{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:01:20Z","timestamp":1759683680958},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/j.expneurol.2004.01.012","type":"journal-article","created":{"date-parts":[[2004,3,6]],"date-time":"2004-03-06T10:39:45Z","timestamp":1078569585000},"page":"178-189","source":"Crossref","is-referenced-by-count":9,"title":["Loss of D 3 receptors in the zitter mutant rat is not reversed by l -dopa treatment"],"prefix":"10.1016","volume":"187","author":[{"given":"Jeffrey N.","family":"Joyce","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.C.","family":"Der","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Renish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Osredkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Hagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Reploge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Sakakibara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2004.01.012_BIB1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/39885","article-title":"Anterograde transport of brain-derived neurotrophic factor and its role in the brain","volume":"389","author":"Altar","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1001\/archneur.59.1.102","article-title":"Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response","volume":"59","author":"Apaydin","year":"2002","journal-title":"Arch. Neurol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0165-0270(90)90139-7","article-title":"The use of 3H standards in 125I autoradiography","volume":"32","author":"Artymyshyn","year":"1990","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB4","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nm875","article-title":"Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function","volume":"9","author":"B\u00e9zard","year":"2003","journal-title":"Nat. Med"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/mds.870080202","article-title":"Suppressive effect of l-dopa on dopamine cells remaining in the ventral tegmental area of rats previously exposed to the neurotoxin 6-hydroxydopamine","volume":"8","author":"Blunt","year":"1993","journal-title":"Mov. Disord"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB6","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1073\/pnas.94.7.3363","article-title":"Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa","volume":"94","author":"Bordet","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB7","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/jnnp.68.6.685","article-title":"Dopamine agonists: their role in the treatment of Parkinson's disease","volume":"68","author":"Brooks","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/jnnp.58.1.51","article-title":"Which factors predict cognitive decline in Parkinson's disease?","volume":"58","author":"Caparros-Lefebvre","year":"1995","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev.pa.33.040193.001433","article-title":"Molecular diversity of the dopamine receptors","volume":"33","author":"Civelli","year":"1993","journal-title":"Annu. Rev. Pharmacol. Toxicol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB10","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1523\/JNEUROSCI.17-07-02295.1997","article-title":"Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport","volume":"17","author":"Conner","year":"1997","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB11","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/ana.410240303","article-title":"Motor fluctuations in Parkinson's disease: central pathophysiological mechanisms, Part I","volume":"24","author":"Fabbrini","year":"1988","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0006-8993(94)90373-5","article-title":"Antioxidant enzymes in the brain of zitter rats: abnormal metabolism of oxygen species and its relevance to pathogenic changes in the brain of zitter rats with genetic spongiform encephalopathy","volume":"653","author":"Gomi","year":"1994","journal-title":"Brain Res"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB13","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1046\/j.1471-4159.2003.01600.x","article-title":"Pattern of levodopa-induced striatal changes is different in normal and MPTP-lesioned mice","volume":"84","author":"Gross","year":"2003","journal-title":"J. Neurochem"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35075076","article-title":"BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization","volume":"411","author":"Guillin","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0893-133X(98)00066-9","article-title":"Distribution of dopamine D3 receptor expressing neurons in the human forebrain: comparison with D2 receptor expressing neurons","volume":"20","author":"Gurevich","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB16","first-page":"587","article-title":"Developmental regulation of expression of the D3 dopamine receptor in rat nucleus accumbens and islands of Calleja","volume":"289","author":"Gurevich","year":"1999","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB17","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1212\/WNL.51.2_Suppl_2.S2","article-title":"Biochemical aspects of Parkinson's disease","volume":"51","author":"Hornykiewicz","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB18","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1212\/WNL.54.8.1596","article-title":"A 10-year study of the incidence of and factors predicting dementia in Parkinson's disease","volume":"54","author":"Hughes","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB19","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1212\/WNL.54.10.1916","article-title":"Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease","volume":"54","author":"Hurtig","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB20","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0896-6273(91)90234-Q","article-title":"BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF","volume":"6","author":"Isackson","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF03159935","article-title":"Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway","volume":"14","author":"Jellinger","year":"1991","journal-title":"Mol. Chem. Neuropathol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0014-4886(91)90016-6","article-title":"Differential response of striatal dopamine and muscarinic cholinergic receptor subtypes to the loss of dopamine: I. Effects of intranigral or intracerebroventricular 6-hydroxydopamine lesions of the mesostriatal dopamine system","volume":"113","author":"Joyce","year":"1991","journal-title":"Exp. Neurol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/syn.1035","article-title":"D2 but not D3 receptors are elevated after 9 or 11 months chronic haloperidol treatment: influence of withdrawal period","volume":"40","author":"Joyce","year":"2001","journal-title":"Synapse"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0163-7258(01)00139-5","article-title":"Dopamine D3 receptor as a therapeutic target for antipsychotic and antiparkinsonian drugs","volume":"90","author":"Joyce","year":"2001","journal-title":"Pharmacol. Ther"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB25","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0006-8993(86)91345-4","article-title":"Hemiparkinsonism in a monkey after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is associated with regional ipsilateral changes in striatal dopamine D-2 receptor density","volume":"382","author":"Joyce","year":"1986","journal-title":"Brain Res"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB26","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1097\/00001756-200007140-00022","article-title":"The zitter mutant rat exhibits loss of D3 receptors with degeneration of the dopamine system","volume":"11","author":"Joyce","year":"2000","journal-title":"NeuroReport"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0006-8993(02)03396-6","article-title":"Loss of response to levodopa in Parkinson's disease and co-occurrence with dementia: role of D3 and not D2 receptors","volume":"955","author":"Joyce","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0014-4886(03)00353-4","article-title":"Neuroprotective effects of the novel D3\/D2 receptor agonist and anitparkinson agent S32504, in vitro against 1-methyl-4-phenylpyridinium (MPP+) and in vivo against 1-methyl- 4-phenyl-1,2,2,6-tetrahydropyridine (MPTP): a comparison to ropinirole","volume":"184","author":"Joyce","year":"2003","journal-title":"Exp. Neurol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/syn.10309","article-title":"Methamphetamine induced loss of striatal dopamine innervation in BNDF heterozygote mice does not further alter D3 receptor concentrations","volume":"52","author":"Joyce","year":"2004","journal-title":"Synapse"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0092-8674(90)90476-U","article-title":"The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain","volume":"61","author":"Klein","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB31","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF01179978","article-title":"Spongy degeneration in the zitter rat: ultrastructural and immunohistochemical studies","volume":"24","author":"Kondo","year":"1995","journal-title":"J. Neurocytol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0006-2952(96)00731-9","article-title":"Dopamine- and l-beta-3,4-dihydroxyphenylalanine hydrochloride (l-dopa)- induced cytotoxicity towards catecholaminergic neuroblastoma SH-SY5Y cells. Effects of oxidative stress and antioxidative factors","volume":"53","author":"Lai","year":"1997","journal-title":"Biochem. Pharmacol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB33","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1073\/pnas.92.5.1719","article-title":"A paradoxical regulation of the dopamine D3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons","volume":"92","author":"L\u00e9vesque","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB34","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1001\/archneur.1995.00540310069018","article-title":"The frequency and associated risk factors for dementia in patients with Parkinson's disease","volume":"52","author":"Marder","year":"1995","journal-title":"Arch. Neurol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s004019900168","article-title":"Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease","volume":"100","author":"Mattila","year":"2000","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB36","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1006\/exnr.1997.6418","article-title":"Specific A10 dopaminergic nuclei in the midbrain degenerate in Parkinson's disease","volume":"144","author":"McRitchie","year":"1997","journal-title":"Exp. Neurol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB37","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1046\/j.1460-9568.1998.00264.x","article-title":"Associative and limbic regions of monkey striatum express high levels of dopamine D3 receptors: effects of MPTP and dopamine agonist replacement therapies","volume":"10","author":"Morissette","year":"1998","journal-title":"Eur. J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB38","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/ana.410240304","article-title":"Motor fluctuations in Parkinson's disease: central pathophysiological mechanisms, Part II","volume":"24","author":"Mouradian","year":"1988","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB39","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/ana.410430504","article-title":"Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions","volume":"43","author":"Murer","year":"1998","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB40","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/ana.410370306","article-title":"Damage to dopamine systems differs between Parkinson's disease and Alzheimer's disease with parkinsonism","volume":"37","author":"Murray","year":"1995","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB41","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3940(99)00532-7","article-title":"Age-related decrease in brain-derived neurotrophic factor gene expression in the brain of the zitter rat with genetic spongiform encephalopathy","volume":"271","author":"Muto","year":"1999","journal-title":"Neurosci. Lett"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB42","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0006-8993(95)00988-7","article-title":"Acute l-DOPA pretreatment potentiates 6-hydroxydopamine-induced toxic effects on nigro-striatal dopamine neurons in mice","volume":"701","author":"Naudin","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB43","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1986"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB44","first-page":"113","article-title":"Alterations of striatal dopamine D2 receptors contribute to deteriorated response to l-dopa in Parkinson's disease: a [123I]-IBZM SPET study","volume":"45","author":"Pizzolato","year":"1995","journal-title":"J. Neural. Transm., Suppl"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB45","first-page":"413","article-title":"Predictive factors for cognitive deterioration and dementia in Parkinson's disease","volume":"45","author":"Portin","year":"1987","journal-title":"Adv. Neurol"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB46","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0306-4522(00)00130-5","article-title":"Expression of D3 receptor messenger RNA and binding sites in monkey striatum and substantia nigra after nigrostriatal degeneration: effect of levodopa treatment","volume":"98","author":"Quik","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB47","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/mds.870130506","article-title":"Dopamine D3 receptor is decreased and D2 receptor is elevated in the striatum of Parkinson's disease","volume":"13","author":"Ryoo","year":"1998","journal-title":"Mov. Disord"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB48","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1097\/00001756-199507310-00004","article-title":"Superoxide-dependent depletion of reduced glutathione by l-DOPA and dopamine. Relevance to Parkinson's disease","volume":"6","author":"Spencer","year":"1995","journal-title":"NeuroReport"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB49","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1212\/WNL.43.9.1690","article-title":"Antecedent clinical features associated with dementia in Parkinson's disease","volume":"43","author":"Stern","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB50","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/(SICI)1098-2396(199809)30:1<62::AID-SYN8>3.0.CO;2-I","article-title":"Age-related degeneration of the serotoninergic fibers in the zitter rat brain","volume":"30","author":"Ueda","year":"1998","journal-title":"Synapse"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB51","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0306-4522(99)00451-0","article-title":"Age-related dopamine deficiency in the mesostriatal dopamine system of zitter mutant rats: regional fiber vulnerability in the striatum and the olfactory tubercle","volume":"95","author":"Ueda","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB52","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0079-6123(02)36025-4","article-title":"Vulnerability of monoaminergic neurons in the brainstem of the zitter rat in oxidative stress","volume":"136","author":"Ueda","year":"2002","journal-title":"Prog. Brain Res"},{"key":"10.1016\/j.expneurol.2004.01.012_BIB53","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0006-8993(01)02513-6","article-title":"Changes in striatal dopamine D3 receptor regulation during expression of and recovery from MPTP-induced parkinsonism","volume":"905","author":"Wade","year":"2001","journal-title":"Brain Res"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488604000238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488604000238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T20:27:26Z","timestamp":1550176046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488604000238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0014488604000238"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2004.01.012","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}