{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:02:07Z","timestamp":1768554127554,"version":"3.49.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":4025,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.exphem.2011.02.013","type":"journal-article","created":{"date-parts":[[2011,3,9]],"date-time":"2011-03-09T10:26:01Z","timestamp":1299666361000},"page":"653-665.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells"],"prefix":"10.1016","volume":"39","author":[{"given":"Gabriella","family":"Marfe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Di Stefano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Gambacurta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Ottone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Martini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Abruzzese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Mologni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Sinibaldi-Salimei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"de Fabritis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Gambacorti-Passerini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Amadori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond B.","family":"Birge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2011.02.013_bib1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/243290a0","article-title":"Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining","volume":"243","author":"Rowley","year":"1973","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2011.02.013_bib2","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/1097-0142(19880401)61:7<1441::AID-CNCR2820610727>3.0.CO;2-C","article-title":"Characteristics of accelerated disease in chronic myelogenous leukemia","volume":"61","author":"Kantarjian","year":"1988","journal-title":"Cancer"},{"key":"10.1016\/j.exphem.2011.02.013_bib3","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1056\/NEJMra020777","article-title":"Chronic myeloid leukemia advances in biology and new approaches to treatment","volume":"349","author":"Goldman","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2011.02.013_bib4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1056\/NEJMoa011573","article-title":"International STI571 CML Study Group. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia","volume":"346","author":"Kantarjian","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2011.02.013_bib5","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1182\/blood.V99.10.3530","article-title":"Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study","volume":"99","author":"Sawyers","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2011.02.013_bib6","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1126\/science.289.5486.1938","article-title":"Structural mechanism for STI-571 inhibition of abelson tyrosine kinase","volume":"289","author":"Schindler","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.exphem.2011.02.013_bib7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1470-2045(03)00979-3","article-title":"Molecular mechanisms of resistance to imatinib in Philadelphia-chromosome-positive leukaemias","volume":"4","author":"Gambacorti-Passerini","year":"2003","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.exphem.2011.02.013_bib8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1054\/drup.2000.0176","article-title":"Mechanisms of resistance to imatinib (STI571) and prospects for combination with conventional chemotherapeutic agents","volume":"4","author":"Krystal","year":"2001","journal-title":"Drug Resis Updates"},{"key":"10.1016\/j.exphem.2011.02.013_bib9","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0925-4439(02)00095-9","article-title":"Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1","volume":"1587","author":"Hegedus","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.exphem.2011.02.013_bib10","doi-asserted-by":"crossref","first-page":"757","DOI":"10.6004\/jnccn.2005.0045","article-title":"Resistance to imatinib: mechanisms and management","volume":"3","author":"Deininger","year":"2005","journal-title":"J\u00a0Natl Compr Canc Netw"},{"key":"10.1016\/j.exphem.2011.02.013_bib11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.critrevonc.2005.06.007","article-title":"Novel targeted therapies to overcome imatinib mesylate resistance in chronic myeloid leukemia (CML)","volume":"57","author":"Walz","year":"2006","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.exphem.2011.02.013_bib12","doi-asserted-by":"crossref","first-page":"10922","DOI":"10.1074\/jbc.M610157200","article-title":"Alterations of ceramide\/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells","volume":"282","author":"Baran","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2011.02.013_bib13","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1172\/JCI33337","article-title":"Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K\/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells","volume":"118","author":"Kharas","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2011.02.013_bib14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nature02866","article-title":"Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity","volume":"431","author":"Um","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2011.02.013_bib15","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nm1052","article-title":"mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of\u00a0apoptotic and HIF-1-dependent pathways","volume":"10","author":"Majumber","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2011.02.013_bib16","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nm1042","article-title":"The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis","volume":"10","author":"Ruggero","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2011.02.013_bib17","doi-asserted-by":"crossref","first-page":"12892","DOI":"10.1021\/bi980744d","article-title":"N N Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide","volume":"37","author":"Edsall","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.exphem.2011.02.013_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0076-6879(00)11084-5","article-title":"Assaying sphingosine kinase activity","volume":"311","author":"Olivera","year":"2000","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.exphem.2011.02.013_bib19","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0960-9822(00)00834-4","article-title":"An oncogenic role of sphingosine kinase","volume":"10","author":"Xia","year":"2000","journal-title":"Curr Biol"},{"key":"10.1016\/j.exphem.2011.02.013_bib20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0145-2126(01)00129-1","article-title":"Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine","volume":"26","author":"Jendiroba","year":"2002","journal-title":"Leuk Res"},{"key":"10.1016\/j.exphem.2011.02.013_bib21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1388-1981(02)00341-4","article-title":"Sphingosine kinase, sphingosine-1-phosphate, and apoptosis","volume":"1585","author":"Maceyka","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.exphem.2011.02.013_bib22","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1182\/blood-2004-12-4832","article-title":"Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression","volume":"106","author":"Le Scolan","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2011.02.013_bib23","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/01.jnen.0000175329.59092.2c","article-title":"Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines","volume":"64","author":"Van Brocklyn","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.exphem.2011.02.013_bib24","doi-asserted-by":"crossref","first-page":"16211","DOI":"10.1074\/jbc.272.26.16211","article-title":"Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk","volume":"272","author":"Blakesly","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2011.02.013_bib25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1478-811X-7-13","article-title":"Crk and CrkL adaptor proteins: networks for physiological and pathological signalling","volume":"7","author":"Birge","year":"2009","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.exphem.2011.02.013_bib26","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1182\/blood.V96.3.1070","article-title":"Selection and characterization of Bcr-Abl positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance","volume":"96","author":"Mahon","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2011.02.013_bib27","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1373\/clinchem.2004.031112","article-title":"Italian Cooperative Study Group on Chronic Myeloid Leukemia; European LeukemiaNet-6th Framework Program of the European Community. Denaturing-HPLC-based assay for detection of ABL mutations in chronic myeloid leukemia patients resistant to Imatinib","volume":"50","author":"Soverini","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.exphem.2011.02.013_bib28","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"10.1016\/j.exphem.2011.02.013_bib29","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1046\/j.1365-2141.1998.00823.x","article-title":"Quantitation of minimal residual disease in Philadelphia chromosome positive chronic myeloid leukaemia patients using real-time quantitative RT-PCR","volume":"102","author":"Mensink","year":"1998","journal-title":"Br J\u00a0Haematol"},{"key":"10.1016\/j.exphem.2011.02.013_bib30","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1042\/BJ20060251","article-title":"Extracellular export of\u00a0sphingosine kinase-1a contributes to the vascular S1P gradient","volume":"397","author":"Venkataraman","year":"2006","journal-title":"Biochem J"},{"key":"10.1016\/j.exphem.2011.02.013_bib31","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1182\/blood.V95.5.1758.005a41_1758_1766","article-title":"Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification","volume":"95","author":"le Coutre","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2011.02.013_bib32","doi-asserted-by":"crossref","first-page":"459","DOI":"10.7164\/antibiotics.53.459","article-title":"F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete","volume":"53","author":"Kono","year":"2000","journal-title":"J Antibiotics (Tokyo)"},{"key":"10.1016\/j.exphem.2011.02.013_bib33","doi-asserted-by":"crossref","first-page":"7211","DOI":"10.1128\/MCB.02341-05","article-title":"Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation","volume":"26","author":"Kohno","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.exphem.2011.02.013_bib34","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/sj.leu.2404023","article-title":"Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1","volume":"20","author":"Bonhoure","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2011.02.013_bib35","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/leu.2008.95","article-title":"Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells","volume":"22","author":"Bonhoure","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2011.02.013_bib36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1365-2141.2008.07474.x","article-title":"In vitro anti-leukaemia activity of sphingosine kinase inhibitor","volume":"144","author":"Ricci","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2011.02.013_bib37","doi-asserted-by":"crossref","first-page":"21446","DOI":"10.1074\/jbc.M109.090043","article-title":"Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner","volume":"285","author":"Pene-Dumitrescu","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2011.02.013_bib38","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1165\/rcmb.2003-0424OC","article-title":"Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus","volume":"30","author":"Monick","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.exphem.2011.02.013_bib39","doi-asserted-by":"crossref","first-page":"35257","DOI":"10.1074\/jbc.M203033200","article-title":"PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)","volume":"277","author":"Johnson","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2011.02.013_bib40","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.bbalip.2008.06.007","article-title":"The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction?","volume":"1781","author":"Vadas","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.exphem.2011.02.013_bib41","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1517\/14728222.12.8.1009","article-title":"Downregulating sphingosine kinase-1 for cancer therapy","volume":"12","author":"Cuvillier","year":"2008","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.exphem.2011.02.013_bib42","doi-asserted-by":"crossref","first-page":"662","DOI":"10.2174\/138945008785132402","article-title":"Targeting SphK1 as a new strategy against cancer","volume":"9","author":"Shida","year":"2008","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.exphem.2011.02.013_bib43","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1038\/sj.leu.2404386","article-title":"Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes","volume":"20","author":"Sobue","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2011.02.013_bib44","doi-asserted-by":"crossref","first-page":"11667","DOI":"10.1158\/0008-5472.CAN-05-2702","article-title":"Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models","volume":"65","author":"Pchejetski","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.exphem.2011.02.013_bib45","doi-asserted-by":"crossref","first-page":"23747","DOI":"10.1074\/jbc.M111794200","article-title":"Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkI","volume":"277","author":"Endo","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2011.02.013_bib46","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/cncr.20026","article-title":"Mammalian target of rapamycin inhibition as therapy for hematologic malignancies","volume":"100","author":"Panwalkar","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.exphem.2011.02.013_bib47","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1158\/0008-5472.CAN-04-3888","article-title":"ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors","volume":"65","author":"Kharas","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.exphem.2011.02.013_bib48","first-page":"5716","article-title":"Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin","volume":"63","author":"Ly","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.exphem.2011.02.013_bib49","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1182\/blood-2004-10-4003","article-title":"Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFN alpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells","volume":"106","author":"Parmar","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2011.02.013_bib50","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1097-2765(02)00568-3","article-title":"Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase\/akt pathway","volume":"10","author":"Manning","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/j.exphem.2011.02.013_bib51","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","article-title":"Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins","volume":"5","author":"Zhang","year":"2003","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.exphem.2011.02.013_bib52","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0092-8674(00)00117-3","article-title":"TOR, a central controller of cell growth","volume":"103","author":"Schmelzle","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2011.02.013_bib53","doi-asserted-by":"crossref","first-page":"32081","DOI":"10.1074\/jbc.M502876200","article-title":"Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity","volume":"280","author":"Hahn-Windgassen","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2011.02.013_bib54","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbaexp.2007.03.005","article-title":"Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells","volume":"269","author":"Francy","year":"2007","journal-title":"Biochim Biophys Acta"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X11001202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X11001202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:29:14Z","timestamp":1759566554000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X11001202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0301472X11001202"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2011.02.013","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2011.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}