{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:52:02Z","timestamp":1788911522479,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01HL136622"],"award-info":[{"award-number":["R01HL136622"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.exphem.2023.02.005","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T09:37:35Z","timestamp":1678959455000},"page":"55-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Reticulocyte mitochondrial retention increases reactive oxygen species and oxygen consumption in mouse models of sickle cell disease and phlebotomy-induced anemia"],"prefix":"10.1016","volume":"122","author":[{"given":"Anne","family":"Gallivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1929-9893","authenticated-orcid":false,"given":"Mikail","family":"Alejandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3214-1911","authenticated-orcid":false,"given":"Amarachi","family":"Kanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2962-3987","authenticated-orcid":false,"given":"Nebeyat","family":"Zekaryas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hart","family":"Horneman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9237-4311","authenticated-orcid":false,"given":"Lenny K.","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott","family":"Vinchinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Lavelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6032-1293","authenticated-orcid":false,"given":"Alan M.","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Molokie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7906-4239","authenticated-orcid":false,"given":"Jagadeesh","family":"Ramasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Rivers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2023.02.005_bib0001","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/ajh.21443","article-title":"The cost of health care for patients with sickle cell disease","volume":"84","author":"Ballas","year":"2009","journal-title":"Am J Hematol"},{"key":"10.1016\/j.exphem.2023.02.005_bib0002","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ajh.21408","article-title":"The cost of health care for children and adults with sickle cell disease","volume":"84","author":"Kauf","year":"2009","journal-title":"Am J Hematol"},{"key":"10.1016\/j.exphem.2023.02.005_bib0003","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1182\/asheducation-2017.1.440","article-title":"Evolving treatment paradigms in sickle cell disease","volume":"2017","author":"Jagadeeswaran","year":"2017","journal-title":"Hematology"},{"key":"10.1016\/j.exphem.2023.02.005_bib0004","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/01926230290166724","article-title":"Invited review: oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification","volume":"30","author":"Kohen","year":"2002","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.exphem.2023.02.005_bib0005","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1365-2141.2010.08320.x","article-title":"Plasma levels of advanced glycation end products are associated with haemolysis-related organ complications in sickle cell patients","volume":"151","author":"Nur","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2023.02.005_bib0006","doi-asserted-by":"crossref","first-page":"639","DOI":"10.2174\/156652408786241366","article-title":"Hypercoagulability in sickle cell disease and beta-thalassemia","volume":"8","author":"Singer","year":"2008","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.exphem.2023.02.005_bib0007","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/10739680490278402","article-title":"The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy","volume":"11","author":"Hebbel","year":"2004","journal-title":"Microcirculation"},{"key":"10.1016\/j.exphem.2023.02.005_bib0008","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/ajh.21475","article-title":"Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions","volume":"84","author":"Kato","year":"2009","journal-title":"Am J Hematol"},{"key":"10.1016\/j.exphem.2023.02.005_bib0009","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/bjh.13938","article-title":"Advances in understanding erythropoiesis: evolving perspectives","volume":"173","author":"Nandakumar","year":"2016","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2023.02.005_bib0010","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/bjh.17416","article-title":"Deficient mitophagy pathways in sickle cell disease","volume":"193","author":"Martino","year":"2021","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2023.02.005_bib0011","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria","volume":"20","author":"Ashrafi","year":"2013","journal-title":"Cell Death Differ"},{"issue":"Supplement 1","key":"10.1016\/j.exphem.2023.02.005_bib0012","first-page":"2237","article-title":"The abnormal presence of mitochondria in circulating red blood cells cause an increased oxygen consumption rate, ros generation and hemolysis in patients with sickle cell disease","volume":"130","author":"Jagadeeswaran","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2023.02.005_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.exphem.2015.04.005","article-title":"RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases \u03b3-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model","volume":"43","author":"Rivers","year":"2015","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2023.02.005_bib0014","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1182\/blood-2015-02-626259","article-title":"The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice","volume":"126","author":"Cui","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2023.02.005_bib0015","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1182\/blood-2012-07-441188","article-title":"Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease","volume":"121","author":"George","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2023.02.005_bib0016","series-title":"FlowJoTM Software MAC Version 10.8.1","year":"2022"},{"key":"10.1016\/j.exphem.2023.02.005_bib0017","series-title":"Seahorse XFe96 Analyzer","year":"2022"},{"key":"10.1016\/j.exphem.2023.02.005_bib0018","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1182\/blood-2012-09-456079","article-title":"Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis","volume":"121","author":"Liu","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2023.02.005_bib0019","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1056\/NEJM200001133420203","article-title":"Prediction of adverse outcomes in children with sickle cell disease","volume":"342","author":"Miller","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2023.02.005_bib0020","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/ajh.23777","article-title":"Reticulocytosis and anemia are associated with an increased risk of death and stroke in the newborn cohort of the Cooperative Study of Sickle Cell Disease","volume":"89","author":"Meier","year":"2014","journal-title":"Am J Hematol"},{"key":"10.1016\/j.exphem.2023.02.005_bib0021","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.exphem.2017.02.003","article-title":"Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease","volume":"50","author":"Jagadeeswaran","year":"2017","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2023.02.005_bib0022","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejcb.2017.11.003","article-title":"Epigenetic and microenvironmental alterations in bone marrow associated with ROS in experimental aplastic anemia","volume":"97","author":"Chatterjee","year":"2018","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.exphem.2023.02.005_bib0023","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1007\/s00277-022-04867-y","article-title":"L-glutamine for sickle cell disease: more than reducing redox","volume":"101","author":"Jafri","year":"2022","journal-title":"Ann Hematol"},{"key":"10.1016\/j.exphem.2023.02.005_bib0024","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fphar.2014.00151","article-title":"Glutathione and mitochondria","volume":"5","author":"Ribas","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.exphem.2023.02.005_bib0025","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1182\/blood-2007-04-081703","article-title":"Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease","volume":"111","author":"Morris","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2023.02.005_bib0026","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1182\/blood.2020006732","article-title":"Arginine for mitochondrial oxidative enzymopathy","volume":"136","author":"Kim-Shapiro","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2023.02.005_bib0027","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/HYPERTENSIONAHA.113.01425","article-title":"Kidney hypoxia, attributable to increased oxygen consumption, induces nephropathy independently of hyperglycemia and oxidative stress","volume":"62","author":"Friederich-Persson","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.exphem.2023.02.005_bib0028","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3324\/haematol.2015.140749","article-title":"The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis)","volume":"101","author":"Rivers","year":"2016","journal-title":"Haematologica"},{"key":"10.1016\/j.exphem.2023.02.005_bib0029","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.cmet.2021.08.008","article-title":"Erythrocyte-derived mitochondria take to the lupus stage","volume":"33","author":"Lepelley","year":"2021","journal-title":"Cell Metab"},{"key":"10.1016\/j.exphem.2023.02.005_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.07.021","article-title":"Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE","volume":"184","author":"Caielli","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2023.02.005_bib0031","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/bjh.18287","article-title":"Retention of functional mitochondria in mature red blood cells from patients with sickle cell disease","volume":"198","author":"Moriconi","year":"2022","journal-title":"Br J Haematol"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X23000334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X23000334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:38:32Z","timestamp":1759567112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X23000334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":31,"alternative-id":["S0301472X23000334"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2023.02.005","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reticulocyte mitochondrial retention increases reactive oxygen species and oxygen consumption in mouse models of sickle cell disease and phlebotomy-induced anemia","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2023.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}