{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:12:40Z","timestamp":1791537160857,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EXPLORE"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.explore.2025.103277","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T15:53:37Z","timestamp":1762012417000},"page":"103277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical efficacy of Guishao Shengxue decoction in the treatment of pediatric immune thrombocytopenia: A randomized controlled trial"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7839-7288","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengtao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.explore.2025.103277_bib0001","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1182\/blood.2020006480","article-title":"An update on pediatric ITP: differentiating primary ITP, IPD, and PID","volume":"140","author":"Grace","year":"2022","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.explore.2025.103277_bib0002","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1182\/asheducation-2018.1.405","article-title":"Pediatric ITP: is it different from adult ITP?","volume":"2018","author":"Despotovic","year":"2018","journal-title":"Hematol Am Soc Hematol Educ Program"},{"issue":"3","key":"10.1016\/j.explore.2025.103277_bib0003","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1055\/s-0039-1683416","article-title":"Epidemiology and Clinical Manifestations of Immune Thrombocytopenia","volume":"39","author":"Kohli","year":"2019","journal-title":"Hamostaseologie"},{"issue":"2","key":"10.1016\/j.explore.2025.103277_bib0004","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s12098-019-03155-4","article-title":"Immune Thrombocytopenia in Children: consensus and Controversies","volume":"87","author":"Singh","year":"2020","journal-title":"Indian J Pediatr"},{"issue":"6","key":"10.1016\/j.explore.2025.103277_bib0005","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/ajh.25086","article-title":"A comparative prospective observational study of children and adults with immune thrombocytopenia: 2-year follow-up","volume":"93","author":"Schifferli","year":"2018","journal-title":"Am J Hematol"},{"issue":"9","key":"10.1016\/j.explore.2025.103277_bib0006","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1182\/blood-2018-02-830844","article-title":"Intravenous immunoglobulin vs observation in childhood immune thrombocytopenia: a randomized controlled trial","volume":"132","author":"Heitink-Poll\u00e9","year":"2018","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.explore.2025.103277_bib0007","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/MBC.0000000000001144","article-title":"Primary immune thrombocytopenia: a 'diagnosis of exclusion'?","volume":"33","author":"Visweshwar","year":"2022","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"4","key":"10.1016\/j.explore.2025.103277_bib0008","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25042163","article-title":"Current Understanding of Immune Thrombocytopenia: a Review of Pathogenesis and Treatment Options","volume":"25","author":"Mititelu","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.explore.2025.103277_bib0009","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1080\/17512433.2021.1903315","article-title":"Update on diagnosis and treatment of immune thrombocytopenia","volume":"14","author":"Sandal","year":"2021","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"12","key":"10.1016\/j.explore.2025.103277_bib0010","article-title":"Immune Thrombocytopenia (ITP): current Limitations in Patient Management","volume":"56","author":"Terrell","year":"2020","journal-title":"Med"},{"issue":"3","key":"10.1016\/j.explore.2025.103277_bib0011","doi-asserted-by":"crossref","DOI":"10.3390\/healthcare9030257","article-title":"Understanding Traditional Chinese Medicine Therapeutics: an Overview of the Basics and Clinical Applications","volume":"9","author":"Matos","year":"2021","journal-title":"Healthc"},{"key":"10.1016\/j.explore.2025.103277_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154413","article-title":"Investigation of the mechanism of action of Shengxuexiaoban Capsules against primary immune thrombocytopenia using network pharmacology and experimental validation","volume":"106","author":"Xu","year":"2022","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.explore.2025.103277_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0275122","article-title":"Effectiveness of shengxuexiaoban capsules combined with glucocorticoid therapy for immune thrombocytopenia: a meta-analysis","volume":"17","author":"Ding","year":"2022","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.explore.2025.103277_bib0014","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/ped4.12305","article-title":"Adapted guideline for the diagnosis and treatment of primary immune thrombocytopenia for Chinese children (2021)","volume":"6","year":"2022","journal-title":"Pediatr Investig"},{"issue":"11","key":"10.1016\/j.explore.2025.103277_bib0015","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2174\/0929867043365189","article-title":"Natural medicine: the genus Angelica","volume":"11","author":"Sarker","year":"2004","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.explore.2025.103277_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115365","article-title":"Aqueous extract of Paeoniae Radix Alba (Paeonia lactiflora Pall.) ameliorates DSS-induced colitis in mice by tunning the intestinal physical barrier, immune responses, and microbiota","volume":"294","author":"Yan","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.explore.2025.103277_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116132","article-title":"Extraction, structure and bioactivities of polysaccharides from Rehmannia glutinosa: a review","volume":"305","author":"Bian","year":"2023","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"10.1016\/j.explore.2025.103277_bib0018","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/pmic.201500257","article-title":"Legume proteomics: progress, prospects, and challenges","volume":"16","author":"Rathi","year":"2016","journal-title":"Proteomics"},{"key":"10.1016\/j.explore.2025.103277_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.138969","article-title":"Direct infusion-multiple reaction monitoring cubed (DI-MRM(3)) enables widely targeted bi-omics of Colla Corii Asini (Chinese name: ejiao)","volume":"447","author":"Li","year":"2024","journal-title":"Food Chem"},{"key":"10.1016\/j.explore.2025.103277_bib0020","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.3389\/fphar.2019.01168","article-title":"Chemical Constituents, Pharmacologic Properties, and Clinical Applications of Bletilla striata","volume":"10","author":"Xu","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.explore.2025.103277_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.127933","article-title":"Immunomodulatory activities of polysaccharides from Ganoderma on immune effector cells","volume":"340","author":"Ren","year":"2021","journal-title":"Food Chem"},{"issue":"3","key":"10.1016\/j.explore.2025.103277_bib0022","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.21037\/apm-21-307","article-title":"The treatment of integrated traditional Chinese and Western medicine to cure severe immune thrombocytopenia in a patient in a minimally conscious state: a case report","volume":"10","author":"Wang","year":"2021","journal-title":"Ann Palliat Med"},{"key":"10.1016\/j.explore.2025.103277_bib0023","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1182\/blood-2024-210064","article-title":"The efficacy and safety of huaiqihuang granules in the treatment of childhood chronic primary immune thrombocytopenia: a multicentre, randomized, double-blind, placebo-controlled clinical study","volume":"144","author":"Han","year":"2024","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.explore.2025.103277_bib0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0275122","article-title":"Effectiveness of shengxuexiaoban capsules combined with glucocorticoid therapy for immune thrombocytopenia: a meta-analysis","volume":"17","author":"Ding","year":"2022","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.explore.2025.103277_bib0025","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12016-012-8332-0","article-title":"Traditional Chinese medicine and immune regulation","volume":"44","author":"Ma","year":"2013","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.explore.2025.103277_bib0026","first-page":"1058","article-title":"Clinical research of Ziyin-Heyang Decoction on the treatment of glucocorticoid-dependent primary immune thrombocytopenia","author":"Ji","year":"2020","journal-title":"Chin med lit database"},{"issue":"4","key":"10.1016\/j.explore.2025.103277_bib0027","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0254-6272(12)60004-1","article-title":"Multi-central clinical research into treating 80 cases of chronic thrombocytopenia with qi-supplementing and yin-nourishing therapy and western medicine","volume":"31","author":"Zhou","year":"2011","journal-title":"J Tradit Chin Med"},{"issue":"1","key":"10.1016\/j.explore.2025.103277_bib0028","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jep.2009.04.007","article-title":"An herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesis and thrombopoiesis","volume":"124","author":"Yang","year":"2009","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.explore.2025.103277_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1510976","article-title":"Pharmacological action of Angelica sinensis polysaccharides: a review","volume":"15","author":"Ren","year":"2025","journal-title":"Front Pharmacol"},{"issue":"32","key":"10.1016\/j.explore.2025.103277_bib0030","article-title":"Available chemical constituents and activities of Ganoderma lucidum (Lingzhi or red Reishi) utilizing in disease treatment: a mini review","volume":"9","author":"Vo","year":"2021","journal-title":"J Clin Med Res"}],"updated-by":[{"DOI":"10.1016\/j.explore.2026.103322","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000}}],"container-title":["EXPLORE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550830725001685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550830725001685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:38:15Z","timestamp":1773315495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550830725001685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1550830725001685"],"URL":"https:\/\/doi.org\/10.1016\/j.explore.2025.103277","relation":{},"ISSN":["1550-8307"],"issn-type":[{"value":"1550-8307","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical efficacy of Guishao Shengxue decoction in the treatment of pediatric immune thrombocytopenia: A randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"EXPLORE","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.explore.2025.103277","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103277"}}