{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:05:13Z","timestamp":1789473913596,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015570","name":"Blood Cancer UK","doi-asserted-by":"publisher","award":["15001"],"award-info":[{"award-number":["15001"]}],"id":[{"id":"10.13039\/501100015570","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015763","name":"Leukaemia UK","doi-asserted-by":"publisher","award":["2021\/JGF\/001"],"award-info":[{"award-number":["2021\/JGF\/001"]}],"id":[{"id":"10.13039\/100015763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/S021469\/1"],"award-info":[{"award-number":["MR\/S021469\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.exphem.2026.105491","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T16:05:18Z","timestamp":1786637118000},"page":"105491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Development of receptor and oncogene-responsive luciferase reporter vectors that are activated via kinase signaling to AP-1"],"prefix":"10.1016","volume":"161","author":[{"given":"Daniel J.L.","family":"Coleman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Ames","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0417-7992","authenticated-orcid":false,"given":"Hurooul","family":"Aain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Gamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Koscielniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherisse","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4410-8174","authenticated-orcid":false,"given":"Peter N.","family":"Cockerill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2026.105491_bib0001","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1152\/physrev.00028.2011","article-title":"Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update","volume":"92","author":"Kyriakis","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1016\/j.exphem.2026.105491_bib0002","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1002\/j.1460-2075.1995.tb00173.x","article-title":"Journey to the surface of the cell: Fos regulation and the SRE","volume":"14","author":"Treisman","year":"1995","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2026.105491_bib0003","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pharmthera.2012.09.001","article-title":"Immediate early response genes and cell transformation","volume":"137","author":"Healy","year":"2013","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.exphem.2026.105491_bib0004","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1042\/BJ20110289","article-title":"Regulation and function of the RSK family of protein kinases","volume":"441","author":"Romeo","year":"2012","journal-title":"Biochem J"},{"key":"10.1016\/j.exphem.2026.105491_bib0005","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/carcin\/16.3.443","article-title":"Signal integration at the c-fos promoter","volume":"16","author":"Janknecht","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.exphem.2026.105491_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2017.04.002","article-title":"RasGRP3 mediates MAPK pathway activation in GNAQ mutant uveal melanoma","volume":"31","author":"Chen","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2026.105491_bib0007","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1042\/BST20110636","article-title":"Immediate-early gene activation by the MAPK pathways: what do and don't we know?","volume":"40","author":"O'Donnell","year":"2012","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.exphem.2026.105491_bib0008","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.642807","article-title":"Stable epigenetic programming of effector and central memory CD4 T cells occurs within 7 days of antigen exposure in vivo","volume":"12","author":"Bevington","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.exphem.2026.105491_bib0009","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.4049\/jimmunol.1602033","article-title":"Integration of kinase and calcium signaling at the level of chromatin underlies inducible gene activation in T cells","volume":"199","author":"Brignall","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2026.105491_bib0010","doi-asserted-by":"crossref","first-page":"7914","DOI":"10.1128\/MCB.24.18.7914-7930.2004","article-title":"GM-CSF enhancer activation requires cooperation between NFAT and AP-1 elements and is associated with extensive nucleosome reorganization","volume":"24","author":"Johnson","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.exphem.2026.105491_bib0011","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/32100","article-title":"Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA","volume":"392","author":"Chen","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105491_bib0012","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41588-018-0270-1","article-title":"Subtype-specific regulatory network rewiring in acute myeloid leukemia","volume":"51","author":"Assi","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.exphem.2026.105491_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109576","article-title":"Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1","volume":"27","author":"Coleman","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.exphem.2026.105491_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113568","article-title":"Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth","volume":"42","author":"Coleman","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.exphem.2026.105491_bib0015","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/plas.2000.1474","article-title":"Cockerill PN. Generation of an improved luciferase reporter gene plasmid that employs a novel mechanism for high-copy replication","volume":"44","author":"Bert","year":"2000","journal-title":"Plasmid"},{"key":"10.1016\/j.exphem.2026.105491_bib0016","doi-asserted-by":"crossref","first-page":"5646","DOI":"10.4049\/jimmunol.165.10.5646","article-title":"Cockerill PN. Reconstitution of T cell-specific transcription directed by composite NFAT\/Oct elements","volume":"165","author":"Bert","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2026.105491_bib0017","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/mt.2008.6","article-title":"A multicolor panel of novel lentiviral \"gene ontology\" (LeGO) vectors for functional gene analysis","volume":"16","author":"Weber","year":"2008","journal-title":"Mol Ther"},{"key":"10.1016\/j.exphem.2026.105491_bib0018","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.exphem.2020.10.005","article-title":"RUNX1\/ETO and mutant KIT both contribute to programming the transcriptional and chromatin landscape in t(8;21) acute myeloid leukemia","volume":"92","author":"Chin","year":"2020","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2026.105491_bib0019","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1128\/JVI.72.1.811-816.1998","article-title":"Minimal requirement for a lentivirus vector based on human immunodeficiency virus type 1","volume":"72","author":"Kim","year":"1998","journal-title":"J Virol"},{"key":"10.1016\/j.exphem.2026.105491_bib0020","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.ymthe.2005.01.005","article-title":"Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation","volume":"11","author":"Mostoslavsky","year":"2005","journal-title":"Mol Ther"},{"key":"10.1016\/j.exphem.2026.105491_bib0021","doi-asserted-by":"crossref","first-page":"8339","DOI":"10.1016\/S0021-9258(18)83187-8","article-title":"Transcriptional regulation of human stromelysin","volume":"264","author":"Quinones","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1016\/j.exphem.2026.105491_bib0022","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1073\/pnas.90.6.2466","article-title":"The GM-CSF\/IL-3 locus is regulated by an inducible cyclosporin A-sensitive enhancer","volume":"90","author":"Cockerill","year":"1993","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.exphem.2026.105491_bib0023","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1128\/MCB.15.4.2071","article-title":"Human GM-CSF enhancer function is associated with cooperative interactions between AP-1 and NFATp\/c","volume":"15","author":"Cockerill","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.exphem.2026.105491_bib0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exphem.2017.01.003","article-title":"Chromatin priming of genes in development: concepts, mechanisms and consequences","volume":"49","author":"Bonifer","year":"2017","journal-title":"Exp Hematol"},{"key":"10.1016\/j.exphem.2026.105491_bib0025","doi-asserted-by":"crossref","DOI":"10.1002\/bies.201600184","article-title":"Chromatin priming elements establish immunological memory in T cells without activating transcription: T cell memory is maintained by DNA elements which stably prime inducible genes without activating steady state transcription","volume":"39","author":"Bevington","year":"2017","journal-title":"Bioessays"},{"key":"10.1016\/j.exphem.2026.105491_bib0026","doi-asserted-by":"crossref","first-page":"515","DOI":"10.15252\/embj.201592534","article-title":"Inducible chromatin priming is associated with the establishment of immunological memory in T cells","volume":"35","author":"Bevington","year":"2016","journal-title":"EMBO J"},{"key":"10.1016\/j.exphem.2026.105491_bib0027","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4049\/jimmunol.155.1.226","article-title":"Transcriptional regulation of mouse granulocyte-macrophage colony-stimulating factor\/IL-3 locus","volume":"155","author":"Osborne","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2026.105491_bib0028","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.4049\/jimmunol.155.3.1240","article-title":"Multiple signals are required for function of the human granulocyte-macrophage colony-stimulating factor gene promoter in T cells","volume":"155","author":"Jenkins","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.exphem.2026.105491_bib0029","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0145-2126(96)00132-4","article-title":"The human bladder carcinoma cell line 5637 constitutively secretes functional cytokines","volume":"21","author":"Quentmeier","year":"1997","journal-title":"Leuk Res"},{"key":"10.1016\/j.exphem.2026.105491_bib0030","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.celrep.2015.06.069","article-title":"Chronic FLT3-ITD signaling in acute myeloid leukemia is connected to a specific chromatin signature","volume":"12","author":"Cauchy","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.exphem.2026.105491_bib0031","first-page":"454","article-title":"Luciferase reporter gene vectors for analysis of promoters and enhancers","volume":"6","author":"Nordeen","year":"1988","journal-title":"Biotechniques"},{"key":"10.1016\/j.exphem.2026.105491_bib0032","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/leu.2012.206","article-title":"Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression","volume":"27","author":"Bomken","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2026.105491_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2018.08.015","article-title":"The oncogenic transcription factor RUNX1\/ETO corrupts cell cycle regulation to drive leukemic transformation","volume":"34","author":"Martinez-Soria","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2026.105491_bib0034","article-title":"Optimized reporters for multiplexed detection of transcription factor activity","volume":"15","author":"Trauernicht","year":"2024","journal-title":"Cell Syst"},{"key":"10.1016\/j.exphem.2026.105491_bib0035","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s40265-019-1062-3","article-title":"Gilteritinib: first global approval","volume":"79","author":"Dhillon","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.exphem.2026.105491_bib0036","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1182\/blood-2014-05-574582","article-title":"Preclinical efficacy of MEK inhibition in Nras-mutant AML","volume":"124","author":"Burgess","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105491_bib0037","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1158\/1078-0432.CCR-13-1311","article-title":"Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial","volume":"20","author":"Jain","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.exphem.2026.105491_bib0038","first-page":"3569","article-title":"Dual inhibition of MEK and p38 impairs tumor growth in KRAS-mutated non\u2013small cell lung cancer","volume":"17","author":"Sunaga","year":"2019","journal-title":"Oncol Lett"},{"key":"10.1016\/j.exphem.2026.105491_bib0039","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.leukres.2007.09.017","article-title":"Blockade of MEK\/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene","volume":"32","author":"Nishioka","year":"2008","journal-title":"Leuk Res"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X26001244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X26001244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:33:20Z","timestamp":1789472000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X26001244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":39,"alternative-id":["S0301472X26001244"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2026.105491","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of receptor and oncogene-responsive luciferase reporter vectors that are activated via kinase signaling to AP-1","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2026.105491","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society for Experimental Hematology.","name":"copyright","label":"Copyright"}],"article-number":"105491"}}