{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:52:12Z","timestamp":1779094332474,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":547,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20am0101086"],"award-info":[{"award-number":["JP20am0101086"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["10101519"],"award-info":[{"award-number":["10101519"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["18072499"],"award-info":[{"award-number":["18072499"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004095","name":"Kyowa Hakko Kirin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009033","name":"Center of Innovation Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.exphem.2023.104137","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T17:20:39Z","timestamp":1702574439000},"page":"104137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["AKT2 inhibition accelerates the acquisition of phagocytic ability in induced pluripotent stem cell\u2013derived neutrophils"],"prefix":"10.1016","volume":"130","author":[{"given":"Toshiya","family":"Hino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1515-8284","authenticated-orcid":false,"given":"Fumio","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8168-6459","authenticated-orcid":false,"given":"Yosuke","family":"Masamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6216-6730","authenticated-orcid":false,"given":"Yuki","family":"Kagoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5480-3189","authenticated-orcid":false,"given":"Hirotatsu","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mineo","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2023.104137_bib0001","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.exphem.2023.104137_bib0002","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bbmt.2014.12.006","article-title":"Incidence rate of fluoroquinolone-resistant gram-negative rod bacteremia among allogeneic hematopoietic cell transplantation patients during an era of levofloxacin prophylaxis","volume":"21","author":"Miles-Jay","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2023.104137_bib0003","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.17652","article-title":"Comparison of antifungal prophylaxis drugs in patients with hematological disease or undergoing hematopoietic stem cell transplantation: a systematic review and network meta-analysis","volume":"3","author":"Wang","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.exphem.2023.104137_bib0004","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/CCM.0b013e31822b50c2","article-title":"Survival in neutropenic patients with severe sepsis or septic shock","volume":"40","author":"Legrand","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.exphem.2023.104137_bib0005","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1182\/blood-2015-05-645986","article-title":"Efficacy of transfusion with granulocytes from G-CSF\/dexamethasone-treated donors in neutropenic patients with infection","volume":"126","author":"Price","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2023.104137_bib0006","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.jcyt.2017.08.012","article-title":"Granulocyte transfusions: a concise review for practitioners","volume":"19","author":"Gea-Banacloche","year":"2017","journal-title":"Cytotherapy"},{"key":"10.1016\/j.exphem.2023.104137_bib0007","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1182\/blood-2016-03-700336","article-title":"Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives","volume":"127","author":"Lahoz-Beneytez","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2023.104137_bib0008","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1189\/jlb.1112571","article-title":"What's your age again? Determination of human neutrophil half-lives revisited","volume":"94","author":"Tak","year":"2013","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.exphem.2023.104137_bib0009","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1182\/blood.2021011576","article-title":"Efficient production of human neutrophils from iPSCs that prevent murine lethal infection with immune cell recruitment","volume":"138","author":"Miyauchi","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2023.104137_bib0010","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1006\/bcmd.2002.0513","article-title":"Surface antigen changes during normal neutrophilic development: a critical review","volume":"28","author":"Elghetany","year":"2002","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.exphem.2023.104137_bib0011","first-page":"624","article-title":"Role of neutrophil Fc gamma RIIa (CD32) and Fc gamma RIIIb (CD16) polymorphic forms in phagocytosis of human IgG1- and IgG3-opsonized bacteria and erythrocytes","volume":"83","author":"Bredius","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.exphem.2023.104137_bib0012","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.3389\/fimmu.2018.03124","article-title":"Fc\u03b3RIIIb restricts antibody-dependent destruction of cancer cells by human neutrophils","volume":"9","author":"Treffers","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.exphem.2023.104137_bib0013","article-title":"beta2 integrin signaling cascade in neutrophils: more than a single function","volume":"11","author":"Bouti","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.exphem.2023.104137_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.660760","article-title":"beta2 integrin regulation of neutrophil functional plasticity and fate in the resolution of inflammation","volume":"12","author":"Sekheri","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.exphem.2023.104137_bib0015","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1128\/iai.63.1.73-81.1995","article-title":"Human immunoglobulin G (IgG) Fc receptor IIA (CD32) polymorphism and IgG2-mediated bacterial phagocytosis by neutrophils","volume":"63","author":"Sanders","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.exphem.2023.104137_bib0016","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4049\/jimmunol.151.1.330","article-title":"Signaling properties of CR3 (CD11b\/CD18) and CR1 (CD35) in relation to phagocytosis of complement-opsonized particles","volume":"151","author":"F\u00e4llman","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2023.104137_bib0017","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.4049\/jimmunol.142.7.2365","article-title":"The 40-kDa Fc gamma receptor (FcRII) on human neutrophils is essential for the IgG-induced respiratory burst and IgG-induced phagocytosis","volume":"142","author":"Huizinga","year":"1989","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2023.104137_bib0018","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41423-020-0412-0","article-title":"Neutrophil chemoattractant receptors in health and disease: double-edged swords","volume":"17","author":"Metzemaekers","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.exphem.2023.104137_bib0019","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1056\/NEJMoa1007097","article-title":"Residual NADPH oxidase and survival in chronic granulomatous disease","volume":"363","author":"Kuhns","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2023.104137_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104806","article-title":"Akt-targeted therapy as a promising strategy to overcome drug resistance in breast cancer \u2013 a comprehensive review from chemotherapy to immunotherapy","volume":"156","author":"Jabbarzadeh Kaboli","year":"2020","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.exphem.2023.104137_bib0021","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1200\/JCO.19.01027","article-title":"MK-2206 and standard neoadjuvant chemotherapy improves response in patients with human epidermal growth factor receptor 2-positive and\/or hormone receptor-negative breast cancers in the I-SPY 2 Trial","volume":"38","author":"Chien","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.exphem.2023.104137_bib0022","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.1021\/jm8004527","article-title":"Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H- imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase","volume":"51","author":"Heerding","year":"2008","journal-title":"J Med Chem"},{"key":"10.1016\/j.exphem.2023.104137_bib0023","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB signaling: navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2023.104137_bib0024","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1158\/1535-7163.MCT-05-0005","article-title":"Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo","volume":"4","author":"Luo","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.exphem.2023.104137_bib0025","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1158\/1535-7163.MCT-10-0760","article-title":"Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930","volume":"10","author":"Yap","year":"2011","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.exphem.2023.104137_bib0026","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.4049\/jimmunol.1300736","article-title":"Kinase AKT1 negatively controls neutrophil recruitment and function in mice","volume":"191","author":"Liu","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2023.104137_bib0027","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1182\/blood-2009-11-255323","article-title":"Akt isoforms differentially regulate neutrophil functions","volume":"115","author":"Chen","year":"2010","journal-title":"Blood"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X23017757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X23017757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:46:07Z","timestamp":1762285567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X23017757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":27,"alternative-id":["S0301472X23017757"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2023.104137","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AKT2 inhibition accelerates the acquisition of phagocytic ability in induced pluripotent stem cell\u2013derived neutrophils","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2023.104137","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 ISEH \u2013 Society for Hematology and Stem Cells. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104137"}}