{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:45:18Z","timestamp":1790203518441,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":4937,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.exphem.2008.07.008","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T13:30:41Z","timestamp":1224077441000},"page":"1625-1633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["4-Arylcoumarin analogues of combretastatins stimulate apoptosis of leukemic cells from chronic lymphocytic leukemia patients"],"prefix":"10.1016","volume":"36","author":[{"given":"Christian","family":"Billard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faouzia","family":"Menasria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Quiney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Faussat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Finet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Combes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Kolb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2008.07.008_bib1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1021\/np50051a008","article-title":"Antineoplastic agents, 122. Constituents of Combretum caffrum","volume":"50","author":"Pettit","year":"1987","journal-title":"J Nat Prod"},{"key":"10.1016\/j.exphem.2008.07.008_bib2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0026-895X(25)09364-2","article-title":"Interactions of tubulin with potent natural and synthetic analogues of the antimitotic agent combretastatin: a structure-activity study","volume":"34","author":"Lin","year":"1988","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.exphem.2008.07.008_bib3","first-page":"3933","article-title":"Anti-tumour and anti-vascular effects of the novel tubulin-binding agent combretastatin A-1 phosphate","volume":"22","author":"Holwell","year":"2002","journal-title":"Anticancer Res"},{"key":"10.1016\/j.exphem.2008.07.008_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-2613.2002.00211.x","article-title":"The biology of the combretastatins as tumour vascular targeting agents","volume":"83","author":"Tozer","year":"2002","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.exphem.2008.07.008_bib5","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1021\/jm00010a011","article-title":"Antineoplastic agents 291. Isolation ans synthesis of combretastatins A-4, A-5 and A-6","volume":"38","author":"Pettit","year":"1995","journal-title":"J Med Chem"},{"key":"10.1016\/j.exphem.2008.07.008_bib6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF02940301","article-title":"Differential cytotoxicity of combretastatins A1 and A4 in two daunorubicin-resistant P388 cell lines","volume":"26","author":"McGown","year":"1990","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.exphem.2008.07.008_bib7","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/bjc.1995.138","article-title":"The interaction with tubulin of a series of stilbenes based on combretastatin A-4","volume":"71","author":"Woods","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1016\/j.exphem.2008.07.008_bib8","first-page":"249","article-title":"Structural and biochemical comparison of the anti-mitotic agents colchicine, combretastatin A4 and amphethinile","volume":"3","author":"McGown","year":"1989","journal-title":"Anticancer Drug Res"},{"key":"10.1016\/j.exphem.2008.07.008_bib9","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1021\/jm030903d","article-title":"Synthesis and biological evaluation of combretastatins","volume":"46","author":"Bailly","year":"2003","journal-title":"J Med Chem"},{"key":"10.1016\/j.exphem.2008.07.008_bib10","doi-asserted-by":"crossref","first-page":"9210","DOI":"10.1021\/bi060476g","article-title":"Interaction of 4-arylcoumarin analogues of combretastatins with microtubule network of HBL1 cells and binding to tubulin","volume":"45","author":"Rappl","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.exphem.2008.07.008_bib11","first-page":"2735","article-title":"Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage","volume":"8","author":"Nabha","year":"2002","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.exphem.2008.07.008_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10495-006-0491-0","article-title":"Combretastatin CA-4 and combretastatin derivative induce mitotic catastrophe dependent on spindle checkpoint and caspase-3 activation in non-small cell lung cancer cells","volume":"12","author":"Vitale","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.exphem.2008.07.008_bib13","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00280-006-0294-6","article-title":"MZ3 induces apoptosis in human leukemia cells","volume":"59","author":"Fang","year":"2007","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.exphem.2008.07.008_bib14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1182\/asheducation-2004.1.163","article-title":"Chronic lymphocytic leukemia","volume":"4","author":"Byrd","year":"2004","journal-title":"Hematology (Am Soc Hematol)"},{"key":"10.1016\/j.exphem.2008.07.008_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2174\/1568006033481384","article-title":"Re-establishment of a normal apoptotic process as a therapeutic approach in B-CLL","volume":"3","author":"Kolb","year":"2003","journal-title":"Curr Drug Targets Cardiovasc Haematol Disord"},{"key":"10.1016\/j.exphem.2008.07.008_bib16","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1182\/blood.V92.3.1031","article-title":"B-cell chronic lymphocytic leukemia cells express a functional inducible nitric oxide synthase displaying anti-apoptotic activity","volume":"92","author":"Zhao","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2008.07.008_bib17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1182\/blood-2003-02-0540","article-title":"Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway","volume":"103","author":"Kern","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2008.07.008_bib18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0145-2126(90)90167-8","article-title":"Establishment of a karyotypically normal B-chronic lymphocytic leukemia cell line: evidence of leukemic origin by immunoglobin gene rearrangement","volume":"14","author":"Saltman","year":"1990","journal-title":"Leukemia Res"},{"key":"10.1016\/j.exphem.2008.07.008_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/pca.888","article-title":"Na\u00eft-Sy. Effect of eluent pH on HPLC\/UV analysis of hyperforin","volume":"17","author":"Fourneron","year":"2006","journal-title":"Phytochem Anal"},{"key":"10.1016\/j.exphem.2008.07.008_bib20","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1182\/blood.V84.5.1415.bloodjournal8451415","article-title":"Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis","volume":"84","author":"Koopman","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2008.07.008_bib21","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1038\/sj.leu.2403139","article-title":"Flavopiridol downregulates the expression of both the inducible NO synthase and p27kip1 in malignant cells from B-cell chronic lymphocytic leukemia","volume":"17","author":"Billard","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2008.07.008_bib22","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.leukres.2003.12.003","article-title":"Flavones and polyphenols inhibit the NO pathway during apoptosis of leukemia B-cells","volume":"28","author":"Quiney","year":"2004","journal-title":"Leukemia Res"},{"key":"10.1016\/j.exphem.2008.07.008_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2141.2002.03520.x","article-title":"Analysis of resveratrol-induced apoptosis in human B-cell chronic leukemia","volume":"117","author":"Roman","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2008.07.008_bib24","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1182\/blood.V92.10.3804","article-title":"Flavopiridol induces apoptosis in chronic lymphocytic leukemia via activation of caspase-3 and without evidence of bcl-2 modulation or dependence on functional p53","volume":"92","author":"Byrd","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2008.07.008_bib25","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/sj.leu.2404098","article-title":"Pro-apoptotic properties of hyperforin in leukemic cells from patients with chronic lymphocytic leukemia","volume":"20","author":"Quiney","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2008.07.008_bib26","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1182\/blood.V91.12.4694","article-title":"Prognostic significance of the cell cycle inhibitor p27Kip1 in chronic lymphocytic leukemia","volume":"91","author":"Vrhorac","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2008.07.008_bib27","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/sj.leu.2402783","article-title":"IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells","volume":"17","author":"Levesque","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2008.07.008_bib28","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1038\/sj.leu.2401896","article-title":"Mechanisms involved in the pro- and anti-apoptotic effects of NO in human leukemia","volume":"4","author":"Kolb","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2008.07.008_bib29","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1080\/1042819021000015952","article-title":"Comparative antiproliferative and apoptotic effects of resveratrol, \u03b5-viniferin and vine-shots derived polyphenols (vineatrols) on chronic B lymphocytic leukemia cells and normal lymphocytes","volume":"43","author":"Billard","year":"2002","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.exphem.2008.07.008_bib30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.beha.2007.03.007","article-title":"Cell proliferation and death: forgotten features of chronic lymphocytic leukemia B cells","volume":"20","author":"Chiorazzi","year":"2007","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1016\/j.exphem.2008.07.008_bib31","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1038\/sj.leu.2402610","article-title":"DNA profiling and cytogenetic analysis of cell line WSU-CLL reveal cross-contamination with cell line REH (preB-ALL)","volume":"16","author":"Drexler","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2008.07.008_bib32","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1182\/blood-2006-05-020735","article-title":"Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia","volume":"109","author":"Byrd","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2008.07.008_bib33","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1182\/blood.V91.9.3379","article-title":"Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses","volume":"91","author":"Kitada","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2008.07.008_bib34","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1046\/j.1365-2141.2001.02895.x","article-title":"Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia","volume":"114","author":"Pepper","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2008.07.008_bib35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/sj.leu.2403237","article-title":"Flavopiridol: where do we stand in chronic lymphocytic leukemia?","volume":"18","author":"Lin","year":"2004","journal-title":"Leukemia"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X08003548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X08003548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:26:22Z","timestamp":1759566382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X08003548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0301472X08003548"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2008.07.008","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"4-Arylcoumarin analogues of combretastatins stimulate apoptosis of leukemic cells from chronic lymphocytic leukemia patients","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2008.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}