{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:29:42Z","timestamp":1784262582295,"version":"3.55.0"},"reference-count":148,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003006","name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.exphem.2021.01.003","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T11:42:03Z","timestamp":1611142923000},"page":"31-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Anti-CD117 immunotherapy to eliminate hematopoietic and leukemia stem cells"],"prefix":"10.1016","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3090-7186","authenticated-orcid":false,"given":"Norman F.","family":"Russkamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renier","family":"Myburgh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Kiefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Neri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus G.","family":"Manz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2021.01.003_bib0001","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1182\/bloodadvances.2016003194","article-title":"Quantification and three-dimensional microanatomical organization of the bone marrow","volume":"1","author":"Nombela-Arrieta","year":"2017","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2021.01.003_bib0002","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","article-title":"Hematopoiesis: an evolving paradigm for stem cell biology","volume":"132","author":"Orkin","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0003","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.stem.2012.01.006","article-title":"Hematopoiesis: a human perspective","volume":"10","author":"Doulatov","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0004","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.tcb.2018.06.001","article-title":"Hematopoietic hierarchy\u2014an updated roadmap","volume":"28","author":"Zhang","year":"2018","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0005","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature14242","article-title":"Fundamental properties of unperturbed haematopoiesis from stem cells in vivo","volume":"518","author":"Busch","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2021.01.003_bib0006","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nature13824","article-title":"Clonal dynamics of native haematopoiesis","volume":"514","author":"Sun","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2021.01.003_bib0007","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1182\/blood-2016-03-706010","article-title":"The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis","volume":"128","author":"Schoedel","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0008","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1182\/blood-2015-10-676072","article-title":"MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells","volume":"128","author":"Sheikh","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0009","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nri2726","article-title":"Awakening dormant haematopoietic stem cells","volume":"10","author":"Trumpp","year":"2010","journal-title":"Nature Rev Immunol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0010","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1182\/blood.2019003079","article-title":"Clonal hematopoiesis in donors and long-term survivors of related allogeneic hematopoietic stem cell transplantation","volume":"135","author":"Boettcher","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0011","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"Jaiswal","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0012","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","article-title":"Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence","volume":"371","author":"Genovese","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0013","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/nm.3733","article-title":"Age-related mutations associated with clonal hematopoietic expansion and malignancies","volume":"20","author":"Xie","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0014","doi-asserted-by":"crossref","first-page":"eaan4673","DOI":"10.1126\/science.aan4673","article-title":"Clonal hematopoiesis in human aging and disease","volume":"366","author":"Jaiswal","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.exphem.2021.01.003_bib0015","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1701719","article-title":"Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease","volume":"377","author":"Jaiswal","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0016","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41586-018-0317-6","article-title":"Prediction of acute myeloid leukaemia risk in healthy individuals","volume":"559","author":"Abelson","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2021.01.003_bib0017","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/s41591-018-0081-z","article-title":"Somatic mutations precede acute myeloid leukemia years before diagnosis","volume":"24","author":"Desai","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0018","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1406184","article-title":"Acute myeloid leukemia","volume":"373","author":"Dohner","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0019","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1182\/blood-2016-10-696054","article-title":"Biology and relevance of human acute myeloid leukemia stem cells","volume":"129","author":"Thomas","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0020","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1182\/blood-2016-01-693879","article-title":"Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia","volume":"128","author":"Metzeler","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0021","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","article-title":"Genomic classification and prognosis in acute myeloid leukemia","volume":"374","author":"Papaemmanuil","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0022","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.ccell.2017.09.004","article-title":"Integrating proteomics and transcriptomics for systematic combinatorial chimeric antigen receptor therapy of AML","volume":"32","author":"Perna","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0023","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41375-018-0180-3","article-title":"Coexpression profile of leukemic stem cell markers for combinatorial targeted therapy in AML","volume":"33","author":"Haubner","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2021.01.003_bib0024","doi-asserted-by":"crossref","first-page":"5502","DOI":"10.1158\/1078-0432.CCR-17-3016","article-title":"Novel approaches to acute myeloid leukemia immunotherapy","volume":"24","author":"Beyar-Katz","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.exphem.2021.01.003_bib0025","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-3-030-02505-2_4","article-title":"Update on immunotherapy in AML and MDS: monoclonal antibodies and checkpoint inhibitors paving the road for clinical practice","volume":"995","author":"Masarova","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0026","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1046\/j.1365-2141.1998.00948.x","article-title":"A systematic collaborative overview of randomized trials comparing idarubicin with daunorubicin (or other anthracyclines) as induction therapy for acute myeloid leukaemia","volume":"103","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0027","series-title":"Cancer Stem Cell Resistance to Targeted Therapy","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-3-030-16624-3_7","article-title":"Targeting leukemia stem cells and the immunological bone marrow microenvironment","author":"Maccalli","year":"2019"},{"key":"10.1016\/j.exphem.2021.01.003_bib0028","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1182\/blood-2016-10-696039","article-title":"Therapeutic targeting of acute myeloid leukemia stem cells","volume":"129","author":"Pollyea","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0029","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1182\/blood-2017-09-801498","article-title":"Minimal\/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party","volume":"131","author":"Schuurhuis","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0030","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1001\/jama.2009.813","article-title":"Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials","volume":"301","author":"Koreth","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.exphem.2021.01.003_bib0031","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.3389\/fonc.2019.01217","article-title":"The graft-versus-leukemia effect in AML","volume":"9","author":"Sweeney","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0032","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMra052638","article-title":"Hematopoietic stem-cell transplantation","volume":"354","author":"Copelan","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0033","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1182\/blood-2014-02-514778","article-title":"Conditioning regimens for hematopoietic cell transplantation: one size does not fit all","volume":"124","author":"Gyurkocza","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0034","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(09)60237-3","article-title":"Graft-versus-host disease","volume":"373","author":"Ferrara","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.exphem.2021.01.003_bib0035","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13045-017-0505-0","article-title":"Recent developments in immunotherapy of acute myeloid leukemia","volume":"10","author":"Lichtenegger","year":"2017","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0036","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/2040620718774268","article-title":"Acute myeloid leukemia chimeric antigen receptor T-cell immunotherapy: how far up the road have we traveled?","volume":"9","author":"Tasian","year":"2018","journal-title":"Ther Adv Hematol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0037","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.blre.2018.12.001","article-title":"Immunotherapy in acute myeloid leukemia and myelodysplastic syndromes: the dawn of a new era?","volume":"34","author":"Liu","year":"2019","journal-title":"Blood Rev"},{"key":"10.1016\/j.exphem.2021.01.003_bib0038","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1182\/blood-2017-09-797712","article-title":"Gemtuzumab ozogamicin for acute myeloid leukemia","volume":"130","author":"Appelbaum","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0039","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1038\/s41591-020-0910-8","article-title":"Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents","volume":"26","author":"Riether","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0040","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1182\/blood-2019-126271","article-title":"The first-in-class anti-CD47 antibody magrolimab (5F9) in combination with azacitidine is effective in MDS and AML patients: ongoing phase 1b results","volume":"134","author":"Sallman","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0041","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.3389\/fonc.2020.01672","article-title":"Targeting CXCR4 in AML and ALL","volume":"10","author":"Cancilla","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0042","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.3390\/ijms20174233","article-title":"Immunotherapy-based targeting and elimination of leukemic stem cells in AML and CML","volume":"20","author":"Valent","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.exphem.2021.01.003_bib0043","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3389\/fonc.2020.00697","article-title":"CAR T cells for acute myeloid leukemia: state of the art and future directions","volume":"10","author":"Mardiana","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0044","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1182\/blood-2019-03-900894","article-title":"Selective CD117(+) HSC exchange therapy","volume":"133","author":"Manz","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0045","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1038\/leu.2012.145","article-title":"Leukemia-associated antigens and their relevance to the immunotherapy of acute myeloid leukemia","volume":"26","author":"Anguille","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2021.01.003_bib0046","series-title":"Targeted Therapy of Acute Myeloid Leukemia","first-page":"531","article-title":"Antibody-based therapeutics targeting CD33, CD45, and CD66","author":"Walter","year":"2015"},{"key":"10.1016\/j.exphem.2021.01.003_bib0047","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.cell.2018.05.013","article-title":"Genetic inactivation of CD33 in hematopoietic stem cells to enable CAR T cell immunotherapy for acute myeloid leukemia","volume":"173","author":"Kim","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0048","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1517\/14728222.2014.909413","article-title":"The role of CD33 as therapeutic target in acute myeloid leukemia","volume":"18","author":"Walter","year":"2014","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.exphem.2021.01.003_bib0049","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1152\/physrev.00046.2011","article-title":"Stem cell factor receptor\/c-Kit: from basic science to clinical implications","volume":"92","author":"Lennartsson","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1016\/j.exphem.2021.01.003_bib0050","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1113\/jphysiol.1994.sp020343","article-title":"Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine","volume":"480","author":"Ward","year":"1994","journal-title":"J Physiol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0051","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0065-2660(08)60549-0","article-title":"Hereditary anemias of the mouse: a review for geneticists","volume":"20","author":"Russell","year":"1979","journal-title":"Adv Genet"},{"key":"10.1016\/j.exphem.2021.01.003_bib0052","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10783","article-title":"Endothelial and perivascular cells maintain haematopoietic stem cells","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2021.01.003_bib0053","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1002\/j.1460-2075.1990.tb08305.x","article-title":"Molecular bases of dominant negative and loss of function mutations at the murine c-kit\/white spotting locus: W37, Wv, W41 and W","volume":"9","author":"Nocka","year":"1990","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2021.01.003_bib0054","first-page":"1","article-title":"The kit ligand, stem cell factor","volume":"55","author":"Galli","year":"1994","journal-title":"Adv Immunol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0055","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1074-7613(02)00386-2","article-title":"Viable c-Kit(W\/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis","volume":"17","author":"Waskow","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.exphem.2021.01.003_bib0056","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.stem.2014.06.001","article-title":"Kit regulates HSC engraftment across the human\u2013mouse species barrier","volume":"15","author":"Cosgun","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0057","doi-asserted-by":"crossref","first-page":"8696","DOI":"10.1073\/pnas.88.19.8696","article-title":"Mutation of the KIT (mast\/stem cell growth factor receptor) protooncogene in human piebaldism","volume":"88","author":"Giebel","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.exphem.2021.01.003_bib0058","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1346-8138.2012.01583.x","article-title":"Piebaldism","volume":"40","author":"Oiso","year":"2013","journal-title":"J Dermatol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0059","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3389\/fimmu.2018.00868","article-title":"Controlling mast cell activation and homeostasis: work influenced by Bill Paul that continues today","volume":"9","author":"Caslin","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0060","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1182\/blood.V90.4.1345","article-title":"Stem cell factor and hematopoiesis","volume":"90","author":"Broudy","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0061","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1158\/1078-0432.CCR-07-5134","article-title":"Regulation of hematopoietic stem cells by the steel factor\/KIT signaling pathway","volume":"14","author":"Kent","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.exphem.2021.01.003_bib0062","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1084\/jem.192.12.1707","article-title":"Hematopoietic stem cells need two signals to prevent apoptosis: BCL-2 can provide one of these, Kitl\/c-Kit signaling the other","volume":"192","author":"Domen","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0063","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1084\/jem.20131128","article-title":"High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias","volume":"211","author":"Shin","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0064","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1084\/jem.20131115","article-title":"Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells","volume":"211","author":"Grinenko","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0065","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1177\/42.11.7523489","article-title":"Expression of c-kit and kit ligand proteins in normal human tissues","volume":"42","author":"Lammie","year":"1994","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.exphem.2021.01.003_bib0066","article-title":"Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage","volume":"145","author":"May","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.exphem.2021.01.003_bib0067","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/jcp.2003.013532","article-title":"KIT expression in fetal, normal adult, and neoplastic renal tissues","volume":"57","author":"Miliaras","year":"2004","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0068","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1440-1827.2005.01856.x","article-title":"KIT expression in normal and neoplastic renal tissues: immunohistochemical and molecular genetic analysis","volume":"55","author":"Kato","year":"2005","journal-title":"Pathol Int"},{"key":"10.1016\/j.exphem.2021.01.003_bib0069","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1038\/s41375-020-0818-9","article-title":"Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells","volume":"34","author":"Myburgh","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2021.01.003_bib0070","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.pai.0000173054.83414.22","article-title":"KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation","volume":"13","author":"Miettinen","year":"2005","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0071","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.acthis.2016.12.003","article-title":"Adult human retinal M\u00fcller glia display distinct peripheral and macular expression of CD117 and CD44 stem cell-associated proteins","volume":"119","author":"Too","year":"2017","journal-title":"Acta Histochem"},{"key":"10.1016\/j.exphem.2021.01.003_bib0072","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/onc.2010.494","article-title":"Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors","volume":"30","author":"Pittoni","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2021.01.003_bib0073","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.cell.2007.05.055","article-title":"Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor","volume":"130","author":"Yuzawa","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0074","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1517\/13543784.2013.740010","article-title":"Therapeutic targeting of c-KIT in cancer","volume":"22","author":"Ashman","year":"2013","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.exphem.2021.01.003_bib0075","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1634\/stemcells.2004-0117","article-title":"Normal and oncogenic forms of the receptor tyrosine kinase kit","volume":"23","author":"Lennartsson","year":"2005","journal-title":"Stem Cells"},{"key":"10.1016\/j.exphem.2021.01.003_bib0076","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.molcel.2014.11.021","article-title":"The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer","volume":"57","author":"Reshetnyak","year":"2015","journal-title":"Mol Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0077","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002068","article-title":"Mutation D816V alters the internal structure and dynamics of c-KIT receptor cytoplasmic region: implications for dimerization and activation mechanisms","volume":"7","author":"Laine","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0078","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1073\/pnas.0812413106","article-title":"KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients","volume":"106","author":"Gajiwala","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1016\/j.exphem.2021.01.003_bib0079","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.molcel.2018.08.040","article-title":"The proto-oncogene c-Kit inhibits tumor growth by behaving as a dependence receptor","volume":"72","author":"Wang","year":"2018","journal-title":"Mol Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0080","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0145-2126(88)90020-3","article-title":"Expression of a 150-kD cell surface antigen identified by monoclonal antibody YB5.B8 is associated with poor prognosis in acute non-lymphoblastic leukaemia","volume":"12","author":"Ashman","year":"1988","journal-title":"Leuk Res"},{"key":"10.1016\/j.exphem.2021.01.003_bib0081","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.leukres.2003.09.008","article-title":"C-kit receptor expression in acute leukemias\u2014association with patient and disease characteristics and with outcome","volume":"28","author":"Tsao","year":"2004","journal-title":"Leuk Res"},{"key":"10.1016\/j.exphem.2021.01.003_bib0082","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1200\/JCO.2006.06.9500","article-title":"Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B study","volume":"24","author":"Paschka","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0083","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1182\/blood-2018-06-858159","article-title":"Anti-CD117 antibody depletes normal and myelodysplastic syndrome human hematopoietic stem cells in xenografted mice","volume":"133","author":"Pang","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0084","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1182\/blood-2002-10-3062","article-title":"Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML)","volume":"101","author":"Guan","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0085","first-page":"285","article-title":"Paracrine and autocrine growth mechanisms of human stem cell factor (c-kit ligand) in myeloid leukemia","volume":"35","author":"Pietsch","year":"1993","journal-title":"Nouv Rev Fr Hematol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0086","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1053\/j.gastro.2015.05.003","article-title":"Maintenance of clonogenic KIT(+) human colon tumor cells requires secretion of stem cell factor by differentiated tumor cells","volume":"149","author":"Fatrai","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.exphem.2021.01.003_bib0087","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1084\/jem.20051714","article-title":"Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning","volume":"203","author":"Bhattacharya","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0088","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1084\/jem.20101643","article-title":"Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation","volume":"208","author":"Takizawa","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0089","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nri.2017.53","article-title":"Adult haematopoietic stem cell niches","volume":"17","author":"Crane","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0090","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nmeth.1309","article-title":"Hematopoietic stem cell transplantation without irradiation","volume":"6","author":"Waskow","year":"2009","journal-title":"Nat Methods"},{"key":"10.1016\/j.exphem.2021.01.003_bib0091","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1002\/j.1460-2075.1991.tb07744.x","article-title":"In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development","volume":"10","author":"Nishikawa","year":"1991","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2021.01.003_bib0092","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1084\/jem.174.1.63","article-title":"Expression and function of c-kit in hemopoietic progenitor cells","volume":"174","author":"Ogawa","year":"1991","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0093","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1073\/pnas.89.4.1502","article-title":"Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation","volume":"89","author":"Ikuta","year":"1992","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1016\/j.exphem.2021.01.003_bib0094","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1126\/science.1149726","article-title":"Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches","volume":"318","author":"Czechowicz","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.exphem.2021.01.003_bib0095","doi-asserted-by":"crossref","first-page":"351ra105","DOI":"10.1126\/scitranslmed.aae0501","article-title":"Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy","volume":"8","author":"Chhabra","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0096","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1182\/blood-2015-12-689083","article-title":"KIT blockade is sufficient for donor hematopoietic stem cell engraftment in Fanconi anemia mice","volume":"129","author":"Chandrakasan","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0097","doi-asserted-by":"crossref","first-page":"5419","DOI":"10.1182\/blood-2010-07-295949","article-title":"Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice","volume":"116","author":"Xue","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0098","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2009.05.046","article-title":"CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis","volume":"138","author":"Jaiswal","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0099","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cell.2009.05.045","article-title":"CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells","volume":"138","author":"Majeti","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0100","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1084\/jem.20120502","article-title":"Disruption of SIRP\u03b1 signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts","volume":"209","author":"Theocharides","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0101","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1182\/blood-2014-02-550327","article-title":"In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice","volume":"124","author":"Derderian","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0102","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1182\/bloodadvances.2018022020","article-title":"Depletion of murine fetal hematopoietic stem cells with c-Kit receptor and CD47 blockade improves neonatal engraftment","volume":"2","author":"Witt","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2021.01.003_bib0103","doi-asserted-by":"crossref","first-page":"eaam6202","DOI":"10.1126\/sciimmunol.aam6202","article-title":"Donor SIRP\u03b1 polymorphism modulates the innate immune response to allogeneic grafts","volume":"2","author":"Dai","year":"2017","journal-title":"Sci Immunol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0104","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.stem.2019.05.018","article-title":"Antibody conditioning enables MHC-mismatched hematopoietic stem cell transplants and organ graft tolerance","volume":"25","author":"George","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0105","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1182\/blood.V79.2.338.338","article-title":"Isolation and characterization of a monoclonal antibody that recognizes the human c-kit receptor","volume":"79","author":"Broudy","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0106","series-title":"Humanized C-kit antibody (US Patent No. 8436150B2), U.S. Patent and Trademark Office","author":"Ng","year":"2013"},{"key":"10.1016\/j.exphem.2021.01.003_bib0107","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1182\/blood-2018-06-853879","article-title":"Anti-human CD117 antibody-mediated bone marrow niche clearance in nonhuman primates and humanized NSG mice","volume":"133","author":"Kwon","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0108","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1089\/hum.2014.031","article-title":"Modeling promising nonmyeloablative conditioning regimens in nonhuman primates","volume":"25","author":"Chandrasekaran","year":"2014","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.exphem.2021.01.003_bib0109","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.immuni.2007.05.001","article-title":"Human-hemato-lymphoid-system mice: opportunities and challenges","volume":"26","author":"Manz","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.exphem.2021.01.003_bib0110","doi-asserted-by":"crossref","first-page":"15970","DOI":"10.1016\/S0021-9258(19)49629-4","article-title":"Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor","volume":"267","author":"Lev","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2021.01.003_bib0111","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0092-8674(90)90302-U","article-title":"Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor","volume":"63","author":"Zsebo","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0112","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0092-8674(90)90301-T","article-title":"Primary structure and functional expression of rat and human stem cell factor DNAs","volume":"63","author":"Martin","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0113","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev-immunol-032712-095921","article-title":"Human hemato-lymphoid system mice: current use and future potential for medicine","volume":"31","author":"Rongvaux","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0114","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1182\/blood-2011-05-353243","article-title":"Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rgamma null mice is enhanced by transgenic expression of membrane-bound human SCF","volume":"119","author":"Brehm","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0115","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1182\/blood-2011-05-353201","article-title":"Membrane-bound human SCF\/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation","volume":"119","author":"Takagi","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0116","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1158\/1078-0432.CCR-16-2152","article-title":"KTN0158, a humanized anti-KIT monoclonal antibody, demonstrates biologic activity against both normal and malignant canine mast cells","volume":"23","author":"London","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.exphem.2021.01.003_bib0117","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1158\/1535-7163.MCT-15-0321","article-title":"Neutralization of KIT oncogenic signaling in leukemia with antibodies targeting KIT membrane proximal domain 5","volume":"14","author":"Le Gall","year":"2015","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.exphem.2021.01.003_bib0118","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.4161\/cbt.29523","article-title":"A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth","volume":"15","author":"Lebron","year":"2014","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.exphem.2021.01.003_bib0119","doi-asserted-by":"crossref","first-page":"17832","DOI":"10.1073\/pnas.1317118110","article-title":"Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region","volume":"110","author":"Reshetnyak","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.exphem.2021.01.003_bib0120","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41467-018-08201-x","article-title":"Selective hematopoietic stem cell ablation using CD117-antibody\u2013drug-conjugates enables safe and effective transplantation with immunity preservation","volume":"10","author":"Czechowicz","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.exphem.2021.01.003_bib0121","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41467-018-08202-w","article-title":"Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody\u2013drug-conjugate conditioning in MHC-mismatched allotransplantation","volume":"10","author":"Li","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.exphem.2021.01.003_bib0122","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.omtm.2020.02.001","article-title":"Effective multi-lineage engraftment in a mouse model of Fanconi anemia using non-genotoxic antibody-based conditioning","volume":"17","author":"Srikanthan","year":"2020","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.exphem.2021.01.003_bib0123","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1182\/blood-2018-99-114881","article-title":"CD117-amanitin antibody drug conjugates effectively deplete human and non-human primate HSCs: proof of concept as a targeted strategy for conditioning patients for bone marrow Transplant","volume":"132","author":"Pearse","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0124","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJMoa1609783","article-title":"Blinatumomab versus chemotherapy for advanced acute lymphoblastic leukemia","volume":"376","author":"Kantarjian","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0125","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1080\/19420862.2016.1268307","article-title":"The making of bispecific antibodies","volume":"9","author":"Brinkmann","year":"2017","journal-title":"MAbs"},{"key":"10.1016\/j.exphem.2021.01.003_bib0126","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1182\/blood-2012-01-400515","article-title":"Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19\/CD3-bispecific BiTE antibody blinatumomab","volume":"119","author":"Klinger","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0127","doi-asserted-by":"crossref","first-page":"5829","DOI":"10.1158\/1078-0432.CCR-16-0350","article-title":"Characterization of CD33\/CD3 tetravalent bispecific tandem diabodies (TandAbs) for the treatment of acute myeloid leukemia","volume":"22","author":"Reusch","year":"2016","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.exphem.2021.01.003_bib0128","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.cell.2019.04.041","article-title":"Multifunctional natural killer cell engagers targeting NKp46 trigger protective tumor immunity","volume":"177","author":"Gauthier","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0129","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1158\/1078-0432.CCR-13-0505","article-title":"Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16\u202f\u00d7\u202f33 bispecific killer cell engager and ADAM17 inhibition","volume":"19","author":"Wiernik","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.exphem.2021.01.003_bib0130","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s11899-018-0472-8","article-title":"Bispecific antibodies for the treatment of acute myeloid leukemia","volume":"13","author":"Guy","year":"2018","journal-title":"Curr Hematol Malig Rep"},{"key":"10.1016\/j.exphem.2021.01.003_bib0131","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1158\/2159-8290.CD-18-0297","article-title":"CARs versus BiTEs: a comparison between T cell\u2013redirection strategies for cancer treatment","volume":"8","author":"Slaney","year":"2018","journal-title":"Cancer Discov"},{"key":"10.1016\/j.exphem.2021.01.003_bib0132","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1126\/science.aar6711","article-title":"CAR T cell immunotherapy for human cancer","volume":"359","author":"June","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.exphem.2021.01.003_bib0133","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.ymthe.2018.03.003","article-title":"Myeloid Conditioning with c-kit-Targeted CAR-T Cells Enables Donor Stem Cell Engraftment","volume":"26","author":"Arai","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.exphem.2021.01.003_bib0134","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1182\/blood-2014-01-545020","article-title":"A highly compact epitope-based marker\/suicide gene for easier and safer T-cell therapy","volume":"124","author":"Philip","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0135","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1089\/hgtb.2012.050","article-title":"Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells","volume":"23","author":"Marin","year":"2012","journal-title":"Hum Gene Ther Methods"},{"key":"10.1016\/j.exphem.2021.01.003_bib0136","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1182\/blood-2004-11-4564","article-title":"An inducible caspase 9 safety switch for T-cell therapy","volume":"105","author":"Straathof","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0137","unstructured":"Stanford University, California Institute for Regenerative Medicine. AMG191 conditioning\/CD34+CD90 stem cell transplant study for SCID patients. 2020. Trial Identifier: NCT02963064, JAS-BMT-CP-001."},{"key":"10.1016\/j.exphem.2021.01.003_bib0138","unstructured":"Jasper Therapeutics, Inc. JSP191 antibody targeting conditioning in MDS\/AML patients Undergoing hematopoietic cell transplantation. 2020. ClinicalTrials.gov Identifier: NCT04429191. Available at: https:\/\/ClinicalTrials.gov\/show\/NCT04429191."},{"key":"10.1016\/j.exphem.2021.01.003_bib0139","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1182\/blood-2017-08-798322","article-title":"Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia","volume":"131","author":"G\u00f6kbuget","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0140","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1182\/blood-2016-08-736041","article-title":"Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia","volume":"129","author":"Tasian","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0141","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1172\/JCI125423","article-title":"CD19 CAR T cell product and disease attributes predict leukemia remission durability","volume":"129","author":"Finney","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2021.01.003_bib0142","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.coi.2012.08.002","article-title":"The road to purified hematopoietic stem cell transplants is paved with antibodies","volume":"24","author":"Logan","year":"2012","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.exphem.2021.01.003_bib0143","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.iac.2010.03.003","article-title":"Purified hematopoietic stem cell transplantation: the next generation of blood and immune replacement","volume":"30","author":"Czechowicz","year":"2010","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.exphem.2021.01.003_bib0144","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/s41409-019-0445-0","article-title":"Targeting the niche: depleting haemopoietic stem cells with targeted therapy","volume":"54","author":"Abadir","year":"2019","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.exphem.2021.01.003_bib0145","doi-asserted-by":"crossref","first-page":"554","DOI":"10.3390\/jcm9020554","article-title":"Is hematopoietic stem cell transplantation required to unleash the full potential of immunotherapy in acute myeloid leukemia?","volume":"9","author":"Abadir","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.exphem.2021.01.003_bib0146","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1182\/blood-2016-09-731893","article-title":"Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts","volume":"129","author":"Valent","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2021.01.003_bib0147","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0092-8674(90)90280-R","article-title":"Steel locus defines new multipotent growth factor","volume":"63","author":"Witte","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2021.01.003_bib0148","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0092-8674(90)90297-R","article-title":"Identification of a ligand for the c-kit proto-oncogene","volume":"63","author":"Williams","year":"1990","journal-title":"Cell"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X21000047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X21000047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:36:06Z","timestamp":1759566966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X21000047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":148,"alternative-id":["S0301472X21000047"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2021.01.003","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-CD117 immunotherapy to eliminate hematopoietic and leukemia stem cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2021.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}