{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:39:17Z","timestamp":1792431557304,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2026A1515010353"],"award-info":[{"award-number":["2026A1515010353"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["GMUCR2024\\u201302022"],"award-info":[{"award-number":["GMUCR2024\\u201302022"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.exger.2026.113307","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:31:54Z","timestamp":1788190314000},"page":"113307","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrated transcriptomic and proteomic analysis reveals ECM disruption and ALDH1L1-linked metabolic remodeling in klotho-deficient post-infarction heart failure"],"prefix":"10.1016","volume":"224","author":[{"given":"Bing","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exger.2026.113307_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/nu15122744","article-title":"Serum anti-aging protein \u03b1-klotho mediates the association between diet quality and kidney function","volume":"15","author":"Cai","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.exger.2026.113307_bb0010","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1161\/CIRCULATIONAHA.113.003668","article-title":"National trends in heart failure hospitalization after acute myocardial infarction for Medicare beneficiaries: 1998-2010","volume":"128","author":"Chen","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.exger.2026.113307_bb0015","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1161\/CIRCRESAHA.120.317348","article-title":"Klotho deficiency causes heart aging via impairing the Nrf2-GR pathway","volume":"128","author":"Chen","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.exger.2026.113307_bb0020","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/s41401-024-01471-w","article-title":"SEC62-dependent ER-phagy contributes to apelin-13\/APJ-induced monocyte-vascular endothelial cell adhesion in atherosclerosis pathogenesis","volume":"46","author":"Chen","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.exger.2026.113307_bb0025","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000030710","article-title":"Anti-aging protein klotho was associated with vitamin B12 concentration in adults","volume":"101","author":"Choi","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.exger.2026.113307_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1082504","article-title":"A cross-sectional analysis of association between visceral adiposity index and serum anti-aging protein klotho in adults","volume":"14","author":"Cui","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.exger.2026.113307_bb0035","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s13105-019-00675-7","article-title":"FGF19 subfamily members: FGF19 and FGF21","volume":"75","author":"Dolegowska","year":"2019","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.exger.2026.113307_bb0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/FJC.0000000000001721","article-title":"Cardiac-specific overexpression of klotho attenuates Paraquat-induced myocardial injury by enhancing the Nrf2\/ARE signaling pathway","volume":"86","author":"Feng","year":"2025","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.exger.2026.113307_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/metabo14120696","article-title":"Untargeted metabolomics reveals dysregulation of glycine- and serine-coupled metabolic pathways in an ALDH1L1-dependent manner in vivo","volume":"14","author":"Fu","year":"2024","journal-title":"Metabolites"},{"key":"10.1016\/j.exger.2026.113307_bb0050","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.recesp.2011.10.027","article-title":"Heart failure in acute myocardial infarction: a comparison between patients with or without heart failure criteria from the FAST-MI registry","volume":"65","author":"Juilli\u00e8re","year":"2012","journal-title":"Rev. Esp. Cardiol."},{"key":"10.1016\/j.exger.2026.113307_bb0055","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ahj.2012.12.005","article-title":"Incidence of heart failure and mortality after acute coronary syndromes","volume":"165","author":"Kaul","year":"2013","journal-title":"Am. Heart J."},{"key":"10.1016\/j.exger.2026.113307_bb0060","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1161\/CIRCULATIONAHA.125.074399","article-title":"Targeting E3 ubiquitin ligase Hrd1 prevents myocardial ischemia-reperfusion injury through enhancing ALDH2 enzymatic activity","volume":"154","author":"Liu","year":"2026","journal-title":"Circulation"},{"key":"10.1016\/j.exger.2026.113307_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/cells13171413","article-title":"Anti-inflammatory role of the klotho protein and relevance to aging","volume":"13","author":"Prud\u2019homme","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.exger.2026.113307_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27238394","article-title":"Exploratory metabolomics underscores the folate enzyme ALDH1L1 as a regulator of Glycine and methylation reactions","volume":"27","author":"Rushing","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.exger.2026.113307_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12050454","article-title":"Sex-specific metabolic effects of dietary folate withdrawal in wild-type and Aldh1l1 knockout mice","volume":"12","author":"Sharma","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.exger.2026.113307_bb0080","doi-asserted-by":"crossref","first-page":"828","DOI":"10.2174\/138920371508141128152429","article-title":"Regulation of cellular transport by klotho protein","volume":"15","author":"Sopjani","year":"2014","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.exger.2026.113307_bb0085","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.amjcard.2017.03.013","article-title":"Incidence and prognostic impact of heart failure hospitalization during follow-up after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction","volume":"119","author":"Taniguchi","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.exger.2026.113307_bb0090","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1007\/s12015-022-10376-2","article-title":"Generation of human iPSC-derived astrocytes with a mature star-shaped phenotype for CNS modeling","volume":"18","author":"Voulgaris","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.exger.2026.113307_bb0095","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s13105-023-00945-5","article-title":"Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction","volume":"79","author":"Wang","year":"2023","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.exger.2026.113307_bb0100","article-title":"The complex link of the folate-homocysteine axis to myocardial hypertrophy and heart failure: from mechanistic exploration to clinical vision","author":"Wang","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.exger.2026.113307_bb0105","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/s41418-025-01604-6","article-title":"Mitochondria-transliterated ALDH1L1 functions as a feedback regulator of redox homeostasis in cancer cells to enhance the resistance to pro-oxidative therapy","volume":"33","author":"Wu","year":"2026","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.exger.2026.113307_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2024.111679","article-title":"The causal relationship between metabolic syndrome and its components and cardiovascular disease: a mendelian randomization study","volume":"211","author":"Wu","year":"2024","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.exger.2026.113307_bb0115","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3892\/etm.2020.9484","article-title":"Klotho gene improves oxidative stress injury after myocardial infarction","volume":"21","author":"Xu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.exger.2026.113307_bb0120","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1056\/NEJMoa2401479","article-title":"Beta-blockers after myocardial infarction and preserved ejection fraction","volume":"390","author":"Yndigegn","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exger.2026.113307_bb0125","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13098-024-01487-6","article-title":"The association between the triglyceride-glucose index and serum anti-aging protein \u03b1- klotho: a population-based study","volume":"16","author":"Zhang","year":"2024","journal-title":"Diabetol. Metab. Syndr."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155652600286X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S053155652600286X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:39:59Z","timestamp":1792427999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S053155652600286X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":25,"alternative-id":["S053155652600286X"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2026.113307","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated transcriptomic and proteomic analysis reveals ECM disruption and ALDH1L1-linked metabolic remodeling in klotho-deficient post-infarction heart failure","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2026.113307","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113307"}}