{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:08:29Z","timestamp":1773288509649,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":4906,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.exphem.2008.09.012","type":"journal-article","created":{"date-parts":[[2008,12,20]],"date-time":"2008-12-20T05:33:57Z","timestamp":1229751237000},"page":"111-121.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Tel\/PDGFR\u03b2 induces stem cell differentiation via the Ras\/ERK and STAT5 signaling pathways"],"prefix":"10.1016","volume":"37","author":[{"given":"Edwina","family":"Dobbin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciaren","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela M.","family":"Corrigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith G.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin W.","family":"Freeburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Wheadon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2008.09.012_bib1","series-title":"World Health Organization of Tumours: Pathology and Genetics. Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe","year":"2001"},{"key":"10.1016\/j.exphem.2008.09.012_bib2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/sj.leu.2404955","article-title":"Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms","volume":"22","author":"Tefferi","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2008.09.012_bib3","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/315550a0","article-title":"Fused transcript of Abl and Bcr genes in chronic myelogenous leukemia","volume":"315","author":"Shtivelman","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2008.09.012_bib4","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrc2210","article-title":"Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders","volume":"7","author":"Levine","year":"2007","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"10.1016\/j.exphem.2008.09.012_bib5","doi-asserted-by":"crossref","first-page":"550","DOI":"10.4161\/cc.6.5.3919","article-title":"Oncogenes in myeloproliferative disorders","volume":"1","author":"Tefferi","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.exphem.2008.09.012_bib6","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0092-8674(94)90322-0","article-title":"Fusion of PDGF receptor [beta] to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation","volume":"77","author":"Golub","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2008.09.012_bib7","doi-asserted-by":"crossref","first-page":"14845","DOI":"10.1073\/pnas.93.25.14845","article-title":"The TEL\/platelet-derived growth factor beta receptor (PDGFbeta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFbeta R kinase-dependent signaling pathways","volume":"93","author":"Carroll","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2008.09.012_bib8","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1172\/JCI8902","article-title":"Fatal myeloproliferation, induced in mice by TEL\/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579\/581","volume":"105","author":"Tomasson","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2008.09.012_bib9","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1182\/blood.V99.5.1758","article-title":"TEL\/platelet-derived growth factor receptor beta activates phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle","volume":"99","author":"Dierov","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2008.09.012_bib10","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0301-472X(00)00138-7","article-title":"TEL\/PDGF[beta]R fusion protein activates STAT1 and STAT5: a common mechanism for transformation by tyrosine kinase fusion proteins","volume":"28","author":"Wilbanks","year":"2000","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2008.09.012_bib11","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1182\/blood-2002-09-2974","article-title":"The coupling of TEL\/PDGF{beta}R to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases","volume":"102","author":"Wheadon","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2008.09.012_bib12","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1182\/blood-2006-07-036335","article-title":"Myeloproliferative disease induced by TEL-PDGFR\u03b2 displays dynamic range sensitivity to STAT5 gene dosage","volume":"109","author":"Cain","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2008.09.012_bib13","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.onc.1201555","article-title":"Activation of STAT5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains","volume":"16","author":"Valgeirsdottir","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2008.09.012_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/emboj\/16.1.69","article-title":"A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein","volume":"16","author":"Jousset","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2008.09.012_bib15","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.leukres.2008.02.007","article-title":"Tel\/PDGFR[beta] inhibits self-renewal and directs myelomonocytic differentiation of ES cells","volume":"32","author":"Dobbin","year":"2008","journal-title":"Leukemia Res"},{"key":"10.1016\/j.exphem.2008.09.012_bib16","doi-asserted-by":"crossref","first-page":"48063","DOI":"10.1074\/jbc.M406467200","article-title":"Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling","volume":"279","author":"Paling","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2008.09.012_bib17","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1093\/emboj\/18.15.4261","article-title":"Stat 3 activation is sufficient to maintain an undifferentiated state of embryonic stem cells","volume":"18","author":"Matsuda","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2008.09.012_bib18","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1101\/gad.12.13.2048","article-title":"Self-renewal of embryonic stem cells is mediated via activation of Stat3","volume":"12","author":"Niwa","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.exphem.2008.09.012_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.1432-0436.1998.6250213.x","article-title":"Transcription factor STAT5 is an early marker of differentiation of murine embryonic stem cells","volume":"62","author":"Nemetz","year":"1998","journal-title":"Differentiation"},{"key":"10.1016\/j.exphem.2008.09.012_bib20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/dbio.1999.9265","article-title":"Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells","volume":"210","author":"Burdon","year":"1999","journal-title":"Dev Biol"},{"key":"10.1016\/j.exphem.2008.09.012_bib21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.cdd.4401337","article-title":"A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells","volume":"11","author":"Duval","year":"2004","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.exphem.2008.09.012_bib22","doi-asserted-by":"crossref","first-page":"30136","DOI":"10.1074\/jbc.271.47.30136","article-title":"gp130-Mediated signal transduction in embryonic stem cells involves activation of Jak and Ras\/mitogen-activated protein kinase pathways","volume":"271","author":"Ernst","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2008.09.012_bib23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0092-8674(00)81769-9","article-title":"Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4","volume":"3","author":"Nichols","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2008.09.012_bib24","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1242\/jcs.03038","article-title":"The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway","volume":"119","author":"Bashamboo","year":"2006","journal-title":"J Cell Sci"},{"key":"10.1016\/j.exphem.2008.09.012_bib25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1196\/annals.1392.006","article-title":"The Cdx-Hox pathway in hematopoietic stem cell formation from embryonic stem cells","volume":"1106","author":"Lengerke","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.exphem.2008.09.012_bib26","doi-asserted-by":"crossref","first-page":"6816","DOI":"10.1038\/sj.onc.1210764","article-title":"Transcriptional control of granulocyte and monocyte development","volume":"26","author":"Friedman","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2008.09.012_bib27","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1093\/emboj\/18.15.4261","article-title":"STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells","volume":"18","author":"Matsuda","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2008.09.012_bib28","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1101\/gad.12.13.2048","article-title":"Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3","volume":"12","author":"Nima","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.exphem.2008.09.012_bib29","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1242\/dev.01670","article-title":"LIF\/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism","volume":"132","author":"Cartwright","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.exphem.2008.09.012_bib30","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1042\/BST0331518","article-title":"The homeodomain protein Nanog and pluripotency in mouse embryonic stem cells","volume":"33","author":"Yates","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.exphem.2008.09.012_bib31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(03)00847-X","article-title":"BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3","volume":"115","author":"Ying","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2008.09.012_bib32","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1038\/sj.onc.1206607","article-title":"Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells","volume":"22","author":"Coppo","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2008.09.012_bib33","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0301-472X(99)00041-7","article-title":"Changes in signal transduction downstream from the granulocyte-macrophage colony-stimulating factor receptor during differentiation of primary hemopoietic cells","volume":"27","author":"Wheadon","year":"1999","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2008.09.012_bib34","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/BF02994005","article-title":"Differentiation, apoptosis, and function of human immature and mature myeloid cells: intracellular signaling mechanism","volume":"73","author":"Yuo","year":"2001","journal-title":"Int J Hematol"},{"key":"10.1016\/j.exphem.2008.09.012_bib35","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.clinthera.2007.11.005","article-title":"Dasatinib: a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia","volume":"29","author":"Steinberg","year":"2007","journal-title":"Clin Ther"},{"key":"10.1016\/j.exphem.2008.09.012_bib36","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1056\/NEJMoa020150","article-title":"Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta","volume":"347","author":"Apperley","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2008.09.012_bib37","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.exphem.2007.04.010","article-title":"Involvement of tyrosine kinase signaling in maintaining murine embryonic stem cell functionality","volume":"35","author":"Lu","year":"2007","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2008.09.012_bib38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1365-2141.1996.6102053.x","article-title":"Interaction of the receptor tyrosine kinase p145c-kit with the p210bcr\/abl kinase in myeloid cells","volume":"94","author":"Hallek","year":"1996","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2008.09.012_bib39","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1038\/sj.onc.1205424","article-title":"BCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor","volume":"21","author":"Pierce","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2008.09.012_bib40","doi-asserted-by":"crossref","first-page":"17456","DOI":"10.1073\/pnas.0407061101","article-title":"Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations","volume":"101","author":"Wong","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2008.09.012_bib41","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/sj.leu.2402341","article-title":"Abnormality of c-kit oncoprotein in certain patients with chronic myelogenous leukemia\u2014potential clinical significance","volume":"16","author":"Inokuchi","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2008.09.012_bib42","first-page":"186","article-title":"Farnesyltransferase inhibitors in myelodysplastic syndrome","volume":"4","author":"Feldman","year":"2005","journal-title":"Curr Hematol Rep"},{"key":"10.1016\/j.exphem.2008.09.012_bib43","first-page":"77","article-title":"Farnesyltransferase inhibitor therapy in acute myelogenous leukemia","volume":"4","author":"Gotlib","year":"2005","journal-title":"Curr Hematol Rep"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X08004621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X08004621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:26:42Z","timestamp":1759566402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X08004621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0301472X08004621"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2008.09.012","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tel\/PDGFR\u03b2 induces stem cell differentiation via the Ras\/ERK and STAT5 signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2008.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}