{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:46:41Z","timestamp":1791838001164,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EXPLORE"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.explore.2024.103083","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T09:15:44Z","timestamp":1731489344000},"page":"103083","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Safety and efficacy of curcumin in the treatment of ulcerative colitis: An updated systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"21","author":[{"given":"Zhao","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gai-Xia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Bin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9853","key":"10.1016\/j.explore.2024.103083_bib0001","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ord\u00e1s","year":"2012","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.explore.2024.103083_bib0002","doi-asserted-by":"crossref","first-page":"135","DOI":"10.7861\/clinmed.2021-0080","article-title":"Ulcerative colitis: an update","volume":"21","author":"Segal","year":"2021","journal-title":"Clin Med (Lond)"},{"issue":"4","key":"10.1016\/j.explore.2024.103083_bib0003","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.gtc.2020.07.001","article-title":"Ulcerative Colitis: making the Diagnosis","volume":"49","author":"Kaenkumchorn","year":"2020","journal-title":"Gastroenterol Clin North Am"},{"issue":"4","key":"10.1016\/j.explore.2024.103083_bib0004","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.gtc.2020.07.005","article-title":"Epidemiology and Pathogenesis of Ulcerative Colitis","volume":"49","author":"Du","year":"2020","journal-title":"Gastroenterol Clin North Am"},{"issue":"3","key":"10.1016\/j.explore.2024.103083_bib0005","doi-asserted-by":"crossref","first-page":"384","DOI":"10.14309\/ajg.0000000000000152","article-title":"ACG Clinical Guideline: ulcerative Colitis in Adults","volume":"114","author":"Rubin","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.explore.2024.103083_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.104763","article-title":"Anti-CD20 monoclonal antibody (mAb) therapy and colitis: a case series and review","volume":"75","author":"Tolaymat","year":"2023","journal-title":"Mult Scler Relat Disord"},{"issue":"2","key":"10.1016\/j.explore.2024.103083_bib0007","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41564-021-01050-3","article-title":"Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity","volume":"7","author":"Mills","year":"2022","journal-title":"Nat Microbiol"},{"issue":"8","key":"10.1016\/j.explore.2024.103083_bib0008","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00595-014-1053-7","article-title":"Laparoscopic surgery for ulcerative colitis: a review of the literature","volume":"45","author":"Hata","year":"2015","journal-title":"Surg Today"},{"issue":"5","key":"10.1016\/j.explore.2024.103083_bib0009","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The essential medicinal chemistry of curcumin","volume":"60","author":"Nelson","year":"2017","journal-title":"J Med Chem"},{"issue":"14","key":"10.1016\/j.explore.2024.103083_bib0010","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.3390\/ijms22147645","article-title":"Curcumin attenuates environment-derived osteoarthritis by Sox9\/NF-kB signaling axis","volume":"22","author":"Buhrmann","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.explore.2024.103083_bib0011","doi-asserted-by":"crossref","first-page":"11947","DOI":"10.1080\/21655979.2021.2009322","article-title":"Improvement of intestinal barrier function, gut microbiota, and metabolic endotoxemia in type 2 diabetes rats by curcumin","volume":"12","author":"Huang","year":"2021","journal-title":"Bioengineered"},{"issue":"5","key":"10.1016\/j.explore.2024.103083_bib0012","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s10787-019-00607-3","article-title":"Curcumin: a modulator of inflammatory signaling pathways in the immune system","volume":"27","author":"Kahkhaie","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.explore.2024.103083_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110189","article-title":"Anti-inflammatory effects of \u03b2-ionone-curcumin hybrid derivatives against ulcerative colitis","volume":"367","author":"Ma","year":"2022","journal-title":"Chem Biol Interact"},{"issue":"4","key":"10.1016\/j.explore.2024.103083_bib0014","first-page":"406","article-title":"Ulcerative colitis: rapid evidence review","volume":"105","author":"Adams","year":"2022","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.explore.2024.103083_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115041","article-title":"Efficacy and safety of adjuvant curcumin therapy in ulcerative colitis: a systematic review and meta-analysis","volume":"289","author":"Yin","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.explore.2024.103083_bib0016","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.explore.2024.103083_bib0017","series-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011)","article-title":"Chapter 8: assessing risk of bias in included studies","author":"Higgins","year":"2011"},{"issue":"8","key":"10.1016\/j.explore.2024.103083_bib0018","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/MCG.0000000000001416","article-title":"Novel bioenhanced curcumin with mesalamine for induction of clinical and endoscopic remission in mild-to-moderate ulcerative colitis: a randomized double-blind placebo-controlled pilot study","volume":"55","author":"Banerjee","year":"2021","journal-title":"J Clin Gastroenterol"},{"issue":"12","key":"10.1016\/j.explore.2024.103083_bib0019","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.cgh.2006.08.008","article-title":"Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial","volume":"4","author":"Hanai","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.explore.2024.103083_bib0020","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4292\/wjgpt.v8.i2.147","article-title":"Low dose oral curcumin is not effective in induction of remission in mild to moderate ulcerative colitis: results from a randomized double blind placebo controlled trial","volume":"8","author":"Kedia","year":"2017","journal-title":"World J Gastrointest Pharmacol Ther"},{"issue":"8","key":"10.1016\/j.explore.2024.103083_bib0021","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.cgh.2015.02.019","article-title":"Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial","volume":"13","author":"Lang","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"11","key":"10.1016\/j.explore.2024.103083_bib0022","doi-asserted-by":"crossref","first-page":"9552","DOI":"10.1002\/jcb.27273","article-title":"The efficacy of curcuminoids in improvement of ulcerative colitis symptoms and patients' self-reported well-being: a randomized double-blind controlled trial","volume":"119","author":"Masoodi","year":"2018","journal-title":"J Cell Biochem"},{"issue":"5","key":"10.1016\/j.explore.2024.103083_bib0023","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/ptr.6581","article-title":"The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis","volume":"34","author":"Sadeghi","year":"2020","journal-title":"Phytother Res"},{"issue":"3","key":"10.1016\/j.explore.2024.103083_bib0024","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.crohns.2013.08.006","article-title":"Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis - a randomized, placebo-controlled, pilot study","volume":"8","author":"Singla","year":"2014","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.explore.2024.103083_bib0025","article-title":"Curcumin-qingdai combination for patients with active ulcerative colitis: a randomized, double-blinded, placebo-controlled trial","author":"Ben-Horin","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.explore.2024.103083_bib0026","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.gtc.2020.08.003","article-title":"Assessing severity of disease in patients with ulcerative colitis","volume":"49","author":"Pabla","year":"2020","journal-title":"Gastroenterol Clin North Am"},{"issue":"7","key":"10.1016\/j.explore.2024.103083_bib0027","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.mayocp.2019.01.018","article-title":"Ulcerative colitis","volume":"94","author":"Feuerstein","year":"2019","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"10.1016\/j.explore.2024.103083_bib0028","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1053\/j.gastro.2018.12.009","article-title":"AGA clinical practice guidelines on the management of mild-to-moderate ulcerative colitis","volume":"156","author":"Ko","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.explore.2024.103083_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.611256","article-title":"The IL23-IL17 immune axis in the treatment of ulcerative colitis: successes, defeats, and ongoing challenges","volume":"12","author":"Noviello","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.explore.2024.103083_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115084","article-title":"Potential activity of traditional chinese medicine against ulcerative colitis: a review","volume":"289","author":"Liu","year":"2022","journal-title":"J Ethnopharmacol"},{"issue":"11","key":"10.1016\/j.explore.2024.103083_bib0031","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1039\/c2fo30097d","article-title":"an active component of turmeric in the prevention and treatment of ulcerative colitis: preclinical and clinical observations","volume":"3","author":"Baliga","year":"2012","journal-title":"Food Funct"},{"issue":"7","key":"10.1016\/j.explore.2024.103083_bib0032","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1089\/jmf.2020.0129","article-title":"Effects of the use of curcumin on ulcerative colitis and crohn's disease: a systematic review","volume":"24","author":"Goulart","year":"2021","journal-title":"J Med Food"},{"issue":"7","key":"10.1016\/j.explore.2024.103083_bib0033","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.cgh.2019.08.041","article-title":"Oral curcumin no more effective than placebo in preventing recurrence of crohn's disease after surgery in a randomized controlled trial","volume":"18","author":"Bommelaer","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.explore.2024.103083_bib0034","first-page":"161","article-title":"Anti-inflammatory effects of enemas containing an oily extract of curcumin in an experimental model of diversion colitis","volume":"32","author":"Kadri","year":"2017","journal-title":"Histol Histopathol"},{"issue":"5","key":"10.1016\/j.explore.2024.103083_bib0035","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3390\/nu11051004","article-title":"Curcumin in autoimmune and rheumatic diseases","volume":"11","author":"Yang","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.explore.2024.103083_bib0036","article-title":"Curcumin alleviates experimental colitis in mice by suppressing necroptosis of intestinal epithelial cells","volume":"14","author":"Zhong","year":"2023","journal-title":"Front Pharmacol"}],"container-title":["EXPLORE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550830724001903?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550830724001903?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T18:10:50Z","timestamp":1737310250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550830724001903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S1550830724001903"],"URL":"https:\/\/doi.org\/10.1016\/j.explore.2024.103083","relation":{},"ISSN":["1550-8307"],"issn-type":[{"value":"1550-8307","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and efficacy of curcumin in the treatment of ulcerative colitis: An updated systematic review and meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"EXPLORE","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.explore.2024.103083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103083"}}