{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:31:57Z","timestamp":1764646317236,"version":"build-2065373602"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007386","name":"Pro-Reitoria de Pesquisa, Universidade de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007374","name":"Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007375","name":"PRPQ","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EXPLORE"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.explore.2021.05.004","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T12:37:00Z","timestamp":1621859820000},"page":"587-590","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The rationality involved in the popular use of coffee (Coffea sp) and sunflower seed (Helianthus annuus) for the treatment of vitiligo: a case report"],"prefix":"10.1016","volume":"18","author":[{"given":"Paula M.","family":"Leite","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie D.O.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel O.","family":"Castilho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.explore.2021.05.004_bib0001","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0140-6736(14)60763-7","article-title":"Vitiligo","volume":"386","author":"Ezzedine","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.explore.2021.05.004_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2016.10.048","article-title":"New discoveries in the pathogenesis and classification of vitiligo","volume":"77","author":"Rodrigues","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.explore.2021.05.004_bib0003","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2340\/00015555-1397","article-title":"Prevalence and clinical profile of vitiligo in China: a community-based study in six cities","volume":"93","author":"Wang","year":"2013","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.explore.2021.05.004_bib0004","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1590\/S0365-05962011000200006","article-title":"Perfil epidemiol\u00f3gico dos pacientes com vitiligo e sua associa\u00e7\u00e3o com doen\u00e7as da tireoide","author":"Nunes","year":"2011","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.explore.2021.05.004_bib0005","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.4103\/2229-5178.144499","article-title":"Epidemiological pattern of psoriasis, vitiligo and atopic dermatitis in India: Hospital-based point prevalence","volume":"5","author":"Kumar","year":"2014","journal-title":"Indian Dermatol Online J"},{"key":"10.1016\/j.explore.2021.05.004_bib0006","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4103\/0378-6323.32708","article-title":"Vitiligo: compendium of clinico-epidemiological features","volume":"73","author":"Sehgal","year":"2007","journal-title":"Indian J Dermatol Venereol Leprol;"},{"key":"10.1016\/j.explore.2021.05.004_bib0007","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1365-2133.2012.11197.x","article-title":"Guidelines for the management of vitiligo: the European Dermatology Forum consensus","volume":"168","author":"Taieb","year":"2013","journal-title":"Br J Dermatol"},{"year":"2009","series-title":"Medicinal natural product - a biosynthetic approach","author":"Dewick","key":"10.1016\/j.explore.2021.05.004_bib0008"},{"year":"2018","series-title":"Fitoterapia Contempor\u00e2nea: tradi\u00e7\u00e3o e ci\u00eancia na pr\u00e1tica cl\u00ednica","author":"Saad","key":"10.1016\/j.explore.2021.05.004_bib0009"},{"key":"10.1016\/j.explore.2021.05.004_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eujim.2020.101270","article-title":"Recent progress in phytotherapy: a Brazilian perspective","volume":"41","author":"Leite","year":"2021","journal-title":"Eur J Integr Med"},{"key":"10.1016\/j.explore.2021.05.004_bib0011","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1590\/S0102-695X2008000400006","article-title":"Acute toxicity of Brosimum gaudichaudii Tr\u00e9cul. root extract in mice: determination of both approximate and median lethal doses","author":"Cunha","year":"2008","journal-title":"Rev Bras Farmacogn Scielo"},{"key":"10.1016\/j.explore.2021.05.004_bib0012","first-page":"1","article-title":"Effect of coffee and stress with the incidence of gastritis","volume":"4","author":"Selviana","year":"2015","journal-title":"Majority"},{"key":"10.1016\/j.explore.2021.05.004_bib0013","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.1365-2036.2003.01429.x","article-title":"Moderate coffee consumption increases plasma glutathione but not homocysteine in healthy subjects","volume":"17","author":"Esposito","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.explore.2021.05.004_bib0014","first-page":"112","article-title":"Sistema antioxidante envolvendo o ciclo metab\u00f3lico da glutationa associado a m\u00e9todos eletroanal\u00edticos na avalia\u00e7\u00e3o do estresse oxidativo","author":"Rover J\u00fanior","year":"2001","journal-title":"Qu\u00edmica Nov Scielo"},{"key":"10.1016\/j.explore.2021.05.004_bib0015","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1590\/S0100-40422008000500046","article-title":"Glutationa e enzimas relacionadas: papel biol\u00f3gico e import\u00e2ncia em processos patol\u00f3gicos","author":"Huber","year":"2008","journal-title":"Qu\u00edmica Nov Scielo"},{"key":"10.1016\/j.explore.2021.05.004_bib0016","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/ajcn\/71.2.480","article-title":"Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial","volume":"71","author":"Grubben","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.explore.2021.05.004_bib0017","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1590\/S1677-54492010000100006","article-title":"Tratamento diet\u00e9tico da hiper-homocisteinemia na doen\u00e7a arterial perif\u00e9rica","author":"Ven\u00e2ncio L de","year":"2010","journal-title":"J Vasc Bras Scielo"},{"key":"10.1016\/j.explore.2021.05.004_bib0018","first-page":"11","article-title":"A review of phytochemistry, metabolite changes, and medicinal uses of the common sunflower seed and sprouts (Helianthus annuus L.)","author":"Guo","year":"2017","journal-title":"Chem Cent J"},{"key":"10.1016\/j.explore.2021.05.004_bib0019","first-page":"27","author":"Carr\u00e3o-Panizzi","year":"1994","journal-title":"Girassol Derivados Prot\u00e9icos"},{"key":"10.1016\/j.explore.2021.05.004_bib0020","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1590\/S0365-05962004000300010","article-title":"Vitiligo artigo de revis\u00e3o","volume":"79","author":"Steiner","year":"2004","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.explore.2021.05.004_bib0021","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.intimp.2008.08.002","article-title":"Chlorogenic acid, a polyphenolic compound, treats mice with septic arthritis caused by Candida albicans","volume":"8","author":"Lee","year":"2008","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.explore.2021.05.004_bib0022","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1248\/bpb.29.2236","article-title":"Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid","volume":"29","author":"dos Santos","year":"2006","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.explore.2021.05.004_bib0023","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.resconrec.2017.10.001","article-title":"Chemical composition and value-adding applications of coffee industry by-products: a review","volume":"128","author":"Janissen","year":"2018","journal-title":"Resour Conserv Recycl"},{"key":"10.1016\/j.explore.2021.05.004_bib0024","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.foodchem.2007.05.091","article-title":"Chlorogenic acid and caffeine contents in various commercial brewed coffees","volume":"106","author":"Fujioka","year":"2008","journal-title":"Food Chem"},{"key":"10.1016\/j.explore.2021.05.004_bib0025","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1590\/S0102-86502004000300005","article-title":"The effects of topical application of sunflower-seed oil on open wound healing in lambs","author":"Marques","year":"2004","journal-title":"Acta Cir\u00fargica Bras"},{"key":"10.1016\/j.explore.2021.05.004_bib0026","first-page":"19","article-title":"Anti-inflammatory and skin barrier repair effects of topical application of some plant oils","author":"Lin","year":"2017","journal-title":"Int J Mol Sci"}],"container-title":["EXPLORE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550830721000926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550830721000926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:34:40Z","timestamp":1761554080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550830721000926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S1550830721000926"],"URL":"https:\/\/doi.org\/10.1016\/j.explore.2021.05.004","relation":{},"ISSN":["1550-8307"],"issn-type":[{"type":"print","value":"1550-8307"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The rationality involved in the popular use of coffee (Coffea sp) and sunflower seed (Helianthus annuus) for the treatment of vitiligo: a case report","name":"articletitle","label":"Article Title"},{"value":"EXPLORE","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.explore.2021.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}