{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:15:23Z","timestamp":1783440923416,"version":"3.54.6"},"reference-count":178,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007390","name":"National Institute of Science and Technology Study Centre of the Adaptations of the Amazon Aquatic Biota","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["S2022105330541"],"award-info":[{"award-number":["S2022105330541"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["202210533013X"],"award-info":[{"award-number":["202210533013X"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.exphem.2025.104833","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T18:32:26Z","timestamp":1749925946000},"page":"104833","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A new anchor point for gut microbiome to regulate complications of allogeneic hematopoietic stem cell transplantation: oxidative stress"],"prefix":"10.1016","volume":"150","author":[{"given":"Wenxuan","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiebin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuhan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamingxi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zisai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2025.104833_bib0001","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev-med-070119-115617","article-title":"Hematopoietic stem cell transplantation for autoimmune disease","volume":"72","author":"Alexander","year":"2021","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0002","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/bmj.321.7258.433","article-title":"Stem cell transplantation","volume":"321","author":"Lennard","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.exphem.2025.104833_bib0003","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrc2804","article-title":"Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer","volume":"10","author":"Jenq","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.exphem.2025.104833_bib0004","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.bbmt.2017.04.019","article-title":"Association of plasma CD163 concentration with de novo-onset chronic graft-versus-host disease","volume":"23","author":"Inamoto","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0005","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.bbmt.2013.07.014","article-title":"Association of an impaired bone marrow microenvironment with secondary poor graft function after allogeneic hematopoietic stem cell transplantation","volume":"19","author":"Kong","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtct.2021.06.017","article-title":"Upregulation of Nrf2 attenuates oxidative stress-induced, complement activation-associated endothelial injury and apoptosis in transplant-associated thrombotic microangiopathy","volume":"27","author":"Zhang","year":"2021","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.exphem.2025.104833_bib0007","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.biotechadv.2016.08.003","article-title":"The gut microbiota: a treasure for human health","volume":"34","author":"Li","year":"2016","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.exphem.2025.104833_bib0008","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3390\/nu13010144","article-title":"Role of gut microbiota and their metabolites on atherosclerosis, hypertension and human blood platelet function: a review","volume":"13","author":"Duttaroy","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.exphem.2025.104833_bib0009","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1021\/acschemneuro.7b00176","article-title":"Gut microbiota, nitric oxide, and microglia as prerequisites for neurodegenerative disorders","volume":"8","author":"Tse","year":"2017","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.exphem.2025.104833_bib0010","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1371\/journal.pbio.0060280","article-title":"The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing","volume":"6","author":"Dethlefsen","year":"2008","journal-title":"PLoS Biol"},{"key":"10.1016\/j.exphem.2025.104833_bib0011","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cmet.2015.06.006","article-title":"Redox homeostasis and mitochondrial dynamics","volume":"22","author":"Willems","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.exphem.2025.104833_bib0012","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"13","author":"Liguori","year":"2018","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.exphem.2025.104833_bib0013","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1089\/ars.2014.5941","article-title":"Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration and development, as well as their bone marrow microenvironment","volume":"21","author":"Ludin","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.exphem.2025.104833_bib0014","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cellsig.2005.04.002","article-title":"Reactive oxygen species generated by hematopoietic cytokines play roles in activation of receptor-mediated signaling and in cell cycle progression","volume":"18","author":"Iiyama","year":"2006","journal-title":"Cell Signal"},{"issue":"7","key":"10.1016\/j.exphem.2025.104833_bib0015","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1182\/blood-2009-06-229443","article-title":"Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice","volume":"115","author":"Kharas","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0016","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1084\/jem.20081297","article-title":"TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species","volume":"205","author":"Chen","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0017","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.stem.2010.11.028","article-title":"Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K\/Akt-dependent manner","volume":"8","author":"Le Belle","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2025.104833_bib0018","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1089\/ars.2010.3405","article-title":"Forkhead homeobox type O transcription factors in the responses to oxidative stress","volume":"14","author":"Storz","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.exphem.2025.104833_bib0019","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1182\/blood-2011-06-358614","article-title":"S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release","volume":"119","author":"Golan","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0020","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/SHK.0000000000001506","article-title":"Modulation of the HGF\/c-Met axis impacts prolonged hematopoietic progenitor mobilization following trauma and chronic stress","volume":"54","author":"Loftus","year":"2020","journal-title":"Shock"},{"key":"10.1016\/j.exphem.2025.104833_bib0021","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1182\/blood-2009-06-230359","article-title":"Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling","volume":"117","author":"Tesio","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0022","doi-asserted-by":"crossref","DOI":"10.1172\/JCI152599","article-title":"ID2 and HIF-1\u03b1 collaborate to protect quiescent hematopoietic stem cells from activation, differentiation, and exhaustion","volume":"132","author":"Jakubison","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2025.104833_bib0023","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/bjh.17230","article-title":"FANCD2 and HES1 suppress inflammation-induced PPAR\u0263 to prevent haematopoietic stem cell exhaustion","volume":"192","author":"Wu","year":"2021","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2025.104833_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.862791","article-title":"Self-sustained regulation or self-perpetuating dysregulation: ROS-dependent HIF-YAP-Notch signaling as a double-edged sword on stem cell physiology and tumorigenesis","volume":"10","author":"Guo","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.exphem.2025.104833_bib0025","doi-asserted-by":"crossref","DOI":"10.15252\/msb.202110480","article-title":"Multistability maintains redox homeostasis in human cells","volume":"17","author":"Huang","year":"2021","journal-title":"Mol Syst Biol"},{"key":"10.1016\/j.exphem.2025.104833_bib0026","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1089\/scd.2010.0093","article-title":"Human mesenchymal stem cells efficiently manage oxidative stress","volume":"19","author":"Valle-Prieto","year":"2010","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.exphem.2025.104833_bib0027","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.1073\/pnas.1120358109","article-title":"Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells","volume":"109","author":"Taniguchi Ishikawa","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2025.104833_bib0028","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.stem.2010.09.013","article-title":"Mdm2 is required for survival of hematopoietic stem cells\/progenitors via dampening of ROS-induced p53 activity","volume":"7","author":"Abbas","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2025.104833_bib0029","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/890671","article-title":"Oxidative stress and heme oxygenase-1 regulated human mesenchymal stem cells differentiation","volume":"2012","author":"Vanella","year":"2012","journal-title":"Int J Hypertens"},{"key":"10.1016\/j.exphem.2025.104833_bib0030","first-page":"158","article-title":"Inflammation, immunity, and hypertension","volume":"49","author":"Agita","year":"2017","journal-title":"Acta Med Indones"},{"key":"10.1016\/j.exphem.2025.104833_bib0031","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.4049\/jimmunol.178.8.4757","article-title":"Regulation of oxidative stress responses by ataxia-telangiectasia mutated is required for T cell proliferation","volume":"178","author":"Bagley","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2025.104833_bib0032","doi-asserted-by":"crossref","first-page":"5142","DOI":"10.4049\/jimmunol.1103538","article-title":"Arsenic trioxide prevents murine sclerodermatous graft-versus-host disease","volume":"188","author":"Kavian","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2025.104833_bib0033","series-title":"The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies","first-page":"347","article-title":"Post transplant Lymphoproliferative Syndromes","author":"Styczynski","year":"2019"},{"key":"10.1016\/j.exphem.2025.104833_bib0034","doi-asserted-by":"crossref","first-page":"30892","DOI":"10.18632\/oncotarget.8810","article-title":"Increased reactive oxygen species and exhaustion of quiescent CD34-positive bone marrow cells may contribute to poor graft function after allotransplants","volume":"7","author":"Kong","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.exphem.2025.104833_bib0035","doi-asserted-by":"crossref","first-page":"652","DOI":"10.7150\/ijms.6337","article-title":"Risk-factor analysis of poor graft function after allogeneic hematopoietic stem cell transplantation","volume":"11","author":"Xiao","year":"2014","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.exphem.2025.104833_bib0036","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s10555-022-10033-7","article-title":"Host-microbe interactions and outcomes in multiple myeloma and hematopoietic stem cell transplantation","volume":"41","author":"Pianko","year":"2022","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.exphem.2025.104833_bib0037","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.bbmt.2018.06.021","article-title":"Dysfunctional bone marrow mesenchymal stem cells in patients with poor graft function after allogeneic hematopoietic stem cell transplantation","volume":"24","author":"Song","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0038","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1182\/blood-2016-03-702803","article-title":"Atorvastatin enhances endothelial cell function in posttransplant poor graft function","volume":"128","author":"Shi","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0039","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/bmt.2015.229","article-title":"The bone marrow microenvironment is similarly impaired in allogeneic hematopoietic stem cell transplantation patients with early and late poor graft function","volume":"51","author":"Kong","year":"2016","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0040","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1182\/bloodadvances.2018029454","article-title":"Prophylactic oral NAC reduced poor hematopoietic reconstitution by improving endothelial cells after haploidentical transplantation","volume":"3","author":"Kong","year":"2019","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2025.104833_bib0041","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1182\/blood.V65.2.368.368","article-title":"Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes","volume":"65","author":"First","year":"1985","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0042","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s12185-021-03272-x","article-title":"Autoimmunemediated thrombocytopenia after allogeneic hematopoietic stem cell transplantation: significance of detecting reticulated platelets and glycoproteinspecific platelet autoantibodies","volume":"115","author":"Akuta","year":"2022","journal-title":"Int J Hematol"},{"issue":"5","key":"10.1016\/j.exphem.2025.104833_bib0043","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.3390\/jcm11051364","article-title":"Thrombocytopenia and therapeutic strategies after allogeneic hematopoietic stem cell transplantation","volume":"11","author":"Bento","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0044","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00277-007-0321-7","article-title":"The oxidative status of blood cells in a murine model of graft-versus-host disease","volume":"86","author":"Amer","year":"2007","journal-title":"Ann Hematol"},{"key":"10.1016\/j.exphem.2025.104833_bib0045","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1182\/blood.2019003990","article-title":"The gut microbial metabolite trimethylamine Noxide aggravates GVHD by inducing M1 macrophage polarization in mice","volume":"136","author":"Wu","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0046","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.4049\/jimmunol.1402609","article-title":"The free radical scavenger NecroX7 attenuates acute graftversushost disease via reciprocal regulation of Th1\/regulatory T cells and inhibition of HMGB1 release","volume":"194","author":"Im","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2025.104833_bib0047","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2011170118","article-title":"IDO1 scavenges reactive oxygen species in myeloidderived suppressor cells to prevent graftversushost disease","volume":"118","author":"Ju","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2025.104833_bib0048","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/bjh.15456","article-title":"Impairment of bone marrow endothelial progenitor cells in acute graft-versus-host disease patients after allotransplant","volume":"182","author":"Cao","year":"2018","journal-title":"Br J Haematol"},{"key":"10.1016\/j.exphem.2025.104833_bib0049","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1182\/blood-2014-01-547612","article-title":"CD8predominant Tcell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis","volume":"123","author":"Kaliyaperumal","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0050","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1182\/blood.2021011671","article-title":"Donor bone marrow-derived macrophage MHC II drives neuroinflammation and altered behavior during chronic GVHD in mice","volume":"139","author":"Adams","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0051","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1182\/blood-2008-07-167098","article-title":"A biomarker panel for acute graftversushost disease","volume":"113","author":"Paczesny","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0052","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1097\/00007890-200110270-00004","article-title":"Regulation of glutathione redox status in lung and liver by conditioning regimens and keratinocyte growth factor in murine allogeneic bone marrow transplantation","volume":"72","author":"Ziegler","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.exphem.2025.104833_bib0053","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1186\/s13287-021-02407-5","article-title":"hPMSCs inhibit the expression of PD1 in CD4\u207aIL10\u207a T cells and mitigate liver damage in a GVHD mouse model by regulating the crosstalk between Nrf2 and NF\u03baB signaling pathway","volume":"12","author":"Zhang","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.exphem.2025.104833_bib0054","article-title":"Human placenta derived mesenchymal stromal cells alleviate GVHD by promoting the generation of GSH and GST in PD1\u207a T cells","volume":"352","author":"Wang","year":"2020","journal-title":"Cell Immunol"},{"key":"10.1016\/j.exphem.2025.104833_bib0055","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1172\/JCI122899","article-title":"Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease","volume":"129","author":"Sofi","year":"2019","journal-title":"J Clin Invest"},{"issue":"60","key":"10.1016\/j.exphem.2025.104833_bib0056","first-page":"3678","article-title":"Investigating intestinal inflammation in DSS-induced model of IBD","author":"Kim","year":"2012","journal-title":"J Vis Exp"},{"key":"10.1016\/j.exphem.2025.104833_bib0057","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.917739","article-title":"A Fenton-like cation can improve arsenic trioxide treatment of sclerodermatous chronic Graft-versus-Host Disease in mice","volume":"13","author":"Ch\u00eane","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.exphem.2025.104833_bib0058","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.2741\/4869","article-title":"Role of reactive oxygen species and iron in host defense against infection","volume":"25","author":"Dickson","year":"2020","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1016\/j.exphem.2025.104833_bib0059","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/QAI.0000000000002121","article-title":"Some aspects of CD8+ T-cell exhaustion are associated with altered T-cell mitochondrial features and ROS content in HIV infection","volume":"82","author":"Deguit","year":"2019","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.exphem.2025.104833_bib0060","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.3390\/nu12061879","article-title":"Patients undergoing myeloablative chemotherapy and hematopoietic stem cell transplantation exhibit depleted vitamin C status in association with febrile neutropenia","volume":"12","author":"Carr","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.exphem.2025.104833_bib0061","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.3390\/cancers14081932","article-title":"Febrile neutropenia duration is associated with the severity of gut microbiota dysbiosis in pediatric allogeneic hematopoietic stem cell transplantation recipients","volume":"14","author":"Masetti","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.exphem.2025.104833_bib0062","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.bbmt.2005.06.001","article-title":"Blood and Marrow Transplant Clinical Trials Network Toxicity Committee consensus summary: thrombotic microangiopathy after hematopoietic stem cell transplantation","volume":"11","author":"Ho","year":"2005","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0063","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1182\/blood-2011-02-321315","article-title":"Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy","volume":"118","author":"Laskin","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0064","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.bbmt.2019.03.002","article-title":"Circulating heme oxygenase-1 and complement activation in transplant-associated thrombotic microangiopathy","volume":"25","author":"Pan","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0065","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S1053-2498(01)00282-0","article-title":"Iron overload and nitric oxide-derived oxidative stress following lung transplantation","volume":"20","author":"Reid","year":"2001","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2021.110647","article-title":"Radiation exposure and mitochondrial insufficiency in chronic fatigue and immune dysfunction syndrome","volume":"154","author":"Rusin","year":"2021","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.exphem.2025.104833_bib0067","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1517\/14728222.2013.818657","article-title":"The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets?","volume":"17","author":"Meeus","year":"2013","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.exphem.2025.104833_bib0068","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.bbmt.2008.04.009","article-title":"High prevalence of iron overload in adult allogeneic hematopoietic cell transplant survivors","volume":"14","author":"Majhail","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0069","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4274\/tjh.2016.0450","article-title":"Current review of iron overload and related complications in hematopoietic stem cell transplantation","volume":"34","author":"Atilla","year":"2017","journal-title":"Turk J Haematol"},{"key":"10.1016\/j.exphem.2025.104833_bib0070","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/bmt.2009.349","article-title":"Hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation: incidence, risk factors, and outcome","volume":"45","author":"Lee","year":"2010","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0071","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/bmt.2008.262","article-title":"Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantation","volume":"42","author":"Pullarkat","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0072","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/j.transproceed.2009.11.049","article-title":"Iron overload: predictor of adverse outcome in hematopoietic stem cell transplantation","volume":"42","author":"Sucak","year":"2010","journal-title":"Transplant Proc"},{"key":"10.1016\/j.exphem.2025.104833_bib0073","article-title":"Effect of pre-transplantation serum ferritin on outcomes in patients undergoing allogeneic hematopoietic stem cell transplantation: a meta-analysis","volume":"97","author":"Yan","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.exphem.2025.104833_bib0074","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1182\/blood-2011-08-373621","article-title":"An acute negative bystander effect of \u03b3-irradiated recipients on transplanted hematopoietic stem cells","volume":"119","author":"Shen","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0075","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.4049\/jimmunol.1400762","article-title":"Microbiota-derived compounds drive steady-state granulopoiesis via MyD88\/TICAM signaling","volume":"193","author":"Balmer","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2025.104833_bib0076","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1182\/blood-2016-06-723742","article-title":"Sensing of the microbiota by NOD1 in mesenchymal stromal cells regulates murine hematopoiesis","volume":"129","author":"Iwamura","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0077","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.chom.2014.02.006","article-title":"Gut microbiota promote hematopoiesis to control bacterial infection","volume":"15","author":"Khosravi","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.exphem.2025.104833_bib0078","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/cimm.1996.0261","article-title":"Level of myelopoiesis in the bone marrow is influenced by intestinal flora","volume":"173","author":"Tada","year":"1996","journal-title":"Cell Immunol"},{"issue":"6","key":"10.1016\/j.exphem.2025.104833_bib0079","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1182\/blood-2016-03-708594","article-title":"Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota","volume":"129","author":"Josefsdottir","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0080","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nm.3542","article-title":"The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice","volume":"20","author":"Deshmukh","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0081","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cell.2016.02.011","article-title":"Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk","volume":"165","author":"Zhu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2025.104833_bib0082","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.thromres.2020.03.012","article-title":"Intestinal microbiota dysbiosis play a role in pathogenesis of patients with primary immune thrombocytopenia","volume":"190","author":"Liu","year":"2020","journal-title":"Thromb Res"},{"key":"10.1016\/j.exphem.2025.104833_bib0083","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1007\/s11427-020-1788-2","article-title":"Gut microbiome alterations and its link to corticosteroid resistance in immune thrombocytopenia","volume":"64","author":"Wang","year":"2021","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.exphem.2025.104833_bib0084","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.3389\/fmicb.2020.01550","article-title":"Gut microbiome and metabolome were altered and strongly associated with platelet count in adult patients with primary immune thrombocytopenia","volume":"11","author":"Zhang","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.exphem.2025.104833_bib0085","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1182\/blood-2007-05-092130","article-title":"Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing","volume":"110","author":"Komanduri","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0086","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41586-020-2971-8","article-title":"The gut microbiota is associated with immune cell dynamics in humans","volume":"588","author":"Schluter","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2025.104833_bib0087","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4049\/jimmunol.1601100","article-title":"Immune reconstitution after allogeneic hematopoietic stem cell transplantation: time to T up the thymus","volume":"198","author":"Chaudhry","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2025.104833_bib0088","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.988121","article-title":"The contribution of the intestinal microbiome to immune recovery after HCT","volume":"13","author":"Wolfe","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.exphem.2025.104833_bib0089","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.molmed.2017.03.006","article-title":"Microbial Tuning of the Mammalian Immune System","volume":"23","author":"Pamer","year":"2017","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0090","doi-asserted-by":"crossref","first-page":"12204","DOI":"10.1073\/pnas.0909122107","article-title":"Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota","volume":"107","author":"Round","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2025.104833_bib0091","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.immuni.2009.08.020","article-title":"The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses","volume":"31","author":"Gaboriau-Routhiau","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.exphem.2025.104833_bib0092","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cmet.2017.05.008","article-title":"Understanding the holobiont: how microbial metabolites affect human health and shape the immune system","volume":"26","author":"Postler","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.exphem.2025.104833_bib0093","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.clim.2016.08.008","article-title":"An altered gut microbiota may trigger autoimmune-mediated acquired bone marrow failure syndromes","volume":"171","author":"Espinoza","year":"2016","journal-title":"Clin Immunol"},{"key":"10.1016\/j.exphem.2025.104833_bib0094","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1080\/21505594.2016.1208866","article-title":"Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection","volume":"7","author":"Mehta","year":"2016","journal-title":"Virulence"},{"key":"10.1016\/j.exphem.2025.104833_bib0095","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1182\/bloodadvances.2021005584","article-title":"Antithymocyte globulin exposure in CD34+ T-cell-depleted allogeneic hematopoietic cell transplantation","volume":"6","author":"Lakkaraja","year":"2022","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2025.104833_bib0096","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.bbmt.2018.02.009","article-title":"The microbiome and hematopoietic cell transplantation: past, present, and future","volume":"24","author":"Andermann","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0097","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrc.2018.10","article-title":"Gut microbiota injury in allogeneic haematopoietic stem cell transplantation","volume":"18","author":"Shono","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.exphem.2025.104833_bib0098","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2018.05.008","article-title":"Transient osmotic perturbation causes long-term alteration to the gut microbiota","volume":"173","author":"Tropini","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2025.104833_bib0099","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature18847","article-title":"The microbiome and innate immunity","volume":"535","author":"Thaiss","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2025.104833_bib0100","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.bbmt.2012.10.030","article-title":"Changing epidemiology of Clostridium difficile-associated disease during stem cell transplantation","volume":"19","author":"Trifilio","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0101","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.semcdb.2018.02.001","article-title":"GI pros: antimicrobial defense in the gastrointestinal tract","volume":"88","author":"Chung","year":"2019","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.exphem.2025.104833_bib0102","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-immunol-070119-115104","article-title":"Interaction between the microbiota, epithelia, and immune cells in the intestine","volume":"38","author":"Kayama","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.exphem.2025.104833_bib0103","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1126\/science.1223490","article-title":"Interactions between the microbiota and the immune system","volume":"336","author":"Hooper","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.exphem.2025.104833_bib0104","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature18848","article-title":"The microbiota in adaptive immune homeostasis and disease","volume":"535","author":"Honda","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2025.104833_bib0105","doi-asserted-by":"crossref","first-page":"11","DOI":"10.12703\/P6-11","article-title":"The mucosal microbiome in shaping health and disease","volume":"6","author":"Pfefferle","year":"2014","journal-title":"F1000Prime Rep"},{"key":"10.1016\/j.exphem.2025.104833_bib0106","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1038\/s41467-018-05901-2","article-title":"Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis","volume":"9","author":"Sun","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.exphem.2025.104833_bib0107","doi-asserted-by":"crossref","first-page":"19376","DOI":"10.1073\/pnas.2000047117","article-title":"Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor","volume":"117","author":"Scott","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2025.104833_bib0108","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1038\/s41591-018-0202-8","article-title":"Precision identification of diverse bloodstream pathogens in the gut microbiome","volume":"24","author":"Tamburini","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0109","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/cid\/cis580","article-title":"Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation","volume":"55","author":"Taur","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.exphem.2025.104833_bib0110","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1136\/gutjnl-2017-313952","article-title":"Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome","volume":"67","author":"Zuo","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.exphem.2025.104833_bib0111","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/advances\/nmx009","article-title":"Butyrate: a double-edged sword for health?","volume":"9","author":"Liu","year":"2018","journal-title":"Adv Nutr"},{"key":"10.1016\/j.exphem.2025.104833_bib0112","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nm.4102","article-title":"CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands","volume":"22","author":"Lamas","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0113","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nature13828","article-title":"Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile","volume":"517","author":"Buffie","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2025.104833_bib0114","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.10.047","article-title":"Commensal Microbiota Modulation of Natural Resistance to Virus Infection","volume":"183","author":"Stefan","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2025.104833_bib0115","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/nm.4380","article-title":"The eukaryotic gut virome in hematopoietic stem cell transplantation: new clues in enteric graft-versus-host disease","volume":"23","author":"Legoff","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0116","first-page":"2978","article-title":"Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT","volume":"131","author":"Haak","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0117","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1182\/blood.V95.9.2754.009k25_2754_2759","article-title":"The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation","volume":"95","author":"Hill","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0118","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1182\/bloodadvances.2020002677","article-title":"Associations of the gut microbiome and clinical factors with acute GVHD in allogeneic HSCT recipients","volume":"4","author":"Ilett","year":"2020","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2025.104833_bib0119","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.bbmt.2015.04.016","article-title":"Intestinal Blautia is associated with reduced death from graft-versus-host disease","volume":"21","author":"Jenq","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0120","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1182\/blood.2019003369","article-title":"The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD","volume":"136","author":"Markey","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0121","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.aax3760","article-title":"Lactose drives Enterococcus expansion to promote graft-versus-host disease","volume":"366","author":"Stein-Thoeringer","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.exphem.2025.104833_bib0122","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/cid\/ciab500","article-title":"Prolonged suppression of butyrate-producing bacteria is associated with acute gastrointestinal graft-versus-host disease and transplantation-related mortality after allogeneic stem cell transplantation","volume":"74","author":"Meedt","year":"2022","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.exphem.2025.104833_bib0123","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.bbmt.2014.01.030","article-title":"Metagenomic analysis of the stool microbiome in patients receiving allogeneic stem cell transplantation: loss of diversity is associated with use of systemic antibiotics and more pronounced in gastrointestinal graft-versus-host disease","volume":"20","author":"Holler","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0124","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.bbmt.2015.10.009","article-title":"Fluticasone, azithromycin, and montelukast treatment for new-onset bronchiolitis obliterans syndrome after hematopoietic cell transplantation","volume":"22","author":"Williams","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0125","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.healun.2018.04.007","article-title":"Bronchiolitis obliterans syndrome susceptibility and the pulmonary microbiome","volume":"37","author":"Schott","year":"2018","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0126","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000013951","article-title":"Association between chronic bacterial airway infection and prognosis of bronchiolitis obliterans syndrome after hematopoietic cell transplantation","volume":"98","author":"Yomota","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.exphem.2025.104833_bib0127","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-15375-4","article-title":"Exposure to bile and gastric juice can impact the aerodigestive microbiome in people with cystic fibrosis","volume":"12","author":"Al-Momani","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.exphem.2025.104833_bib0128","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2015.02.049","article-title":"Associations between gut microbial colonization in early life and respiratory outcomes in cystic fibrosis","volume":"167","author":"Hoen","year":"2015","journal-title":"J Pediatr"},{"key":"10.1016\/j.exphem.2025.104833_bib0129","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1164\/rccm.201207-1228OC","article-title":"Interaction between Pseudomonas and CXC chemokines increases risk of bronchiolitis obliterans syndrome and death in lung transplantation","volume":"187","author":"Gregson","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0130","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1021\/pr900099x","article-title":"Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity","volume":"8","author":"Martin","year":"2009","journal-title":"J Proteome Res"},{"key":"10.1016\/j.exphem.2025.104833_bib0131","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00558-21","article-title":"Nitric oxide impacts human gut microbiota diversity and functionalities","volume":"6","author":"Leclerc","year":"2021","journal-title":"mSystems"},{"key":"10.1016\/j.exphem.2025.104833_bib0132","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.3390\/ijms21041542","article-title":"Acetate and butyrate improve \u03b2-cell metabolism and mitochondrial respiration under oxidative stress","volume":"21","author":"Hu","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.exphem.2025.104833_bib0133","first-page":"549","article-title":"Bile acids, oxidative stress, and renal function in biliary obstruction","volume":"17","author":"Bomzon","year":"1997","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.exphem.2025.104833_bib0134","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1136\/gutjnl-2019-319766","article-title":"Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents","volume":"69","author":"Wang","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.exphem.2025.104833_bib0135","doi-asserted-by":"crossref","first-page":"13580","DOI":"10.1073\/pnas.0804437105","article-title":"Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome","volume":"105","author":"Jones","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2025.104833_bib0136","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","article-title":"Bile salt biotransformations by human intestinal bacteria","volume":"47","author":"Ridlon","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1016\/j.exphem.2025.104833_bib0137","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1128\/aem.33.1.15-18.1977","article-title":"Deconjugation of bile acids by intestinal lactobacilli","volume":"33","author":"Gilliland","year":"1977","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.exphem.2025.104833_bib0138","doi-asserted-by":"crossref","first-page":"G125","DOI":"10.1152\/ajpgi.00261.2020","article-title":"Production of hydrogen sulfide by the intestinal microbiota and epithelial cells and consequences for the colonic and rectal mucosa","volume":"320","author":"Blachier","year":"2021","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.exphem.2025.104833_bib0139","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.niox.2014.06.003","article-title":"Working with \u201cH2S\u201d: facts and apparent artifacts","volume":"41","author":"Wedmann","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.exphem.2025.104833_bib0140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbagen.2005.06.002","article-title":"Adaptative metabolic response of human colonic epithelial cells to the adverse effects of the luminal compound sulfide","volume":"1725","author":"Leschelle","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.exphem.2025.104833_bib0141","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/BJ20111389","article-title":"Biochemical insight into physiological effects of H\u2082S: reaction with peroxynitrite and formation of a new nitric oxide donor, sulfinyl nitrite","volume":"441","author":"Filipovic","year":"2012","journal-title":"Biochem J"},{"key":"10.1016\/j.exphem.2025.104833_bib0142","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1515\/hsz-2019-0368","article-title":"Dr. NO and Mr. Toxic \u2013 the versatile role of nitric oxide","volume":"401","author":"Porrini","year":"2020","journal-title":"Biol Chem"},{"key":"10.1016\/j.exphem.2025.104833_bib0143","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003874","article-title":"NsrR, GadE, and GadX interplay in repressing expression of the Escherichia coli O157:H7 LEE pathogenicity island in response to nitric oxide","volume":"10","author":"Branchu","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.exphem.2025.104833_bib0144","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000451","article-title":"The base excision repair system of Salmonella enterica serovar Typhimurium counteracts DNA damage by host nitric oxide","volume":"5","author":"Richardson","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.exphem.2025.104833_bib0145","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4077\/CJP.2011.AMK011","article-title":"Effects of L-arginine and NG-nitro L-arginine methyl ester (L-NAME) on ischemia\/reperfusion injury of skeletal muscle, small and large intestines","volume":"54","author":"Krauss","year":"2011","journal-title":"Chin J Physiol"},{"key":"10.1016\/j.exphem.2025.104833_bib0146","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbrc.2009.04.091","article-title":"Peroxynitrite-induced p38 MAPK pro-apoptotic signaling in enterocytes","volume":"384","author":"Guner","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.exphem.2025.104833_bib0147","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jpedsurg.2005.11.003","article-title":"Mechanism of nitric oxide-mediated intestinal barrier failure: insight into the pathogenesis of necrotizing enterocolitis","volume":"41","author":"Ford","year":"2006","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.exphem.2025.104833_bib0148","doi-asserted-by":"crossref","first-page":"e312","DOI":"10.1371\/journal.pone.0000312","article-title":"LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity","volume":"2","author":"Tester","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.exphem.2025.104833_bib0149","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.immuni.2012.10.020","article-title":"Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling","volume":"38","author":"Sena","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.exphem.2025.104833_bib0150","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nm.3517","article-title":"Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage","volume":"20","author":"Schwab","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0151","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.763507","article-title":"The gut microbiome and metabolites are altered and interrelated in patients with rheumatoid arthritis","volume":"11","author":"Yu","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.exphem.2025.104833_bib0152","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn3071","article-title":"Gut feelings: the emerging biology of gut-brain communication","volume":"12","author":"Mayer","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.exphem.2025.104833_bib0153","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1097\/PSY.0000000000000512","article-title":"The microbiome in posttraumatic stress disorder and trauma-exposed controls: an exploratory study","volume":"79","author":"Hemmings","year":"2017","journal-title":"Psychosom Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0154","first-page":"621","article-title":"Increased d-lactic acid intestinal bacteria in patients with chronic fatigue syndrome","volume":"23","author":"Sheedy","year":"2009","journal-title":"In Vivo."},{"key":"10.1016\/j.exphem.2025.104833_bib0155","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006055","article-title":"Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in mammalian cells","volume":"5","author":"Kalghatgi","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0156","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ccm.2017.07.002","article-title":"Noninfectious acute lung injury syndromes early after hematopoietic stem cell transplantation","volume":"38","author":"Ahya","year":"2017","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0157","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107272","article-title":"Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4\/NF-\u03baB signaling pathway","volume":"91","author":"Tang","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.exphem.2025.104833_bib0158","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1182\/blood.2021014134","article-title":"The gut-bone marrow axis: a novel player in HSC aging","volume":"139","author":"Matteini","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0159","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1182\/blood.2021011570","article-title":"IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice","volume":"139","author":"Kovtonyuk","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.908174","article-title":"Microbiota-derived propionate modulates megakaryopoiesis and platelet function","volume":"13","author":"D\u00fcrholz","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.exphem.2025.104833_bib0161","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2021.12.009","article-title":"The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow","volume":"29","author":"Zhang","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2025.104833_bib0162","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.cmet.2015.08.020","article-title":"Microbiota from obese mice regulate hematopoietic stem cell differentiation by altering the bone niche","volume":"22","author":"Luo","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.exphem.2025.104833_bib0163","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/s12276-021-00667-y","article-title":"Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells","volume":"53","author":"Lee","year":"2021","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0164","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1182\/blood-2008-04-153544","article-title":"Blood-borne human plasma cells in steady state are derived from mucosal immune responses","volume":"113","author":"Mei","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0165","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.immuni.2016.02.006","article-title":"Gut microbiota-induced immunoglobulin G controls systemic infection by symbiotic bacteria and pathogens","volume":"44","author":"Zeng","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.exphem.2025.104833_bib0166","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1128\/IAI.68.5.2566-2572.2000","article-title":"Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein are released by Escherichia coli bacteria into serum","volume":"68","author":"Hellman","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.exphem.2025.104833_bib0167","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1086\/315302","article-title":"Release of gram-negative outer-membrane proteins into human serum and septic rat blood and their interactions with immunoglobulin in antiserum to Escherichia coli J5","volume":"181","author":"Hellman","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.exphem.2025.104833_bib0168","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw0720","article-title":"Intestinal goblet cells protect against GVHD after allogeneic stem cell transplantation via Lypd8","volume":"12","author":"Ara","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0169","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1182\/blood.2020005957","article-title":"Glucagon-like peptide 2 for intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans","volume":"136","author":"Norona","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0170","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.136841","article-title":"A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD","volume":"6","author":"Sofi","year":"2021","journal-title":"JCI Insight"},{"issue":"7","key":"10.1016\/j.exphem.2025.104833_bib0171","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.154344","article-title":"Microbiota dynamics in a randomized trial of gut decontamination during allogeneic hematopoietic cell transplantation","volume":"7","author":"Severyn","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.exphem.2025.104833_bib0172","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.13361","article-title":"The association between the incidence of intestinal graft-vs-host disease and antibiotic use after allogeneic hematopoietic stem cell transplantation","volume":"32","author":"Hidaka","year":"2018","journal-title":"Clin Transplant"},{"key":"10.1016\/j.exphem.2025.104833_bib0173","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1164\/rccm.201712-2456OC","article-title":"Lung dysbiosis, inflammation, and injury in hematopoietic cell transplantation","volume":"198","author":"O\u2019Dwyer","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.exphem.2025.104833_bib0174","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1097\/01.tp.0000286040.85007.89","article-title":"Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide","volume":"84","author":"Garantziotis","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.exphem.2025.104833_bib0175","first-page":"2978","article-title":"Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT","volume":"131","author":"Haak","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0176","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2991\/chi.d.190316.002","article-title":"Fecal microbiota transplantation for treatment of acute graft-versus-host disease","volume":"1","author":"Shouval","year":"2019","journal-title":"Clin Hematol Int"},{"key":"10.1016\/j.exphem.2025.104833_bib0177","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1182\/blood-2016-05-717652","article-title":"Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut","volume":"128","author":"Kakihana","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2025.104833_bib0178","doi-asserted-by":"crossref","first-page":"eaaz8926","DOI":"10.1126\/scitranslmed.aaz8926","article-title":"Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients","volume":"12","author":"van Lier","year":"2020","journal-title":"Sci Transl Med"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X25001249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X25001249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:18:01Z","timestamp":1783437481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X25001249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":178,"alternative-id":["S0301472X25001249"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2025.104833","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new anchor point for gut microbiome to regulate complications of allogeneic hematopoietic stem cell transplantation: oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2025.104833","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society for Experimental Hematology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104833"}}