factor\u2014analysis performed in healthy donors","volume":"24","author":"Szyma\u0144ska","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acschemneuro.3c00531","article-title":"Aging hallmarks and progression and age-related diseases: a landscape view of research advancement","volume":"15","author":"Tenchov","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.exger.2026.113279_bb0310","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1016\/j.csbj.2021.07.038","article-title":"From pyroptosis, apoptosis and necroptosis to PANoptosis: a mechanistic compendium of programmed cell death pathways","volume":"19","author":"Wang","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.exger.2026.113279_bb0315","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.620089","article-title":"Senescence and apoptosis: architects of mammalian development","volume":"8","author":"Wanner","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.exger.2026.113279_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.mocell.2024.100113","article-title":"The role of p21 in cellular senescence and aging-related diseases","volume":"47","author":"Yan","year":"2024","journal-title":"Mol. Cells"},{"key":"10.1016\/j.exger.2026.113279_bb0325","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1025945","article-title":"Apoptosis in megakaryocytes: safeguard and threat for thrombopoiesis","volume":"13","author":"Yang","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0330","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-020-00994-z","article-title":"Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches","volume":"13","author":"Zhang","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"23","key":"10.1016\/j.exger.2026.113279_bb0335","first-page":"2765","article-title":"Platelet factor 4 (PF4) regulates hematopoietic stem cell aging","volume":"146","author":"Zhang","year":"2024","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0340","doi-asserted-by":"crossref","DOI":"10.1186\/s43556-026-00415-6","article-title":"The extracellular matrix in inflammation and cancer","volume":"7","author":"Zhang","year":"2026","journal-title":"Mol. Biomed."},{"issue":"1","key":"10.1016\/j.exger.2026.113279_bb0345","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41514-025-00250-z","article-title":"Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging","volume":"11","author":"Zhou","year":"2025","journal-title":"npj Aging"}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:14:00Z","timestamp":1789546440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556526002585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":69,"alternative-id":["S0531556526002585"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2026.113279","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age-associated inflammation is accompanied by JAK1\u2013STAT1 signaling activation, megakaryocyte apoptosis, and enhanced thrombopoiesis in naturally aged mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2026.113279","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113279"}}