{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:43:44Z","timestamp":1792773824856,"version":"4.5.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"NCATS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","exphem.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Hematology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.exphem.2026.105956","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:07:19Z","timestamp":1792739239000},"page":"105956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arid1a and Arid1b maintain B cell lineage fidelity and constrain myeloid transformation in mice"],"prefix":"10.1016","author":[{"given":"Phyo Nay","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3923-3963","authenticated-orcid":false,"given":"Sarah M.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joohyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0978-5348","authenticated-orcid":false,"given":"Yoon-A","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2196-8662","authenticated-orcid":false,"given":"George P.","family":"Souroullas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exphem.2026.105956_bib0001","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500447","article-title":"Mammalian SWI\/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics","volume":"1","author":"Kadoch","year":"2015","journal-title":"Sci Adv"},{"key":"10.1016\/j.exphem.2026.105956_bib0002","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41571-020-0357-3","article-title":"The SWI\/SNF complex in cancer \u2014 biology, biomarkers and therapy","volume":"17","author":"Mittal","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.exphem.2026.105956_bib0003","doi-asserted-by":"crossref","DOI":"10.1038\/s41388-021-01748-y","article-title":"ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer","author":"Moreno","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.exphem.2026.105956_bib0004","doi-asserted-by":"crossref","first-page":"eaeb3627","DOI":"10.1126\/science.aeb3627","article-title":"A SWI\/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform","volume":"392","author":"Jain","year":"2026","journal-title":"Science"},{"key":"10.1016\/j.exphem.2026.105956_bib0005","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1016\/j.exphem.2026.105956_bib0006","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci Signal"},{"key":"10.1016\/j.exphem.2026.105956_bib0007","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1158\/2159-8290.CD-17-0151","article-title":"AACR Project GENIE: Powering Precision Medicine through an International Consortium","volume":"7","year":"2017","journal-title":"Cancer Discov"},{"key":"10.1016\/j.exphem.2026.105956_bib0008","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1038\/s41375-019-0438-4","article-title":"Chromatin remodeling mediated by ARID1A is indispensable for normal hematopoiesis in mice","volume":"33","author":"Han","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2026.105956_bib0009","doi-asserted-by":"crossref","first-page":"6553","DOI":"10.1182\/bloodadvances.2023009946","article-title":"Dissecting the role of SWI\/SNF component ARID1B in steady-state hematopoiesis","volume":"7","author":"Madan","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.exphem.2026.105956_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0312616","article-title":"The SWI\/SNF subunit ARID1B is important for regenerative ability of hematopoietic stem cells in normal hematopoiesis","volume":"19","author":"Arnold","year":"2024","journal-title":"PloS One"},{"key":"10.1016\/j.exphem.2026.105956_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2024.02.010","article-title":"ARID1A orchestrates SWI\/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis","author":"Barisic","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.exphem.2026.105956_bib0012","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1038\/s41590-024-01920-y","article-title":"Arid1a-dependent canonical BAF complex suppresses inflammatory programs to drive efficient germinal center B cell responses","volume":"25","author":"Abraham","year":"2024","journal-title":"Nat Immunol"},{"key":"10.1016\/j.exphem.2026.105956_bib0013","doi-asserted-by":"crossref","DOI":"10.1158\/2159-8290.CD-23-0110","article-title":"Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy","author":"Kazansky","year":"2024","journal-title":"Cancer Discov"},{"key":"10.1016\/j.exphem.2026.105956_bib0014","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S1470-2045(20)30451-4","article-title":"Tazemetostat in advanced epithelioid sarcoma with loss of INI1\/SMARCB1: an international, open-label, phase 2 basket study","volume":"21","author":"Gounder","year":"2020","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.exphem.2026.105956_bib0015","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2022.40.16_suppl.10009","article-title":"Tazemetostat in patients with tumors with alterations in EZH2 or the SWI\/SNF complex: Results from NCI-COG Pediatric MATCH trial Arm C (APEC1621C)","volume":"40","author":"Chi","year":"2022","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.exphem.2026.105956_bib0016","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1200\/JCO.2016.70.7836","article-title":"Genetic Basis of Acute Lymphoblastic Leukemia","volume":"35","author":"Iacobucci","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.exphem.2026.105956_bib0017","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/cancers9010002","article-title":"The Role of Histone Protein Modifications and Mutations in Histone Modifiers in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia","volume":"9","author":"Janczar","year":"2017","journal-title":"Cancers"},{"key":"10.1016\/j.exphem.2026.105956_bib0018","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1182\/blood-2014-05-577270","article-title":"The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia","volume":"125","author":"Van der Meulen","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.exphem.2026.105956_bib0019","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature09727","article-title":"CREBBP mutations in relapsed acute lymphoblastic leukaemia","volume":"471","author":"Mullighan","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.exphem.2026.105956_bib0020","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1007\/s00432-016-2174-8","article-title":"EZH2 mutations and promoter hypermethylation in childhood acute lymphoblastic leukemia","volume":"142","author":"Sch\u00e4fer","year":"2016","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.exphem.2026.105956_bib0021","doi-asserted-by":"crossref","first-page":"64071","DOI":"10.18632\/oncotarget.11773","article-title":"Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes","volume":"7","author":"Lindqvist","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.exphem.2026.105956_bib0022","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1038\/ncomms4469","article-title":"Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia","volume":"5","author":"Mar","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.exphem.2026.105956_bib0023","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1038\/ncomms4630","article-title":"The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes","volume":"5","author":"Huether","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.exphem.2026.105956_bib0024","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/leu.2013.204","article-title":"Point mutation E1099K in MMSET\/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies","volume":"28","author":"Oyer","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.exphem.2026.105956_bib0025","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1471-2105-10-161","article-title":"GAGE: generally applicable gene set enrichment for pathway analysis","volume":"10","author":"Luo","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.exphem.2026.105956_bib0026","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/nar\/25.6.1317","article-title":"B lymphocyte-specific, Cre-mediated mutagenesis in mice","volume":"25","author":"Rickert","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.exphem.2026.105956_bib0027","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.stem.2015.05.003","article-title":"Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions","volume":"17","author":"Pietras","year":"2015","journal-title":"Cell Stem Cell"}],"container-title":["Experimental Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X26005898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301472X26005898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:16:36Z","timestamp":1792772196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301472X26005898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":27,"alternative-id":["S0301472X26005898"],"URL":"https:\/\/doi.org\/10.1016\/j.exphem.2026.105956","relation":{},"ISSN":["0301-472X"],"issn-type":[{"value":"0301-472X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arid1a and Arid1b maintain B cell lineage fidelity and constrain myeloid transformation in mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exphem.2026.105956","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of International Society for Experimental Hematology.","name":"copyright","label":"Copyright"}],"article-number":"105956"}}