{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:32:57Z","timestamp":1789950777231,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":4816,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.exphem.2009.01.003","type":"journal-article","created":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T07:52:09Z","timestamp":1237449129000},"page":"423-434.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Silencing of genes required for glycosylphosphatidylinositol anchor biosynthesis in Burkitt lymphoma"],"prefix":"10.1016","volume":"37","author":[{"given":"Rong","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina L.","family":"Mukhina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul T.","family":"Englund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul J.","family":"Sharkis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Thomas","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Brodsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2009.01.003_bib1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.3276003","article-title":"Structural and functional roles of glycosyl-phosphatidylinositol in membranes","volume":"239","author":"Low","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.exphem.2009.01.003_bib2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.bi.64.070195.003023","article-title":"How glycosylphosphatidylinositol-anchored membrane proteins are made","volume":"64","author":"Udenfriend","year":"1995","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.exphem.2009.01.003_bib3","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S1367-5931(00)00151-4","article-title":"Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis","volume":"4","author":"Kinoshita","year":"2000","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.exphem.2009.01.003_bib4","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1074\/jbc.273.4.2355","article-title":"Glycosylphosphatidylinositol anchors of membrane glycoproteins are binding determinants for the channel-forming toxin aerolysin","volume":"273","author":"Diep","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2009.01.003_bib5","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1182\/blood.V93.5.1749","article-title":"Resistance of paroxysmal nocturnal hemoglobinuria cells to the glycosylphosphatidylinositol-binding toxin aerolysin","volume":"93","author":"Brodsky","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2009.01.003_bib6","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.7680492","article-title":"The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis","volume":"259","author":"Miyata","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.exphem.2009.01.003_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/bbrc.1996.1332","article-title":"PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2","volume":"226","author":"Inoue","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.exphem.2009.01.003_bib8","doi-asserted-by":"crossref","first-page":"20733","DOI":"10.1016\/S0021-9258(19)36842-5","article-title":"Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk- cells by a human cDNA clone","volume":"268","author":"Kamitani","year":"1993","journal-title":"J Biol Chem"},{"issue":"334(Pt 3)","key":"10.1016\/j.exphem.2009.01.003_bib9","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/bj3340609","article-title":"Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants","volume":"15","author":"Tiede","year":"1998","journal-title":"Biochem J"},{"key":"10.1016\/j.exphem.2009.01.003_bib10","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/emboj\/17.4.877","article-title":"The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1","volume":"17","author":"Watanabe","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2009.01.003_bib11","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1091\/mbc.e05-08-0743","article-title":"The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component","volume":"16","author":"Murakami","year":"2005","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.exphem.2009.01.003_bib12","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1093\/emboj\/19.16.4402","article-title":"Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2","volume":"19","author":"Watanabe","year":"2000","journal-title":"EMBO J"},{"issue":"Pt 1","key":"10.1016\/j.exphem.2009.01.003_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1042\/bj3390185","article-title":"Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis","volume":"339","author":"Watanabe","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.exphem.2009.01.003_bib14","doi-asserted-by":"crossref","first-page":"16479","DOI":"10.1074\/jbc.274.23.16479","article-title":"A cell-free assay for glycosylphosphatidylinositol anchoring in African trypanosomes. Demonstration of a transamidation reaction mechanism","volume":"274","author":"Sharma","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2009.01.003_bib15","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/0968-0004(92)90491-Q","article-title":"How to make a glycoinositol phospholipid anchor","volume":"17","author":"Tartakoff","year":"1992","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.exphem.2009.01.003_bib16","first-page":"2362","article-title":"Anchoring and degradation of glycolipid-anchored membrane proteins by L929 versus by LM-TK- mouse fibroblasts: implications for anchor biosynthesis","volume":"11","author":"Singh","year":"1991","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.exphem.2009.01.003_bib17","unstructured":"Brodsky RA. Paroxysmal nocturnal hemoglobinuria. In: Hoffman R, Benz EJ Jr, Shattil SJ, et\u00a0al., eds. Hematology: Basic Principles and Practice. 4th ed. Philadelphia: Elsevier Churchill Livingstone; 2005. p. 419\u2013427."},{"key":"10.1016\/j.exphem.2009.01.003_bib18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2141.2004.04992.x","article-title":"Natural history of paroxysmal nocturnal hemoglobinuria using modern diagnostic assays","volume":"126","author":"Moyo","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2009.01.003_bib19","doi-asserted-by":"crossref","first-page":"587","DOI":"10.7326\/0003-4819-148-8-200804150-00003","article-title":"Narrative review: paroxysmal nocturnal hemoglobinuria: the physiology of complement-related hemolytic anemia","volume":"148","author":"Brodsky","year":"2008","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.exphem.2009.01.003_bib20","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/ajcp\/114.3.459","article-title":"Improved detection and characterization of paroxysmal nocturnal hemoglobinuria using fluorescent aerolysin","volume":"114","author":"Brodsky","year":"2000","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.exphem.2009.01.003_bib21","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1046\/j.1365-2141.2001.03127.x","article-title":"Multilineage glycosylphosphatidylinositol anchor deficient hematopoiesis in untreated aplastic anemia","volume":"115","author":"Mukhina","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2009.01.003_bib22","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1084\/jem.177.2.517","article-title":"Deficient biosynthesis of N-acetylglucosaminyl-phosphatidylinositol, the first intermediate of glycosyl phosphatidylinositol anchor biosynthesis, in cell lines established from patients with paroxysmal nocturnal hemoglobinuria","volume":"177","author":"Takahaski","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2009.01.003_bib23","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/j.1460-2075.1994.tb06240.x","article-title":"Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene","volume":"13","author":"Bessler","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2009.01.003_bib24","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1182\/blood.V86.12.4656.bloodjournal86124656","article-title":"Genetic defects underlying paroxysmal nocturnal hemoglobinuria that arises out of aplastic anemia","volume":"86","author":"Nagarajan","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2009.01.003_bib25","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/hmg\/3.5.751","article-title":"Genomic organization of the X-linked gene (PIG-A) that is mutated in paroxysmal nocturnal haemoglobinuria and of a related autosomal pseudogene mapped to 12q21","volume":"43","author":"Bessler","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.exphem.2009.01.003_bib26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1046\/j.1365-2141.1999.01676.x","article-title":"The PNH phenotype\u00a0cells that emerge in most patients after CAMPATH-1H therapy are present prior to treatment","volume":"107","author":"Rawstron","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2009.01.003_bib27","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1073\/pnas.96.9.5209","article-title":"Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria genotype and phenotype are present in normal individuals","volume":"96","author":"Araten","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2009.01.003_bib28","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0301-472X(01)00746-9","article-title":"Circulating PIG-A mutant T lymphocytes in healthy adults and patients with bone marrow failure syndromes","volume":"29","author":"Ware","year":"2001","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2009.01.003_bib29","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1182\/blood-2004-04-1472","article-title":"PIG-A mutations in normal hematopoiesis","volume":"105","author":"Hu","year":"2005","journal-title":"Blood"},{"issue":"Pt 3","key":"10.1016\/j.exphem.2009.01.003_bib30","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1042\/bj3220919","article-title":"Antibody selection against CD52 produces a paroxysmal nocturnal haemoglobinuria phenotype in human lymphocytes by a novel mechanism","volume":"322","author":"Taylor","year":"1997","journal-title":"Biochem J"},{"key":"10.1016\/j.exphem.2009.01.003_bib31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/intimm\/7.1.69","article-title":"Cross-linking of the CAMPATH-1 antigen (CD52) triggers activation of normal human T lymphocytes","volume":"7","author":"Rowan","year":"1995","journal-title":"Int Immunol"},{"issue":"Pt 3","key":"10.1016\/j.exphem.2009.01.003_bib32","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1042\/bj3140969","article-title":"Mechanisms by which the surface expression of the glycosyl-phosphatidylinositol-anchored complement regulatory proteins decay-accelerating factor (CD55) and CD59 is lost in human leukaemia cell lines","volume":"314","author":"Hatanaka","year":"1996","journal-title":"Biochem J"},{"key":"10.1016\/j.exphem.2009.01.003_bib33","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.1158\/1078-0432.CCR-06-1275","article-title":"Heterogeneous CD52 expression among hematologic neoplasms: implications for the use of alemtuzumab (CAMPATH-1H)","volume":"12","author":"Rodig","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.exphem.2009.01.003_bib34","doi-asserted-by":"crossref","first-page":"11168","DOI":"10.1016\/S0021-9258(18)60444-2","article-title":"Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine","volume":"264","author":"Doering","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2009.01.003_bib35","doi-asserted-by":"crossref","first-page":"9718","DOI":"10.1016\/S0021-9258(18)98407-3","article-title":"Regulation of glycosylphosphatidylinositol biosynthesis by GTP. Stimulation of N-acetylglucosamine-phosphatidylinositol deacetylation","volume":"268","author":"Stevens","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2009.01.003_bib36","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1073\/pnas.88.9.3762","article-title":"Assembly and deacetylation of N-acetylglucosaminyl-plasmanylinositol in normal and affected paroxysmal nocturnal hemoglobinuria cells","volume":"88","author":"Hirose","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2009.01.003_bib37","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMra023075","article-title":"Gene silencing in cancer in association with promoter hypermethylation","volume":"349","author":"Herman","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2009.01.003_bib38","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.cell.2004.05.003","article-title":"Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER","volume":"117","author":"Sobering","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2009.01.003_bib39","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/emboj\/20.1.250","article-title":"PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER","volume":"20","author":"Maeda","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2009.01.003_bib40","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF01233060","article-title":"Sodium butyrate causes reexpression of three membrane proteins on glycolipid-anchoring mutants","volume":"17","author":"Tisdale","year":"1991","journal-title":"Somat Cell Mol Genet"},{"key":"10.1016\/j.exphem.2009.01.003_bib41","first-page":"2191","article-title":"Carcinoembryonic antigen and other glycoconjugates act as ligands for galectin-3 in human colon carcinoma cells","volume":"55","author":"Ohannesian","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.exphem.2009.01.003_bib42","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nm1410","article-title":"Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency","volume":"12","author":"Almeida","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2009.01.003_bib43","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1056\/NEJMoa063369","article-title":"Targeted therapy for inherited GPI deficiency","volume":"356","author":"Almeida","year":"2007","journal-title":"N Engl J Med"},{"issue":"274","key":"10.1016\/j.exphem.2009.01.003_bib44","doi-asserted-by":"crossref","first-page":"27274","DOI":"10.1074\/jbc.274.38.27274","article-title":"Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors","volume":"17","author":"Gordon","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2009.01.003_bib45","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/10428190310001625700","article-title":"Enhanced cytotoxicity of rituximab following genetic and biochemical disruption of glycosylphosphatidylinositol anchored proteins","volume":"45","author":"Nagajothi","year":"2004","journal-title":"Leuk Lymphoma"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X0900006X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X0900006X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:26:42Z","timestamp":1759566402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X0900006X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0301472X0900006X"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2009.01.003","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Silencing of genes required for glycosylphosphatidylinositol anchor biosynthesis in Burkitt lymphoma","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2009.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}