{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:01:07Z","timestamp":1791396067439,"version":"4.3.3"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":3720,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.exphem.2011.12.004","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T10:40:32Z","timestamp":1324377632000},"page":"295-306.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Mice heterozygous for CREB binding protein are hypersensitive to \u03b3-radiation and invariably develop myelodysplastic\/myeloproliferative neoplasm"],"prefix":"10.1016","volume":"40","author":[{"given":"Stephanie N.","family":"Zimmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine E.","family":"Lemieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijal P.","family":"Karia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Kung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uthra","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha C.","family":"Kinney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.R.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivienne I.","family":"Rebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2011.12.004_bib1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nrc2047","article-title":"Myelodysplastic syndromes: the complexity of stem-cell diseases","volume":"7","author":"Corey","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.exphem.2011.12.004_bib2","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1053\/j.seminoncol.2008.04.012","article-title":"Therapy-related myeloid leukemia","volume":"35","author":"Godley","year":"2008","journal-title":"Semin Oncol"},{"key":"10.1016\/j.exphem.2011.12.004_bib3","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1182\/blood-2002-04-1199","article-title":"The World Health Organization (WHO) classification of the myeloid neoplasms","volume":"100","author":"Vardiman","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2011.12.004_bib4","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1182\/blood-2007-05-092510","article-title":"Internal tandem duplication of FLT3 (FLT3\/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML","volume":"111","author":"Sallmyr","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2011.12.004_bib5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1182\/blood-2005-07-2815","article-title":"BCR\/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance","volume":"108","author":"Koptyra","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2011.12.004_bib6","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1182\/blood-2004-05-1941","article-title":"BCR\/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks","volume":"104","author":"Nowicki","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2011.12.004_bib7","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1182\/blood-2008-01-134114","article-title":"JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders","volume":"112","author":"Plo","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2011.12.004_bib8","first-page":"3230","article-title":"A mutator phenotype in cancer","volume":"61","author":"Loeb","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.exphem.2011.12.004_bib9","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/sj.leu.2405055","article-title":"Base excision repair dysfunction in a subgroup of patients with myelodysplastic syndrome","volume":"22","author":"Jankowska","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2011.12.004_bib10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.leukres.2008.07.005","article-title":"Oxidative DNA damage in bone marrow cells of patients with low-risk myelodysplastic syndrome","volume":"33","author":"Novotna","year":"2009","journal-title":"Leuk Res"},{"key":"10.1016\/j.exphem.2011.12.004_bib11","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1038\/sj.leu.2402703","article-title":"Chromosomal instability and radiosensitivity in myelodysplastic syndrome cells","volume":"16","author":"Kuramoto","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2011.12.004_bib12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2141.2010.08212.x","article-title":"Malignancies and survival patterns in the National Cancer Institute inherited bone marrow failure syndromes cohort study","volume":"150","author":"Alter","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2011.12.004_bib13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2169\/internalmedicine.32.399","article-title":"Bloom\u2019s syndrome complicated by myelodysplastic syndrome and multiple neoplasia","volume":"32","author":"Iwahara","year":"1993","journal-title":"Intern Med"},{"key":"10.1016\/j.exphem.2011.12.004_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0165-4608(01)00392-2","article-title":"Chromosomal aberrations in Bloom syndrome patients with myeloid malignancies","volume":"128","author":"Poppe","year":"2001","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.exphem.2011.12.004_bib15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1046\/j.1525-1470.2001.018003210.x","article-title":"Rothmund-Thomson syndrome with myelodysplasia","volume":"18","author":"Narayan","year":"2001","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.exphem.2011.12.004_bib16","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1046\/j.1525-1470.2001.01971.x","article-title":"Rothmund-Thomson syndrome (Thomson-type) and myelodysplasia","volume":"18","author":"Pianigiani","year":"2001","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.exphem.2011.12.004_bib17","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0092-8674(00)80521-8","article-title":"Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain","volume":"90","author":"Gu","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2011.12.004_bib18","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/42972","article-title":"Synergistic activation of transcription by CBP and p53","volume":"387","author":"Gu","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2011.12.004_bib19","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1073\/pnas.97.3.1020","article-title":"CBP\/p300 interact with and function as transcriptional coactivators of BRCA1","volume":"97","author":"Pao","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2011.12.004_bib20","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1038\/sj.onc.1210174","article-title":"Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments","volume":"26","author":"Karagiannis","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2011.12.004_bib21","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nature03714","article-title":"A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response","volume":"436","author":"Masumoto","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2011.12.004_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molcel.2010.06.017","article-title":"The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets","volume":"39","author":"Krishnakumar","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.exphem.2011.12.004_bib23","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1073\/pnas.94.4.1074","article-title":"Nuclear integration of JAK\/STAT and Ras\/AP-1 signaling by CBP and p300","volume":"94","author":"Horvai","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2011.12.004_bib24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0092-8674(00)81118-6","article-title":"A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors","volume":"85","author":"Kamei","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2011.12.004_bib25","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1101\/gad.14.3.272","article-title":"Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP","volume":"14","author":"Kung","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.exphem.2011.12.004_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4161\/epi.5.1.10449","article-title":"Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases","volume":"5","author":"Bedford","year":"2010","journal-title":"Epigenetics"},{"key":"10.1016\/j.exphem.2011.12.004_bib27","series-title":"R: A language and environment for statistical computing","year":"2009"},{"key":"10.1016\/j.exphem.2011.12.004_bib28","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/biomet\/69.3.553","article-title":"A class of rank test procedures for sensored survival data","volume":"69","author":"Harrington","year":"1982","journal-title":"Biometrika"},{"key":"10.1016\/j.exphem.2011.12.004_bib29","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1101\/gad.1248505","article-title":"Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing","volume":"19","author":"Kanellopoulou","year":"2005","journal-title":"Genes Dev"},{"key":"10.1016\/j.exphem.2011.12.004_bib30","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1126\/science.1067081","article-title":"Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors","volume":"295","author":"Lois","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.exphem.2011.12.004_bib31","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1101\/gad.8.23.2831","article-title":"Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development","volume":"8","author":"Tsai","year":"1994","journal-title":"Genes Dev"},{"key":"10.1016\/j.exphem.2011.12.004_bib32","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1089\/hum.1996.7.6-743","article-title":"Consistent and high rates of gene transfer can be obtained using flow-through transduction over a wide range of retroviral titers","volume":"7","author":"Chuck","year":"1996","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.exphem.2011.12.004_bib33","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol"},{"key":"10.1016\/j.exphem.2011.12.004_bib34","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nature04209","article-title":"Towards a proteome-scale map of the human protein-protein interaction network","volume":"437","author":"Rual","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2011.12.004_bib35","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"affy\u2013analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exphem.2011.12.004_bib36","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1038\/nprot.2007.324","article-title":"Integration of biological networks and gene expression data using Cytoscape","volume":"2","author":"Cline","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.exphem.2011.12.004_bib37","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1093\/bioinformatics\/bti551","article-title":"BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks","volume":"21","author":"Maere","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exphem.2011.12.004_bib38","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0092-8674(00)81165-4","article-title":"Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300","volume":"93","author":"Yao","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2011.12.004_bib39","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.hoc.2010.02.002","article-title":"Mouse models of myelodysplastic syndromes","volume":"24","author":"Beachy","year":"2010","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.exphem.2011.12.004_bib40","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","first-page":"88","article-title":"Myelodysplastic syndromes\/neoplasms, overview","author":"Brunning","year":"2008"},{"key":"10.1016\/j.exphem.2011.12.004_bib41","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1182\/blood-2009-03-209262","article-title":"The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes","volume":"114","author":"Vardiman","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2011.12.004_bib42","doi-asserted-by":"crossref","first-page":"R258","DOI":"10.1186\/gb-2007-8-12-r258","article-title":"Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes","volume":"8","author":"McGary","year":"2007","journal-title":"Genome Biol"},{"key":"10.1016\/j.exphem.2011.12.004_bib43","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4161\/cc.10.2.14542","article-title":"Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways","volume":"10","author":"Kasper","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.exphem.2011.12.004_bib44","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.semcancer.2010.10.010","article-title":"Variant base excision repair proteins: contributors to genomic instability","volume":"20","author":"Nemec","year":"2010","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.exphem.2011.12.004_bib45","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35004599","article-title":"A clonogenic common myeloid progenitor that gives rise to all myeloid lineages","volume":"404","author":"Akashi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2011.12.004_bib46","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0092-8674(00)80453-5","article-title":"Identification of clonogenic common lymphoid progenitors in mouse bone marrow","volume":"91","author":"Kondo","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2011.12.004_bib47","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.273.5272.242","article-title":"Long-term lymphohematopoietic reconstitution by a single CD34-low\/negative hematopoietic stem cell","volume":"273","author":"Osawa","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.exphem.2011.12.004_bib48","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1126\/science.1073823","article-title":"A stem cell molecular signature","volume":"298","author":"Ivanova","year":"2002","journal-title":"Science"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X11005960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X11005960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:29:28Z","timestamp":1759566568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X11005960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0301472X11005960"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2011.12.004","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mice heterozygous for CREB binding protein are hypersensitive to \u03b3-radiation and invariably develop myelodysplastic\/myeloproliferative neoplasm","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2011.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}