{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:29:56Z","timestamp":1790072996212,"version":"4.0.1"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":1346,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.exphem.2018.07.001","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T12:30:40Z","timestamp":1533126640000},"page":"17-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Germline mutations in the bone marrow microenvironment and dysregulated hematopoiesis"],"prefix":"10.1016","volume":"66","author":[{"given":"Lane H.","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Kui","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Pauly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2018.07.001_bib0001","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","article-title":"The bone marrow niche for haematopoietic stem cells","volume":"505","author":"Morrison","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2018.07.001_bib0002","doi-asserted-by":"crossref","first-page":"9499","DOI":"10.1074\/jbc.R700043200","article-title":"Stem cell niche: microenvironment and beyond","volume":"283","author":"Zhang","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2018.07.001_bib0003","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1196\/annals.1402.086","article-title":"HSC trafficking: regulated adhesion and attraction to bone marrow microenvironment","volume":"1116","author":"Mendez-Ferrer","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.exphem.2018.07.001_bib0004","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1182\/blood-2014-09-570192","article-title":"Making sense of HSC niches","volume":"125","author":"Boulais","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0005","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.it.2013.10.002","article-title":"Regulation of HSCs by bone marrow stromal cells","volume":"35","author":"Anthony","year":"2014","journal-title":"Trends Immunol"},{"key":"10.1016\/j.exphem.2018.07.001_bib0006","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1182\/blood-2010-08-303537","article-title":"The replication rate of human HSCs in vivo","volume":"117","author":"Catlin","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0007","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nri.2017.53","article-title":"Adult haematopoietic stem cell niches","volume":"17","author":"Crane","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.exphem.2018.07.001_bib0008","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/jcb.24952","article-title":"The bone marrow endosteal niche: how far from the surface?","volume":"116","author":"Cordeiro\u00e2\u20ac\u201cSpinetti","year":"2015","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.exphem.2018.07.001_bib0009","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fcell.2017.00062","article-title":"Use of imaging techniques to illuminate dynamics of HSCs and their niches","volume":"5","author":"Morikawa","year":"2017","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.exphem.2018.07.001_bib0010","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1182\/blood.V46.1.65.65","article-title":"The relative spatial distributions of CFUs and CFUc in the normal mouse femur","volume":"46","author":"Lord","year":"1975","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0011","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0092-8674(02)00754-7","article-title":"Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of Kit-ligand","volume":"109","author":"Heissig","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2018.07.001_bib0012","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature02040","article-title":"Osteoblastic cells regulate the haematopoietic stem cell niche","volume":"425","author":"Calvi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2018.07.001_bib0013","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nature02041","article-title":"Identification of the haematopoietic stem cell niche and control of the niche size","volume":"425","author":"Zhang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2018.07.001_bib0014","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cell.2004.07.004","article-title":"Tie2\/Angiopoietin\u20131 signaling regulates HSC quiescence in the bone marrow niche","volume":"118","author":"Arai","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2018.07.001_bib0015","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1182\/blood.V97.8.2293","article-title":"Spatial localization of transplanted HSCs: inferences for the localization of stem cell niches","volume":"97","author":"Nilsson","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0016","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature07639","article-title":"Detection of functional haematopoietic stem cell niche using real\u2013time imaging","volume":"457","author":"Xie","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2018.07.001_bib0017","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1182\/blood.V77.8.1706.1706","article-title":"Transforming growth factor\u2013beta trans\u2013modulates the expression of colony stimulating factor receptors on murine hematopoietic progenitor cell lines","volume":"77","author":"Jacobsen","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0018","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","article-title":"SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells","volume":"121","author":"Kiel","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2018.07.001_bib0019","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1182\/blood-2005-02-0671","article-title":"Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells","volume":"106","author":"Yao","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0020","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.immuni.2006.10.016","article-title":"Maintenance of the HSC pool by CXCL12\u2013CXCR4 chemokine signaling in bone marrow stromal cell niches","volume":"25","author":"Sugiyama","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.exphem.2018.07.001_bib0021","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and HSCs form a unique bone marrow niche","volume":"466","author":"Mendez-Ferrer","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2018.07.001_bib0022","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1749-6632.2010.05390.x","article-title":"Cooperation of \u03b22- and \u03b23-adrenergic receptors in hematopoietic progenitor cell mobilization","volume":"1192","author":"Mendez-Ferrer","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.exphem.2018.07.001_bib0023","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1038\/nm.2969","article-title":"Vascular niche E\u2013selectin regulates HSC dormancy, self-renewal and chemoresistance","volume":"18","author":"Winkler","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2018.07.001_bib0024","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10783","article-title":"Endothelial and perivascular cells maintain haematopoietic stem cells","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2018.07.001_bib0025","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature12612","article-title":"Arteriolar niches maintain haematopoietic stem cell quiescence","volume":"502","author":"Kunisaki","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2018.07.001_bib0026","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s12185-014-1580-4","article-title":"Influences of vascular niches on HSC fate","volume":"99","author":"Kunisaki","year":"2014","journal-title":"Int J Hematol"},{"key":"10.1016\/j.exphem.2018.07.001_bib0027","doi-asserted-by":"crossref","first-page":"C621","DOI":"10.1152\/ajpcell.00228.2013","article-title":"Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages","volume":"306","author":"Turturici","year":"2014","journal-title":"Am J Physiol Cell Biol"},{"key":"10.1016\/j.exphem.2018.07.001_bib0028","first-page":"1321","article-title":"Megakaryocytes maintain homeostatic quiescence and promote post\u2013injury regeneration of HSCs","volume":"20","author":"Zhao","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2018.07.001_bib0029","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/nm.3707","article-title":"Megakaryocytes regulate HSC quiescence through CXCL4 secretion","volume":"20","author":"Bruns","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2018.07.001_bib0030","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.stem.2007.06.001","article-title":"Lack of evidence that HSCs depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance","volume":"1","author":"Kiel","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2018.07.001_bib0031","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.stem.2008.10.005","article-title":"HSCs do not depend on N-cadherin to regulate their maintenance","volume":"4","author":"Kiel","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2018.07.001_bib0032","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1182\/blood-2011-09-377457","article-title":"N-cadherin in osteolineage cells is not required for maintenance of HSCs","volume":"120","author":"Greenbaum","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0033","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1182\/blood-2011-09-377853","article-title":"Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells","volume":"120","author":"Bromberg","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0034","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.stem.2015.02.019","article-title":"Mesenchymal cell contributions to the stem cell niche","volume":"16","author":"Kfoury","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2018.07.001_bib0035","first-page":"1109","article-title":"Commonly used mesenchymal stem cell markers and tracking labels: limitations and challenges","volume":"28","author":"Lin","year":"2013","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.exphem.2018.07.001_bib0036","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/bs.acr.2015.04.007","article-title":"Influence of bone marrow microenvironment on leukemic stem cells: breaking up an intimate relationship","volume":"127","author":"Agarwal","year":"2015","journal-title":"Adv Cancer Res"},{"key":"10.1016\/j.exphem.2018.07.001_bib0037","first-page":"507","article-title":"Therapeutically targeting SELF-reinforcing leukemic niches in acute myeloid leukemia: a worthy endeavor?","volume":"91","author":"Bernasconi","year":"2016","journal-title":"Hematology"},{"key":"10.1016\/j.exphem.2018.07.001_bib0038","doi-asserted-by":"crossref","first-page":"C621","DOI":"10.1152\/ajpcell.00228.2013","article-title":"Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages","volume":"306","author":"Turturici","year":"2014","journal-title":"Cell Physiol"},{"key":"10.1016\/j.exphem.2018.07.001_bib0039","doi-asserted-by":"crossref","first-page":"e62785","DOI":"10.1371\/journal.pone.0062785","article-title":"TGF-\u03b2-neutralizing antibody 1D11 enhances cytarabine-induced apoptosis in AML cells in the bone marrow microenvironment","volume":"8","author":"Tabe","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exphem.2018.07.001_bib0040","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.leukres.2015.12.012","article-title":"Regulatory role of megakaryocytes on HSCs quiescence by CXCL4\/PF4 in bone marrow niche","volume":"48","author":"Norozi","year":"2016","journal-title":"Leuk Res"},{"key":"10.1016\/j.exphem.2018.07.001_bib0041","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1038\/leu.2014.211","article-title":"Pre-leukemic evolution of HSCs: the importance of early mutations in leukemogenesis","volume":"28","author":"Corces-Zimmerman","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2018.07.001_bib0042","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.exphem.2006.10.012","article-title":"Chromosomal aberrations in bone marrow mesenchymal stroma cells from patients with myelodysplastic syndrome and acute myeloblastic leukemia","volume":"35","author":"Blau","year":"2007","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2018.07.001_bib0043","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1158\/0008-5472.CAN-17-0282","article-title":"Epigenetically aberrant stroma in MDS propagates disease via Wnt\/\u03b2-Catenin activation","volume":"77","author":"Bhagat","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.exphem.2018.07.001_bib0044","article-title":"Increased expression of interferon signaling genes in the bone marrow microenvironment of myelodysplastic syndromes","volume":"10","author":"Kim","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exphem.2018.07.001_bib0045","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1182\/blood-2011-05-355396","article-title":"Effects of plerixafor in combination with BCR\u2013ABL kinase inhibition in a murine model of CML","volume":"120","author":"Agarwal","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0046","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ccr.2011.10.012","article-title":"IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development","volume":"20","author":"Reynaud","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2018.07.001_bib0047","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/leusup.2014.1","article-title":"Altered microenvironmental regulation of CML stem cells","volume":"3","author":"Bhatia","year":"2014","journal-title":"Leuk Suppl"},{"key":"10.1016\/j.exphem.2018.07.001_bib0048","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1089\/scd.2011.0390","article-title":"Intrinsic growth deficiencies of mesenchymal stromal cells in myelodysplastic syndromes","volume":"21","author":"Aanei","year":"2012","journal-title":"Stem Cell Dev"},{"key":"10.1016\/j.exphem.2018.07.001_bib0049","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.stem.2013.06.009","article-title":"Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche","volume":"13","author":"Schepers","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2018.07.001_bib0050","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.bbmt.2010.10.010","article-title":"Donor cell leukemia: a review","volume":"17","author":"Wiseman","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2018.07.001_bib0051","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.leukres.2015.06.017","article-title":"Bone marrow niche in the myelodysplastic syndromes","volume":"39","author":"Cogle","year":"2015","journal-title":"Leuk Res"},{"key":"10.1016\/j.exphem.2018.07.001_bib0052","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.canlet.2011.08.030","article-title":"Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes","volume":"317","author":"Zhao","year":"2012","journal-title":"Cancer Lett"},{"key":"10.1016\/j.exphem.2018.07.001_bib0053","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1179\/1607845413Y.0000000111","article-title":"Bone marrow neoplastic niche in leukemia","volume":"19","author":"Azizidoost","year":"2013","journal-title":"Hematology"},{"key":"10.1016\/j.exphem.2018.07.001_bib0054","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.exphem.2016.09.009","article-title":"Alterations in the bone marrow microenvironment may elicit defective hematopoiesis: a comparison of aplastic anemia, chronic myeloid leukemia, and normal bone marrow","volume":"45","author":"Park","year":"2017","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2018.07.001_bib0055","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1038\/leu.2013.193","article-title":"Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells","volume":"27","author":"Geyh","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2018.07.001_bib0056","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.02.009","article-title":"Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha","volume":"22","author":"Rupec","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.exphem.2018.07.001_bib0057","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.cell.2007.05.014","article-title":"A microenvironment\u2013induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency","volume":"129","author":"Walkley","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2018.07.001_bib0058","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.cell.2007.03.055","article-title":"Rb regulates interactions between HSCs and their bone marrow microenvironment","volume":"129","author":"Walkley","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2018.07.001_bib0059","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1182\/blood-2008-03-148999","article-title":"Defective Notch activation in microenvironment leads to myeloproliferative disease","volume":"112","author":"Kim","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0060","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nature08851","article-title":"Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia","volume":"464","author":"Raaijmakers","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2018.07.001_bib0061","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1182\/blood-2010-09-307942","article-title":"Crebbp haploinsufficiency in mice alters the bone marrow microenvironment leading to loss of stem cells and excessive myelopoiesis","volume":"118","author":"Zimmer","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0062","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.stem.2014.04.021","article-title":"Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-kappaB dependent manner","volume":"15","author":"Wang","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2018.07.001_bib0063","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nature12883","article-title":"Leukemogenesis induced by an activating \u03b2-catenin mutation in osteoblasts","volume":"506","author":"Kode","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2018.07.001_bib0064","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.stem.2016.08.021","article-title":"Mesenchymal inflammation drives genotoxic stress in HSCs and predicts disease evolution in human pre-leukemia","volume":"19","author":"Zambetti","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2018.07.001_bib0065","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nature20131","article-title":"Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment","volume":"539","author":"Dong","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2018.07.001_bib0066","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3324\/haematol.2016.158717","article-title":"An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in Fanconi anemia","volume":"102","author":"Zhou","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.exphem.2018.07.001_bib0067","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/ng772","article-title":"Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome","volume":"29","author":"Tartaglia","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2018.07.001_bib0068","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0140-6736(12)61023-X","article-title":"Noonan syndrome","volume":"381","author":"Roberts","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.exphem.2018.07.001_bib0069","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1136\/jmedgenet-2014-102611","article-title":"Juvenile myelomonocytic leukaemia and Noonan syndrome","volume":"51","author":"Strullu","year":"2014","journal-title":"J Med Genet"},{"key":"10.1016\/j.exphem.2018.07.001_bib0070","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/14712598.2018.1384463","article-title":"Advances in immunotherapy for pediatric acute myeloid leukemia","volume":"18","author":"Bonifant","year":"2018","journal-title":"Exp Opin Biol Ther"},{"key":"10.1016\/j.exphem.2018.07.001_bib0071","doi-asserted-by":"crossref","first-page":"E1660","DOI":"10.3390\/ijms18081660","article-title":"Immunotherapeutic concepts to target acute myeloid leukemia: focusing on the role of monoclonal antibodies, hypomethylating agents and the leukemic microenvironment","volume":"18","author":"Gbolahan","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.exphem.2018.07.001_bib0072","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/bjh.15078","article-title":"Immune checkpoint molecules in acute myeloid leukaemia: managing the double-edged sword","volume":"181","author":"Hobo","year":"2018","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2018.07.001_bib0073","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1158\/1078-0432.CCR-07-4079","article-title":"Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies","volume":"14","author":"Berger","year":"2008","journal-title":"Clinical Cancer Res"},{"key":"10.1016\/j.exphem.2018.07.001_bib0074","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1182\/blood.V128.22.763.763","article-title":"Phase IB\/II study of nivolumab in combination with azacytidine (AZA) in patients (pts) with relapsed acute myeloid leukemia (AML)","volume":"128","author":"Daver","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0075","doi-asserted-by":"crossref","unstructured":"Cooper TM, Sison EAR, Baker SD, et\u00a0al. A phase 1 study of the CXCR4 antagonist plerixafor in combination with high-dose cytarabine and etoposide in children with relapsed or refractory acute leukemias or myelodysplastic syndrome: A Pediatric \nExperimental Therapeutics Investigators\u2019 Consortium study (POE 10-03). Pediatr Blood Cancer 64, 2017, 10.1002\/pbc.26414.","DOI":"10.1002\/pbc.26414"},{"key":"10.1016\/j.exphem.2018.07.001_bib0076","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1182\/blood-2011-10-383406","article-title":"A phase 1\/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia","volume":"119","author":"Uy","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0077","doi-asserted-by":"crossref","first-page":"e542","DOI":"10.1038\/bcj.2017.21","article-title":"A phase 1\/2 study of chemosensitization with plerixafor plus G-CSF in relapsed or refractory acute myeloid leukemia","volume":"7","author":"Uy","year":"2017","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.exphem.2018.07.001_bib0078","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3904\/kjim.2016.244","article-title":"Targeting the CXCL12\/CXCR4 axis in acute myeloid leukemia: from bench to bedside","volume":"32","author":"Cho","year":"2017","journal-title":"Korean J Intern Med"},{"key":"10.1016\/j.exphem.2018.07.001_bib0079","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1080\/21645515.2017.1327107","article-title":"Transforming growth factor-\u03b2: a therapeutic target for cancer","volume":"13","author":"Haque","year":"2017","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.exphem.2018.07.001_bib0080","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0140-6736(08)60690-X","article-title":"Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study","volume":"371","author":"Le Blanc","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.exphem.2018.07.001_bib0081","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1182\/blood-2007-04-087056","article-title":"Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation","volume":"110","author":"Ball","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2018.07.001_bib0082","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1056\/NEJMoa1207285","article-title":"Cord-blood engraftment with ex vivo mesenchymal-cell coculture","volume":"367","author":"de Lima","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2018.07.001_bib0083","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.2217\/imt-2016-0098","article-title":"Mesenchymal stromal cells with enhanced therapeutic properties","volume":"8","author":"Girdlestone","year":"2016","journal-title":"Immunotherapy"},{"key":"10.1016\/j.exphem.2018.07.001_bib0084","doi-asserted-by":"crossref","unstructured":"Miura Y, Yoshioka S, Yao H, Takaori-Kondo A, Maekawa T, Ichinohe T. Chimerism of bone marrow mesenchymal stem\/stromal cells in allogeneic hematopoietic cell transplantation: is it clinically relevant? Chimerism. 2013;4:78\u201383.","DOI":"10.4161\/chim.25609"},{"key":"10.1016\/j.exphem.2018.07.001_bib0085","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbmt.2005.02.001","article-title":"Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and HSCs in hematologic malignancy patients","volume":"11","author":"Lazarus","year":"2005","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2018.07.001_bib0086","doi-asserted-by":"crossref","first-page":"8932","DOI":"10.1073\/pnas.132252399","article-title":"Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone","volume":"99","author":"Horwitz","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2018.07.001_bib0087","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/01.TP.0000128334.93343.B3","article-title":"Dynamic of distribution of human bone marrow-derived mesenchymal stem cells after transplantation into adult unconditioned mice","volume":"78","author":"Allers","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.exphem.2018.07.001_bib0088","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.beha.2011.04.003","article-title":"A novel BMT technique for treatment of various currently intractable diseases","volume":"24","author":"Ikehara","year":"2011","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1016\/j.exphem.2018.07.001_bib0089","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jcyt.2015.11.010","article-title":"Co-transplantation of multipotent mesenchymal stromal cells in allogeneic HSC transplantation: a systematic review and meta-analysis","volume":"18","author":"Kallekleiv","year":"2016","journal-title":"Cytotherapy"},{"key":"10.1016\/j.exphem.2018.07.001_bib0090","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.omtn.2017.09.009","article-title":"CRISPR\/Cas9 genome-editing system in human stem cells: current status and future prospects","volume":"9","author":"Zhang","year":"2017","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.exphem.2018.07.001_bib0091","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s12015-017-9760-2","article-title":"Gene delivery approaches for mesenchymal stem cell therapy: strategies to increase efficiency and specificity","volume":"13","author":"Oggu","year":"2017","journal-title":"Stem Cell Rev"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X18306337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X18306337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:33:18Z","timestamp":1759566798000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X18306337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":91,"alternative-id":["S0301472X18306337"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2018.07.001","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Germline mutations in the bone marrow microenvironment and dysregulated hematopoiesis","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2018.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}