{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:39:29Z","timestamp":1792431569988,"version":"4.5.0"},"reference-count":170,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["12Z8622N"],"award-info":[{"award-number":["12Z8622N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["G086823N"],"award-info":[{"award-number":["G086823N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Gerontology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.exger.2026.113312","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:46:17Z","timestamp":1788565577000},"page":"113312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Endocannabinoid system dysregulation in non-communicable diseases: implications for skeletal muscle health"],"prefix":"10.1016","volume":"224","author":[{"given":"Kaat","family":"Vanderbeke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan","family":"Dalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Koppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0005","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/oby.20498","article-title":"Circulating endocannabinoids in insulin sensitive vs. insulin resistant obese postmenopausal women. A MONET group study","volume":"22","author":"Abdulnour","year":"2014","journal-title":"Obesity"},{"key":"10.1016\/j.exger.2026.113312_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanepe.2024.101014","article-title":"Encouraging mortality trends among the obese population in England, but public health challenges from rising obesity prevalence remain","author":"Adair","year":"2024","journal-title":"Lancet Reg. Health Eur."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0015","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cmet.2007.11.012","article-title":"The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake","volume":"7","author":"Addy","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.exger.2026.113312_bb0020","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009099","article-title":"Cannabinoids, the heart of the matter","author":"Alfulaij","year":"2018","journal-title":"J. Am. Heart Assoc."},{"issue":"8","key":"10.1016\/j.exger.2026.113312_bb0025","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1096\/fj.10-176602","article-title":"Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation","volume":"25","author":"Alhouayek","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.exger.2026.113312_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/cells12101419","article-title":"Cannabinoid signaling in kidney disease","author":"Arceri","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.exger.2026.113312_bb0035","article-title":"Cancer cachexia: understanding the molecular basis","volume":"754\u201362","author":"Argil\u00e9s","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.exger.2026.113312_bb0040","article-title":"Bone is not alone: the effects of skeletal muscle dysfunction in chronic kidney disease","volume":"173\u20139","author":"Avin","year":"2015","journal-title":"Curr. Osteoporos. Rep."},{"issue":"17","key":"10.1016\/j.exger.2026.113312_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26178493","article-title":"\u03b2-Caryophyllene ameliorates thioacetamide-induced liver fibrosis in rats: a preventative approach","volume":"26","author":"Bader Eddin","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2026.113312_bb0050","doi-asserted-by":"crossref","DOI":"10.1007\/s11892-018-0975-7","article-title":"Cannabinoid receptors in diabetic kidney disease","author":"Barutta","year":"2018","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.exger.2026.113312_bb0055","article-title":"The role of cannabinoid signaling in acute and chronic kidney diseases","volume":"252\u20138","author":"Barutta","year":"2018","journal-title":"Kidney Int."},{"key":"10.1016\/j.exger.2026.113312_bb0060","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/89953","article-title":"Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis","volume":"7","author":"Batkai","year":"2001","journal-title":"Nat. Med."},{"issue":"14","key":"10.1016\/j.exger.2026.113312_bb0065","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1161\/01.CIR.0000143230.23252.D2","article-title":"Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension","volume":"110","author":"B\u00e1tkai","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.exger.2026.113312_bb0070","series-title":"Endocannabinoids acting at CB 1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats","author":"B\u00e1tkai","year":"2007"},{"key":"10.1016\/j.exger.2026.113312_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2020.106520","article-title":"Understanding the possible role of endocannabinoid system in obesity","author":"Behl","year":"2021","journal-title":"Prostaglandins Other Lipid Mediators"},{"key":"10.1016\/j.exger.2026.113312_bb0080","article-title":"The endocannabinoid system, eating behavior and energy homeostasis: the end or a new beginning?","volume":"375\u201382","author":"Bermudez-Silva","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0085","doi-asserted-by":"crossref","DOI":"10.1186\/s10020-026-01457-w","article-title":"Progressive endocannabinoid system dysregulation in autosomal dominant polycystic kidney disease","volume":"32","author":"Betkar","year":"2026","journal-title":"Mol. Med."},{"key":"10.1016\/j.exger.2026.113312_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2025.156291","article-title":"Evaluation of tetrahydropyridazine-based peripherally restricted dual inhibitors of CB1R and inducible nitric oxide synthase (iNOS) for treating metabolic syndrome disorders","volume":"170","author":"Bhattacharjee","year":"2025","journal-title":"Metab. Clin. Exp."},{"issue":"5","key":"10.1016\/j.exger.2026.113312_bb0095","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1053\/jhep.2003.50459","article-title":"Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis","volume":"38","author":"Biswas","year":"2003","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.exger.2026.113312_bb0100","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.2337\/db06-0812","article-title":"Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity","volume":"55","author":"Bl\u00fcher","year":"2006","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.exger.2026.113312_bb0105","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00109-009-0512-x","article-title":"Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis","volume":"87","author":"Borrelli","year":"2009","journal-title":"J. Mol. Med."},{"issue":"3","key":"10.1016\/j.exger.2026.113312_bb0110","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ejphar.2005.05.032","article-title":"Anandamide induced PPAR\u03b3 transcriptional activation and 3T3-L1 preadipocyte differentiation","volume":"517","author":"Bouaboula","year":"2005","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.exger.2026.113312_bb0115","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1093\/annonc\/mdq727","article-title":"Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial","volume":"22","author":"Brisbois","year":"2011","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.exger.2026.113312_bb0120","article-title":"Inflammatory bowel disease","volume":"411\u201327","author":"Bruner","year":"2023","journal-title":"Prim. Care"},{"issue":"6","key":"10.1016\/j.exger.2026.113312_bb0125","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/j.1478-3231.2009.02137.x","article-title":"Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis","volume":"30","author":"Caraceni","year":"2010","journal-title":"Liver Int."},{"issue":"10","key":"10.1016\/j.exger.2026.113312_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2022.166456","article-title":"Inactivation of fatty acid amide hydrolase protects against ischemic reperfusion injury-induced renal fibrogenesis","volume":"1868","author":"Chen","year":"2022","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.exger.2026.113312_bb0135","article-title":"Muscle wasting in chronic kidney disease: mechanism and clinical implications\u2014a narrative review","author":"Cheng","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2026.113312_bb0140","article-title":"Peripherally restricted CB1 receptor blockers","volume":"4751\u201360","author":"Chorvat","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.exger.2026.113312_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107477","article-title":"The therapeutic potential of second and third generation CB1R antagonists","author":"Cinar","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.exger.2026.113312_bb0150","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/oby.24019","article-title":"Seventeen years since rimonabant\u2019s downfall: reassessing its suicidality risk profile","author":"Cohen","year":"2024","journal-title":"Obesity"},{"issue":"8","key":"10.1016\/j.exger.2026.113312_bb0155","first-page":"7","article-title":"Cardiovascular disease. Introduction","volume":"3","author":"Corday","year":"2018","journal-title":"Compr. Ther."},{"key":"10.1016\/j.exger.2026.113312_bb0160","series-title":"The psychiatric side-effects of rimonabant","author":"Crippa","year":"2009"},{"key":"10.1016\/j.exger.2026.113312_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2025.101342","article-title":"The endocannabinoid system & malignant hyperthermia: from molecular signaling towards clinical implications","volume":"99","author":"Dalle","year":"2025","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.exger.2026.113312_bb0170","article-title":"Molecular networks underlying cannabinoid signaling in skeletal muscle plasticity","volume":"3517\u201340","author":"Dalle","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.exger.2026.113312_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2023.111854","article-title":"The cannabinoid receptor 1 antagonist AM6545 stimulates the Akt-mTOR axis and in vivo muscle protein synthesis in a dexamethasone-induced muscle atrophy model","volume":"563","author":"Dalle","year":"2023","journal-title":"Mol. Cell. Endocrinol."},{"issue":"5","key":"10.1016\/j.exger.2026.113312_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167179","article-title":"Endocannabinoid remodeling in murine cachexic muscle associates with catabolic and metabolic regulation","volume":"1870","author":"Dalle","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.exger.2026.113312_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.123296","article-title":"The CB1 antagonist Rimonabant improves muscle regeneration and remodels the inflammatory and endocannabinoid profile upon injury in male mice","volume":"361","author":"Dalle","year":"2025","journal-title":"Life Sci."},{"issue":"10","key":"10.1016\/j.exger.2026.113312_bb0190","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glaf189","article-title":"Rimonabant treatment partly attenuates skeletal muscle loss following immobilization in young and old sarcopenic male mice","volume":"80","author":"Dalle","year":"2025","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.exger.2026.113312_bb0195","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1161\/CIRCULATIONAHA.123.064071","article-title":"Sarcopenia and cardiovascular diseases","author":"Damluji","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.exger.2026.113312_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.720734","article-title":"Cannabinoid receptor 1 inhibition in chronic kidney disease: a new therapeutic toolbox","author":"Dao","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.exger.2026.113312_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/nu10091195","article-title":"Muscle loss in chronic liver diseases: the example of nonalcoholic liver disease","author":"De Bandt","year":"2018","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0210","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s44276-026-00208-y","article-title":"Changes in levels of endocannabinoidome mediators in mice with cancer cachexia: links with steatosis and gut microbial dysbiosis","volume":"4","author":"Degraeve","year":"2026","journal-title":"BJC Rep."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0215","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s43556-026-00541-1","article-title":"Activating cannabinoid receptor 2 alleviates iron overload-induced liver damage via dual modulation of STAT3\/hepcidin and Nrf2\/FPN1 pathways","volume":"7","author":"Deng","year":"2026","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.exger.2026.113312_bb0220","volume":"353","author":"Despr\u00e9s","year":"2005","journal-title":"Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia"},{"key":"10.1016\/j.exger.2026.113312_bb0225","article-title":"Global burden of liver disease: 2023 update","volume":"516\u201337","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.exger.2026.113312_bb0230","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1189\/jlb.0703303","article-title":"Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine\/chemokines and PMN","volume":"75","author":"Di Filippo","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.exger.2026.113312_bb0235","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1007\/s00125-008-1048-2","article-title":"The endocannabinoid system in obesity and type 2 diabetes","author":"Di Marzo","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.exger.2026.113312_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2025.115809","article-title":"The synthetic cannabinoid CUMYL-4CN-BINACA induces hepatic injury in rats via oxidative stress, NF-\u03baB activation, Nrf2 suppression, EDEM-1, ER stress-mediated apoptotic pathways","volume":"207","author":"Dogan","year":"2026","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0245","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1161\/ATVBAHA.108.168757","article-title":"Rimonabant, a selective cannabinoid CB1 receptor antagonist, inhibits atherosclerosis in LDL receptor-deficient mice","volume":"29","author":"Dol-Gleizes","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.exger.2026.113312_bb0250","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1021\/ml500439x","article-title":"Conformational restriction leading to a selective CB2 cannabinoid receptor agonist orally active against colitis","volume":"6","author":"El Bakali","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.exger.2026.113312_bb0255","series-title":"Activation of the peripheral endocannabinoid system in human obesity","author":"Engeli","year":"2005"},{"key":"10.1016\/j.exger.2026.113312_bb0260","article-title":"Impaired skeletal muscle regeneration in diabetes: from cellular and molecular mechanisms to novel treatments","volume":"1204\u201336","author":"Espino-Gonzalez","year":"2024","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.exger.2026.113312_bb0265","doi-asserted-by":"crossref","first-page":"E176","DOI":"10.1152\/ajpendo.00258.2022","article-title":"Inhibition of the endocannabinoid system reverses obese phenotype in aged mice and partly restores skeletal muscle function","volume":"324","author":"Fajardo","year":"2023","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.exger.2026.113312_bb0270","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/2049463717710042","article-title":"Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies","volume":"11","author":"Fallon","year":"2017","journal-title":"Br. J. Pain"},{"issue":"10","key":"10.1016\/j.exger.2026.113312_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109115","article-title":"Cannabinoids alleviate experimentally induced intestinal inflammation by acting at central and peripheral receptors","volume":"9","author":"Fichna","year":"2014","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.exger.2026.113312_bb0280","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/labinvest.2011.191","article-title":"Reversal of liver fibrosis by the antagonism of endocannabinoid CB1 receptor in a rat model of CCl 4-induced advanced cirrhosis","volume":"92","author":"Giannone","year":"2012","journal-title":"Lab. Invest."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0285","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-38865-4","article-title":"Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer","volume":"9","author":"Grill","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2026.113312_bb0290","article-title":"Synthetic cannabinoids-related cardiovascular emergencies: a review of the literature","author":"Hasan","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.exger.2026.113312_bb0295","doi-asserted-by":"crossref","DOI":"10.1021\/acsptsci.5c00610","article-title":"Cannabinoid 2 receptor activation mitigates high-fat diet\/streptozotocin-induced nonalcoholic fatty liver disease in diabetic mice by modulation of oxidative stress, inflammation, and fibrosis","author":"Hashiesh","year":"2026","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.exger.2026.113312_bb0300","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.743710","article-title":"Relationship between sarcopenia and cardiovascular diseases in the elderly: an overview","author":"He","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.exger.2026.113312_bb0305","article-title":"Pathophysiological changes of the liver-muscle axis in end-stage liver disease: what is the right target?","volume":"611\u201324","author":"Henin","year":"2022","journal-title":"Acta Gastroenterol. Belg."},{"issue":"5","key":"10.1016\/j.exger.2026.113312_bb0310","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/sj.bjp.0707347","article-title":"PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB 1 receptors with hypophagic effects in rats","volume":"152","author":"Horswill","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.exger.2026.113312_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmr.2025.100070","article-title":"The endocannabinoidomes: pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets","volume":"77","author":"Iannotti","year":"2025","journal-title":"Pharmacol. Rev."},{"issue":"24","key":"10.1016\/j.exger.2026.113312_bb0320","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1406728111","article-title":"The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels","volume":"111","author":"Iannotti","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0325","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-06267-1","article-title":"Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy","volume":"9","author":"Iannotti","year":"2018","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.exger.2026.113312_bb0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205467","article-title":"Muscle regeneration is disrupted by cancer cachexia without loss of muscle stem cell potential","volume":"13","author":"Inaba","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.exger.2026.113312_bb0335","volume":"134","author":"Izzo","year":"2001","journal-title":"Cannabinoid CB 1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal in\u00afammation"},{"issue":"2","key":"10.1016\/j.exger.2026.113312_bb0340","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1200\/JCO.2002.20.2.567","article-title":"Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study","volume":"20","author":"Jatoi","year":"2002","journal-title":"J. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.exger.2026.113312_bb0345","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cmet.2007.12.007","article-title":"Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver","volume":"7","author":"Jeong","year":"2008","journal-title":"Cell Metab."},{"issue":"10","key":"10.1016\/j.exger.2026.113312_bb0350","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.jamda.2019.05.015","article-title":"Association between muscular strength and mortality in clinical populations: a systematic review and meta-analysis","volume":"20","author":"Jochem","year":"2019","journal-title":"J. Am. Med. Dir. Assoc."},{"issue":"2","key":"10.1016\/j.exger.2026.113312_bb0355","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpainsymman.2009.06.008","article-title":"Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain","volume":"39","author":"Johnson","year":"2010","journal-title":"J. Pain Symptom Manage."},{"issue":"2","key":"10.1016\/j.exger.2026.113312_bb0360","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jpainsymman.2012.07.014","article-title":"An open-label extension study to investigate the long-term safety and tolerability of THC\/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics","volume":"46","author":"Johnson","year":"2013","journal-title":"J. Pain Symptom Manage."},{"issue":"4","key":"10.1016\/j.exger.2026.113312_bb0365","doi-asserted-by":"crossref","first-page":"926","DOI":"10.2337\/db09-1482","article-title":"CB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese mice","volume":"59","author":"Jourdan","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.exger.2026.113312_bb0370","volume":"55","author":"Joyeux","year":"2002","journal-title":"E ndocannabinoids are implicated in the infarct size-reducing effect conferred by heat stress preconditioning in isolated rat hearts"},{"issue":"3","key":"10.1016\/j.exger.2026.113312_bb0375","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1053\/j.gastro.2004.12.050","article-title":"Antifibrogenic role of the cannabinoid receptor CB2 in the liver","volume":"128","author":"Julien","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.exger.2026.113312_bb0380","article-title":"Chronic kidney disease","volume":"786\u2013802","author":"Kalantar-Zadeh","year":"2021","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.exger.2026.113312_bb0385","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155076","article-title":"Activation of cannabinoid receptor 2 ameliorates dss-induced colitis through inhibiting nlrp3 inflammasome in macrophages","volume":"11","author":"Ke","year":"2016","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.exger.2026.113312_bb0390","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00407.2005","article-title":"Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium","volume":"291","author":"Kimball","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"4","key":"10.1016\/j.exger.2026.113312_bb0395","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000522113","article-title":"Endocannabinoid system in polycystic kidney disease","volume":"53","author":"Klawitter","year":"2022","journal-title":"Am. J. Nephrol."},{"issue":"11","key":"10.1016\/j.exger.2026.113312_bb0400","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S2213-8587(25)00216-5","article-title":"Efficacy and safety of monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial","volume":"13","author":"Knop","year":"2025","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.exger.2026.113312_bb0405","series-title":"GENERAL PATHOLOGY AND PATHOLOGICAL PHYSIOLOGY Activation of type II cannabinoid receptors improves myocardial tolerance to arrhythmogenic effects of coronary occlusion and reperfusion","volume":"131","author":"Krylatov","year":"2001"},{"key":"10.1016\/j.exger.2026.113312_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178114","article-title":"Postconditioning of AM-1241 mitigates myocardial ischemia-reperfusion injury via modulation of inflammatory, fibrosis, apoptotic and autophagy pathway in rats","volume":"1005","author":"Kumar","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0415","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-03353-5","article-title":"Liver fibrosis-induced muscle atrophy is mediated by elevated levels of circulating TNF\u03b1","volume":"12","author":"Kurosawa","year":"2021","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.exger.2026.113312_bb0420","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1002\/jcp.30034","article-title":"Acute rimonabant treatment promotes protein synthesis in C2C12 myotubes through a CB1-independent mechanism","volume":"236","author":"Le Bacquer","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0425","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/ki.2015.63","article-title":"Cannabinoid receptor 1 is a major mediator of renal fibrosis","volume":"88","author":"Lecru","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.exger.2026.113312_bb0430","doi-asserted-by":"crossref","DOI":"10.1093\/ibd\/izag066","article-title":"CB2R promotes T cell gut homing and exacerbates ileitis in a murine Crohn\u2019s model","author":"Leddy","year":"2026","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.exger.2026.113312_bb0435","article-title":"Role of the gut microbiome in skeletal muscle physiology and pathophysiology","volume":"422\u201332","author":"Lefevre","year":"2022","journal-title":"Curr. Osteoporos. Rep."},{"issue":"11","key":"10.1016\/j.exger.2026.113312_bb0440","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/ecco-jcc\/jjx096","article-title":"Cannabinoid receptor-2 ameliorates inflammation in Murine model of Crohn\u2019s disease","volume":"11","author":"Leinwand","year":"2017","journal-title":"J. Crohn\u2019s Colitis"},{"issue":"4","key":"10.1016\/j.exger.2026.113312_bb0445","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/sj.bjp.0705313","article-title":"Endocannabinoids protect the rat isolated heart against ischaemia","volume":"139","author":"L\u00e9picier","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.exger.2026.113312_bb0450","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuropharm.2013.03.029","article-title":"A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice","volume":"71","author":"Li","year":"2013","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0455","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-026-03077-z","article-title":"Cannabinoid type 2 receptor regulates skeletal muscle regeneration by NLRP3-GSDMD mediated macrophage pyroptosis after injury","volume":"12","author":"Li","year":"2026","journal-title":"Cell Death Discov."},{"issue":"3","key":"10.1016\/j.exger.2026.113312_bb0460","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/eurjpc\/zwac285","article-title":"Global trends and regional differences in incidence and mortality of cardiovascular disease, 1990\u22122019: findings from 2019 global burden of disease study","volume":"30","author":"Li","year":"2023","journal-title":"Eur. J. Prev. Cardiol."},{"issue":"3","key":"10.1016\/j.exger.2026.113312_bb0465","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0016-5085(03)00881-3","article-title":"Possible endocannabinoid control of colorectal cancer growth","volume":"125","author":"Ligresti","year":"2003","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.exger.2026.113312_bb0470","doi-asserted-by":"crossref","first-page":"392","DOI":"10.5217\/ir.2021.00160","article-title":"Involvement of the cannabinoid system in chronic inflammatory intestinal diseases: opportunities for new therapies","volume":"20","author":"Lima","year":"2022","journal-title":"Intest. Res."},{"key":"10.1016\/j.exger.2026.113312_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2025.156308","article-title":"Hepatic CB1 receptor signaling triggers Gi\/o\u03b1-mediated lipolysis in lean mice but Gs\u03b1-mediated lipogenesis in obese mice","volume":"170","author":"Liu","year":"2025","journal-title":"Metab. Clin. Exp."},{"issue":"4","key":"10.1016\/j.exger.2026.113312_bb0480","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1210\/jc.2006-2240","article-title":"Human adipose tissue cannabinoid receptor 1 gene expression is not related to fat cell function or adiponectin level","volume":"92","author":"L\u00f6fgren","year":"2007","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.exger.2026.113312_bb0485","article-title":"CB2 receptors as new therapeutic targets for liver diseases","volume":"286\u20139","author":"Lotersztajn","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.exger.2026.113312_bb0490","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179472","article-title":"The endocannabinoid system: a potential target for the treatment of various diseases","author":"Lowe","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.exger.2026.113312_bb0495","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1124\/pharmrev.122.000600","article-title":"Goods and bads of the endocannabinoid system as a therapeutic target: lessons learned after 30 years","volume":"75","author":"Maccarrone","year":"2023","journal-title":"Pharmacol. Rev."},{"issue":"9","key":"10.1016\/j.exger.2026.113312_bb0500","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006893","article-title":"Ulcerative colitis induces changes on the expression of the endocannabinoid system in the human colonic tissue","volume":"4","author":"Marqu\u00e9z","year":"2009","journal-title":"PloS One"},{"issue":"8","key":"10.1016\/j.exger.2026.113312_bb0505","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1210\/jc.2005-2679","article-title":"Regulation, function, and dysregulation of endocannabinoids in models of adipose and \u03b2-pancreatic cells and in obesity and hyperglycemia","volume":"91","author":"Matias","year":"2006","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"1\u20132 SUPPL. 1","key":"10.1016\/j.exger.2026.113312_bb0510","article-title":"Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: effect of high fat diets","volume":"286","author":"Matias","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"issue":"7","key":"10.1016\/j.exger.2026.113312_bb0515","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042399","article-title":"Endocannabinoids measurement in human saliva as potential biomarker of obesity","volume":"7","author":"Matias","year":"2012","journal-title":"PloS One"},{"issue":"10","key":"10.1016\/j.exger.2026.113312_bb0520","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/s41386-025-02128-w","article-title":"The efficacy of elevating anandamide via inhibition of fatty acid amide hydrolase (FAAH) combined with internet-delivered cognitive behavioral therapy in the treatment of post-traumatic stress disorder: a randomized, placebo-controlled clinical trial","volume":"50","author":"Mayo","year":"2025","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.exger.2026.113312_bb0525","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/sj.npp.1300695","article-title":"Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa","volume":"30","author":"Monteleone","year":"2005","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0530","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1089\/can.2016.0013","article-title":"Increased renal 2-arachidonoylglycerol level is associated with improved renal function in a mouse model of acute kidney injury","volume":"1","author":"Moradi","year":"2016","journal-title":"Cannabis Cannabinoid Res."},{"issue":"10","key":"10.1016\/j.exger.2026.113312_bb0535","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1210\/js.2019-00242","article-title":"Serum endocannabinoid levels in patients with end-stage renal disease","volume":"3","author":"Moradi","year":"2019","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.exger.2026.113312_bb0540","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2020.569904","article-title":"Exploring the impact of obesity on skeletal muscle function in older age","author":"Morgan","year":"2020","journal-title":"Front. Nutr."},{"issue":"6","key":"10.1016\/j.exger.2026.113312_bb0545","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jacc.2007.03.057","article-title":"Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity","volume":"50","author":"Mukhopadhyay","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.exger.2026.113312_bb0550","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.694217","article-title":"Inflammatory bowel diseases and sarcopenia: the role of inflammation and gut microbiota in the development of muscle failure","author":"Nardone","year":"2021","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.exger.2026.113312_bb0555","doi-asserted-by":"crossref","DOI":"10.3390\/ph16111580","article-title":"Cancer-cachexia-induced human skeletal muscle myotube degeneration is prevented via cannabinoid receptor 2 agonism in vitro","volume":"16","author":"Noone","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.exger.2026.113312_bb0560","doi-asserted-by":"crossref","DOI":"10.1111\/bph.70507","article-title":"Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut\u2013brain vagal axis","author":"Onimus","year":"2026","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.exger.2026.113312_bb0565","volume":"10","author":"Osei-Hyiaman","year":"2007","journal-title":"Endocannabinoid system in cancer cachexia."},{"issue":"5","key":"10.1016\/j.exger.2026.113312_bb0570","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI200523057","article-title":"Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity","volume":"115","author":"Osei-Hyiaman","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.exger.2026.113312_bb0575","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.clnesp.2023.02.020","article-title":"The association of circulating endocannabinoids with cancer cachexia: a cross-sectional study","volume":"55","author":"Ota","year":"2023","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.exger.2026.113312_bb0580","article-title":"The emerging role of the endocannabinoid system in cardiovascular disease","volume":"63\u201377","author":"Pacher","year":"2009","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.exger.2026.113312_bb0585","series-title":"Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: first evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level*","author":"Pagotto","year":"2001"},{"issue":"4","key":"10.1016\/j.exger.2026.113312_bb0590","doi-asserted-by":"crossref","first-page":"7057","DOI":"10.3390\/ijms16047057","article-title":"Elevated levels of endocannabinoids in chronic hepatitis c may modulate cellular immune response and hepatic stellate cell activation","volume":"16","author":"Patsenker","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exger.2026.113312_bb0595","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.peptides.2015.03.007","article-title":"Cannabinoid receptor 1 and acute resistance exercise - in vivo and in vitro studies in human skeletal muscle","volume":"67","author":"Pekkala","year":"2015","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.exger.2026.113312_bb0600","doi-asserted-by":"crossref","DOI":"10.4253\/wjge.v18.i2.113576","article-title":"Altered endocannabinoid system gene expression in inflammatory bowel disease mucosa: new perspectives in inflammatory bowel disease management","volume":"18","author":"Pelisenco","year":"2026","journal-title":"World J. Gastrointest. Endosc."},{"key":"10.1016\/j.exger.2026.113312_bb0605","article-title":"The pharmacology of cannabinoid receptors and their ligands: an overview","volume":"S13\u20138","author":"Pertwee","year":"2006","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.exger.2026.113312_bb0610","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1124\/pr.110.003004","article-title":"International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2","author":"Pertwee","year":"2010","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.exger.2026.113312_bb0615","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1471-4159.2005.03013.x","article-title":"Endocannabinoid metabolism in human glioblastomas and meningiomas compared to human non-tumour brain tissue","volume":"93","author":"Petersen","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.exger.2026.113312_bb0620","volume":"295","author":"Pi-Sunyer","year":"2006","journal-title":"Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients"},{"issue":"11","key":"10.1016\/j.exger.2026.113312_bb0625","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/eurheartj\/ehr029","article-title":"Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity","volume":"32","author":"Quercioli","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.exger.2026.113312_bb0630","series-title":"Definition and classification of cancer cachexia: an international consensus","first-page":"489","volume":"12","author":"Raff","year":"2011"},{"key":"10.1016\/j.exger.2026.113312_bb0635","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.00430","article-title":"Modulation of the endocannabinoid system as a potential anticancer strategy","author":"Ramer","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exger.2026.113312_bb0640","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108140","article-title":"Rimonabant ameliorates hepatic ischemia\/reperfusion injury in rats: involvement of autophagy via modulating ERK- and PI3K\/AKT-mTOR pathways","volume":"100","author":"Rezq","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.exger.2026.113312_bb0645","article-title":"Role of cannabinoid signaling in cardiovascular function and ischemic injury","volume":"265\u201376","author":"Rorabaugh","year":"2023","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/j.exger.2026.113312_bb0650","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24044216","article-title":"Systemic changes in endocannabinoids and endocannabinoid-like molecules in response to partial nephrectomy-induced ischemia in humans","volume":"24","author":"Rothner","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.exger.2026.113312_bb0655","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/sj.bjp.0707460","article-title":"The orphan receptor GPR55 is a novel cannabinoid receptor","volume":"152","author":"Ryberg","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.exger.2026.113312_bb0660","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1096\/fj.15-270637","article-title":"Multitarget fatty acid amide hydrolase\/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage","volume":"29","author":"Sasso","year":"2015","journal-title":"FASEB Journal"},{"key":"10.1016\/j.exger.2026.113312_bb0665","article-title":"Molecular mechanisms through which cannabidiol may affect skeletal muscle metabolism, inflammation, tissue regeneration, and anabolism: a narrative review","volume":"745\u201357","author":"Schouten","year":"2022","journal-title":"Cannabis Cannabinoid Res."},{"key":"10.1016\/j.exger.2026.113312_bb0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.apjon.2023.100292","article-title":"Cannabinoids in the treatment of cancer anorexia and cachexia: where have we been, where are we going?","author":"Seymour-Jackson","year":"2023","journal-title":"Asia Pac. J. Oncol. Nurs."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0675","doi-asserted-by":"crossref","DOI":"10.1186\/s12882-024-03720-w","article-title":"Global forecasting of chronic kidney disease mortality rates and numbers with the generalized additive model","volume":"25","author":"Shahbazi","year":"2024","journal-title":"BMC Nephrol."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0680","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.apsb.2021.07.007","article-title":"[18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models","volume":"12","author":"Shao","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"11","key":"10.1016\/j.exger.2026.113312_bb0685","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1096\/fj.06-7717com","article-title":"The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species","volume":"21","author":"Siegmund","year":"2007","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.exger.2026.113312_bb0690","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.taap.2011.11.005","article-title":"Cannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10 -\/- mice by attenuating the activation of T cells and promoting their apoptosis","volume":"258","author":"Singh","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0695","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008792","article-title":"Biomarkers of endocannabinoid system activation in severe obesity","volume":"5","author":"Sipe","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.exger.2026.113312_bb0700","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.867267","article-title":"The microbiome and gut endocannabinoid system in the regulation of stress responses and metabolism","author":"Srivastava","year":"2022","journal-title":"Front. Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.exger.2026.113312_bb0705","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/oby.2007.106","article-title":"Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet","volume":"16","author":"Starowicz","year":"2008","journal-title":"Obesity"},{"key":"10.1016\/j.exger.2026.113312_bb0710","series-title":"Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice","author":"Steffens","year":"2005"},{"key":"10.1016\/j.exger.2026.113312_bb0715","article-title":"Role of cannabinoid receptors and RAGE in inflammatory bowel disease","volume":"26","author":"Stintzing","year":"2011","journal-title":"Histol. Histopathol."},{"issue":"11","key":"10.1016\/j.exger.2026.113312_bb0720","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1002\/ibd.20960","article-title":"Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis","volume":"15","author":"Storr","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"issue":"21","key":"10.1016\/j.exger.2026.113312_bb0725","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1200\/JCO.2005.05.1847","volume":"24","author":"Strasser","year":"2006","journal-title":"J. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.exger.2026.113312_bb0730","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037729","article-title":"Ulcerative colitis impairs the acylethanolamide-based anti-inflammatory system reversal by 5-aminosalicylic acid and glucocorticoids","volume":"7","author":"Su\u00e1rez","year":"2012","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0735","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/CIRCULATIONAHA.108.811992","article-title":"Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages","volume":"119","author":"Sugamura","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.exger.2026.113312_bb0740","article-title":"The emerging role of the endocannabinoid system in the pathogenesis and treatment of kidney diseases","volume":"267\u201376","author":"Tam","year":"2016","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0745","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/hep.24077","article-title":"Endocannabinoids in liver disease","volume":"53","author":"Tam","year":"2011","journal-title":"Hepatology"},{"issue":"12","key":"10.1016\/j.exger.2026.113312_bb0750","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1111\/bph.15010","article-title":"The peripheral CB1 receptor antagonist JD5037 attenuates liver fibrosis via a CB1 receptor\/\u03b2-arrestin1\/Akt pathway","volume":"177","author":"Tan","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.exger.2026.113312_bb0755","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nm1421","article-title":"CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis","volume":"12","author":"Teixeira-Clerc","year":"2006","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.exger.2026.113312_bb0760","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1478-3231.2011.02496.x","article-title":"Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts","volume":"31","author":"Trebicka","year":"2011","journal-title":"Liver Int."},{"key":"10.1016\/j.exger.2026.113312_bb0765","article-title":"Endovanilloids: putative endogenous ligands of transient receptor potential vanilloid 1 channels","volume":"1827\u201334","author":"Van Der Stelt","year":"2004","journal-title":"Eur. J. Biochem."},{"issue":"5","key":"10.1016\/j.exger.2026.113312_bb0770","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/ejendo\/lvaf212","article-title":"Inhibition of endocannabinoid synthesis enzymes DAGL and NAPE-PLD transiently lowers body weight and alters glucose homeostasis during a high-fat diet challenge in mice","volume":"193","author":"Van Eenige","year":"2025","journal-title":"Eur. J. Endocrinol."},{"issue":"9468","key":"10.1016\/j.exger.2026.113312_bb0775","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(05)66374-X","article-title":"Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study","volume":"365","author":"Van Gaal","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.exger.2026.113312_bb0780","article-title":"GLP\u22121 receptor agonists for the treatment of obesity: role as a promising approach","author":"Wang","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"3","key":"10.1016\/j.exger.2026.113312_bb0785","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-065186","article-title":"Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the Global Burden of Disease Study 2019","volume":"13","author":"Wang","year":"2023","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0790","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/abio.2001.5015","article-title":"Simultaneous measurement of anandamide and 2-arachidonoylglycerol by polymyxin B-selective adsorption and subsequent high-performance liquid chromatography analysis: increase in endogenous cannabinoids in the sera of patients with endotoxic shock","volume":"294","author":"Wang","year":"2001","journal-title":"Anal. Biochem."},{"issue":"6 June","key":"10.1016\/j.exger.2026.113312_bb0795","article-title":"Low skeletal muscle mass index and all-cause mortality risk in adults: a systematic review and meta-analysis of prospective cohort studies","volume":"18","author":"Wang","year":"2023","journal-title":"PLoS ONE"},{"key":"10.1016\/j.exger.2026.113312_bb0800","article-title":"Symphony of the gut microbiota and endocannabinoidome: a molecular and functional perspective","author":"Wang","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.exger.2026.113312_bb0805","article-title":"MAGL-18c attenuates LPS-induced sepsis-associated liver injury by inhibiting TGF-\u03b2\/Smad signaling and remodeling medium- and long-chain fatty acid metabolism","volume":"17","author":"Wang","year":"2026","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0810","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1172\/JCI88880","article-title":"Skeletal muscle inflammation and insulin resistance in obesity","volume":"127","author":"Wu","year":"2017","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.exger.2026.113312_bb0815","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-99592-3","article-title":"Relationship between chronic kidney disease and sarcopenia","volume":"11","author":"Yu","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exger.2026.113312_bb0820","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.lfs.2019.05.056","article-title":"Activation of cannabinoid type 2 receptor protects skeletal muscle from ischemia-reperfusion injury partly via Nrf2 signaling","volume":"230","author":"Zhang","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.exger.2026.113312_bb0825","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2025.171456","article-title":"DR8 (DHNNPQIR), a rapeseed-derived peptide, mitigates fibrosis and muscle atrophy in chronic kidney disease by targeting CNR1\u2013ERK\/ELK-1 signaling","volume":"194","author":"Zhang","year":"2025","journal-title":"Peptides"},{"key":"10.1016\/j.exger.2026.113312_bb0830","article-title":"The intervention of cannabinoid receptor in chronic and acute kidney disease animal models: a systematic review and meta-analysis","author":"Zhao","year":"2024","journal-title":"Diabetol. Metab. Syndr."},{"issue":"2","key":"10.1016\/j.exger.2026.113312_bb0835","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.kint.2020.09.025","article-title":"Cannabinoid receptor type 2 promotes kidney fibrosis through orchestrating \u03b2-catenin signaling","volume":"99","author":"Zhou","year":"2021","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.exger.2026.113312_bb0840","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.7150\/thno.92848","article-title":"MAGL protects against renal fibrosis through inhibiting tubular cell lipotoxicity","volume":"14","author":"Zhou","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.exger.2026.113312_bb0845","article-title":"Sarcopenia and cardiovascular diseases: a systematic review and meta-analysis","volume":"1183\u201398","author":"Zuo","year":"2023","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.exger.2026.113312_bb0850","article-title":"Cannabinoids, inflammation, and fibrosis","volume":"3682\u20139","author":"Zurier","year":"2016","journal-title":"FASEB J."}],"container-title":["Experimental Gerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0531556526002913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:40:21Z","timestamp":1792428021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0531556526002913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":170,"alternative-id":["S0531556526002913"],"URL":"https:\/\/doi.org\/10.1016\/j.exger.2026.113312","relation":{},"ISSN":["0531-5565"],"issn-type":[{"value":"0531-5565","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endocannabinoid system dysregulation in non-communicable diseases: implications for skeletal muscle health","name":"articletitle","label":"Article Title"},{"value":"Experimental Gerontology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exger.2026.113312","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113312"}}