{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:49:51Z","timestamp":1777560591549,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":1803,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01-CA185353"],"award-info":[{"award-number":["R01-CA185353"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01-CA163896"],"award-info":[{"award-number":["R01-CA163896"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","exphem.org","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.exphem.2017.04.005","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T10:32:45Z","timestamp":1492770765000},"page":"63-70.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Lkb1 deletion in murine B lymphocytes promotes cell death and cancer"],"prefix":"10.1016","volume":"51","author":[{"given":"George P.","family":"Souroullas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Fedoriw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis M.","family":"Staudt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman E.","family":"Sharpless","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2017.04.005_bib1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/34432","article-title":"A serine\/threonine kinase gene defective in Peutz\u2013Jeghers syndrome","volume":"391","author":"Hemminki","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2017.04.005_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.75.103004.142702","article-title":"LKB1-dependent signaling pathways","volume":"75","author":"Alessi","year":"2006","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.exphem.2017.04.005_bib3","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1158\/0008-5472.CAN-07-6620","article-title":"LKB1 and lung cancer: More than the usual suspects","volume":"68","author":"Shah","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.exphem.2017.04.005_bib4","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1158\/1078-0432.CCR-06-0083","article-title":"Frequency and spectrum of cancers in the Peutz\u2013Jeghers syndrome","volume":"12","author":"Hearle","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.exphem.2017.04.005_bib5","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/ajg.2009.725","article-title":"High cancer risk in Peutz\u2013Jeghers syndrome: A systematic review and surveillance recommendations","volume":"105","author":"van Lier","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.exphem.2017.04.005_bib6","first-page":"3659","article-title":"Inactivation of LKB1\/STK11 is a common event in adenocarcinomas of the lung","volume":"62","author":"Sanchez-Cespedes","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.exphem.2017.04.005_bib7","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0002-9440(10)65314-X","article-title":"LKB1 somatic mutations in sporadic tumors","volume":"154","author":"Avizienyte","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.exphem.2017.04.005_bib8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nature06030","article-title":"LKB1 modulates lung cancer differentiation and metastasis","volume":"448","author":"Ji","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2017.04.005_bib9","doi-asserted-by":"crossref","first-page":"e5137","DOI":"10.1371\/journal.pone.0005137","article-title":"Somatic LKB1 mutations promote cervical cancer progression","volume":"4","author":"Wingo","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.exphem.2017.04.005_bib10","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1046\/j.1523-1747.1999.00551.x","article-title":"Somatic mutations in the Peutz\u2013Jeghers (LKB1\/STKII) gene in sporadic malignant melanomas","volume":"112","author":"Rowan","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.exphem.2017.04.005_bib11","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1038\/sj.onc.1202486","article-title":"Somatic mutation of the Peutz\u2013Jeghers syndrome gene, LKB1\/STK11, in malignant melanoma","volume":"18","author":"Guldberg","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2017.04.005_bib12","doi-asserted-by":"crossref","first-page":"D805","DOI":"10.1093\/nar\/gku1075","article-title":"COSMIC: Exploring the world's knowledge of somatic mutations in human cancer","volume":"43","author":"Forbes","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.exphem.2017.04.005_bib13","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nature09571","article-title":"Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells","volume":"468","author":"Nakada","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2017.04.005_bib14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nature09572","article-title":"The Lkb1 metabolic sensor maintains haematopoietic stem cell survival","volume":"468","author":"Gurumurthy","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2017.04.005_bib15","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nature09595","article-title":"Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells","volume":"468","author":"Gan","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2017.04.005_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.1100367","article-title":"The liver kinase B1 is a central regulator of T cell development, activation, and metabolism","volume":"187","author":"MacIver","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2017.04.005_bib17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/gcc.20127","article-title":"Cytogenetic features of de novo CD5-positive diffuse large B-cell lymphoma: Chromosome aberrations affecting 8p21 and 11q13 constitute major subgroups with different overall survival","volume":"42","author":"Yoshioka","year":"2005","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.exphem.2017.04.005_bib18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/gcc.10298","article-title":"Analysis of chromosomal imbalances in de novo CD5-positive diffuse large-B-cell lymphoma detected by comparative genomic hybridization","volume":"39","author":"Karnan","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.exphem.2017.04.005_bib19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/gcc.20836","article-title":"High-resolution genomic screening in mantle cell lymphoma-specific changes correlate with genomic complexity, the proliferation signature and survival","volume":"50","author":"Halld\u00f3rsd\u00f3ttir","year":"2010","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.exphem.2017.04.005_bib20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/gcc.10104","article-title":"Comparative genomic hybridization analysis of primary cutaneous B-cell lymphomas: Identification of common genomic alterations in disease pathogenesis","volume":"35","author":"Mao","year":"2002","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.exphem.2017.04.005_bib21","doi-asserted-by":"crossref","first-page":"E830","DOI":"10.1002\/ijc.27416","article-title":"Recurrent deletions of the TNFSF7 and TNFSF9 genes in 19p13.3 in diffuse large B-cell and Burkitt lymphomas","volume":"131","author":"Scholtysik","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.exphem.2017.04.005_bib22","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ccr.2012.07.014","article-title":"Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma","volume":"22","author":"Monti","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2017.04.005_bib23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nature01045","article-title":"Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation","volume":"419","author":"Bardeesy","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2017.04.005_bib24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1535-6108(04)00085-6","article-title":"Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects","volume":"5","author":"Tuveson","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2017.04.005_bib25","doi-asserted-by":"crossref","first-page":"13520","DOI":"10.1073\/pnas.0804295105","article-title":"Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways","volume":"105","author":"Lenz","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.exphem.2017.04.005_bib26","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1016\/j.exphem.2017.04.005_bib27","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Science Signal"},{"key":"10.1016\/j.exphem.2017.04.005_bib28","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cell.2008.03.028","article-title":"Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency","volume":"133","author":"Hanna","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2017.04.005_bib29","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/sj.bjc.6602928","article-title":"COSMIC 2005","volume":"94","author":"Forbes","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.exphem.2017.04.005_bib30","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa1403088","article-title":"Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia","volume":"371","author":"Roberts","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2017.04.005_bib31","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ccr.2012.03.048","article-title":"LKB1\/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma [Internet]","volume":"21","author":"Liu","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2017.04.005_bib32","doi-asserted-by":"crossref","first-page":"753","DOI":"10.15252\/embr.201439505","article-title":"LKB1 inhibition of NF-\u03baB in B cells prevents T follicular helper cell differentiation and germinal center formation","volume":"16","author":"Walsh","year":"2015","journal-title":"EMBO Rep"},{"key":"10.1016\/j.exphem.2017.04.005_bib33","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.1038\/sj.onc.1210418","article-title":"Prevalence and specificity of LKB1 genetic alterations in lung cancers","volume":"26","author":"Matsumoto","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2017.04.005_bib34","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1053\/j.gastro.2010.04.055","article-title":"LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest","volume":"139","author":"Morton","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.exphem.2017.04.005_bib35","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1172\/JCI35090","article-title":"Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras\u2013initiated leukemia","volume":"118","author":"Chiang","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2017.04.005_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1158\/0008-5472.CAN-07-3225","article-title":"LKB1 Deficiency sensitizes mice to carcinogen-induced tumorigenesis","volume":"68","author":"Gurumurthy","year":"2008","journal-title":"Cancer Res"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X17301376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X17301376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T05:26:38Z","timestamp":1654925198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X17301376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":36,"alternative-id":["S0301472X17301376"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2017.04.005","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lkb1 deletion in murine B lymphocytes promotes cell death and cancer","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2017.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}