{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:10:46Z","timestamp":1772507446021,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.exphem.2010.03.018","type":"journal-article","created":{"date-parts":[[2010,4,12]],"date-time":"2010-04-12T06:06:17Z","timestamp":1271052377000},"page":"653-660.e1","source":"Crossref","is-referenced-by-count":16,"title":["Aberrantly expressed CEACAM6 is involved in the signaling leading to apoptosis of acute lymphoblastic leukemia cells"],"prefix":"10.1016","volume":"38","author":[{"given":"Veronika","family":"Kanderov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ond\u0159ej","family":"Hru\u0161\u00e1k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Kalina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2010.03.018_bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/scbi.1998.0119","article-title":"The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues","volume":"9","author":"Hammarstrom","year":"1999","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.exphem.2010.03.018_bib2","doi-asserted-by":"crossref","first-page":"e1353","DOI":"10.1371\/journal.pone.0001353","article-title":"Colorectal hyperplasia and dysplasia due to human carcinoembryonic antigen (CEA) family member expression in transgenic mice","volume":"2","author":"Chan","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.exphem.2010.03.018_bib3","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1158\/0008-5472.CAN-04-0424","article-title":"A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells","volume":"64","author":"Duxbury","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.exphem.2010.03.018_bib4","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1200\/JCO.2003.55.135","article-title":"Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance","volume":"21","author":"Jantscheff","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.exphem.2010.03.018_bib5","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/01.sla.0000140755.97224.9a","article-title":"Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer","volume":"240","author":"Duxbury","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.exphem.2010.03.018_bib6","doi-asserted-by":"crossref","first-page":"8809","DOI":"10.1158\/0008-5472.CAN-05-0420","article-title":"Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen)","volume":"65","author":"Blumenthal","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.exphem.2010.03.018_bib7","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/cimm.2001.1772","article-title":"Adhesion of neutrophils to fibronectin: role of the cd66 antigens","volume":"208","author":"Nair","year":"2001","journal-title":"Cell Immunol"},{"key":"10.1016\/j.exphem.2010.03.018_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-0039.1998.tb03017.x","article-title":"CD66c antigen expression is myeloid restricted in normal bone marrow but is a common feature of CD10+ early-B-cell malignancies","volume":"52","author":"Boccuni","year":"1998","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.exphem.2010.03.018_bib9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12185-008-0044-0","article-title":"Differential expression of the carcinoembryonic antigen-related cell adhesion molecules panCD66, CD66a, CD66c and of sialyl-Lewis x (CD15s) on blast cells of acute leukemias","volume":"87","author":"Ratei","year":"2008","journal-title":"Int J Hematol"},{"key":"10.1016\/j.exphem.2010.03.018_bib10","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/sj.leu.2401408","article-title":"The KOR-SA3544 antigen predominantly expressed on the surface of Philadelphia chromosome-positive acute lymphoblastic leukemia cells is nonspecific cross-reacting antigen-50\/90 (CD66c) and invariably expressed in cytoplasm of human leukemia cells","volume":"13","author":"Sugita","year":"1999","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2010.03.018_bib11","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/sj.leu.2401072","article-title":"Aberrant expression of KOR-SA3544 antigen in childhood acute lymphoblastic leukemia predicts TEL-AML1 negativity. The Pediatric Hematology Working Group in the Czech Republic","volume":"12","author":"Hrusak","year":"1998","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2010.03.018_bib12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2407-5-38","article-title":"Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens","volume":"5","author":"Kalina","year":"2005","journal-title":"BMC Cancer"},{"key":"10.1016\/j.exphem.2010.03.018_bib13","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/sj.leu.2402504","article-title":"Antigen expression patterns reflecting genotype of acute leukemias","volume":"16","author":"Hrusak","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2010.03.018_bib14","doi-asserted-by":"crossref","first-page":"23176","DOI":"10.1074\/jbc.M402051200","article-title":"CEACAM6 cross-linking induces caveolin-1-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells","volume":"279","author":"Duxbury","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2010.03.018_bib15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3747\/co.2007.109","article-title":"Recent advances in the tumour biology of the GPI-anchored carcinoembryonic antigen family members CEACAM5 and CEACAM6","volume":"14","author":"Chan","year":"2007","journal-title":"Curr Oncol"},{"key":"10.1016\/j.exphem.2010.03.018_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00232-002-1002-z","article-title":"Evidence for segregation of heterologous GPI-anchored proteins into separate lipid rafts within the plasma membrane","volume":"189","author":"Wang","year":"2002","journal-title":"J Membr Biol"},{"key":"10.1016\/j.exphem.2010.03.018_bib17","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1083\/jcb.200605001","article-title":"Specific inhibition of GPI-anchored protein function by homing and self-association of specific GPI anchors","volume":"175","author":"Nicholson","year":"2006","journal-title":"J Cell Biol"},{"key":"10.1016\/j.exphem.2010.03.018_bib18","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/jcp.20887","article-title":"GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through enhanced integrin alpha5beta1-fibronectin interaction","volume":"210","author":"Ordonez","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.exphem.2010.03.018_bib19","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/sj.cdd.4401658","article-title":"Integrins as a distinct subtype of dependence receptors","volume":"12","author":"Stupack","year":"2005","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.exphem.2010.03.018_bib20","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0955-0674(00)00129-0","article-title":"Avidity regulation of integrins: the driving force in leukocyte adhesion","volume":"12","author":"van Kooyk","year":"2000","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.exphem.2010.03.018_bib21","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1182\/blood.V96.5.1926","article-title":"Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy","volume":"96","author":"Mudry","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2010.03.018_bib22","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1080\/1042819021000003009","article-title":"The role of Aktand RAFTK in beta1 integrin mediated survival of precursor B-acute lymphoblastic leukemia cells","volume":"43","author":"Sarkar","year":"2002","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.exphem.2010.03.018_bib23","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1182\/blood.V94.2.754","article-title":"High frequency of adhesion defects in B-lineage acute lymphoblastic leukemia","volume":"94","author":"Geijtenbeek","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2010.03.018_bib24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jim.2005.12.005","article-title":"A novel flow-cytometry-based assay for quantification of affinity and avidity changes of integrins","volume":"310","author":"Konstandin","year":"2006","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.exphem.2010.03.018_bib25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/(SICI)1097-0320(19981001)33:2<197::AID-CYTO14>3.0.CO;2-P","article-title":"Determination of CD4 antigen density on cells: role of antibody valency, avidity, clones, and conjugation","volume":"33","author":"Davis","year":"1998","journal-title":"Cytometry"},{"key":"10.1016\/j.exphem.2010.03.018_bib26","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/jcp.20989","article-title":"A co-clustering model involving alpha5beta1 integrin for the biological effects of GPI-anchored human carcinoembryonic antigen (CEA)","volume":"211","author":"Camacho-Leal","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.exphem.2010.03.018_bib27","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1179\/102453308X348315","article-title":"Fibronectin promotes cell proliferation of human pre-B cell line via its interactions with VLA-4 and VLA-5","volume":"13","author":"Harima","year":"2008","journal-title":"Hematology"},{"key":"10.1016\/j.exphem.2010.03.018_bib28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/sj.leu.2405017","article-title":"Combination therapy of an anticancer drug with the FNIII14 peptide of fibronectin effectively overcomes cell adhesion-mediated drug resistance of acute myelogenous leukemia","volume":"22","author":"Matsunaga","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2010.03.018_bib29","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1242\/jcs.115.5.963","article-title":"The involvement of lipid rafts in the regulation of integrin function","volume":"115","author":"Leitinger","year":"2002","journal-title":"J Cell Sci"},{"key":"10.1016\/j.exphem.2010.03.018_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/1042819031000139620","article-title":"Regulation of lymphoid and myeloid leukemic cell survival: role of stromal cell adhesion molecules","volume":"45","author":"Hall","year":"2004","journal-title":"Leuk Lymphoma"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X10001335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X10001335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T20:45:09Z","timestamp":1635194709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X10001335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0301472X10001335"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2010.03.018","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}