{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:49:58Z","timestamp":1785368998009,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","award":["DFF-1032-00242B"],"award-info":[{"award-number":["DFF-1032-00242B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","award":["SBF003\\\\1096"],"award-info":[{"award-number":["SBF003\\\\1096"]}],"id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk A\/S","doi-asserted-by":"publisher","award":["NNF18OC0053231"],"award-info":[{"award-number":["NNF18OC0053231"]}],"id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009001","name":"University of York","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/W018578\/1"],"award-info":[{"award-number":["MR\/W018578\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000315","name":"Aberystwyth University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000315","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.exphem.2024.104689","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T23:11:54Z","timestamp":1732835514000},"page":"104689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Chronic murine schistosomiasis causes aberrant hemostasis"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4282-4046","authenticated-orcid":false,"given":"Joanna H.","family":"Greenman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8174-8069","authenticated-orcid":false,"given":"Lucie","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9711-8766","authenticated-orcid":false,"given":"Shinjini","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Whitehead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Palmfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6673-8505","authenticated-orcid":false,"given":"Peter","family":"Nejsum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Hewitson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S.","family":"Hitchcock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2024.104689_bib0001","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","volume":"4","author":"McManus","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.exphem.2024.104689_bib0002","unstructured":"Schistosomiasis [Internet]. WHO. [cited 2023 May 1]. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/schistosomiasis."},{"key":"10.1016\/j.exphem.2024.104689_bib0003","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-3-030-18616-6_3","article-title":"Schistosomiasis","volume":"1154","author":"LoVerde","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.exphem.2024.104689_bib0004","first-page":"27","article-title":"Basic coagulation profiles and platelet count among Schistosoma mansoni-infected adults attending Sanja Primary Hospital, Northwest Ethiopia","volume":"11","author":"Eyayu","year":"2020","journal-title":"Res Rep Trop Med."},{"key":"10.1016\/j.exphem.2024.104689_bib0005","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1590\/s0102-865020180120000008","article-title":"Correlation between the values of circulating blood elements with the size of spleen in the presence of schistosomal splenomegaly","volume":"33","author":"Vasconcellos","year":"2018","journal-title":"Acta Cir\u00fargica Brasileira"},{"key":"10.1016\/j.exphem.2024.104689_bib0006","doi-asserted-by":"crossref","first-page":"e2314","DOI":"10.1371\/journal.pntd.0002314","article-title":"Hemostatic dysfunction is increased in patients with hepatosplenic schistosomiasis mansoni and advanced periportal fibrosis","volume":"7","author":"Leite","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.exphem.2024.104689_bib0007","first-page":"218","article-title":"Disseminated intravascular coagulation in endemic hepatosplenic schistosomiasis","volume":"25","author":"Omran","year":"1995","journal-title":"Haemostasis"},{"key":"10.1016\/j.exphem.2024.104689_bib0008","doi-asserted-by":"crossref","first-page":"eadl1965","DOI":"10.1126\/sciimmunol.adl1965","article-title":"Early symptom-associated inflammatory responses shift to type 2 responses in controlled human schistosome infection","volume":"9","author":"Houlder","year":"2024","journal-title":"Sci Immunol"},{"key":"10.1016\/j.exphem.2024.104689_bib0009","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3181\/00379727-193-42993","article-title":"Blood platelets and schistosome egg excretion","volume":"193","author":"Ngaiza","year":"1990","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.exphem.2024.104689_bib0010","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s11239-015-1298-z","article-title":"The impact of schistosomes and schistosomiasis on murine blood coagulation and fibrinolysis as determined by thromboelastography (TEG)","volume":"41","author":"Da'dara","year":"2016","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.exphem.2024.104689_bib0011","article-title":"Pathological and immunological evaluation of different regimens of praziquantel treatment in a mouse model of Schistosoma mansoni infection","volume":"16","author":"Femoe","year":"2022","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"10.1016\/j.exphem.2024.104689_bib0012","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s12964-023-01329-4","article-title":"Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice","volume":"21","author":"Schmid","year":"2023","journal-title":"Cell Communication and Signaling"},{"key":"10.1016\/j.exphem.2024.104689_bib0013","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.exphem.2024.104689_bib0014","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat Methods"},{"key":"10.1016\/j.exphem.2024.104689_bib0015","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1002\/cpz1.90","article-title":"Gene set knowledge discovery with Enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr Protoc"},{"key":"10.1016\/j.exphem.2024.104689_bib0016","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1165\/rcmb.2017-0401OC","article-title":"Platelets play a central role in sensitization to allergen","volume":"59","author":"Amison","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.exphem.2024.104689_bib0017","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1007\/s42399-020-00521-8","article-title":"Immune thrombocytopenia secondary to COVID-19: a systematic review","volume":"2","author":"Bhattacharjee","year":"2020","journal-title":"SN Compr Clin Med"},{"key":"10.1016\/j.exphem.2024.104689_bib0018","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1182\/bloodadvances.2020004082","article-title":"Dissecting pathways to thrombocytopenia in a mouse model of visceral leishmaniasis","volume":"5","author":"Rani","year":"2021","journal-title":"Blood Advances"},{"key":"10.1016\/j.exphem.2024.104689_bib0019","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/jth.14788","article-title":"Large and small platelets\u2014(When) do they differ?","volume":"18","author":"Handtke","year":"2020","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.exphem.2024.104689_bib0020","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1055\/s-0038-1641715","article-title":"The essential ectoenzyme smnpp5 from the human intravascular parasite Schistosoma mansoni is an ADPase and a potent inhibitor of platelet aggregation","volume":"118","author":"Elzoheiry","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.exphem.2024.104689_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.molbiopara.2019.111190","article-title":"Schistosomes can hydrolyze proinflammatory and prothrombotic polyphosphate (polyP) via tegumental alkaline phosphatase, SmAP","volume":"232","author":"Elzoheiry","year":"2019","journal-title":"Mol Biochem Parasitol."},{"key":"10.1016\/j.exphem.2024.104689_bib0022","doi-asserted-by":"crossref","first-page":"e1011","DOI":"10.1371\/journal.pntd.0001011","article-title":"Characterization of schistosome tegumental alkaline phosphatase (SmAP)","volume":"5","author":"Bhardwaj","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.exphem.2024.104689_bib0023","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/00062752-199909000-00012","article-title":"Laboratory markers of platelet activation and their clinical significance","volume":"6","author":"Michelson","year":"1999","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.exphem.2024.104689_bib0024","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/cyto.10114","article-title":"Flow cytometric detection of activated mouse integrin \u03b1IIb\u03b23 with a novel monoclonal antibody","volume":"48","author":"Bergmeier","year":"2002","journal-title":"Cytometry"},{"key":"10.1016\/j.exphem.2024.104689_bib0025","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s11658-020-00214-z","article-title":"The role of phosphatidylserine recognition receptors in multiple biological functions","volume":"25","author":"Naeini","year":"2020","journal-title":"Cell Mol Biol Lett"},{"key":"10.1016\/j.exphem.2024.104689_bib0026","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0163-7827(03)00025-0","article-title":"Exposure of platelet membrane phosphatidylserine regulates blood coagulation","volume":"42","author":"Lentz","year":"2003","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.exphem.2024.104689_bib0027","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fcvm.2020.00015","article-title":"Procoagulant phosphatidylserine-exposing platelets in vitro and in vivo","volume":"7","author":"Reddy","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.exphem.2024.104689_bib0028","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1182\/bloodadvances.2017007021","article-title":"Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets","volume":"1","author":"Zufferey","year":"2017","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2024.104689_bib0029","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5954536","article-title":"A comparative cross-sectional study of coagulation profiles and platelet parameters of Schistosoma mansoni-infected adults at Haik Primary Hospital, Northeast Ethiopia","volume":"2022","author":"Bisetegn","year":"2022","journal-title":"Interdiscip Perspect Infect Dis"},{"issue":"Suppl 1","key":"10.1016\/j.exphem.2024.104689_bib0030","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2036.2007.03509.x","article-title":"Review article: coagulation disorders in chronic liver disease","volume":"26","author":"Peck-Radosavljevic","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.exphem.2024.104689_bib0031","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.1177\/1076029618806424","article-title":"Disseminated intravascular coagulation: an update on pathogenesis, diagnosis, and therapeutic strategies","volume":"24","author":"Papageorgiou","year":"2018","journal-title":"Clin Appl Thromb Hemost"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X2400554X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X2400554X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T15:31:31Z","timestamp":1767367891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X2400554X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":31,"alternative-id":["S0301472X2400554X"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2024.104689","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic murine schistosomiasis causes aberrant hemostasis","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2024.104689","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 International Society for Experimental Hematology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104689"}}