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Nutr."},{"key":"10.1016\/j.exger.2026.113320_bb0460","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/acel.12338","article-title":"Interventions to Slow Aging in Humans: Are We Ready?","volume":"14","author":"Longo","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2026.113320_bb0465","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.exger.2026.113320_bb0470","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: An expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.exger.2026.113320_bb0475","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI57132","article-title":"Inflammatory links between obesity and metabolic disease","volume":"121","author":"Lumeng","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exger.2026.113320_bb0480","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/imr.12858","article-title":"Immunometabolism: From basic mechanisms to translation","volume":"295","author":"Makowski","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.exger.2026.113320_bb0485","doi-asserted-by":"crossref","first-page":"268ra179","DOI":"10.1126\/scitranslmed.3009892","article-title":"mTOR inhibition improves immune function in the elderly","volume":"6","author":"Mannick","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.exger.2026.113320_bb0490","doi-asserted-by":"crossref","first-page":"eaaq1564","DOI":"10.1126\/scitranslmed.aaq1564","article-title":"TORC1 inhibition enhances immune function and reduces infections in the elderly","volume":"10","author":"Mannick","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.exger.2026.113320_bb0495","doi-asserted-by":"crossref","first-page":"1051076","DOI":"10.3389\/fendo.2022.1051076","article-title":"Crucial role of T cells in NAFLD-related disease: A review and prospect","volume":"13","author":"Mao","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.exger.2026.113320_bb0500","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41467-020-14396-9","article-title":"Sexual-dimorphism in human immune system aging","volume":"11","author":"M\u00e1rquez","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2026.113320_bb0505","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nri2922","article-title":"Immunometabolism: An emerging frontier","volume":"11","author":"Mathis","year":"2011","journal-title":"Nat. Rev. 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Immunol."},{"key":"10.1016\/j.exger.2026.113320_bb0525","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.exger.2026.113320_bb0530","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41590-021-00927-z","article-title":"Hallmarks of T cell aging","volume":"22","author":"Mittelbrunn","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.exger.2026.113320_bb0535","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. 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Immunol."},{"key":"10.1016\/j.exger.2026.113320_bb0565","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-017-0006-x","article-title":"The twilight of immunity: emerging concepts in aging of the immune system","volume":"19","author":"Nikolich-\u017dugich","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.exger.2026.113320_bb0570","doi-asserted-by":"crossref","first-page":"15691","DOI":"10.1038\/ncomms15691","article-title":"Cellular senescence drives age-dependent hepatic steatosis","volume":"8","author":"Ogrodnik","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2026.113320_bb0575","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, Inflammation, and Insulin Resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.exger.2026.113320_bb0580","first-page":"4","article-title":"Circulating inflamma-miRs in aging and age-related diseases","author":"Olivieri","year":"2013","journal-title":"Front. Genet."},{"key":"10.1016\/j.exger.2026.113320_bb0585","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O\u2019Neill","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.exger.2026.113320_bb0590","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/jcsm.12409","article-title":"Fibroblast growth factor 21 controls mitophagy and muscle mass","volume":"10","author":"Oost","year":"2019","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.exger.2026.113320_bb0595","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nm.2627","article-title":"The cellular and signaling networks linking the immune system and metabolism in disease","volume":"18","author":"Osborn","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.exger.2026.113320_bb0600","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41419-022-04752-6","article-title":"Adipose tissue aging: Mechanisms and therapeutic implications","volume":"13","author":"Ou","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.exger.2026.113320_bb0605","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12950","article-title":"Targeting senescent cells alleviates obesity-induced metabolic dysfunction","volume":"18","author":"Palmer","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.exger.2026.113320_bb0610","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2015.00001","article-title":"Glucose metabolism regulates T cell activation, differentiation, and functions","volume":"6","author":"Palmer","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exger.2026.113320_bb0615","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41573-020-0067-7","article-title":"The quest to slow aging through drug discovery","volume":"19","author":"Partridge","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.exger.2026.113320_bb0620","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.exger.2017.10.024","article-title":"Age and immunity: What is \u201cimmunosenescence\u201d?","volume":"105","author":"Pawelec","year":"2018","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.exger.2026.113320_bb0625","doi-asserted-by":"crossref","first-page":"1242454","DOI":"10.1126\/science.1242454","article-title":"Fueling immunity: insights into metabolism and lymphocyte function","volume":"342","author":"Pearce","year":"2013","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exger.2026.113320_bb0630","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2337\/db10-0705","article-title":"Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2\/M1 Polarization in Obese Mice","volume":"60","author":"Prieur","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.exger.2026.113320_bb0635","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1749-6632.2011.06320.x","article-title":"Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications","volume":"1243","author":"Ramasamy","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.exger.2026.113320_bb0640","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11892-021-01446-9","article-title":"Adipose Tissue Inflammation and Cardiovascular Disease: An Update","volume":"22","author":"Rana","year":"2022","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.exger.2026.113320_bb0645","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-021-03634-9","article-title":"Exploring tissue architecture using spatial transcriptomics","volume":"596","author":"Rao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.exger.2026.113320_bb0650","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrendo.2017.90","article-title":"Adapting to obesity with adipose tissue inflammation","volume":"13","author":"Reilly","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.exger.2026.113320_bb0655","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0295059","article-title":"The effect of sodium-glucose cotransporter 2 inhibitors in patients with chronic kidney disease with or without type 2 diabetes mellitus on cardiovascular and renal outcomes: A systematic review and meta-analysis","volume":"18","author":"Reyes-Farias","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.exger.2026.113320_bb0660","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exger.2026.113320_bb0665","doi-asserted-by":"crossref","first-page":"1251086","DOI":"10.1126\/science.1251086","article-title":"Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity","volume":"345","author":"Saeed","year":"2014","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.exger.2026.113320_bb0670","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1172\/JCI77812","article-title":"The pathogenesis of insulin resistance: Integrating signaling pathways and substrate flux","volume":"126","author":"Samuel","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exger.2026.113320_bb0675","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jcmgh.2018.10.016","article-title":"Resolving the Paradox of Hepatic Insulin Resistance","volume":"7","author":"Santoleri","year":"2019","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.exger.2026.113320_bb0680","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41467-020-20123-1","article-title":"Mechanisms of muscle atrophy and hypertrophy: Implications in health and disease","volume":"12","author":"Sartori","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.exger.2026.113320_bb0685","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/s43587-021-00082-y","article-title":"An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging","volume":"1","author":"Sayed","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.exger.2026.113320_bb0690","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1172\/JCI200114002","article-title":"The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses","volume":"108","author":"Schmidt","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exger.2026.113320_bb0695","doi-asserted-by":"crossref","DOI":"10.1002\/cbf.3970","article-title":"Exploring the emerging bidirectional association between inflamm-aging and cellular senescence in organismal aging and disease","volume":"42","author":"Sharma","year":"2024","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.exger.2026.113320_bb0700","series-title":"Advanced Glycation End-Products Acting as Immunomodulators for Chronic Inflammation","first-page":"12","author":"Shen","year":"2024"},{"key":"10.1016\/j.exger.2026.113320_bb0705","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid-induced insulin resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J. Clin. 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