{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:39:34Z","timestamp":1792431574832,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Korea Ministry of Education","doi-asserted-by":"publisher","award":["RS-2021-NR066083"],"award-info":[{"award-number":["RS-2021-NR066083"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Korea Ministry of Education","doi-asserted-by":"publisher","award":["00211435"],"award-info":[{"award-number":["00211435"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Korea Ministry of Education","doi-asserted-by":"publisher","award":["RS-2021-NR060136"],"award-info":[{"award-number":["RS-2021-NR060136"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.exger.2026.113299","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:37:55Z","timestamp":1787701075000},"page":"113299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Increased TWEAK and decreased MyoG expression in age-related impairment of muscle regeneration and H2O2-induced senescence-associated changes in C2C12 cells"],"prefix":"10.1016","volume":"224","author":[{"given":"Jin-Hwa","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Tae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Soo","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Ha","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan-Hoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Hun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je-Won","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.exger.2026.113299_bb0005","doi-asserted-by":"crossref","first-page":"7792","DOI":"10.1038\/s41467-022-35547-0","article-title":"Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice","volume":"13","author":"Ang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2026.113299_bb0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.maturitas.2016.11.006","article-title":"Inflammation and sarcopenia: a systematic review and meta-analysis","volume":"96","author":"Bano","year":"2017","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.exger.2026.113299_bb0015","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/jcp.22821","article-title":"TWEAK causes myotube atrophy through coordinated activation of ubiquitin-proteasome system, autophagy, and caspases","volume":"227","author":"Bhatnagar","year":"2012","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.exger.2026.113299_bb0020","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3390\/ijms25010512","article-title":"Regulation of satellite cells functions during skeletal muscle regeneration: a critical step in physiological and pathological conditions","volume":"25","author":"Careccia","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2026.113299_bb0025","article-title":"The TWEAK\/Fn14 signaling promotes skeletal muscle wasting during cancer cachexia","volume":"2024","author":"da Silva","year":"2024","journal-title":"bioRxiv"},{"issue":"3","key":"10.1016\/j.exger.2026.113299_bb0030","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/j.2040-4603.2015.tb00646.x","article-title":"Satellite cells and skeletal muscle regeneration","volume":"5","author":"Dumont","year":"2015","journal-title":"Compr. Physiol."},{"issue":"5","key":"10.1016\/j.exger.2026.113299_bb0035","doi-asserted-by":"crossref","first-page":"7018","DOI":"10.1096\/fj.202000111RR","article-title":"In vivo analysis of \u03b3H2AX+ cells in skeletal muscle from aged and obese humans","volume":"34","author":"Dungan","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.exger.2026.113299_bb0040","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ab.2016.03.023","article-title":"Housekeeping proteins: how useful are they in skeletal muscle diabetes studies and muscle hypertrophy models?","volume":"504","author":"Fortes","year":"2016","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.exger.2026.113299_bb0045","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1038\/s41467-018-06583-6","article-title":"Myogenin promotes myocyte fusion to balance fibre number and size","volume":"9","author":"Ganassi","year":"2018","journal-title":"Nat. Commun."},{"issue":"24","key":"10.1016\/j.exger.2026.113299_bb0050","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.3390\/cells12242787","article-title":"Therapeutic consequences of targeting the IGF-1\/PI3K\/AKT\/FOXO3 axis in sarcopenia: a narrative review","volume":"12","author":"Gellhaus","year":"2023","journal-title":"Cells"},{"issue":"13","key":"10.1016\/j.exger.2026.113299_bb0055","doi-asserted-by":"crossref","first-page":"7124","DOI":"10.3390\/ijms23137124","article-title":"Modeling of the senescence-associated phenotype in human skin fibroblasts","volume":"23","author":"Gerasymchuk","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.exger.2026.113299_bb0060","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ab.2013.05.027","article-title":"Stain-free total protein staining is a superior loading control to \u03b2-actin for Western blots","volume":"440","author":"Gilda","year":"2013","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.exger.2026.113299_bb0065","doi-asserted-by":"crossref","first-page":"1301805","DOI":"10.3389\/fmicb.2023.1301805","article-title":"Metabolites of the gut microbiota may serve as precise diagnostic markers for sarcopenia in the elderly","volume":"14","author":"He","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.exger.2026.113299_bb0070","doi-asserted-by":"crossref","first-page":"9210494","DOI":"10.1155\/2017\/9210494","article-title":"Myogenic differentiation from MYOGENIN-mutated human iPS cells by CRISPR\/Cas9","volume":"2017","author":"Higashioka","year":"2017","journal-title":"Stem Cells Int."},{"issue":"18","key":"10.1016\/j.exger.2026.113299_bb0075","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.3390\/nu16183177","article-title":"Filbertone reduces senescence in C2C12 myotubes treated with doxorubicin or H2O2 through MuRF1 and myogenin","volume":"16","author":"Jung","year":"2024","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.exger.2026.113299_bb0080","first-page":"47","article-title":"Recombinant ADAMTS-1 promotes muscle regeneration accompanied by downregulation of Notch signaling","volume":"57","author":"Kim","year":"2026","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.exger.2026.113299_bb0085","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.00061.2017","article-title":"Sarcopenia: aging-related loss of muscle mass and function","volume":"99","author":"Larsson","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exger.2026.113299_bb0090","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/10715762.2022.2037582","article-title":"Changes in tumor suppressors and inflammatory responses during hydrogen peroxide-induced senescence in rat fibroblasts","volume":"56","author":"Liu","year":"2022","journal-title":"Free Radic. Res."},{"issue":"1","key":"10.1016\/j.exger.2026.113299_bb0095","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1096\/fj.12-212290","article-title":"Impaired myogenesis in estrogen-related receptor \u03b3 (ERR\u03b3)-deficient skeletal myocytes due to oxidative stress","volume":"27","author":"Murray","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.exger.2026.113299_bb0100","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fimmu.2014.00018","article-title":"TWEAK\/Fn14 signaling axis mediates skeletal muscle atrophy and metabolic dysfunction","volume":"5","author":"Sato","year":"2014","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.exger.2026.113299_bb0105","doi-asserted-by":"crossref","first-page":"afac220","DOI":"10.1093\/ageing\/afac220","article-title":"Sarcopenia definition, diagnosis and treatment: consensus is growing","volume":"51","author":"Sayer","year":"2022","journal-title":"Age Ageing"},{"issue":"8","key":"10.1016\/j.exger.2026.113299_bb0110","first-page":"7141","article-title":"Aberrant expression of thyroidal hormone receptor \u03b1 exasperating mitochondrial dysfunction induced sarcopenia in aged mice","volume":"16","author":"Sheng","year":"2024","journal-title":"Aging (Albany NY)"},{"issue":"7","key":"10.1016\/j.exger.2026.113299_bb0115","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1007\/s11739-023-03339-z","article-title":"Sarcopenia, a condition shared by various diseases: can we alleviate or delay the progression?","volume":"18","author":"Tarantino","year":"2023","journal-title":"Intern. Emerg. Med."},{"issue":"8","key":"10.1016\/j.exger.2026.113299_bb0120","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1172\/JCI77361","article-title":"Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity","volume":"125","author":"Tsai","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exger.2026.113299_bb0125","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-1-62703-556-9_11","article-title":"Methods of cellular senescence induction using oxidative stress","volume":"1048","author":"Wang","year":"2013","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.exger.2026.113299_bb0130","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1096\/fj.201800973R","article-title":"Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia","volume":"33","author":"Wang","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.exger.2026.113299_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2024.112390","article-title":"Sarcopenia is associated with hypomethylation of TWEAK and increased plasma levels of TWEAK and its downstream inflammatory factor TNF-\u03b1 in older adults: a case-control study","volume":"188","author":"Xuekelati","year":"2024","journal-title":"Exp. Gerontol."},{"issue":"1","key":"10.1016\/j.exger.2026.113299_bb0145","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3177\/jnsv.48.59","article-title":"Oral administration of leucine stimulates phosphorylation of 4E-bP1 and S6K 1 in skeletal muscle but not in liver of diabetic rats","volume":"48","author":"Yoshizawa","year":"2002","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"key":"10.1016\/j.exger.2026.113299_bb0150","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.semcdb.2017.11.011","article-title":"Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis","volume":"72","author":"Zammit","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.exger.2026.113299_bb0155","article-title":"Quantitative evaluation of hindlimb grip strength in mice as a measure of neuromuscular function","volume":"14","author":"Zheng","year":"2024","journal-title":"MethodsX"},{"issue":"1","key":"10.1016\/j.exger.2026.113299_bb0160","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s10020-024-00998-2","article-title":"Melatonin ameliorates age-related sarcopenia by inhibiting fibrogenic conversion of satellite cell","volume":"30","author":"Zhu","year":"2024","journal-title":"Mol. Med."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:44:46Z","timestamp":1792428286000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556526002780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":31,"alternative-id":["S0531556526002780"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2026.113299","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased TWEAK and decreased MyoG expression in age-related impairment of muscle regeneration and H2O2-induced senescence-associated changes in C2C12 cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2026.113299","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113299"}}