{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:31:06Z","timestamp":1768275066620,"version":"3.49.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.expneurol.2004.05.010","type":"journal-article","created":{"date-parts":[[2004,7,6]],"date-time":"2004-07-06T11:17:14Z","timestamp":1089112634000},"page":"66-77","source":"Crossref","is-referenced-by-count":8,"title":["Valacyclovir treatment ameliorates the persistently increased pentylenetetrazol-induced seizure susceptibility in mice with herpes simplex virus type 1 infection"],"prefix":"10.1016","volume":"189","author":[{"given":"Hung-Ming","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Ching","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiung-Chun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Heng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Jane","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Liang","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuei-Sen","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2004.05.010_BIB1","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1212\/WNL.38.9.1407","article-title":"The risk of unprovoked seizures after encephalitis and meningitis","volume":"38","author":"Annegers","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0306-4522(91)90380-7","article-title":"Synaptic reorganization by mossy fibers in human epileptic fascia dentata","volume":"42","author":"Babb","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/0092-8674(88)90419-9","article-title":"Latency comes of age for herpesviruses","volume":"52","author":"Baichwal","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1517\/14656566.3.1.51","article-title":"Valacyclovir in the treatment of genital herpes and herpes zoster","volume":"3","author":"Baker","year":"2002","journal-title":"Expert Opin. Pharmacother"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0306-4522(85)90299-4","article-title":"Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy","volume":"14","author":"Ben-Ari","year":"1985","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB7","series-title":"Epilepsy and the Reticular Formation: The Role of the Reticular Core in Convulsive Seizures","first-page":"137","article-title":"Effect of lesions on seizures in experimental animals","author":"Browning","year":"1987"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0014-4886(91)90070-S","article-title":"Effect of norepinephrine depletion on audiogenic-like seizures elicited by microinfusion of an excitant amino acid into the inferior colliculus of normal rats","volume":"112","author":"Browning","year":"1991","journal-title":"Exp. Neurol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB9","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1523\/JNEUROSCI.11-09-02795.1991","article-title":"Mossy fiber synaptic reorganization induced by kindling: time course of development, progression, and permanence","volume":"11","author":"Cavazos","year":"1991","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB10","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1128\/JVI.71.8.5878-5884.1997","article-title":"A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus","volume":"71","author":"Chen","year":"1997","journal-title":"J. Virol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB11","doi-asserted-by":"crossref","DOI":"10.1111\/j.0013-9580.2004.37403.x","article-title":"Seizure, neuronal loss, and mossy fiber sprouting in herpes simplex virus type-1-infected organotypic hippocampal cultures","author":"Chen","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/infdis\/142.3.451","article-title":"Combined effects of acycloguanosine and humoral antibodies in experimental encephalitis due to Herpesvirus hominis","volume":"142","author":"Cho","year":"1980","journal-title":"J. Infect. Dis"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB59","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1128\/JVI.53.2.477-488.1985","article-title":"Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus","volume":"53","author":"Coen","year":"1985","journal-title":"J. Virol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB13","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1073\/pnas.86.12.4736","article-title":"Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate","volume":"86","author":"Coen","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB14","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1212\/WNL.48.2.425","article-title":"Adult-onset temporal lobe epilepsy associated with smoldering herpes simplex 2 infection","volume":"48","author":"Cornford","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(92)90454-C","article-title":"Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study","volume":"222","author":"Cutrufo","year":"1992","journal-title":"Eur. J. Pharmacol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/ana.410050103","article-title":"An explanation for the localization of herpes simplex encephalitis?","volume":"5","author":"Davis","year":"1979","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB17","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0006-8993(89)91434-0","article-title":"Anticonvulsant action of GABA receptor blockade in the nigrotectal target region","volume":"477","author":"Dean","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0165-3806(92)90164-R","article-title":"An experimental model of generalized seizures for the measurement of local cerebral glucose utilization in the immature rat. I. Behavioral characterization and determination of lumped constant","volume":"69","author":"El Hamdi","year":"1992","journal-title":"Dev. Brain Res"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0014-4886(87)90087-2","article-title":"Increased susceptibility to hippocampal and amygdala kindling following intrahippocampal kainic acid","volume":"97","author":"Feldblum","year":"1987","journal-title":"Exp. Neurol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB20","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1523\/JNEUROSCI.19-16-06733.1999","article-title":"Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice","volume":"19","author":"Ferraro","year":"1999","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB21","series-title":"Neuroinflammation: Mechanisms and Management","first-page":"171","article-title":"Neuroinflammation-mediated neurotoxin production in neurodegenerative diseases","author":"Floyd","year":"2003"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0140-6736(85)92043-4","article-title":"Herpes simplex viral DNA in temporal lobe epilepsy","volume":"1","author":"Gannicliffe","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0006-8993(92)91316-7","article-title":"Activation of the dentate gyrus by pentylenetetrazol evoked seizures induces mossy fiber synaptic reorganization","volume":"593","author":"Golarai","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB24","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0014-2999(77)90086-3","article-title":"Effect of anticonvulsants on seizures developing in the course of daily administration of pentetrazol to rats","volume":"45","author":"Ito","year":"1977","journal-title":"Eur. J. Pharmacol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0002-9343(82)90077-8","article-title":"Optimal treatment of herpes simplex virus encephalitis in mice with oral acyclovir","volume":"73","author":"Kern","year":"1982","journal-title":"Am. J. Med"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0022-510X(82)90227-1","article-title":"Neuron to neuron transmission of herpes simplex virus. Transport of virus from skin to brainstem nuclei","volume":"54","author":"Kristensson","year":"1982","journal-title":"J. Neurol. Sci"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB27","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1086\/314962","article-title":"The comparative effects of famciclovir and valacyclovir on herpes simplex virus type 1 infection, latency, and reactivation in mice","volume":"180","author":"LeBlanc","year":"1999","journal-title":"J. Infect. Dis"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB28","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1128\/JVI.63.2.759-768.1989","article-title":"Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency","volume":"63","author":"Leib","year":"1989","journal-title":"J. Virol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0165-5728(97)00159-8","article-title":"Evidence for deficiencies in intracerebral cytokine production, adhesion molecule induction, and T cell recruitment in herpes simplex virus type-2 infected mice","volume":"81","author":"Lewandowski","year":"1998","journal-title":"J. Neuroimmunol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0165-5728(94)90143-0","article-title":"Alteration of intracerebral cytokine production in mice infected with herpes simplex virus types 1 and 2","volume":"55","author":"Lewandowski","year":"1994","journal-title":"J. Neuroimmunol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0165-5728(97)00160-4","article-title":"Evidence that deficient IFN-gamma production is a biological basis of herpes simplex virus type-2 neurovirulence","volume":"81","author":"Lewandowski","year":"1998","journal-title":"J. Neuroimmunol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0920-1211(91)90062-K","article-title":"The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models","volume":"8","author":"L\u00f6scher","year":"1991","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0166-3542(90)90047-B","article-title":"Comparison of antiviral efficacies of 1-beta-d-arabinofuranosyl-E-5-(2-bromovinyl)uracil (brovavir) and acyclovir against herpes simplex virus type 1 infections in mice","volume":"14","author":"Machida","year":"1990","journal-title":"Antiviral Res"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB34","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1212\/WNL.42.8.1513","article-title":"Characteristics of intractable seizures following meningitis and encephalitis","volume":"42","author":"Marks","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB35","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/jnnp.63.3.321","article-title":"Herpes simplex encephalitis treated with acyclovir: diagnosis and long term outcome","volume":"63","author":"McGrath","year":"1997","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB36","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1528-1157.1993.tb02123.x","article-title":"Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting","volume":"34","author":"Mello","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB37","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/271676a0","article-title":"Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells","volume":"271","author":"Nadler","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB38","first-page":"12","article-title":"Recent developments in herpesvirus therapy","volume":"8","author":"Naesens","year":"2001","journal-title":"Herpes"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB39","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1056\/NEJM196712142772401","article-title":"Herpesvirus infections of the human central nervous system","volume":"277","author":"Olson","year":"1967","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB40","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1093\/infdis\/140.5.802","article-title":"Acylovir in oral and ganglionic herpes simplex virus infections","volume":"140","author":"Park","year":"1979","journal-title":"J. Infect. Dis"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB41","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0006-8993(80)90938-5","article-title":"Spontaneously recurrent seizures after intracerebral injections of kainic acid in rat: a possible model of human temporal lobe epilepsy","volume":"200","author":"Pisa","year":"1980","journal-title":"Brain Res"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB42","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1086\/341405","article-title":"Outcome of and prognostic factors for herpes simplex encephalitis in adult patients: results of a multicenter study","volume":"35","author":"Raschilas","year":"2002","journal-title":"Clin. Infect. Dis"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/ana.410210106","article-title":"Risk factors of complex partial seizures: a population-based case-control study","volume":"21","author":"Rocca","year":"1987","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB44","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1001\/archneur.1997.00550200020005","article-title":"Presence of herpes simplex DNA in surgical tissue from human epileptic seizure foci detected by polymerase chain reaction: preliminary study","volume":"54","author":"Sanders","year":"1997","journal-title":"Arch. Neurol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB45","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0006-8993(88)90998-5","article-title":"Neurovirulence in an experimental focal herpes encephalitis: relationship to observed seizures","volume":"440","author":"Schlitt","year":"1988","journal-title":"Brain Res"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB46","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s004150170155","article-title":"Viral infections of the CNS with special emphasis on herpes simplex infections","volume":"248","author":"Schmutzhard","year":"2001","journal-title":"J. Neurol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB48","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1528-1157.1993.tb02374.x","article-title":"Rapid cessation of focally induced generalized seizures in rats through microinfusion of lidocaine hydrochloride into the focus","volume":"34","author":"Smith","year":"1993","journal-title":"Epilepsia"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0301-0082(94)90019-1","article-title":"Kainic acid seizures in the rat","volume":"42","author":"Sperk","year":"1994","journal-title":"Prog. Neurobiol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0006-8993(85)90159-3","article-title":"Kainic acid-induced seizures: dose-relationship of behavioural, neurochemical and histopathological changes","volume":"338","author":"Sperk","year":"1985","journal-title":"Brain Res"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB51","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00005072-198903000-00004","article-title":"Neurovirulence of two clonally related herpes simplex virus type 1 strains in a rabbit seizure model","volume":"48","author":"Stroop","year":"1989","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB52","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/ana.410260303","article-title":"Mossy fiber synaptic reorganization in the epileptic human temporal lobe","volume":"26","author":"Sutula","year":"1989","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB53","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1523\/JNEUROSCI.05-04-01016.1985","article-title":"Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats","volume":"5","author":"Tauck","year":"1985","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB54","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1056\/NEJM199007263230406","article-title":"Viral encephalitis","volume":"323","author":"Whitley","year":"1990","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB55","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1056\/NEJM197708112970601","article-title":"Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis. National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study","volume":"297","author":"Whitley","year":"1977","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB56","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1056\/NEJM198102053040602","article-title":"Herpes simplex encephalitis: vidarabine therapy and diagnostic problems","volume":"304","author":"Whitley","year":"1981","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB57","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1056\/NEJM198601163140303","article-title":"Vidarabine versus acyclovir therapy in herpes simplex encephalitis","volume":"314","author":"Whitley","year":"1986","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.expneurol.2004.05.010_BIB58","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1111\/j.1460-9568.2003.03075.x","article-title":"Herpes simplex virus type 1 inoculation enhances hippocampal excitability and seizure susceptibility in mice","volume":"18","author":"Wu","year":"2003","journal-title":"Eur. J. Neurosci"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488604001815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488604001815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T12:56:59Z","timestamp":1585832219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488604001815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0014488604001815"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2004.05.010","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}