{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T01:15:27Z","timestamp":1772154927887,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Korea Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2023-KH139336"],"award-info":[{"award-number":["RS-2023-KH139336"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["EXPLORE"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.explore.2026.103340","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T07:49:04Z","timestamp":1770104944000},"page":"103340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative Korean medicine intervention incorporating angelica gigas for refractory chronic fibromyalgia: A clinical case report"],"prefix":"10.1016","volume":"22","author":[{"given":"Suna","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Jeong","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga Yeong","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaekyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5020-6723","authenticated-orcid":false,"given":"In-Hyuk","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.explore.2026.103340_bib0001","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1001\/jama.2014.3266","article-title":"Fibromyalgia: a clinical review","volume":"311","author":"Clauw","year":"2014","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.explore.2026.103340_bib0002","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3390\/biomedicines8070223","article-title":"Key milestones contributing to the understanding of the mechanisms underlying fibromyalgia","volume":"8","author":"Littlejohn","year":"2020","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.explore.2026.103340_bib0003","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.semarthrit.2016.08.012","article-title":"2016 Revisions to the 2010\/2011 fibromyalgia diagnostic criteria","volume":"46","author":"Wolfe","year":"2016","journal-title":"Semin Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.explore.2026.103340_bib0004","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/j.pain.0000000000001384","article-title":"Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)","volume":"160","author":"Treede","year":"2019","journal-title":"Pain"},{"issue":"10","key":"10.1016\/j.explore.2026.103340_bib0005","first-page":"441","article-title":"Prevalence, epidemiologic profiles and economic costs","volume":"149","author":"Cabo-Meseguer","year":"2017","journal-title":"Med Cl\u00edn (Engl Ed)"},{"issue":"12","key":"10.1016\/j.explore.2026.103340_bib0006","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-071735","article-title":"Trends in the treatment of fibromyalgia in South Korea between 2011 and 2018: a retrospective analysis of cross-sectional health insurance data","volume":"13","author":"Yu","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.explore.2026.103340_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2022.152060","article-title":"The economic burden of fibromyalgia: a systematic literature review","volume":"56","author":"D'Onghia","year":"2022","journal-title":"Semin Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.explore.2026.103340_bib0008","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3390\/medicina60020272","article-title":"Unraveling the complex web of fibromyalgia: a narrative review","volume":"60","author":"Al Sharie","year":"2024","journal-title":"Medicina (Kaunas)"},{"issue":"7","key":"10.1016\/j.explore.2026.103340_bib0009","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.3390\/biomedicines12071543","article-title":"Fibromyalgia: a review of the pathophysiological mechanisms and multidisciplinary treatment strategies","volume":"12","author":"Jurado-Priego","year":"2024","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.explore.2026.103340_bib0010","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00281-018-0672-2","article-title":"Neurogenic inflammation in fibromyalgia","volume":"40","author":"Littlejohn","year":"2018","journal-title":"Semin Immunopathol"},{"issue":"12","key":"10.1016\/j.explore.2026.103340_bib0011","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s11916-024-01277-9","article-title":"Pharmacological treatment of Fibromyalgia syndrome: a practice-based review","volume":"28","author":"Giorgi","year":"2024","journal-title":"Curr Pain Headache Rep"},{"issue":"10","key":"10.1016\/j.explore.2026.103340_bib0012","article-title":"Beyond the pain: a systematic narrative review of the latest advancements in fibromyalgia treatment","volume":"15","author":"Ram","year":"2023","journal-title":"Cureus"},{"issue":"21","key":"10.1016\/j.explore.2026.103340_bib0013","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.3390\/ijms21217877","article-title":"Recent advances in diagnosis, classification, pharmacotherapy and alternative remedies","volume":"21","author":"Fibromyalgia Maffei","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.explore.2026.103340_bib0014","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2147\/JPR.S450735","article-title":"Complementary and alternative medicine to treat fibromyalgia symptoms. A systematic review","volume":"17","author":"Badanta","year":"2024","journal-title":"J Pain Res"},{"issue":"7","key":"10.1016\/j.explore.2026.103340_bib0015","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.3390\/healthcare10071176","article-title":"Efficacy of acupuncture, intravenous lidocaine, and diet in the management of patients with Fibromyalgia: a systematic review and network meta-analysis","volume":"10","author":"Almutairi","year":"2022","journal-title":"Healthcare (Basel)"},{"key":"10.1016\/j.explore.2026.103340_bib0016","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2147\/JPR.S439906","article-title":"Effectiveness of complementary and alternative medicine in Fibromyalgia syndrome: a network meta-analysis","volume":"17","author":"Ye","year":"2024","journal-title":"J Pain Res"},{"issue":"6","key":"10.1016\/j.explore.2026.103340_bib0017","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11726-014-0811-9","article-title":"Efficacy observation of tuina therapy for fibromyalgia syndrome","volume":"12","author":"Zhang","year":"2014","journal-title":"J Acupunct Tuina Sci"},{"issue":"2","key":"10.1016\/j.explore.2026.103340_bib0018","doi-asserted-by":"crossref","first-page":"55","DOI":"10.18325\/jkmr.2017.27.2.55","article-title":"Literature Review of korean Medicine Studies for Fibromyalgia Syndrome (FMS)","volume":"27","author":"Lee","year":"2017","journal-title":"J Korean Med Rehabil"},{"issue":"4","key":"10.1016\/j.explore.2026.103340_bib0019","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1136\/acupmed-2011-010052","article-title":"Traditional Chinese medicine diagnoses in a sample of women with fibromyalgia","volume":"29","author":"Mist","year":"2011","journal-title":"Acupunct Med"},{"issue":"5","key":"10.1016\/j.explore.2026.103340_bib0020","doi-asserted-by":"crossref","first-page":"712","DOI":"10.3390\/ph18050712","article-title":"A direct relationship between \u201cBlood stasis\u201d and fibrinaloid microclots in chronic, inflammatory, and vascular diseases, and some traditional natural products approaches to treatment","volume":"18","author":"Kell","year":"2025","journal-title":"Pharmaceuticals (Basel)"},{"issue":"4","key":"10.1016\/j.explore.2026.103340_bib0021","first-page":"1","article-title":"A review of pharmacological effects of Angelica gigas, Angelica sinensis, Angelica acutiloba and their bioactive compounds","volume":"32","author":"Kim","year":"2011","journal-title":"J Korean Orient Med"},{"key":"10.1016\/j.explore.2026.103340_bib0022","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.2147\/DDDT.S476279","article-title":"Chemistry, pharmacology and therapeutic potential of decursin: a promising natural lead for new drug discovery and development","volume":"18","author":"Muralikrishnan","year":"2024","journal-title":"Drug Des Dev Ther"},{"issue":"9","key":"10.1016\/j.explore.2026.103340_bib0023","first-page":"939","article-title":"Antithrombotic effect of the ethanol extract of Angelica gigas Nakai (AGE 232)","volume":"11","author":"Bravo","year":"2021","journal-title":"Life (Basel)"},{"key":"10.1016\/j.explore.2026.103340_bib0024","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jclinepi.2017.04.026","article-title":"CARE guidelines for case reports: explanation and elaboration document","volume":"89","author":"Riley","year":"2017","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"10.1016\/j.explore.2026.103340_bib0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.56986\/pim.2023.02.003","article-title":"Clinical research on pharmacopuncture in Korea: a scoping review","volume":"2","author":"Kim","year":"2023","journal-title":"Perspect Integr Med"},{"key":"10.1016\/j.explore.2026.103340_bib0026","first-page":"451","volume":"xv","author":"Kendall","year":"1993"},{"key":"10.1016\/j.explore.2026.103340_bib0027","series-title":"Measurement of Joint Motion: A Guide to Goniometry","author":"Norkin","year":"2016"},{"issue":"3","key":"10.1016\/j.explore.2026.103340_bib0028","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2024-004466","article-title":"Long versus short-term opioid therapy for fibromyalgia syndrome and risk of depression, sleep disorders and suicidal ideation: a population-based, propensity-weighted cohort study","volume":"10","author":"Hurtado","year":"2024","journal-title":"RMD Open"},{"key":"10.1016\/j.explore.2026.103340_bib0029","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9869250","article-title":"Acupuncture for fibromyalgia: an open-label pragmatic study on effects on disease severity, neuropathic pain features, and pain catastrophizing","volume":"2020","author":"Di Carlo","year":"2020","journal-title":"Evid Based Complement Altern Med"},{"issue":"11","key":"10.1016\/j.explore.2026.103340_bib0030","article-title":"Early-phase intervention with traditional Japanese acupuncture and moxibustion for fibromyalgia: a case report","volume":"16","author":"Masuda","year":"2024","journal-title":"Cureus"},{"issue":"9","key":"10.1016\/j.explore.2026.103340_bib0031","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3390\/brainsci14090869","article-title":"Electroacupuncture reduced fibromyalgia-pain-like behavior through inactivating transient receptor potential V1 and interleukin-17 in intermittent cold stress mice model","volume":"14","author":"Yeh","year":"2024","journal-title":"Brain Sci"},{"issue":"8","key":"10.1016\/j.explore.2026.103340_bib0032","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.3390\/molecules26082161","article-title":"Therapeutic effects of decursin and Angelica gigas Nakai root extract in gerbil brain after transient ischemia via protecting BBB leakage and astrocyte endfeet damage","volume":"26","author":"Lee","year":"2021","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.explore.2026.103340_bib0033","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.3892\/mmr.2017.6404","article-title":"Inhibitory effect of Angelica gigas on cold\u2011induced RhoA activation in vascular cells","volume":"15","author":"Lee","year":"2017","journal-title":"Mol Med Rep"},{"issue":"11","key":"10.1016\/j.explore.2026.103340_bib0034","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1111\/1750-3841.15476","article-title":"Optimization of extraction conditions of Angelica archangelica extract and activity evaluation in experimental fibromyalgia","volume":"85","author":"Kaur","year":"2020","journal-title":"J Food Sci"},{"key":"10.1016\/j.explore.2026.103340_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1378208","article-title":"Adverse events associated with herbal medicine products reported in the Korea Adverse Event Reporting System from 2012 to 2021","volume":"15","author":"Choi","year":"2024","journal-title":"Front Pharmacol"}],"container-title":["EXPLORE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550830726000273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550830726000273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:23:55Z","timestamp":1772151835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550830726000273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1550830726000273"],"URL":"https:\/\/doi.org\/10.1016\/j.explore.2026.103340","relation":{},"ISSN":["1550-8307"],"issn-type":[{"value":"1550-8307","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative Korean medicine intervention incorporating angelica gigas for refractory chronic fibromyalgia: A clinical case report","name":"articletitle","label":"Article Title"},{"value":"EXPLORE","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.explore.2026.103340","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103340"}}