{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:48:08Z","timestamp":1790812088466,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EXPLORE"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.explore.2021.12.004","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T11:57:22Z","timestamp":1639396642000},"page":"342-346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical evaluation of the effect of Zataria multiflora Boiss and Trachyspermum copticum (L.) on the patients with irritable bowel syndrome"],"prefix":"10.1016","volume":"18","author":[{"given":"Hossein","family":"Jamalizadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijan","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Shariffar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Setayesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armita","family":"Shahesmaeili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haleh","family":"Tajadini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.explore.2021.12.004_bib0001","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1751-2980.2011.00526.x","article-title":"Economic burden attributable to functional bowel disorders in Iran: a cross-sectional population-based study","volume":"12","author":"Moghimi-Dehkordi","year":"2011","journal-title":"J Dig Dis"},{"issue":"2","key":"10.1016\/j.explore.2021.12.004_bib0002","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3390\/medicina55020046","article-title":"Use of complementary and alternative medicine by patients with irritable bowel syndrome according to the roma iv criteria: A single-center italian survey","volume":"55","author":"Larussa","year":"2019","journal-title":"Medicina (Kaunas, Lithuania)"},{"issue":"4","key":"10.1016\/j.explore.2021.12.004_bib0003","doi-asserted-by":"crossref","first-page":"213","DOI":"10.23736\/S0031-0808.18.03541-3","article-title":"Irritable bowel syndrome: the clinical approach","volume":"60","author":"Adriani","year":"2018","journal-title":"Panminerva Med"},{"issue":"4","key":"10.1016\/j.explore.2021.12.004_bib0004","first-page":"217","article-title":"Cumin extract for symptom control in patients with irritable bowel syndrome: a case series","volume":"5","author":"Agah","year":"2013","journal-title":"Middle East J Dig Dis"},{"issue":"2","key":"10.1016\/j.explore.2021.12.004_bib0005","first-page":"143","article-title":"Complementary and alternative medicine for treatment of irritable bowel syndrome","volume":"55","author":"Shen","year":"2009","journal-title":"Can Fam Phys"},{"key":"10.1016\/j.explore.2021.12.004_bib0006","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.lfs.2018.10.001","article-title":"Updated review of current pharmacological and non-pharmacological management of irritable bowel syndrome","volume":"212","author":"Rawla","year":"2018","journal-title":"Life Sci"},{"issue":"5","key":"10.1016\/j.explore.2021.12.004_bib0007","first-page":"419","article-title":"Diagnosis and management of IBS in adults","volume":"86","author":"Wilkins","year":"2012","journal-title":"Am Fam Phys"},{"issue":"6","key":"10.1016\/j.explore.2021.12.004_bib0008","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11894-019-0692-7","article-title":"Update on pharmacotherapy for irritable bowel syndrome","volume":"21","author":"Munjal","year":"2019","journal-title":"Curr Gastroenterol Rep"},{"issue":"4","key":"10.1016\/j.explore.2021.12.004_bib0009","doi-asserted-by":"crossref","first-page":"426","DOI":"10.5056\/jnm.2012.18.4.426","article-title":"Association between irritable bowel syndrome and restless legs syndrome: a comparative study with control group","volume":"18","author":"Borji","year":"2012","journal-title":"J Neurogastroenterol Motil"},{"issue":"2","key":"10.1016\/j.explore.2021.12.004_bib0010","article-title":"Irritable bowel syndrome: are complementary and alternative medicine treatments useful?","volume":"55","author":"Birtwhistle","year":"2009","journal-title":"Can Fam Phys"},{"issue":"11","key":"10.1016\/j.explore.2021.12.004_bib0011","first-page":"705","article-title":"Complementary and alternative medicine modalities for the treatment of irritable bowel syndrome: facts or myths?","volume":"6","author":"Wu","year":"2010","journal-title":"Gastroenterol Hepatol (N Y)"},{"issue":"6","key":"10.1016\/j.explore.2021.12.004_bib0012","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S1726-4901(09)70375-2","article-title":"Treatment of irritable bowel syndrome using complementary and alternative medicine","volume":"72","author":"Chang","year":"2009","journal-title":"J Chin Med Assoc"},{"issue":"2","key":"10.1016\/j.explore.2021.12.004_bib0013","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/apt.15325","article-title":"Systematic review with meta-analysis: the prevalence of anxiety and depression in patients with irritable bowel syndrome","volume":"50","author":"Zamani","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.explore.2021.12.004_bib0014","first-page":"79","article-title":"New insights in IBS-like disorders: pandora's box has been opened; a review","volume":"10","author":"Borghini","year":"2017","journal-title":"Gastroenterol Hepatol Bed Bench"},{"issue":"9","key":"10.1016\/j.explore.2021.12.004_bib0015","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/jama.2015.0954","article-title":"Irritable bowel syndrome: a clinical review","volume":"313","author":"Chey","year":"2015","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.explore.2021.12.004_bib0016","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/apt.12938","article-title":"Review article: the economic impact of the irritable bowel syndrome","volume":"40","author":"Canavan","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.explore.2021.12.004_bib0017","first-page":"222","article-title":"Traditional Persian topical medications for gastrointestinal diseases","volume":"20","author":"Tafti","year":"2017","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.explore.2021.12.004_bib0018","series-title":"Qanun Fi Al Tib [Canon of Medicine]","year":"2010"},{"key":"10.1016\/j.explore.2021.12.004_bib0019","series-title":"(Rhazes) Al-Havi (Liber Continens)","author":"Razi","year":"2005"},{"key":"10.1016\/j.explore.2021.12.004_bib0020","first-page":"1","article-title":"Therapeutic potential of zataria multiflora boiss in treatment of irritable bowel syndrome (IBS)","author":"Mahboubi","year":"2018","journal-title":"J Diet Suppl"},{"key":"10.1016\/j.explore.2021.12.004_bib0021","series-title":"Ministry of Health and Medical Publications","first-page":"51","year":"2002"},{"issue":"3","key":"10.1016\/j.explore.2021.12.004_bib0022","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jep.2012.12.018","article-title":"Zataria multiflora Boiss. (Shirazi thyme)- an ancient condiment with modern pharmaceutical uses","volume":"145","author":"Sajed","year":"2013","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"10.1016\/j.explore.2021.12.004_bib0023","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3923\/pjbs.2013.180.184","article-title":"Anti herpes simplex-1 activity of a standard extract of Zataria multiflora Boiss","volume":"16","author":"Arabzadeh","year":"2013","journal-title":"Pak J Biol Sci"},{"issue":"2","key":"10.1016\/j.explore.2021.12.004_bib0024","first-page":"93","article-title":"Anticonvulsant effect of the essential oil and methanolic extracts of Zataria multiflora Boiss","volume":"13","author":"Mandegary","year":"2013","journal-title":"Central Nerv Syst Agents Med Chem (Formerly Curr Med Chem-Central Nerv Syst Agents)"},{"issue":"1","key":"10.1016\/j.explore.2021.12.004_bib0025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3923\/pjbs.2012.49.53","article-title":"Essential oil and methanolic extract of Zataria multiflora Boiss with anticholinesterase effect","volume":"15","author":"Sharififar","year":"2012","journal-title":"Pak J Biol Sci"},{"issue":"5","key":"10.1016\/j.explore.2021.12.004_bib0026","doi-asserted-by":"crossref","first-page":"752","DOI":"10.3109\/13880209.2015.1079223","article-title":"Chemical composition along with anti-leishmanial and cytotoxic activity of Zataria multiflora","volume":"54","author":"Saedi Dezaki","year":"2016","journal-title":"Pharm Biol"},{"issue":"3","key":"10.1016\/j.explore.2021.12.004_bib0027","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4103\/0973-8398.160316","article-title":"Antimutagenic activity of major fractions of Zataria multiflora Boiss by Ames method","volume":"9","author":"Dehgan Noudeh","year":"2015","journal-title":"Asian J Pharm (AJP): Asian J Pharm"},{"issue":"4","key":"10.1016\/j.explore.2021.12.004_bib0028","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s13596-016-0238-6","article-title":"Hepatoprotective effect of Zataria Multiflora Boiss against malathion-induced oxidative stress in male rats","volume":"16","author":"Ahmadipour","year":"2016","journal-title":"Orient Pharm Exp Med"},{"issue":"2","key":"10.1016\/j.explore.2021.12.004_bib0029","first-page":"221","article-title":"In vitro antioxident activity of Zataria Multifora boiss essential oil","volume":"24","author":"Sharififar","year":"2011","journal-title":"Pak J Pharm Sci."},{"issue":"10","key":"10.1016\/j.explore.2021.12.004_bib0030","doi-asserted-by":"crossref","first-page":"175","DOI":"10.32598\/bcn.10.2.1104.1","article-title":"Amelioration of prenatal lead-induced learning and memory impairments by methanolic extract of zataria multiflora in male rats","volume":"2","author":"Taheri","year":"2019","journal-title":"Basic Clin Neurosci"},{"issue":"6","key":"10.1016\/j.explore.2021.12.004_bib0031","article-title":"Zataria multiflora Boiss. extract improves spatial memory and learning capacity in scopolamine-induced amnesic rats","volume":"9","author":"Sheibani","year":"2019","journal-title":"Avicenna J Phytomed"},{"issue":"1","key":"10.1016\/j.explore.2021.12.004_bib0032","first-page":"1","article-title":"The inhibitory effect of some Iranian plants extracts on the alpha glucosidase","volume":"11","author":"Ahmad","year":"2008","journal-title":"Iran J Basic Med Sci"},{"issue":"4","key":"10.1016\/j.explore.2021.12.004_bib0033","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4103\/0973-8258.94348","article-title":"In vitro screening of selected Iranian medicinal plants against Helicobacter pylori","volume":"5","author":"Hosseininejad","year":"2011","journal-title":"Int J Green Pharm (IJGP)"},{"issue":"4","key":"10.1016\/j.explore.2021.12.004_bib0034","first-page":"65","article-title":"Evaluation of cytotoxicity of methanolic extract Zataria multiflora boiss and its fractions on the colorectal adenocarcinoma cell lines (Caco-2)","volume":"4","author":"Mirimoghadam","year":"2017","journal-title":"Res J Pharm"},{"issue":"6","key":"10.1016\/j.explore.2021.12.004_bib0035","first-page":"554","article-title":"Effect of Apium graveolens and Trachyspermum copticom on clinical symptoms of patients with functional dyspepsia","volume":"7","author":"Azimi","year":"2017","journal-title":"Avicenna J Phytomed"},{"key":"10.1016\/j.explore.2021.12.004_bib0036","first-page":"00","article-title":"The Chemical composition and anti-mycobacterial activities of Trachyspermum copticum and Pelargonium graveolens essential oils","volume":"4","author":"Kardan-Yamchi","year":"2019","journal-title":"Recent Pat Antiinfect Drug Discov"},{"issue":"4","key":"10.1016\/j.explore.2021.12.004_bib0037","first-page":"188","article-title":"A cytotoxicity and comparative antibacterial study on the effect of Zataria multiflora Boiss, Trachyspermum copticum essential oils, and Enrofloxacin on Aeromonas hydrophila","volume":"2","author":"Malekinejad","year":"2012","journal-title":"Avicenna J Phytomed"},{"issue":"7","key":"10.1016\/j.explore.2021.12.004_bib0038","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.apjtm.2017.07.006","article-title":"Chemical analysis and in vitro antimicrobial effects and mechanism of action of Trachyspermum copticum essential oil against Escherichia coli","volume":"10","author":"Huang","year":"2017","journal-title":"Asian Pac J Trop Med"},{"issue":"1","key":"10.1016\/j.explore.2021.12.004_bib0039","first-page":"127","article-title":"TLC-Bioautography and GC\u2013MS analyses for detection and identification of antioxidant constituents of trachyspermum copticum essential oil","volume":"13","author":"Nickavar","year":"2014","journal-title":"Iran J Pharm Res: IJPR"},{"issue":"1","key":"10.1016\/j.explore.2021.12.004_bib0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00580-015-2151-7","article-title":"The effects of aqueous extracts of Lippia citriodora, Trachyspermum copticum, Dracocepalum polychaetum on repair of ethanol induced gastric ulcer in rats","volume":"25","author":"Tajik","year":"2016","journal-title":"Comp Clin Path"},{"issue":"12","key":"10.1016\/j.explore.2021.12.004_bib0041","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/ptr.5200","article-title":"Antiinflammatory, antioxidant, and immunological effects of Carum copticum L. and some of its constituents","volume":"28","author":"Alavinezhad","year":"2014","journal-title":"Phytother Res"},{"key":"10.1016\/j.explore.2021.12.004_bib0042","series-title":"Quality Control Methods for Herbal Materials","year":"2011"},{"issue":"5","key":"10.1016\/j.explore.2021.12.004_bib0043","doi-asserted-by":"crossref","first-page":"270","DOI":"10.56499\/jppres16.195_5.5.270","article-title":"Quercus infectoria and Terminalia chebula decrease melanin content and tyrosinase activity in B16\/F10 cell lines","volume":"5","author":"Jamshidzadeh","year":"2017","journal-title":"J Pharm Pharm Res"},{"issue":"1","key":"10.1016\/j.explore.2021.12.004_bib0044","first-page":"2","article-title":"Recommendations guiding physicians in biomedical research involving human subjects","volume":"35","year":"1997","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.explore.2021.12.004_bib0045","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jep.2016.10.083","article-title":"Efficacy and safety of enteric coated capsules of anise oil to treat irritable bowel syndrome","volume":"194","author":"Mosaffa-Jahromi","year":"2016","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"10.1016\/j.explore.2021.12.004_bib0047","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1741-7015-8-18","article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials","volume":"8","author":"Schulz","year":"2010","journal-title":"BMC Med"},{"key":"10.1016\/j.explore.2021.12.004_bib0048","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ctim.2018.09.010","article-title":"The effects of Zataria multiflora Boiss. (Shirazi thyme) on nonalcoholic fatty liver disease and insulin resistance: a randomized double-blind placebo-controlled clinical trial","volume":"41","author":"Zamani","year":"2018","journal-title":"Complement Ther Med"},{"issue":"4","key":"10.1016\/j.explore.2021.12.004_bib0049","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1055\/s-0029-1186179","article-title":"Impact of thymol in thyme extracts on their antispasmodic action and ciliary clearance","volume":"76","author":"Begrow","year":"2010","journal-title":"Planta Med"}],"container-title":["EXPLORE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550830721002512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550830721002512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:36:23Z","timestamp":1761554183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550830721002512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S1550830721002512"],"URL":"https:\/\/doi.org\/10.1016\/j.explore.2021.12.004","relation":{},"ISSN":["1550-8307"],"issn-type":[{"value":"1550-8307","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical evaluation of the effect of Zataria multiflora Boiss and Trachyspermum copticum (L.) on the patients with irritable bowel syndrome","name":"articletitle","label":"Article Title"},{"value":"EXPLORE","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.explore.2021.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}