{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:07:46Z","timestamp":1791349666111,"version":"4.3.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":6308,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.exphem.2004.11.006","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T07:14:19Z","timestamp":1109142859000},"page":"344-352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Mechanisms of resistance to natural killer cell-mediated cytotoxicity in acute lymphoblastic leukemia"],"prefix":"10.1016","volume":"33","author":[{"given":"Annette","family":"Romanski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesine","family":"Bug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Kampfmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhard","family":"Seifried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Hoelzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver G.","family":"Ottmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Tonn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2004.11.006_bib1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0145-2126(92)90067-H","article-title":"Cytotoxicity of interleukin 2-induced lymphokine-activated killer (LAK) cells against human leukemia and augmentation of killing by interferons and tumor necrosis factor","volume":"16","author":"Teichmann","year":"1992","journal-title":"Leuk Res"},{"key":"10.1016\/j.exphem.2004.11.006_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/cbr.1994.9.265","article-title":"MHC-unrestricted immune surveillance of leukemia","volume":"9","author":"Pawelec","year":"1994","journal-title":"Cancer Biother"},{"key":"10.1016\/j.exphem.2004.11.006_bib3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00007890-198101000-00014","article-title":"Natural killer cell activity in human bone marrow recipients: early reappearance of peripheral natural killer activity in graft-versus-host disease","volume":"31","author":"Dokhelar","year":"1981","journal-title":"Transplantation"},{"key":"10.1016\/j.exphem.2004.11.006_bib4","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/sj.leu.2401145","article-title":"Induction of sensitivity to NK-mediated cytotoxicity by TNF-alpha treatment: possible role of ICAM-3 and CD44","volume":"12","author":"Maki","year":"1998","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2004.11.006_bib5","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nrc928","article-title":"New aspects of natural-killer-cell surveillance and therapy of cancer","volume":"2","author":"Smyth","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.exphem.2004.11.006_bib6","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1084\/jem.189.7.1093","article-title":"A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells","volume":"189","author":"Rajagopalan","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2004.11.006_bib7","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1073\/pnas.96.10.5674","article-title":"Inhibitory receptors sensing HLA-G1 molecules in pregnancy: decidua-associated natural killer cells express LIR-1 and CD94\/NKG2A and acquire p49, an HLA-G1-specific receptor","volume":"96","author":"Ponte","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2004.11.006_bib8","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.1073\/pnas.96.10.5343","article-title":"Natural killer cells fertile with receptors for HLA-G?","volume":"96","author":"Lanier","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2004.11.006_bib9","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1006\/cimm.1994.1125","article-title":"Resistance of HLA-G and HLA-A2 transfectants to lysis by decidual NK cells","volume":"155","author":"Chumbley","year":"1994","journal-title":"Cell Immunol"},{"key":"10.1016\/j.exphem.2004.11.006_bib10","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1126\/science.274.5288.792","article-title":"Protection from natural killer cell-mediated lysis by HLA-G expression on target cells","volume":"274","author":"Pazmany","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.exphem.2004.11.006_bib11","doi-asserted-by":"crossref","first-page":"14666","DOI":"10.1073\/pnas.94.26.14666","article-title":"Multiple receptors for HLA-G on human natural killer cells","volume":"94","author":"Mandelboim","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2004.11.006_bib12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/(SICI)1521-4141(199901)29:01<277::AID-IMMU277>3.0.CO;2-4","article-title":"The ILT2(LIR1) and CD94\/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells","volume":"29","author":"Navarro","year":"1999","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.exphem.2004.11.006_bib13","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1126\/science.1068440","article-title":"Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants","volume":"295","author":"Ruggeri","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.exphem.2004.11.006_bib14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0952-7915(00)00094-7","article-title":"Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo","volume":"12","author":"Trapani","year":"2000","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.exphem.2004.11.006_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/369031a0","article-title":"Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice","volume":"369","author":"Kagi","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2004.11.006_bib16","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1182\/blood.V96.2.594.014k36_594_600","article-title":"Impaired binding of perforin on the surface of tumor cells is a cause of target cell resistance against cytotoxic effector cells","volume":"96","author":"Lehmann","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2004.11.006_bib17","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1046\/j.1365-2141.2001.02995.x","article-title":"Activation of natural killer cells with interleukin 2 (IL-2) and IL-12 increases perforin binding and subsequent lysis of tumour cells","volume":"114","author":"Lehmann","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2004.11.006_bib18","first-page":"2859","article-title":"Antileukemia activity of a natural killer cell line against human leukemias","volume":"4","author":"Yan","year":"1998","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.exphem.2004.11.006_bib19","first-page":"652","article-title":"Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells","volume":"8","author":"Gong","year":"1994","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2004.11.006_bib20","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/S0041-1345(99)00186-4","article-title":"Expression and regulation of HLA-G in human glioma cell lines","volume":"31","author":"Maier","year":"1999","journal-title":"Transplant Proc"},{"key":"10.1016\/j.exphem.2004.11.006_bib21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0145-2126(98)00172-6","article-title":"Establishment of a double Philadelphia chromosome-positive acute lymphoblastic leukemia-derived cell line, TMD5: effects of cytokines and differentiation inducers on growth of the cells","volume":"23","author":"Tohda","year":"1999","journal-title":"Leuk Res"},{"key":"10.1016\/j.exphem.2004.11.006_bib22","first-page":"68","article-title":"A cytotoxic NK-cell line (NK-92) for ex vivo purging of leukemia from blood","volume":"2","author":"Klingemann","year":"1996","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2004.11.006_bib23","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/(SICI)1097-0215(19970611)71:6<1086::AID-IJC27>3.0.CO;2-A","article-title":"Decreased expression of ICAM-1 and its induction by tumor necrosis factor on breast-cancer cells in vitro","volume":"71","author":"Budinsky","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1016\/j.exphem.2004.11.006_bib24","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1182\/blood-2003-01-0019","article-title":"Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia","volume":"102","author":"Salih","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2004.11.006_bib25","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.4049\/jimmunol.157.7.2909","article-title":"Involvement of Fas ligand and Fas-mediated pathway in the cytotoxicity of human natural killer cells","volume":"157","author":"Oshimi","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2004.11.006_bib26","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s002620050384","article-title":"The participation of the Fas-mediated cytotoxic pathway by natural killer cells is tumor-cell-dependent","volume":"44","author":"Mori","year":"1997","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.exphem.2004.11.006_bib27","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/4779","article-title":"Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells","volume":"5","author":"Bossi","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2004.11.006_bib28","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.4049\/jimmunol.168.7.3484","article-title":"Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin","volume":"168","author":"Seki","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2004.11.006_bib29","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1182\/blood.V94.1.333.413a31_333_339","article-title":"Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation","volume":"94","author":"Ruggeri","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2004.11.006_bib30","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.4049\/jimmunol.160.6.2967","article-title":"Bi-directional induction of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 during T lymphoma\/endothelial cell contact: implication of ICAM-1","volume":"160","author":"Aoudjit","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2004.11.006_bib31","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1038\/sj.onc.1205684","article-title":"Matrix metalloproteinase 9 (MMP-9\/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity","volume":"21","author":"Fiore","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2004.11.006_bib32","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0145-2126(02)00228-X","article-title":"Analysis of HLA-G expression in malignant hematopoetic cells from leukemia patients","volume":"27","author":"Polakova","year":"2003","journal-title":"Leuk Res"},{"key":"10.1016\/j.exphem.2004.11.006_bib33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1089\/152581601750288975","article-title":"Factors regulating the cytotoxic activity of the human natural killer cell line, NK-92","volume":"10","author":"Maki","year":"2001","journal-title":"J Hematother Stem Cell Res"},{"key":"10.1016\/j.exphem.2004.11.006_bib34","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1182\/blood.V99.10.3661","article-title":"Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia","volume":"99","author":"Costello","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2004.11.006_bib35","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1182\/blood.V100.4.1265.h81602001265_1265_1273","article-title":"Retargeting of natural killercell cytolytic activity to ErbB2-expressing cancer cells results in efficient and selective tumor cell destruction","volume":"100","author":"Uherek","year":"2002","journal-title":"Blood"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X04004084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X04004084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:19:30Z","timestamp":1759565970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X04004084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0301472X04004084"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2004.11.006","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of resistance to natural killer cell-mediated cytotoxicity in acute lymphoblastic leukemia","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2004.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 International Society for Experimental Hematology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}