{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T09:10:55Z","timestamp":1759569055206,"version":"build-2065373602"},"reference-count":43,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":3629,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Canadian Cancer Society to A.M. and the Canadian Institutes of Health Research, the Leukemia and Lymphoma Society of Canada and the Lymphoma Foundation of Canada to S.A.B"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.exphem.2012.02.002","type":"journal-article","created":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T16:01:33Z","timestamp":1330012893000},"page":"548-563.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Induction of apoptosis in E\u03bc-myc lymphoma cells in\u00a0vitro and in\u00a0vivo through calpain inhibition"],"prefix":"10.1016","volume":"40","author":[{"given":"Hongbing","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev M.","family":"Nepal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart A.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2012.02.002_bib1","doi-asserted-by":"crossref","first-page":"7837","DOI":"10.1073\/pnas.79.24.7837","article-title":"Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells","volume":"79","author":"Taub","year":"1982","journal-title":"Proc Natl Acad Sci U S\u00a0A"},{"key":"10.1016\/j.exphem.2012.02.002_bib2","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1210\/endo-117-6-2547","article-title":"Human growth hormone induces and maintains c-myc gene expression in Nb2 lymphoma cells","volume":"117","author":"Fleming","year":"1985","journal-title":"Endocrinology"},{"key":"10.1016\/j.exphem.2012.02.002_bib3","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1182\/blood.V81.9.2257.bloodjournal8192257","article-title":"Myeloblastic leukemia cells conditionally blocked by myc-estrogen receptor chimeric transgenes for terminal differentiation coupled to growth arrest and apoptosis","volume":"81","author":"Selvakumaran","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2012.02.002_bib4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/excr.1995.1166","article-title":"Apoptosis induced by c-myc overexpression is dependent on growth conditions","volume":"218","author":"Gibson","year":"1995","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.exphem.2012.02.002_bib5","first-page":"17","article-title":"Role of c-myc in myeloid differentiation, growth arrest and apoptosis","volume":"211","author":"Hoffman","year":"1996","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.exphem.2012.02.002_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MCB.19.1.1","article-title":"c-Myc target genes involved in cell growth, apoptosis, and metabolism","volume":"19","author":"Dang","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.exphem.2012.02.002_bib7","doi-asserted-by":"crossref","first-page":"8164","DOI":"10.1073\/pnas.1332764100","article-title":"A global transcriptional regulatory role for c-Myc in Burkitt\u2019s lymphoma cells","volume":"100","author":"Li","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2012.02.002_bib8","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/318533a0","article-title":"The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice","volume":"318","author":"Adams","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2012.02.002_bib9","first-page":"423","article-title":"Oncogene cooperation and B-lymphoid tumorigenesis in Emu-myc transgenic mice","volume":"32","author":"Alexander","year":"1989","journal-title":"Haematol Blood Transfus"},{"key":"10.1016\/j.exphem.2012.02.002_bib10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1471-4914(01)02049-4","article-title":"The calpain family and human disease","volume":"7","author":"Huang","year":"2001","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.exphem.2012.02.002_bib11","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/physrev.00029.2002","article-title":"The calpain system","volume":"83","author":"Goll","year":"2003","journal-title":"Physiol Rev"},{"key":"10.1016\/j.exphem.2012.02.002_bib12","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3109\/02713689509000005","article-title":"Age-related changes of calpain II and alpha-crystallin in the lens of hereditary cataract (Nakano) mouse","volume":"4","author":"Yoshida","year":"1985","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.exphem.2012.02.002_bib13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0197-4580(90)90009-O","article-title":"Calpain and calpastatin in normal and Alzheimer-degenerated human brain tissue","volume":"11","author":"Nilssone","year":"1990","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.exphem.2012.02.002_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0092-8674(95)90368-2","article-title":"Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A","volume":"81","author":"Richard","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2012.02.002_bib15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/79876","article-title":"Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus","volume":"26","author":"Horikawa","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2012.02.002_bib16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1349-7006.2000.tb00967.x","article-title":"Isolation of two novel genes, down-regulated in gastric cancer","volume":"91","author":"Yoshikawa","year":"2000","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/j.exphem.2012.02.002_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00001756-199612200-00050","article-title":"Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis","volume":"8","author":"Nath","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.exphem.2012.02.002_bib18","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.4049\/jimmunol.158.8.3690","article-title":"Calpain, an upstream regulator of thymocyte apoptosis","volume":"158","author":"Squier","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2012.02.002_bib19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(199903)178:3<311::AID-JCP5>3.0.CO;2-T","article-title":"Calpain and calpastatin regulate neutrophil apoptosis","volume":"178","author":"Squier","year":"1999","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.exphem.2012.02.002_bib20","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S1043-6618(03)00245-7","article-title":"Apoptosis induced by simvastatin in rat vascular smooth muscle cell through Ca2+-calpain and caspase-3 dependent pathway","volume":"48","author":"Cheng","year":"2003","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.exphem.2012.02.002_bib21","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1002\/ijc.23378","article-title":"Calpain-mediated pathway dominates cisplatin-induced apoptosis in human lung adenocarcinoma cells as determined by real-time single cell analysis","volume":"122","author":"Liu","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.exphem.2012.02.002_bib22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/abbi.1996.0443","article-title":"Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells","volume":"334","author":"Lu","year":"1996","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.exphem.2012.02.002_bib23","first-page":"2456","article-title":"Calpain inhibitor II induces caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin\u2019s lymphoma cells as well as some solid tumor cells","volume":"6","author":"Zhu","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.exphem.2012.02.002_bib24","first-page":"655","article-title":"Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines","volume":"29","author":"Guan","year":"2006","journal-title":"Int J Oncol"},{"key":"10.1016\/j.exphem.2012.02.002_bib25","doi-asserted-by":"crossref","first-page":"7598","DOI":"10.1158\/0008-5472.CAN-05-2614","article-title":"Combined effect of proteasome and calpain inhibition on cisplatin-resistant human melanoma cells","volume":"66","author":"Mlynarczuk-Bialy","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.exphem.2012.02.002_bib26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.abb.2008.04.027","article-title":"Apoptosis-suppressing and autophagy-promoting effects of calpain on oridonin-induced L929 cell death","volume":"475","author":"Cheng","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.exphem.2012.02.002_bib27","doi-asserted-by":"crossref","first-page":"21371","DOI":"10.1074\/jbc.M801462200","article-title":"Regulation of calpain activity by c-Myc through calpastatin and promotion of transformation in c-Myc-negative cells by calpastatin suppression","volume":"283","author":"Niapour","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2012.02.002_bib28","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/onc.2008.425","article-title":"Calpain small-1 modulates Akt\/FoxO3A signaling and apoptosis through PP2A","volume":"28","author":"Bertoli","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2012.02.002_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1476-5586(04)80053-8","article-title":"Calpain activity is generally elevated during transformation but has oncogene-specific biological functions","volume":"6","author":"Carragher","year":"2004","journal-title":"Neoplasia"},{"key":"10.1016\/j.exphem.2012.02.002_bib30","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1038\/onc.2008.111","article-title":"AID and RAG1 do not contribute to lymphomagenesis in Emu c-myc transgenic mice","volume":"27","author":"Nepal","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2012.02.002_bib31","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/cyto.a.20399","article-title":"Flow cytometric measurement of calpain activity in living cells","volume":"71","author":"Niapour","year":"2007","journal-title":"Cytometry A"},{"issue":"41","key":"10.1016\/j.exphem.2012.02.002_bib32","doi-asserted-by":"crossref","DOI":"10.3791\/2050","article-title":"Measuring calpain activity in fixed and living cells by flow cytometry","volume":"8","author":"Farr","year":"2010","journal-title":"J Vis Exp"},{"key":"10.1016\/j.exphem.2012.02.002_bib33","doi-asserted-by":"crossref","first-page":"6687","DOI":"10.1073\/pnas.93.13.6687","article-title":"An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective","volume":"93","author":"Wang","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2012.02.002_bib34","first-page":"499","article-title":"Elimination of malignant clonogenic cells from human bone marrow using multiple monoclonal antibodies and complement","volume":"45","author":"Bast","year":"1985","journal-title":"Cancer Res"},{"key":"10.1016\/j.exphem.2012.02.002_bib35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-4613-0335-0_11","article-title":"Alpha-mercaptoacrylic acid derivatives as novel selective calpain inhibitors","volume":"389","author":"Wang","year":"1996","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.exphem.2012.02.002_bib36","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s10495-009-0440-9","article-title":"Cellular responses to etoposide: cell death despite cell cycle arrest and repair of DNA damage","volume":"15","author":"Schonn","year":"2010","journal-title":"Apoptosis"},{"key":"10.1016\/j.exphem.2012.02.002_bib37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/376037a0","article-title":"Identification and inhibition of the ICE\/CED-3 protease necessary for mammalian apoptosis","volume":"376","author":"Nicholson","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2012.02.002_bib38","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.1073\/pnas.111085198","article-title":"Maintenance of caspase-3 proenzyme dormancy by an intrinsic \u201csafety catch\u201d regulatory tripeptide","volume":"98","author":"Roy","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2012.02.002_bib39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1189\/jlb.0506358","article-title":"Aspartic protease and caspase 3\/7 activation are central for macrophage apoptosis following infection with Escherichia coli","volume":"81","author":"Albee","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.exphem.2012.02.002_bib40","doi-asserted-by":"crossref","first-page":"13432","DOI":"10.1074\/jbc.272.20.13432","article-title":"A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in\u00a0vitro","volume":"272","author":"Han","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2012.02.002_bib41","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.bcp.2003.12.021","article-title":"Calpain as a multi-site regulator of cell cycle","volume":"67","author":"Janossy","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.exphem.2012.02.002_bib42","first-page":"247","article-title":"Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines","volume":"11","author":"Atencio","year":"2000","journal-title":"Cell Growth Differ"},{"key":"10.1016\/j.exphem.2012.02.002_bib43","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1038\/sj.leu.2404723","article-title":"Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-kappaB (RelB\/p52) in non-Hodgkin\u2019s lymphoma cells","volume":"21","author":"Lwin","year":"2007","journal-title":"Leukemia"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X12000525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X12000525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:29:51Z","timestamp":1759566591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X12000525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0301472X12000525"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2012.02.002","relation":{},"ISSN":["0301-472X"],"issn-type":[{"type":"print","value":"0301-472X"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Induction of apoptosis in E\u03bc-myc lymphoma cells in\u00a0vitro and in\u00a0vivo through calpain inhibition","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2012.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}