{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T17:05:23Z","timestamp":1779555923283,"version":"3.53.1"},"reference-count":224,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,4,3]],"date-time":"2027-04-03T00:00:00Z","timestamp":1806710400000},"content-version":"am","delay-in-days":306,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["R01DK50107"],"award-info":[{"award-number":["R01DK50107"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["R01DK68634"],"award-info":[{"award-number":["R01DK68634"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01CA257666"],"award-info":[{"award-number":["U01CA257666"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.exphem.2026.105405","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:00:35Z","timestamp":1773334835000},"page":"105405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Genetic variation and inflammation intersections: GATA2- and RUNX1-linked mechanisms of blood pathogenesis"],"prefix":"10.1016","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5320-3280","authenticated-orcid":false,"given":"Vu L.","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0236-7482","authenticated-orcid":false,"given":"Kirby D.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-5654","authenticated-orcid":false,"given":"Emery H.","family":"Bresnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2026.105405_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/SQB.1989.054.01.003","article-title":"Approaching the asymptote? Evolution and revolution in immunology","volume":"54","author":"Janeway","year":"1989","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"10.1016\/j.exphem.2026.105405_bib0002","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1126\/science.abi5200","article-title":"The spectrum of inflammatory responses","volume":"374","author":"Medzhitov","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.exphem.2026.105405_bib0003","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0092-8674(00)80172-5","article-title":"The dorsoventral regulatory gene cassette spatzle\/Toll\/cactus controls the potent antifungal response in Drosophila adults","volume":"86","author":"Lemaitre","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0004","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105405_bib0005","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.exphem.2026.105405_bib0006","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1084\/jem.189.4.615","article-title":"Endotoxin-tolerant mice have mutations in toll-like receptor 4 (Tlr4)","volume":"189","author":"Qureshi","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2026.105405_bib0007","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product","volume":"162","author":"Hoshino","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2026.105405_bib0008","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0092-8674(86)90346-6","article-title":"Multiple nuclear factors interact with the immunoglobulin enhancer sequences","volume":"46","author":"Sen","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0009","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/0092-8674(87)90612-X","article-title":"Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements","volume":"49","author":"Lee","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0010","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1126\/science.1496401","article-title":"Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor","volume":"257","author":"Schindler","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.exphem.2026.105405_bib0011","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1126\/science.1281555","article-title":"Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein","volume":"258","author":"Shuai","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.exphem.2026.105405_bib0012","doi-asserted-by":"crossref","first-page":"7840","DOI":"10.1073\/pnas.89.16.7840","article-title":"The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction","volume":"89","author":"Fu","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2026.105405_bib0013","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/366583a0","article-title":"Interferon-induced nuclear signalling by Jak protein tyrosine kinases","volume":"366","author":"Silvennoinen","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105405_bib0014","first-page":"3951","article-title":"The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds","volume":"13","author":"Kanno","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.exphem.2026.105405_bib0015","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-immunol-030409-101311","article-title":"The sterile inflammatory response","volume":"28","author":"Rock","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.exphem.2026.105405_bib0016","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.exphem.2026.105405_bib0017","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-pathmechdis-012419-032847","article-title":"DAMPs, PAMPs, and LAMPs in immunity and sterile inflammation","volume":"15","author":"Zindel","year":"2020","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.exphem.2026.105405_bib0018","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12070-011-0286-7","article-title":"Histopathological study of lesions of nose and paranasal sinuses","volume":"64","author":"Kulkarni","year":"2012","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.exphem.2026.105405_bib0019","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/nature03546","article-title":"A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera","volume":"434","author":"James","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105405_bib0020","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(05)71142-9","article-title":"Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders","volume":"365","author":"Baxter","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.exphem.2026.105405_bib0021","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1056\/NEJMoa051113","article-title":"A gain-of-function mutation of JAK2 in myeloproliferative disorders","volume":"352","author":"Kralovics","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2026.105405_bib0022","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ccr.2005.03.023","article-title":"Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis","volume":"7","author":"Levine","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0023","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nsmb.2348","article-title":"Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F","volume":"19","author":"Bandaranayake","year":"2012","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.exphem.2026.105405_bib0024","doi-asserted-by":"crossref","DOI":"10.1172\/JCI152673","article-title":"Bone marrow-confined IL-6 signaling mediates the progression of myelodysplastic syndromes to acute myeloid leukemia","volume":"132","author":"Mei","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2026.105405_bib0025","doi-asserted-by":"crossref","first-page":"eaax5104","DOI":"10.1126\/scitranslmed.aax5104","article-title":"IL-6 blockade reverses bone marrow failure induced by human acute myeloid leukemia","volume":"12","author":"Zhang","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.exphem.2026.105405_bib0026","doi-asserted-by":"crossref","DOI":"10.1172\/JCI184285","article-title":"Mutant p53 promotes clonal hematopoiesis by generating a chronic inflammatory microenvironment","volume":"136","author":"Chen","year":"2026","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2026.105405_bib0027","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.immuni.2006.04.008","article-title":"Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment","volume":"24","author":"Nagai","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.exphem.2026.105405_bib0028","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nature07815","article-title":"IFNalpha activates dormant haematopoietic stem cells in vivo","volume":"458","author":"Essers","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105405_bib0029","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nature09135","article-title":"Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection","volume":"465","author":"Baldridge","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105405_bib0030","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1101\/gad.253302.114","article-title":"Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production","volume":"28","author":"Li","year":"2014","journal-title":"Genes Dev"},{"key":"10.1016\/j.exphem.2026.105405_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2020.08.001","article-title":"Single-cell analysis of neonatal HSC Ontogeny Reveals gradual and uncoordinated transcriptional reprogramming that begins before birth","volume":"27","author":"Li","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0032","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.exphem.2021.07.004","article-title":"Transcriptional reprogramming in neonatal hematopoietic stem and progenitor cells","volume":"101\u2013102","author":"Li","year":"2021","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2026.105405_bib0033","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.exphem.2023.08.008","article-title":"Chronic inflammation can transform the fate of normal and mutant hematopoietic stem cells","volume":"127","author":"Li","year":"2023","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2026.105405_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111677","article-title":"Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity","volume":"41","author":"L\u00f3pez","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.exphem.2026.105405_bib0035","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112693","article-title":"Both maternal IFNgamma exposure and acute prenatal infection with Toxoplasma gondii activate fetal hematopoietic stem cells","volume":"42","author":"L\u00f3pez","year":"2023","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2026.105405_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114365","article-title":"Prenatal inflammation remodels lung immunity and function by programming ILC2 hyperactivation","volume":"43","author":"L\u00f3pez","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.exphem.2026.105405_bib0037","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1182\/blood-2018-06-856500","article-title":"Anemia of inflammation","volume":"133","author":"Weiss","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0038","doi-asserted-by":"crossref","DOI":"10.1242\/dev.151423","article-title":"Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond","volume":"145","author":"Bresnick","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.exphem.2026.105405_bib0039","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJMra1804281","article-title":"Anemia of inflammation","volume":"381","author":"Ganz","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2026.105405_bib0040","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nm.3814","article-title":"Anemia: progress in molecular mechanisms and therapies","volume":"21","author":"Sankaran","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.exphem.2026.105405_bib0041","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.mcna.2016.09.005","article-title":"Anemia of inflammation: a review","volume":"101","author":"Fraenkel","year":"2017","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.exphem.2026.105405_bib0042","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.hoc.2014.04.005","article-title":"Anemia of inflammation","volume":"28","author":"Nemeth","year":"2014","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.exphem.2026.105405_bib0043","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1200\/JCO.2016.71.3271","article-title":"Outcome of lower-risk patients with myelodysplastic syndromes without 5q deletion after failure of erythropoiesis-stimulating agents","volume":"35","author":"Park","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.exphem.2026.105405_bib0044","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1182\/blood-2003-03-0672","article-title":"Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation","volume":"102","author":"Ganz","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0045","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/978-3-031-92033-2_13","article-title":"Anemia of inflammation","volume":"1480","author":"Lanser","year":"2025","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.exphem.2026.105405_bib0046","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1182\/blood.V90.6.2244","article-title":"Interferon gamma downregulates stem cell factor and erythropoietin receptors but not insulin-like growth factor-I receptors in human erythroid colony-forming cells","volume":"90","author":"Taniguchi","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0047","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1182\/blood-2010-10-315218","article-title":"Chronic IFN-gamma production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1\/PU.1 axis","volume":"118","author":"Libregts","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0048","doi-asserted-by":"crossref","first-page":"eaar5551","DOI":"10.1126\/science.aar5551","article-title":"Sphingosine 1-phosphate: lipid signaling in pathology and therapy","volume":"366","author":"Cartier","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.exphem.2026.105405_bib0049","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature13475","article-title":"Sphingolipid metabolites in inflammatory disease","volume":"510","author":"Maceyka","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105405_bib0050","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.exphem.2026.105405_bib0051","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.1038\/s41467-023-42978-w","article-title":"A transcriptional network governing ceramide homeostasis establishes a cytokine-dependent developmental process","volume":"14","author":"Liao","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.exphem.2026.105405_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.exphem.2024.104252","article-title":"Endogenous small molecule effectors in GATA transcription factor mechanisms governing biological and pathological processes","volume":"137","author":"Liao","year":"2024","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2026.105405_bib0053","doi-asserted-by":"crossref","first-page":"eabk3521","DOI":"10.1126\/sciadv.abk3521","article-title":"Conditionally pathogenic genetic variants of a hematopoietic disease-suppressing enhancer","volume":"7","author":"Soukup","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0054","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1172\/JCI120854","article-title":"Transcription factor mutations as a cause of familial myeloid neoplasms","volume":"129","author":"Churpek","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2026.105405_bib0055","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"Jaiswal","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2026.105405_bib0056","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","article-title":"Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence","volume":"371","author":"Genovese","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2026.105405_bib0057","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2015-03-631747","article-title":"Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes","volume":"126","author":"Steensma","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib224","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature14131","article-title":"Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells","volume":"520","author":"Walter","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105405_bib0058","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1158\/2159-8290.CD-21-1146","article-title":"The impact of inflammation-induced tumor plasticity during myeloid transformation","volume":"12","author":"Yeaton","year":"2022","journal-title":"Cancer Discov"},{"key":"10.1016\/j.exphem.2026.105405_bib0059","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/s41588-023-01480-1","article-title":"Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution","volume":"55","author":"Rodriguez-Meira","year":"2023","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2026.105405_bib0060","doi-asserted-by":"crossref","first-page":"eadv3169","DOI":"10.1126\/sciadv.adv3169","article-title":"Dual mechanism of inflammation sensing by the hematopoietic progenitor genome","volume":"11","author":"Tran","year":"2025","journal-title":"Sci Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0061","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/371221a0","article-title":"An early haematopoietic defect in mice lacking the transcription factor GATA-2","volume":"371","author":"Tsai","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105405_bib0062","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500503","article-title":"Cis-regulatory mechanisms governing stem and progenitor cell transitions","volume":"1","author":"Johnson","year":"2015","journal-title":"Sci Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0063","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1084\/jem.20130733","article-title":"Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo","volume":"210","author":"Gao","year":"2013","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2026.105405_bib0064","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1172\/JCI61623","article-title":"Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity","volume":"122","author":"Johnson","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2026.105405_bib0065","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1182\/blood-2004-08-2989","article-title":"Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis","volume":"106","author":"Rodrigues","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0066","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1084\/jem.20130751","article-title":"Gata2 is required for HSC generation and survival","volume":"210","author":"de Pater","year":"2013","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2026.105405_bib0067","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1182\/bloodadvances.2021004726","article-title":"Gata2 haploinsufficiency promotes proliferation and functional decline of hematopoietic stem cells with myeloid bias during aging","volume":"5","author":"Abdelfattah","year":"2021","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0068","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1182\/blood-2008-01-136564","article-title":"GATA-2 regulates granulocyte-macrophage progenitor cell function","volume":"112","author":"Rodrigues","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0069","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1084\/jem.20031556","article-title":"GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells","volume":"200","author":"Ling","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2026.105405_bib0070","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1182\/blood.V89.10.3636","article-title":"Transcription factor GATA-2 is required for proliferation\/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation","volume":"89","author":"Tsai","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0071","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1182\/blood-2016-09-687871","article-title":"GATA Factor Mechanisms Group. The GATA factor revolution in hematology","volume":"129","author":"Katsumura","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0072","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1182\/blood-2013-07-515528","article-title":"GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity","volume":"123","author":"Spinner","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0073","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1182\/blood-2013-07-517151","article-title":"The evolution of cellular deficiency in GATA2 mutation","volume":"123","author":"Dickinson","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0074","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ccr.2014.02.008","article-title":"A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression","volume":"25","author":"Yamazaki","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0075","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1182\/bloodadvances.2020002993","article-title":"Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish","volume":"5","author":"Gioacchino","year":"2021","journal-title":"Blood Adv"},{"issue":"Suppp 1","key":"10.1016\/j.exphem.2026.105405_bib0076","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1182\/blood.V130.Suppl_1.7.7","article-title":"Integrating enhancer mechanisms to establish a hierarchical blood development program","volume":"130","author":"Mehta","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0077","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1172\/JCI122694","article-title":"Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer","volume":"129","author":"Soukup","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2026.105405_bib0078","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1182\/bloodadvances.2021006182","article-title":"GATA2 deficiency elevates interferon Regulatory Factor-8 to subvert a progenitor cell differentiation program","volume":"6","author":"Johnson","year":"2022","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0079","doi-asserted-by":"crossref","first-page":"7564","DOI":"10.1182\/bloodadvances.2023011003","article-title":"Gata2 noncoding genetic variation as a determinant of hematopoietic stem\/progenitor cell mobilization efficiency","volume":"7","author":"Soukup","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0080","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1182\/bloodadvances.2018017137","article-title":"GATA2 deficiency and human hematopoietic development modeled using induced pluripotent stem cells","volume":"2","author":"Jung","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0081","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1182\/bloodadvances.2022008019","article-title":"Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition","volume":"7","author":"Koyunlar","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0082","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112571","article-title":"Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency","volume":"42","author":"Mahony","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.exphem.2026.105405_bib0083","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1038\/s41375-025-02771-8","article-title":"CRISPR-engineered human GATA2 deficiency model uncovers mitotic dysfunction and premature aging in HSPCs, impairing hematopoietic fitness","volume":"39","author":"Romero-Moya","year":"2025","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2026.105405_bib0084","doi-asserted-by":"crossref","first-page":"7056","DOI":"10.1128\/MCB.01033-06","article-title":"Distinct functions of dispersed GATA factor complexes at an endogenous gene locus","volume":"26","author":"Grass","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.exphem.2026.105405_bib0085","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/MOH.0000000000000576","article-title":"GATA2 +9.5 enhancer: from principles of hematopoiesis to genetic diagnosis in precision medicine","volume":"27","author":"Soukup","year":"2020","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.exphem.2026.105405_bib0086","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191526","article-title":"Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories","volume":"217","author":"Johnson","year":"2020","journal-title":"J Exp Med"},{"key":"10.1016\/j.exphem.2026.105405_bib0087","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1182\/bloodadvances.2019000378","article-title":"Blood disease-causing and -suppressing transcriptional enhancers: general principles and GATA2 mechanisms","volume":"3","author":"Bresnick","year":"2019","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0088","doi-asserted-by":"crossref","first-page":"S3831","DOI":"10.1182\/blood-2012-08-452763","article-title":"GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome","volume":"121","author":"Hsu","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0089","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cell.2014.02.019","article-title":"A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia","volume":"157","author":"Gr\u00f6schel","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0090","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1158\/2159-8290.CD-20-1793","article-title":"Selective requirement of MYB for oncogenic hyperactivation of a translocated enhancer in leukemia","volume":"11","author":"Smeenk","year":"2021","journal-title":"Cancer Discov"},{"key":"10.1016\/j.exphem.2026.105405_bib0091","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106297","article-title":"Restricting genomic actions of innate immune mediators on fetal hematopoietic progenitor cells","volume":"26","author":"Tran","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.exphem.2026.105405_bib0092","doi-asserted-by":"crossref","DOI":"10.1172\/JCI162685","article-title":"Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks","volume":"133","author":"Jung","year":"2023","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2026.105405_bib0093","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1056\/NEJMoa1100066","article-title":"IRF8 mutations and human dendritic-cell immunodeficiency","volume":"365","author":"Hambleton","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.exphem.2026.105405_bib0094","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1182\/blood-2012-06-437863","article-title":"Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation","volume":"121","author":"Kurotaki","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0095","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41590-021-00871-y","article-title":"A RUNX-CBFbeta-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes","volume":"22","author":"Murakami","year":"2021","journal-title":"Nat Immunol"},{"key":"10.1016\/j.exphem.2026.105405_bib0096","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116344","article-title":"GATA2 decommissioning of enhancers: a mechanism to constrain inflammatory signaling","volume":"44","author":"Jung","year":"2025","journal-title":"Cell Rep"},{"key":"10.1016\/j.exphem.2026.105405_bib0097","doi-asserted-by":"crossref","DOI":"10.1172\/JCI173116","article-title":"A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice","volume":"133","author":"Rajagopalan","year":"2023","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2026.105405_bib0098","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1182\/blood-2011-07-367706","article-title":"IFNgamma induces monopoiesis and inhibits neutrophil development during inflammation","volume":"119","author":"de Bruin","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0099","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1002\/stem.1799","article-title":"Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells","volume":"32","author":"Matatall","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.exphem.2026.105405_bib0100","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1038\/leu.2009.155","article-title":"The TLR1\/2 agonist PAM3CSK4 instructs commitment of human hematopoietic stem cells to a myeloid cell fate","volume":"23","author":"De Luca","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2026.105405_bib0101","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/stem.1110","article-title":"Direct toll-like receptor-mediated stimulation of hematopoietic stem and progenitor cells occurs in vivo and promotes differentiation toward macrophages","volume":"30","author":"Meg\u00edas","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.exphem.2026.105405_bib0102","doi-asserted-by":"crossref","first-page":"13641","DOI":"10.1073\/pnas.1108440108","article-title":"Genetic framework for GATA factor function in vascular biology","volume":"108","author":"Linnemann","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2026.105405_bib0103","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1074\/jbc.274.8.4939","article-title":"C-Jun is a JNK-independent coactivator of the PU.1 transcription factor","volume":"274","author":"Behre","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2026.105405_bib0104","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/s42003-022-03888-7","article-title":"PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development","volume":"5","author":"Zhao","year":"2022","journal-title":"Commun Biol"},{"key":"10.1016\/j.exphem.2026.105405_bib0105","doi-asserted-by":"crossref","unstructured":"Ohmori S, Takai J, Uemura S, et al. The Il6 \u221239 kb enhancer containing clustered GATA2- and PU.1-binding sites is essential for Il6 expression in murine mast cells. iScience. 2022;25:104942. doi:10.1016\/j.isci.2022.104942","DOI":"10.1016\/j.isci.2022.104942"},{"key":"10.1016\/j.exphem.2026.105405_bib0106","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.1038\/s41467-025-60084-x","article-title":"A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages","volume":"16","author":"Schmerer","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.exphem.2026.105405_bib0107","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110372","article-title":"Induction of the zinc finger transcription factor GATA2 promotes kidney inflammation-related gene expression","volume":"301","author":"Takai","year":"2025","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2026.105405_bib0108","doi-asserted-by":"crossref","unstructured":"Takai J, Shimada T, Nakamura T, Engel JD, Moriguchi T. Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance. iScience. 2021;24:102836. doi:10.1016\/j.isci.2021.102836","DOI":"10.1016\/j.isci.2021.102836"},{"key":"10.1016\/j.exphem.2026.105405_bib0109","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/11926","article-title":"Klf4 is a transcription factor required for establishing the barrier function of the skin","volume":"22","author":"Segre","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2026.105405_bib0110","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.4049\/jimmunol.180.8.5645","article-title":"Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo","volume":"180","author":"Alder","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2026.105405_bib0111","doi-asserted-by":"crossref","DOI":"10.1016\/j.exphem.2025.104730","article-title":"KLF4 enhances transplantation-induced hematopoiesis by inhibiting TLRs and noncanonical NF\u03baB signaling at a steady state","volume":"144","author":"Park","year":"2025","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2026.105405_bib0112","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1073\/pnas.93.8.3444","article-title":"Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis","volume":"93","author":"Wang","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2026.105405_bib0113","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0092-8674(00)80986-1","article-title":"AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis","volume":"84","author":"Okuda","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0114","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2019655118","article-title":"Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell commitment via dynamic genomic site switching","volume":"118","author":"Shin","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2026.105405_bib0115","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/s41590-023-01585-z","article-title":"Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms","volume":"24","author":"Shin","year":"2023","journal-title":"Nat Immunol"},{"key":"10.1016\/j.exphem.2026.105405_bib0116","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/13793","article-title":"Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia","volume":"23","author":"Song","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2026.105405_bib0117","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1182\/blood.2023019746","article-title":"Natural history study of patients with familial platelet disorder with associated myeloid malignancy","volume":"142","author":"Cunningham","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0118","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF02982056","article-title":"Point mutations of the RUNx1\/AML1 gene in sporadic and familial myeloid leukemias","volume":"74","author":"Osato","year":"2001","journal-title":"Int J Hematol"},{"key":"10.1016\/j.exphem.2026.105405_bib0119","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.3324\/haematol.2021.278762","article-title":"The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy","volume":"106","author":"Homan","year":"2021","journal-title":"Haematologica"},{"key":"10.1016\/j.exphem.2026.105405_bib0120","doi-asserted-by":"crossref","DOI":"10.1182\/bloodadvances.2025017808","article-title":"Hematologic malignancies in pediatric patients with RUNX1-familial platelet disorder with associated myeloid malignancy","author":"Kajdic","year":"2026","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0121","doi-asserted-by":"crossref","first-page":"eadn9832","DOI":"10.1126\/scitranslmed.adn9832","article-title":"Targeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis in RUNX1-familial platelet disorder","volume":"17","author":"Mohammadhosseini","year":"2025","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.exphem.2026.105405_bib0122","doi-asserted-by":"crossref","DOI":"10.3324\/haematol.2024.287013","article-title":"GATA2 at 14: genotype-phenotype correlations","author":"Hsu","year":"2026","journal-title":"Haematologica"},{"key":"10.1016\/j.exphem.2026.105405_bib0123","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1182\/blood-2014-06-580340","article-title":"GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia","volume":"125","author":"Ganapathi","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0124","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1182\/bloodadvances.2020002953","article-title":"Human GATA2 mutations and hematologic disease: how many paths to pathogenesis?","volume":"4","author":"Bresnick","year":"2020","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0125","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/MOH.0000000000000763","article-title":"Interferon regulatory factor-8-dependent innate immune alarm senses GATA2 deficiency to alter hematopoietic differentiation and function","volume":"30","author":"Johnson","year":"2023","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.exphem.2026.105405_bib0126","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1182\/bloodadvances.2019000785","article-title":"Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to toll-like receptor signaling","volume":"4","author":"Bellissimo","year":"2020","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0127","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1101\/gad.350418.123","article-title":"RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils","volume":"37","author":"Zezulin","year":"2023","journal-title":"Genes Dev"},{"key":"10.1016\/j.exphem.2026.105405_bib0128","doi-asserted-by":"crossref","first-page":"7304","DOI":"10.1182\/bloodadvances.2023010398","article-title":"Runx1-R188Q germ line mutation induces inflammation and predisposition to hematologic malignancies in mice","volume":"7","author":"Ahmad","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0129","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.exphem.2018.10.009","article-title":"RUNX1 and the endothelial origin of blood","volume":"68","author":"Gao","year":"2018","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2026.105405_bib0130","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/ng.913","article-title":"Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia","volume":"43","author":"Hahn","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2026.105405_bib0131","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1182\/blood-2011-06-360313","article-title":"Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency","volume":"118","author":"Dickinson","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0132","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1182\/blood-2011-05-356352","article-title":"Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome","volume":"118","author":"Hsu","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0133","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ng.923","article-title":"Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)","volume":"43","author":"Ostergaard","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2026.105405_bib0134","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/sj.emboj.7601568","article-title":"Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles","volume":"26","author":"Matheny","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2026.105405_bib0135","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1182\/blood.V99.4.1364","article-title":"In vitro analyses of known and novel RUNX1\/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis","volume":"99","author":"Michaud","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0136","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1182\/bloodadvances.2023011165","article-title":"Genomic landscape of patients with germline RUNX1 variants and familial platelet disorder with myeloid malignancy","volume":"8","author":"Yu","year":"2024","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0137","doi-asserted-by":"crossref","DOI":"10.1172\/JCI167053","article-title":"RUNX1 loss renders hematopoietic and leukemic cells dependent on IL-3 and sensitive to JAK inhibition","volume":"133","author":"Fan","year":"2023","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2026.105405_bib0138","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.stem.2010.07.016","article-title":"Combinatorial transcriptional control in blood stem\/progenitor cells: genome-wide analysis of ten major transcriptional regulators","volume":"7","author":"Wilson","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0139","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1182\/blood.2023021120","article-title":"Genome-wide transcription factor-binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs","volume":"142","author":"Subramanian","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0140","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1073\/pnas.85.16.5976","article-title":"An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes","volume":"85","author":"Evans","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2026.105405_bib0141","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1101\/gad.2.9.1089","article-title":"The human beta-globin gene 3\u2032 enhancer contains multiple binding sites for an erythroid-specific protein","volume":"2","author":"Wall","year":"1988","journal-title":"Genes Dev"},{"key":"10.1016\/j.exphem.2026.105405_bib0142","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1073\/pnas.90.5.1676","article-title":"A small single-\u201cfinger\u201d peptide from the erythroid transcription factor GATA-1 binds specifically to DNA as a zinc or iron complex","volume":"90","author":"Omichinski","year":"1993","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.exphem.2026.105405_bib0143","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2009.11.001","article-title":"Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy","volume":"36","author":"Fujiwara","year":"2009","journal-title":"Mol Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0144","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1128\/jvi.64.2.534-542.1990","article-title":"Alignment of U3 region sequences of mammalian type C viruses: identification of highly conserved motifs and implications for enhancer design","volume":"64","author":"Golemis","year":"1990","journal-title":"J Virol"},{"key":"10.1016\/j.exphem.2026.105405_bib0145","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1128\/jvi.67.4.2408-2411.1993","article-title":"Sequence specificity of the core-binding factor","volume":"67","author":"Melnikova","year":"1993","journal-title":"J Virol"},{"key":"10.1016\/j.exphem.2026.105405_bib0146","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/86264","article-title":"The leukemia-associated AML1 (Runx1)\u2014CBF beta complex functions as a DNA-induced molecular clamp","volume":"8","author":"Bravo","year":"2001","journal-title":"Nat Struct Biol"},{"key":"10.1016\/j.exphem.2026.105405_bib0147","doi-asserted-by":"crossref","first-page":"26251","DOI":"10.1074\/jbc.271.42.26251","article-title":"Biochemical and biophysical properties of the core-binding factor alpha2 (AML1) DNA-binding domain","volume":"271","author":"Crute","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2026.105405_bib0148","doi-asserted-by":"crossref","first-page":"33097","DOI":"10.1074\/jbc.M303972200","article-title":"Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit","volume":"278","author":"Zhang","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2026.105405_bib0149","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1093\/emboj\/16.11.3145","article-title":"The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1\/NLI proteins","volume":"16","author":"Wadman","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2026.105405_bib0150","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.1128\/MCB.01061-08","article-title":"Molecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesis","volume":"28","author":"Wozniak","year":"2008","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.exphem.2026.105405_bib0151","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.molcel.2009.11.002","article-title":"Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis","volume":"36","author":"Yu","year":"2009","journal-title":"Mol Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0152","doi-asserted-by":"crossref","first-page":"14665","DOI":"10.1074\/jbc.M700792200","article-title":"Context-dependent GATA factor function: combinatorial requirements for transcriptional control in hematopoietic and endothelial cells","volume":"282","author":"Wozniak","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2026.105405_bib0153","doi-asserted-by":"crossref","first-page":"E1091","DOI":"10.1073\/pnas.1400065111","article-title":"Mechanism governing a stem cell-generating cis-regulatory element","volume":"111","author":"Sanalkumar","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2026.105405_bib0154","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.molcel.2015.05.020","article-title":"Hematopoietic signaling mechanism revealed from a stem\/progenitor cell cistrome","volume":"59","author":"Hewitt","year":"2015","journal-title":"Mol Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0155","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/bs.ctdb.2016.01.002","article-title":"The hematopoietic stem and progenitor cell cistrome: GATA factor-dependent cis-regulatory mechanisms","volume":"118","author":"Hewitt","year":"2016","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.exphem.2026.105405_bib0156","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2017.07.009","article-title":"GATA factor-regulated Samd14 enhancer confers red blood cell regeneration and survival in severe anemia","volume":"42","author":"Hewitt","year":"2017","journal-title":"Dev Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0157","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1074-7613(00)00042-X","article-title":"Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo","volume":"13","author":"Cai","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.exphem.2026.105405_bib0158","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1182\/blood-2003-12-4349","article-title":"Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors","volume":"104","author":"Sun","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0159","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/ni.1617","article-title":"The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells","volume":"9","author":"Loughran","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.exphem.2026.105405_bib0160","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1101\/gad.2009211","article-title":"ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification","volume":"25","author":"Taoudi","year":"2011","journal-title":"Genes Dev"},{"key":"10.1016\/j.exphem.2026.105405_bib0161","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1182\/blood-2013-01-477133","article-title":"Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia","volume":"122","author":"Goldberg","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0162","first-page":"2316","article-title":"Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency","volume":"108","author":"Rein","year":"2023","journal-title":"Haematologica"},{"key":"10.1016\/j.exphem.2026.105405_bib0163","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1182\/blood.2022017764","article-title":"The spectrum of GATA2 deficiency syndrome","volume":"141","author":"Calvo","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0164","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1126\/science.8079170","article-title":"Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages","volume":"265","author":"Scott","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.exphem.2026.105405_bib0165","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1002\/j.1460-2075.1996.tb00949.x","article-title":"Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities","volume":"15","author":"McKercher","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2026.105405_bib0166","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/ng1361","article-title":"Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1","volume":"36","author":"Rosenbauer","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2026.105405_bib0167","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/ng1679","article-title":"Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1","volume":"38","author":"Rosenbauer","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2026.105405_bib0168","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41586-020-2432-4","article-title":"Single-molecule imaging of transcription dynamics in somatic stem cells","volume":"583","author":"Wheat","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105405_bib0169","doi-asserted-by":"crossref","first-page":"938","DOI":"10.15252\/embr.201438808","article-title":"Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2","volume":"15","author":"Katsumura","year":"2014","journal-title":"EMBO Rep"},{"key":"10.1016\/j.exphem.2026.105405_bib0170","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1016\/j.celrep.2016.07.058","article-title":"GATA factor-dependent positive-feedback circuit in acute myeloid leukemia cells","volume":"16","author":"Katsumura","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.exphem.2026.105405_bib0171","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2024.02.004","article-title":"The transcription factor NF-\u03baB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling","volume":"57","author":"Feng","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.exphem.2026.105405_bib0172","doi-asserted-by":"crossref","first-page":"eado8860","DOI":"10.1126\/scisignal.ado8860","article-title":"IRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages","volume":"18","author":"Chavez","year":"2025","journal-title":"Sci Signal"},{"key":"10.1016\/j.exphem.2026.105405_bib0173","doi-asserted-by":"crossref","first-page":"E10109","DOI":"10.1073\/pnas.1813015115","article-title":"Human leukemia mutations corrupt but do not abrogate GATA-2 function","volume":"115","author":"Katsumura","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2026.105405_bib0174","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2317147121","article-title":"Pathogenic GATA2 genetic variants utilize an obligate enhancer mechanism to distort a multilineage differentiation program","volume":"121","author":"Katsumura","year":"2024","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2026.105405_bib0175","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41375-020-0820-2","article-title":"Breaking the spatial constraint between neighboring zinc fingers: a new germline mutation in GATA2 deficiency syndrome","volume":"35","author":"Cavalcante de Andrade Silva","year":"2021","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2026.105405_bib0176","article-title":"GATA3 differentially regulates the transcriptome via zinc finger 2-modulated phase separation","volume":"44","author":"Chen","year":"2025","journal-title":"Cell Rep"},{"key":"10.1016\/j.exphem.2026.105405_bib0177","doi-asserted-by":"crossref","first-page":"45620","DOI":"10.1074\/jbc.M306410200","article-title":"Determinants of GATA-1 binding to DNA: the role of non-finger residues","volume":"278","author":"Ghirlando","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2026.105405_bib0178","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/s42003-022-03316-w","article-title":"Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding","volume":"5","author":"Hasegawa","year":"2022","journal-title":"Commun Biol"},{"key":"10.1016\/j.exphem.2026.105405_bib0179","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41408-025-01213-z","article-title":"GATA2 mutated allele specific expression is associated with a hyporesponsive state of HSC in GATA2 deficiency syndrome","volume":"15","author":"Largeaud","year":"2025","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.exphem.2026.105405_bib0180","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41375-024-02508-z","article-title":"Modeling GATA2 deficiency in mice: the R396Q mutation disrupts normal hematopoiesis","volume":"39","author":"Hall","year":"2025","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2026.105405_bib0181","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.exphem.2022.02.002","article-title":"Specific effects of somatic GATA2 zinc finger mutations on erythroid differentiation","volume":"108","author":"Redondo Monte","year":"2022","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2026.105405_bib0182","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ccr.2008.02.008","article-title":"Modeling of C\/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells","volume":"13","author":"Kirstetter","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0183","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ccr.2009.09.036","article-title":"Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C\/EBPalpha mutant AML","volume":"16","author":"Bereshchenko","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0184","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2020.03.022","article-title":"C\/EBPalpha and GATA-2 mutations induce Bilineage acute erythroid leukemia through transformation of a neomorphic neutrophil-erythroid progenitor","volume":"37","author":"Di Genua","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0185","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1038\/s41467-023-41927-x","article-title":"TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression","volume":"14","author":"Heyes","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.exphem.2026.105405_bib0186","doi-asserted-by":"crossref","first-page":"11655","DOI":"10.1073\/pnas.91.24.11655","article-title":"The secondary structure of the ets domain of human Fli-1 resembles that of the helix-turn-helix DNA-binding motif of the Escherichia coli catabolite gene activator protein","volume":"91","author":"Liang","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2026.105405_bib0187","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1038\/emboj.2010.106","article-title":"Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo","volume":"29","author":"Wei","year":"2010","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2026.105405_bib0188","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cyto.2012.10.003","article-title":"Inflammatory intestinal damage induced by 5-fluorouracil requires IL-4","volume":"61","author":"Soares","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.exphem.2026.105405_bib0189","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbi.2019.02.020","article-title":"Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota","volume":"80","author":"Sougiannis","year":"2019","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.exphem.2026.105405_bib0190","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/ng.3253","article-title":"Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia","volume":"47","author":"Noetzli","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2026.105405_bib0191","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005262","article-title":"Germline ETV6 mutations confer susceptibility to acute lymphoblastic leukemia and thrombocytopenia","volume":"11","author":"Topka","year":"2015","journal-title":"PLOS Genet"},{"key":"10.1016\/j.exphem.2026.105405_bib0192","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng.3177","article-title":"Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy","volume":"47","author":"Zhang","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2026.105405_bib0193","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1182\/bloodadvances.2022009313","article-title":"ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in mice","volume":"7","author":"Bloom","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0194","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.celrep.2014.07.062","article-title":"Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-\u03baB gene network","volume":"8","author":"Fang","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.exphem.2026.105405_bib0195","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1038\/s41467-021-22641-y","article-title":"MicroRNA-146a limits tumorigenic inflammation in colorectal cancer","volume":"12","author":"Garo","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.exphem.2026.105405_bib0196","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109809","article-title":"Dysregulated innate immune signaling cooperates with RUNX1 mutations to transform an MDS-like disease to AML","volume":"27","author":"Barreyro","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.exphem.2026.105405_bib0197","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1093\/nar\/26.11.2536","article-title":"Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells","volume":"26","author":"Okano","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.exphem.2026.105405_bib0198","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","article-title":"DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development","volume":"99","author":"Okano","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0199","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nature09303","article-title":"Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification","volume":"466","author":"Ito","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105405_bib0200","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1126\/science.1210597","article-title":"Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine","volume":"333","author":"Ito","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.exphem.2026.105405_bib0201","doi-asserted-by":"crossref","first-page":"eaau6986","DOI":"10.1126\/sciadv.aau6986","article-title":"TET2 coactivates gene expression through demethylation of enhancers","volume":"4","author":"Wang","year":"2018","journal-title":"Sci Adv"},{"key":"10.1016\/j.exphem.2026.105405_bib0202","doi-asserted-by":"crossref","first-page":"eaau7523","DOI":"10.1126\/sciimmunol.aau7523","article-title":"TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer","volume":"4","author":"Lio","year":"2019","journal-title":"Sci Immunol"},{"key":"10.1016\/j.exphem.2026.105405_bib0203","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ccr.2014.02.010","article-title":"The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers","volume":"25","author":"Russler-Germain","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0204","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10071","article-title":"Acute loss of TET function results in aggressive myeloid cancer in mice","volume":"6","author":"An","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.exphem.2026.105405_bib0205","doi-asserted-by":"crossref","first-page":"16933","DOI":"10.1073\/pnas.1903059116","article-title":"Paradoxical association of TET loss of function with genome-wide DNA hypomethylation","volume":"116","author":"L\u00f3pez-Moyado","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2026.105405_bib0206","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/ng.1009","article-title":"Dnmt3a is essential for hematopoietic stem cell differentiation","volume":"44","author":"Challen","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2026.105405_bib0207","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1182\/blood-2014-08-594648","article-title":"Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation","volume":"125","author":"Mayle","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0208","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1182\/blood-2014-08-594564","article-title":"Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation","volume":"125","author":"Celik","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0209","doi-asserted-by":"crossref","first-page":"14566","DOI":"10.1073\/pnas.1112317108","article-title":"Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice","volume":"108","author":"Ko","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2026.105405_bib0210","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccr.2011.06.001","article-title":"Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation","volume":"20","author":"Moran-Crusio","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0211","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1182\/blood-2010-12-325241","article-title":"Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies","volume":"118","author":"Li","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105405_bib0212","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ccr.2011.06.003","article-title":"TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis","volume":"20","author":"Quivoron","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0213","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1038\/leu.2016.29","article-title":"DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice","volume":"30","author":"Scourzic","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2026.105405_bib0214","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ng.3610","article-title":"DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells","volume":"48","author":"Zhang","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2026.105405_bib0215","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature08966","article-title":"Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB","volume":"465","author":"Scheuermann","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105405_bib0216","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2413302121","article-title":"A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia","volume":"122","author":"Dong","year":"2025","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.exphem.2026.105405_bib0217","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41586-025-08938-8","article-title":"Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1","volume":"642","author":"Agarwal","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105405_bib0218","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41586-018-0433-3","article-title":"Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose","volume":"561","author":"Zhou","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105405_bib0219","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1038\/s41467-023-36906-1","article-title":"Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis","volume":"14","author":"Zioni","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.exphem.2026.105405_bib0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109122","article-title":"Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation","volume":"27","author":"Reyes","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.exphem.2026.105405_bib0221","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2018.10.013","article-title":"Inhibition of inflammatory signaling in Tet2 mutant preleukemic cells mitigates stress-induced abnormalities and clonal hematopoiesis","volume":"23","author":"Cai","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.exphem.2026.105405_bib0222","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140707","article-title":"Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine-induced lncRNA Morrbid","volume":"131","author":"Cai","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.exphem.2026.105405_bib0223","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature15252","article-title":"Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X2600038X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X2600038X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T16:43:30Z","timestamp":1779554610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X2600038X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":224,"alternative-id":["S0301472X2600038X"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2026.105405","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic variation and inflammation intersections: GATA2- and RUNX1-linked mechanisms of blood pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2026.105405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Society for Experimental Hematology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105405"}}