{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:58:35Z","timestamp":1789016315546,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":2076,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","exphem.org","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.exphem.2016.06.252","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T22:22:35Z","timestamp":1467757355000},"page":"940-946","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Targeting Mac-1-mediated leukocyte\u2013RBC interactions uncouples the benefits for acute vaso-occlusion and chronic organ damage"],"prefix":"10.1016","volume":"44","author":[{"given":"Grace","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungshan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dachuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Pinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Eun","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Frenette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2016.06.252_bib1","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0140-6736(04)17192-4","article-title":"Sickle-cell disease","volume":"364","author":"Stuart","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.exphem.2016.06.252_bib2","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1172\/JCI30920","article-title":"Sickle cell disease: old discoveries, new concepts, and future promise","volume":"117","author":"Frenette","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2016.06.252_bib3","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJM199406093302303","article-title":"Mortality in sickle cell disease: life expectancy and risk factors for early death","volume":"330","author":"Platt","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2016.06.252_bib4","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1749-6632.1989.tb24179.x","article-title":"Erythrocytic and vascular factors influencing the microcirculatory behavior of blood in sickle cell anemia","volume":"565","author":"Kaul","year":"1989","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.exphem.2016.06.252_bib5","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1073\/pnas.86.9.3356","article-title":"Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: pathophysiological implications","volume":"86","author":"Kaul","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2016.06.252_bib6","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1182\/blood.V92.10.3924","article-title":"Interaction of sickle erythrocytes with endothelial cells in the presence of endothelial cell conditioned medium induces oxidant stress leading to transendothelial migration of monocytes","volume":"92","author":"Sultana","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.06.252_bib7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0022-2143(97)90005-6","article-title":"Platelet activation and platelet-erythrocyte aggregates in patients with sickle cell anemia","volume":"129","author":"Wun","year":"1997","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.exphem.2016.06.252_bib8","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1067\/mlc.2001.115450","article-title":"Thrombogenesis in sickle cell disease","volume":"137","author":"Tomer","year":"2001","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.exphem.2016.06.252_bib9","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1046\/j.1365-2141.1998.00627.x","article-title":"Platelet activation in patients with sickle cell disease","volume":"100","author":"Wun","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2016.06.252_bib10","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1073\/pnas.052522799","article-title":"Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm","volume":"99","author":"Turhan","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2016.06.252_bib11","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1182\/blood-2009-12-260513","article-title":"GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice","volume":"116","author":"Chang","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.06.252_bib12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nm.1939","article-title":"Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury","volume":"15","author":"Hidalgo","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2016.06.252_bib13","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1182\/blood.V96.7.2451","article-title":"Activated monocytes in sickle cell disease: potential role in the activation of\u00a0vascular endothelium and vaso-occlusion","volume":"96","author":"Belcher","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.06.252_bib14","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1182\/blood-2005-07-2839","article-title":"Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease","volume":"107","author":"Manci","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.06.252_bib15","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1126\/science.278.5339.873","article-title":"Knockout-transgenic mouse model of sickle cell disease","volume":"278","author":"Ryan","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.exphem.2016.06.252_bib16","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1126\/science.278.5339.876","article-title":"Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease","volume":"278","author":"Paszty","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.exphem.2016.06.252_bib17","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1182\/blood-2007-04-084061","article-title":"Intravenous immunoglobulins reverse acute vaso-occlusive crises in sickle cell mice through rapid inhibition of neutrophil adhesion","volume":"111","author":"Chang","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.06.252_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1600-0609.1998.tb01036.x","article-title":"Peripheral blood neutrophil count and candidacidal activity correlate with the clinical severity of sickle cell anaemia (SCA)","volume":"60","author":"Anyaegbu","year":"1998","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.exphem.2016.06.252_bib19","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1542\/peds.103.3.640","article-title":"Silent cerebral infarcts in sickle cell anemia: a risk factor analysis: the Cooperative Study of Sickle Cell Disease","volume":"103","author":"Kinney","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.exphem.2016.06.252_bib20","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1182\/blood.V84.2.643.643","article-title":"The acute chest syndrome in sickle cell disease: incidence and risk factors: the Cooperative Study of Sickle Cell Disease","volume":"84","author":"Castro","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.06.252_bib21","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease: rates and risk factors","volume":"91","author":"Ohene-Frempong","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.06.252_bib22","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nmeth1018","article-title":"Imaging receptor microdomains on leukocyte subsets in live mice","volume":"4","author":"Chiang","year":"2007","journal-title":"Nat Methods"},{"key":"10.1016\/j.exphem.2016.06.252_bib23","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1182\/blood-2015-09-618538","article-title":"Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology","volume":"127","author":"Zhang","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.06.252_bib24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.blre.2006.07.001","article-title":"Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes","volume":"21","author":"Kato","year":"2007","journal-title":"Blood Rev"},{"key":"10.1016\/j.exphem.2016.06.252_bib25","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/ajh.22012","article-title":"Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management","volume":"86","author":"Nur","year":"2011","journal-title":"Am J Hematol"},{"key":"10.1016\/j.exphem.2016.06.252_bib26","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1182\/blood-2012-11-451229","article-title":"Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins","volume":"121","author":"Schaer","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.06.252_bib27","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1182\/blood-2014-07-589283","article-title":"Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease","volume":"125","author":"Camus","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.06.252_bib28","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1182\/blood.V98.6.1802","article-title":"Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase","volume":"98","author":"Wagener","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.06.252_bib29","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1182\/blood-2010-06-290643","article-title":"Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease","volume":"116","author":"Wallace","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.06.252_bib30","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1182\/blood-2013-10-529982","article-title":"Heme-induced neutrophil extracellular traps contribute to the\u00a0pathogenesis of sickle cell disease","volume":"123","author":"Chen","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.06.252_bib31","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature15367","article-title":"Neutrophil ageing is regulated by the microbiome","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X1630457X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X1630457X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T05:18:02Z","timestamp":1654924682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X1630457X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0301472X1630457X"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2016.06.252","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting Mac-1-mediated leukocyte\u2013RBC interactions uncouples the benefits for acute vaso-occlusion and chronic organ damage","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2016.06.252","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}