{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:39:26Z","timestamp":1792431566147,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2022QH363"],"award-info":[{"award-number":["ZR2022QH363"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401545"],"award-info":[{"award-number":["82401545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971111"],"award-info":[{"award-number":["81971111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371331"],"award-info":[{"award-number":["82371331"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.exger.2026.113296","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T14:44:58Z","timestamp":1787409898000},"page":"113296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The relationship between plasma FOXO3 and cognitive impairment and depressive symptoms in cerebral small vessel disease"],"prefix":"10.1016","volume":"224","author":[{"given":"Qiqi","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2026.113296_bb0005","doi-asserted-by":"crossref","first-page":"29864","DOI":"10.1074\/jbc.M502149200","article-title":"Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia","volume":"280","author":"Abid","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exger.2026.113296_bb0010","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12667","article-title":"Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation","volume":"69","author":"Ali","year":"2020","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.exger.2026.113296_bb0015","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1001\/jama.1992.03490110111047","article-title":"The journal of neuropsychiatry and clinical neurosciences. JAMA","volume":"268","author":"Bowden","year":"1992","journal-title":"JAMA"},{"key":"10.1016\/j.exger.2026.113296_bb0020","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20160091","article-title":"Forkhead box O (FOXO) 3 modulates hypoxia-induced autophagy through AMPK signalling pathway in cardiomyocytes","volume":"36","author":"Chi","year":"2016","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.exger.2026.113296_bb0025","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1091\/mbc.e07-08-0811","article-title":"Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling","volume":"19","author":"D\u00e1vila","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.exger.2026.113296_bb0030","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1139\/cjpp-2022-0341","article-title":"Activation of the akt\/FoxO3 signaling pathway enhances oxidative stress-induced autophagy and alleviates brain damage in a rat model of ischemic stroke","volume":"101","author":"Deng","year":"2023","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.exger.2026.113296_bb0035","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1093\/gerona\/glac132","article-title":"FOXO3, a resilience gene: impact on lifespan, healthspan, and deathspan","volume":"77","author":"Donlon","year":"2022","journal-title":"J. Gerontol.: Ser. A"},{"key":"10.1016\/j.exger.2026.113296_bb0040","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1161\/STROKEAHA.109.564914","article-title":"Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease","volume":"41","author":"Doubal","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.exger.2026.113296_bb0045","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S1474-4422(23)00131-X","article-title":"Neuroimaging standards for research into small vessel disease\u2014advances since 2013","volume":"22","author":"Duering","year":"2023","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.exger.2026.113296_bb0050","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1042\/CS20160727","article-title":"Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia","volume":"131","author":"Duncombe","year":"2017","journal-title":"Clin. Sci."},{"key":"10.1016\/j.exger.2026.113296_bb0055","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1038\/s41598-017-04256-w","article-title":"The stress response factor daf-16\/FOXO is required for multiple compound families to prolong the function of neurons with huntington\u2019s disease","volume":"7","author":"Farina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2026.113296_bb0060","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1080\/15548627.2018.1475819","article-title":"FOXO3 links autophagy to apoptosis","volume":"14","author":"Fitzwalter","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.exger.2026.113296_bb0065","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fneur.2019.00238","article-title":"Characterization of white matter hyperintensities in large-scale MRI-studies","volume":"10","author":"Frey","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.exger.2026.113296_bb0070","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1186\/s12967-025-06501-7","article-title":"Around-the-clock noise exposure induces hippocampus apoptosis and subsequent cognitive impairment via the PI3K\/SGK1\/Foxo3 signaling pathway","volume":"23","author":"Fu","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.exger.2026.113296_bb0075","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1186\/s12967-025-06501-7","article-title":"Around-the-clock noise exposure induces hippocampus apoptosis and subsequent cognitive impairment via the PI3K\/SGK1\/Foxo3 signaling pathway","volume":"23","author":"Fu","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.exger.2026.113296_bb0080","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.yexcr.2018.04.027","article-title":"Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-\u03baB pathway by targeting FOXO3","volume":"369","author":"Guo","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.exger.2026.113296_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.865307","article-title":"Insidious attentional deficits in patients with cerebral small vessel disease revealed by attention network test","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.exger.2026.113296_bb0090","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/ijs.12357","article-title":"Part I: frequency of depression after stroke: an updated systematic review and meta-analysis of observational studies","volume":"9","author":"Hackett","year":"2014","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.exger.2026.113296_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12640-021-00446-7","article-title":"Interfering TUG1 attenuates cerebrovascular endothelial apoptosis and inflammatory injury after cerebral ischemia\/reperfusion via TUG1\/miR-410\/FOXO3 ceRNA axis","volume":"40","author":"He","year":"2022","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.exger.2026.113296_bb0100","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.modgep.2005.07.003","article-title":"Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain","volume":"6","author":"Hoekman","year":"2006","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.exger.2026.113296_bb0105","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.bbrc.2014.07.055","article-title":"Hypoxia induces FoxO3a-mediated dysfunction of blood\u2013brain barrier","volume":"450","author":"Hyun","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exger.2026.113296_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116778","article-title":"Possible involvement of NAMPT in neuronal survival in cerebral ischemic injury under high-glucose conditions through the FoxO3a\/LC3 pathway","volume":"176","author":"Iwatani","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exger.2026.113296_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116778","article-title":"Possible involvement of NAMPT in neuronal survival in cerebral ischemic injury under high-glucose conditions through the FoxO3a\/LC3 pathway","volume":"176","author":"Iwatani","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exger.2026.113296_bb0120","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1093\/gerona\/glac016","article-title":"Effect of FOXO3 and air pollution on cognitive function: a longitudinal cohort study of older adults in China from 2000 to 2014","volume":"77","author":"Ji","year":"2022","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.exger.2026.113296_bb0125","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1161\/ATVBAHA.107.150664","article-title":"Forkhead factor, FOXO3a, induces apoptosis of endothelial cells through activation of matrix metalloproteinases","volume":"28","author":"Lee","year":"2008","journal-title":"ATVB"},{"key":"10.1016\/j.exger.2026.113296_bb0130","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3389\/fneur.2018.00577","article-title":"Poststroke depression biomarkers: a narrative review","volume":"9","author":"Levada","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.exger.2026.113296_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2017.05.001","article-title":"AMPK activates FOXO3a and promotes neuronal apoptosis in the developing rat brain during the early phase after hypoxia-ischemia","volume":"132","author":"Li","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.exger.2026.113296_bb0140","article-title":"Regional white matter hyperintensity volume predicts persistent cognitive impairment in acute lacunar infarct patients","volume":"14","author":"Li","year":"2023","journal-title":"Front. Neurol."},{"key":"10.1016\/j.exger.2026.113296_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202404882","article-title":"Role of STAT3-FOXO3 signaling in the modulation of neuroplasticity by PD-L1-HGF-decorated mesenchymal stem cell-derived exosomes in a murine stroke model","volume":"11","author":"Lin","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.exger.2026.113296_bb0150","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/0891988711422528","article-title":"Montreal cognitive assessment in detecting cognitive impairment in Chinese elderly individuals: a population-based study","volume":"24","author":"Lu","year":"2011","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.exger.2026.113296_bb0155","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/17474930221144911","article-title":"Cerebral small vessel disease: Recent advances and future directions","volume":"18","author":"Markus","year":"2023","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.exger.2026.113296_bb0160","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/s12276-022-00790-4","article-title":"MeCP2 inhibits ischemic neuronal injury by enhancing methylation of the FOXO3a promoter to repress the SPRY2-ZEB1 axis","volume":"54","author":"Meng","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.exger.2026.113296_bb0165","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/agm2.12073","article-title":"Clinical practice guideline for cognitive impairment of cerebral small vessel disease","volume":"2","author":"Peng","year":"2019","journal-title":"Aging Med. (Milton (N.S.W))"},{"key":"10.1016\/j.exger.2026.113296_bb0170","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/sj.jcbfm.9600413","article-title":"Deletion of the c-jun N-terminal kinase 3 gene protects neonatal mice against cerebral hypoxic\u2014ischaemic injury","volume":"27","author":"Pirianov","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.exger.2026.113296_bb0175","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.biopsych.2008.08.005","article-title":"Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation","volume":"65","author":"Polter","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.exger.2026.113296_bb0180","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1242\/jcs.185009","article-title":"Cdk5\u2013Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer\u2019s disease models","volume":"129","author":"Shi","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.exger.2026.113296_bb0185","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1038\/s41467-017-02221-9","article-title":"Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a","volume":"8","author":"Spinelli","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2026.113296_bb0190","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.bbrc.2016.12.001","article-title":"Neuroprotective effects of miR-27a against traumatic brain injury via suppressing FoxO3a-mediated neuronal autophagy","volume":"482","author":"Sun","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exger.2026.113296_bb0195","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1212\/WNL.0b013e31829bfde3","article-title":"Epidemiology of stroke and its subtypes in Chinese vs white populations: A systematic review","volume":"81","author":"Tsai","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.exger.2026.113296_bb0200","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/jamapsychiatry.2017.0984","article-title":"Association of microvascular dysfunction with late-life depression: a systematic review and meta-analysis","volume":"74","author":"Van Agtmaal","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.exger.2026.113296_bb0205","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1176\/appi.ajp.2014.14050578","article-title":"Cerebral small vessel disease and association with higher incidence of depressive symptoms in a general elderly population: The AGES-Reykjavik Study","volume":"172","author":"Van Sloten","year":"2015","journal-title":"AJP"},{"key":"10.1016\/j.exger.2026.113296_bb0210","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/STROKEAHA.120.032611","article-title":"Imaging markers of vascular brain health: quantification, clinical implications, and future directions","volume":"53","author":"Vemuri","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.exger.2026.113296_bb0215","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1111\/bph.16474","article-title":"Microglial forkhead box O3a deficiency attenuates LPS-induced neuro-inflammation and depressive-like behaviour through regulating the expression of peroxisome proliferator-activated receptor-\u03b3","volume":"181","author":"Wang","year":"2024","journal-title":"Brit. J. Pharmacol."},{"key":"10.1016\/j.exger.2026.113296_bb0220","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1474-4422(13)70060-7","article-title":"Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.exger.2026.113296_bb0225","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","article-title":"Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.exger.2026.113296_bb0230","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nn.2575","article-title":"Autophagy gone awry in neurodegenerative diseases","volume":"13","author":"Wong","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.exger.2026.113296_bb0235","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jad.2017.05.039","article-title":"Structural network connectivity impairment and depressive symptoms in cerebral small vessel disease","volume":"220","author":"Xie","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.exger.2026.113296_bb0240","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s11064-011-0648-2","article-title":"FoxO3a changes in pyramidal neurons and expresses in non-pyramidal neurons and astrocytes in the gerbil hippocampal CA1 region after transient cerebral ischemia","volume":"37","author":"Yoo","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.exger.2026.113296_bb0245","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12940","article-title":"KCNQ1OT1 promotes autophagy by regulating miR-200a\/FOXO3\/ATG7 pathway in cerebral ischemic stroke","volume":"18","author":"Yu","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2026.113296_bb0250","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fncel.2020.00193","article-title":"FKBP5 exacerbates impairments in cerebral ischemic stroke by inducing autophagy via the AKT\/FOXO3 pathway","volume":"14","author":"Yu","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.exger.2026.113296_bb0255","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/WCO.0000000000000913","article-title":"Cerebral small vessel disease and vascular cognitive impairment: from diagnosis to management","volume":"34","author":"Zanon Zotin","year":"2021","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.exger.2026.113296_bb0260","article-title":"Long non-coding RNA XIST promotes cerebral ischemia\/reperfusion injury by modulating miR-27a-3p\/FOXO3 signaling","volume":"24","author":"Zhang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.exger.2026.113296_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14121495","article-title":"Luteolin in safflower leaves suppresses microglial inflammation through FOXO3-mediated Trem2 transcription","volume":"14","author":"Zhang","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.exger.2026.113296_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119453","article-title":"A newly discovered bioactive equivalence of combinatorial components of angong niuhuang pill improves ischemic stroke via the PI3K\/AKT axis","volume":"343","author":"Zhang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.exger.2026.113296_bb0275","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s12035-023-03563-w","article-title":"Investigating the potential mechanisms and therapeutic targets of inflammatory cytokines in post-stroke depression","volume":"61","author":"Zhang","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.exger.2026.113296_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119688","article-title":"Inhibition of oxidative stress contributes to the protective effect of herba siegesbeckiae on ischemic stroke by PI3K\/STAT3\/FOXO3a signal axis","volume":"346","author":"Zhang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.exger.2026.113296_bb0285","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3389\/fmed.2020.00397","article-title":"Cognitive frailty among elderly Chinese patients with cerebral small vessel disease: a structural MRI study","volume":"7","author":"Zh\u00e0o","year":"2020","journal-title":"Front. Med."},{"key":"10.1016\/j.exger.2026.113296_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102760","article-title":"Energy stress modulation of AMPK\/FoxO3 signaling inhibits mitochondria-associated ferroptosis","volume":"63","author":"Zhong","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.exger.2026.113296_bb0295","doi-asserted-by":"crossref","DOI":"10.1017\/S0033291725001011","article-title":"A longitudinal analysis of the relationship between emotional symptoms and cognitive function in patients with major depressive disorder","volume":"55","author":"Zhou","year":"2025","journal-title":"Psychol. Med."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:41:47Z","timestamp":1792428107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556526002755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":59,"alternative-id":["S0531556526002755"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2026.113296","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The relationship between plasma FOXO3 and cognitive impairment and depressive symptoms in cerebral small vessel disease","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2026.113296","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113296"}}