{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:51:48Z","timestamp":1790247108150,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":2015,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","exphem.org","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.exphem.2016.09.002","type":"journal-article","created":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T14:28:27Z","timestamp":1475332107000},"page":"1123-1129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Variegated RHOA mutations in human cancers"],"prefix":"10.1016","volume":"44","author":[{"given":"Keisuke","family":"Kataoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seishi","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2016.09.002_bib1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nri2606","article-title":"Rho family GTPases and their regulators in lymphocytes","volume":"9","author":"Tybulewicz","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.exphem.2016.09.002_bib2","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nrm2476","article-title":"Mammalian Rho GTPases: New insights into their functions from in\u00a0vivo studies","volume":"9","author":"Heasman","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.exphem.2016.09.002_bib3","doi-asserted-by":"crossref","first-page":"e29019","DOI":"10.4161\/sgtp.29019","article-title":"Rho GTPases modulate malignant transformation of tumor cells","volume":"5","author":"Orgaz","year":"2014","journal-title":"Small GTPases"},{"key":"10.1016\/j.exphem.2016.09.002_bib4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4161\/sgtp.25131","article-title":"Dynamic functions of RhoA in tumor cell migration and invasion","volume":"4","author":"O'Connor","year":"2013","journal-title":"Small GTPases"},{"key":"10.1016\/j.exphem.2016.09.002_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/ng.2872","article-title":"Somatic RHOA mutation in angioimmunoblastic T cell lymphoma","volume":"46","author":"Sakata-Yanagimoto","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2016.09.002_bib6","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ng.2873","article-title":"Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas","volume":"46","author":"Palomero","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2016.09.002_bib7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/ng.2916","article-title":"A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma","volume":"46","author":"Yoo","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2016.09.002_bib8","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1182\/blood-2015-06-644948","article-title":"Variegated RHOA mutations in adult T-cell leukemia\/lymphoma","volume":"127","author":"Nagata","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.09.002_bib9","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/gcc.22202","article-title":"Recurrent RHOA mutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols","volume":"53","author":"Rohde","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.exphem.2016.09.002_bib10","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/ng.2984","article-title":"Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma","volume":"46","author":"Kakiuchi","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2016.09.002_bib11","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci Signal"},{"key":"10.1016\/j.exphem.2016.09.002_bib12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1016\/j.exphem.2016.09.002_bib13","doi-asserted-by":"crossref","first-page":"e1005158","DOI":"10.1371\/journal.ppat.1005158","article-title":"Distinct viral and mutational spectrum of endemic Burkitt lymphoma","volume":"11","author":"Abate","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.exphem.2016.09.002_bib14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/ng.2983","article-title":"Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer","volume":"46","author":"Wang","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2016.09.002_bib15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/PAS.0000000000000555","article-title":"Angioimmunoblastic T-cell lymphomas with the RHOA p.Gly17Val mutation have classic clinical and pathologic features","volume":"40","author":"Ondrejka","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.exphem.2016.09.002_bib16","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1182\/blood-2012-02-408542","article-title":"Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters","volume":"120","author":"Lemonnier","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.09.002_bib17","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1182\/blood-2013-10-531509","article-title":"A targeted mutational landscape of angioimmunoblastic T-cell lymphoma","volume":"123","author":"Odejide","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.09.002_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/sj.onc.1203259","article-title":"Loss of Rho function in the thymus is accompanied by the development of thymic lymphoma","volume":"19","author":"Cleverley","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2016.09.002_bib19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrc2111","article-title":"Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation","volume":"7","author":"Matsuoka","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.exphem.2016.09.002_bib20","doi-asserted-by":"crossref","first-page":"e517","DOI":"10.1016\/S1470-2045(14)70202-5","article-title":"Human T-cell leukaemia virus type I and adult T-cell leukaemia\u2013lymphoma","volume":"15","author":"Ishitsuka","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.exphem.2016.09.002_bib21","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.immunol.25.022106.141623","article-title":"Regulatory T cells: Mechanisms of differentiation and function","volume":"30","author":"Josefowicz","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.exphem.2016.09.002_bib22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nri3403","article-title":"T cell receptor signalling networks: Branched, diversified and bounded","volume":"13","author":"Brownlie","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.exphem.2016.09.002_bib23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/ni.2785","article-title":"NF-kappaB control of T cell development","volume":"15","author":"Gerondakis","year":"2014","journal-title":"Nat Immunol"},{"key":"10.1016\/j.exphem.2016.09.002_bib24","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1034\/j.1600-065X.2003.00028.x","article-title":"GTPases and T cell activation","volume":"192","author":"Cantrell","year":"2003","journal-title":"Immunol Rev"},{"key":"10.1016\/j.exphem.2016.09.002_bib25","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ng.3415","article-title":"Integrated molecular analysis of adult T cell leukemia\/lymphoma","volume":"47","author":"Kataoka","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2016.09.002_bib26","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1182\/blood-2016-03-707141","article-title":"Integrated mate\u2013pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma","volume":"128","author":"Boddicker","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.09.002_bib27","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1182\/blood-2016-02-698977","article-title":"Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas","volume":"128","author":"Vallois","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2016.09.002_bib28","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/ng.2469","article-title":"Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing","volume":"44","author":"Richter","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2016.09.002_bib29","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1038\/onc.2015.442","article-title":"Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: A tumor suppressor function for the G\u03b1\/RhoA axis in B cells","volume":"35","author":"O'Hayre","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2016.09.002_bib30","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nri3814","article-title":"Germinal centres and B cell lymphomagenesis","volume":"15","author":"Basso","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.exphem.2016.09.002_bib31","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10351","article-title":"Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma","volume":"476","author":"Morin","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2016.09.002_bib32","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nature13765","article-title":"Loss of signalling via Galpha13 in germinal centre B-cell-derived lymphoma","volume":"516","author":"Muppidi","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2016.09.002_bib33","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/ni.2047","article-title":"The sphingosine 1-phosphate receptor S1P(2) maintains the homeostasis of germinal center B cells and promotes niche confinement","volume":"12","author":"Green","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.exphem.2016.09.002_bib34","doi-asserted-by":"crossref","first-page":"8686","DOI":"10.1158\/0008-5472.CAN-09-1110","article-title":"Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation","volume":"69","author":"Cattoretti","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.exphem.2016.09.002_bib35","doi-asserted-by":"crossref","first-page":"6677","DOI":"10.1021\/bi700235f","article-title":"Biologic functions of the G12 subfamily of heterotrimeric g proteins: Growth, migration, and metastasis","volume":"46","author":"Kelly","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.exphem.2016.09.002_bib36","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1200\/JCO.2012.47.1714","article-title":"Molecular profiling of gastric cancer: toward personalized cancer medicine","volume":"31","author":"Nadauld","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.exphem.2016.09.002_bib37","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/32918","article-title":"E-cadherin germline mutations in familial gastric cancer","volume":"392","author":"Guilford","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2016.09.002_bib38","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature13480","article-title":"Comprehensive molecular characterization of gastric adenocarcinoma","volume":"513","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2016.09.002_bib39","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10120-015-0493-0","article-title":"RHOA mutation in diffuse-type gastric cancer: A comparative clinicopathology analysis of 87 cases","volume":"19","author":"Ushiku","year":"2016","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.exphem.2016.09.002_bib40","doi-asserted-by":"crossref","first-page":"11596","DOI":"10.1074\/jbc.273.19.11596","article-title":"Determination of interaction sites on the small G protein RhoA for phospholipase D","volume":"273","author":"Bae","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2016.09.002_bib41","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1093\/emboj\/17.5.1350","article-title":"RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation","volume":"17","author":"Sahai","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2016.09.002_bib42","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1126\/science.271.5250.810","article-title":"Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS","volume":"271","author":"Joneson","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.exphem.2016.09.002_bib43","doi-asserted-by":"crossref","first-page":"16953","DOI":"10.1074\/jbc.273.27.16953","article-title":"E-cadherin regulates anchorage-independent growth and survival in oral squamous cell carcinoma cells","volume":"273","author":"Kantak","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2016.09.002_bib44","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.ccell.2015.10.003","article-title":"Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche","volume":"28","author":"Hayakawa","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2016.09.002_bib45","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.celrep.2015.06.020","article-title":"Recurrent fusion genes in gastric cancer: CLDN18-ARHGAP26 induces loss of epithelial integrity","volume":"12","author":"Yao","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.exphem.2016.09.002_bib46","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1053\/j.gastro.2011.10.040","article-title":"Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1\u03b2, and atrophic gastritis in mice","volume":"142","author":"Hayashi","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.exphem.2016.09.002_bib47","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature12912","article-title":"Discovery and saturation analysis of cancer genes across 21 tumour types","volume":"505","author":"Lawrence","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2016.09.002_bib48","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ng.3593","article-title":"Functional characterization of somatic mutations in cancer using network-based inference of protein activity","volume":"48","author":"Alvarez","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2016.09.002_bib49","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nbt.3391","article-title":"Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity","volume":"34","author":"Chang","year":"2016","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.exphem.2016.09.002_bib50","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes","volume":"339","author":"Vogelstein","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.exphem.2016.09.002_bib51","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.exphem.2016.09.002_bib52","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/ng.518","article-title":"Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin","volume":"42","author":"Morin","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2016.09.002_bib53","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/ng.621","article-title":"Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders","volume":"42","author":"Ernst","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2016.09.002_bib54","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1158\/1078-0432.CCR-12-0052","article-title":"Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma","volume":"18","author":"Menzies","year":"2012","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.exphem.2016.09.002_bib55","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1158\/2159-8290.CD-14-0729","article-title":"Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma","volume":"4","author":"Burd","year":"2014","journal-title":"Cancer Discov"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X16306129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X16306129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T05:21:22Z","timestamp":1654924882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X16306129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0301472X16306129"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2016.09.002","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Variegated RHOA mutations in human cancers","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2016.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}