{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:59:14Z","timestamp":1791421154659,"version":"4.3.3"},"reference-count":84,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS042794"],"award-info":[{"award-number":["NS042794"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS020402"],"award-info":[{"award-number":["NS020402"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1016\/j.expneurol.2004.06.015","type":"journal-article","created":{"date-parts":[[2004,8,10]],"date-time":"2004-08-10T15:55:27Z","timestamp":1092153327000},"page":"356-372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Overexpression of glial cell line-derived neurotrophic factor in the CNS rescues motoneurons from programmed cell death and promotes their long-term survival following axotomy"],"prefix":"10.1016","volume":"190","author":[{"given":"Zhongqiu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald W.","family":"Oppenheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Prevette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"Evenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Parsadanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2004.06.015_bb0005","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn812","article-title":"The GDNF family: signalling, biological functions and therapeutic value","volume":"3","author":"Airaksinen","year":"2002","journal-title":"Nat. Rev., Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0010","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1006\/exnr.1998.6878","article-title":"Neuroprotection of spinal motoneurons following targeted transduction with an adenoviral vector carrying the gene for glial cell line-derived neurotrophic factor","volume":"153","author":"Baumgartner","year":"1998","journal-title":"Exp. Neurol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0015","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/(SICI)1097-4547(19981215)54:6<766::AID-JNR4>3.0.CO;2-A","article-title":"Permanent rescue of lesioned neonatal motoneurons and enhanced axonal regeneration by adenovirus-mediated expression of glial cell-line-derived neurotrophic factor","volume":"54","author":"Baumgartner","year":"1998","journal-title":"J. Neurosci. Res"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0020","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/meth.1996.0113","article-title":"GFAP transgenic mice","volume":"10","author":"Brenner","year":"1996","journal-title":"Methods"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0025","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1523\/JNEUROSCI.14-03-01030.1994","article-title":"GFAP promoter directs astrocyte-specific expression in transgenic mice","volume":"14","author":"Brenner","year":"1994","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0030","series-title":"Cell Death and Diseases of the Nervous System","first-page":"145","article-title":"Cellular interactions that regulate cell death in the developing vertebrate nervous system","author":"Burek","year":"1998"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0035","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0896-6273(00)80514-0","article-title":"GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney","volume":"21","author":"Cacalano","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0040","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0014-4886(03)00023-2","article-title":"Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats","volume":"181","author":"Chan","year":"2003","journal-title":"Exp. Neurol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0045","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1044-7431(03)00098-8","article-title":"GDNF increases the survival of developing oculomotor neurons through a target-derived mechanism","volume":"24","author":"Chen","year":"2003","journal-title":"Mol. Cell. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0050","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0091-679X(08)61933-0","article-title":"Neuron death in vertebrate development: in vitro methods","volume":"46","author":"Clarke","year":"1995","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0055","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.1086071","article-title":"Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice","volume":"302","author":"Clement","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0060","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0896-6273(00)80173-7","article-title":"BAX is required for neuronal death after trophic factor deprivation and during development","volume":"17","author":"Deckwerth","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0065","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/sj.gt.3302222","article-title":"Delivery of GDNF by an E1,E3\/E4 deleted adenoviral vector and driven by a GFAP promoter prevents dopaminergic neuron degeneration in a rat model of Parkinson's disease","volume":"11","author":"Do Thi","year":"2004","journal-title":"Gene Ther"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0070","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1073\/pnas.91.8.3309","article-title":"Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death","volume":"91","author":"Dubois-Dauphin","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0075","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1006\/nbdi.1999.0266","article-title":"Experimental models of amyotrophic lateral sclerosis","volume":"6","author":"Elliott","year":"1999","journal-title":"Neurobiol. Dis"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0080","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1212\/WNL.47.4_Suppl_2.47S","article-title":"Motor neuron growth factors","volume":"47","author":"Elliott","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0085","series-title":"Cell Death and Diseases of the Nervous System","first-page":"181","article-title":"Axotomy-induced motor neuron death","author":"Elliott","year":"1998"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jnr.490320102","article-title":"Isolation of cDNA clones encoding rat glial fibrillary acidic protein: expression in astrocytes and in Schwann cells","volume":"32","author":"Feinstein","year":"1992","journal-title":"J. Neurosci. Res"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0095","doi-asserted-by":"crossref","first-page":"8854","DOI":"10.1523\/JNEUROSCI.23-26-08854.2003","article-title":"Cardiotrophin-like cytokine\/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo","volume":"23","author":"Forger","year":"2003","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0100","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.1523\/JNEUROSCI.20-13-04992.2000","article-title":"GFRalpha 1 is required for development of distinct subpopulations of motoneuron","volume":"20","author":"Garces","year":"2000","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0105","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/(SICI)1096-9861(19980202)391:1<42::AID-CNE4>3.0.CO;2-R","article-title":"Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous system","volume":"391","author":"Glazner","year":"1998","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0110","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/(SICI)1096-9861(19980817)398:1<139::AID-CNE9>3.0.CO;2-2","article-title":"Expression of neurturin, GDNF, and their receptors in the adult mouse CNS","volume":"398","author":"Golden","year":"1998","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0115","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1006\/exnr.1999.7127","article-title":"Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse","volume":"158","author":"Golden","year":"1999","journal-title":"Exp. Neurol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0120","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1523\/JNEUROSCI.20-02-00660.2000","article-title":"Restricted expression of G86R Cu\/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration","volume":"20","author":"Gong","year":"2000","journal-title":"J. Neurosci"},{"issue":"Suppl 1","key":"10.1016\/j.expneurol.2004.06.015_bb0125","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/S0022-510X(97)00247-5","article-title":"The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies","volume":"152","author":"Gurney","year":"1997","journal-title":"J. Neurol. Sci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0130","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/1531-8249(199903)45:3<296::AID-ANA4>3.0.CO;2-8","article-title":"Therapeutic benefit of ciliary neurotrophic factor in progressive motor neuronopathy depends on the route of delivery","volume":"45","author":"Haase","year":"1999","journal-title":"Ann. Neurol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0135","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/1096-9861(20001030)426:4<587::AID-CNE7>3.0.CO;2-R","article-title":"Differential regulation of trophic factor receptor mRNAs in spinal motoneurons after sciatic nerve transection and ventral root avulsion in the rat","volume":"426","author":"Hammarberg","year":"2000","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0140","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/(SICI)1096-9861(19990628)409:2<169::AID-CNE1>3.0.CO;2-O","article-title":"Analysis of cell death in the trochlear nucleus of the chick embryo: calibration of the optical disector counting method reveals systematic bias","volume":"409","author":"Hatton","year":"1999","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0145","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.7973664","article-title":"GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle","volume":"266","author":"Henderson","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0150","series-title":"Cell Death and Diseases of the Nervous System","first-page":"593","article-title":"Early experiences with trophic factors as drug for neurological diseases: brain-derived neurotrophic factor and ciliary neurotrophic factor for ALS","author":"Hilt","year":"1998"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0155","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/cne.10529","article-title":"Differential expression of the GDNF family receptors RET and GFRalpha1, 2, and 4 in subsets of motoneurons: a relationship between motoneuron birthdate and receptor expression","volume":"456","author":"Homma","year":"2003","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0160","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1523\/JNEUROSCI.20-15-05587.2000","article-title":"Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus","volume":"20","author":"Hottinger","year":"2000","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0165","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF01148114","article-title":"Molecular identity, distribution and heterogeneity of glial fibrillary acidic protein: an immunoblotting and immunohistochemical study of Schwann cells, satellite cells, enteric glia and astrocytes","volume":"13","author":"Jessen","year":"1984","journal-title":"J. Neurocytol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0170","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.1086137","article-title":"Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model","volume":"301","author":"Kaspar","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0175","first-page":"248.8","article-title":"Glial overexpression of GDNF protects facial motoneurons against axotomy-induced cell death","volume":"23","author":"Keller-Peck","year":"1997","journal-title":"Abstr.-Soc. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0180","doi-asserted-by":"crossref","first-page":"6136","DOI":"10.1523\/JNEUROSCI.21-16-06136.2001","article-title":"Glial cell line-derived neurotrophic factor administration in postnatal life results in motor unit enlargement and continuous synaptic remodeling at the neuromuscular junction","volume":"21","author":"Keller-Peck","year":"2001","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0185","series-title":"Cell Death and Diseases of the Nervous System","first-page":"545","article-title":"Trophic factors as therapeutic agents for diseases characterized by neuronal death","author":"Koliatsos","year":"1998"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0190","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/cne.903420105","article-title":"Ventral root avulsion: an experimental model of death of adult motor neurons","volume":"342","author":"Koliatsos","year":"1994","journal-title":"J. Comp. Neurol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0195","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/neu.480270410","article-title":"Differential regulation of motor neuron survival and choline acetyltransferase expression following axotomy","volume":"27","author":"Kou","year":"1995","journal-title":"J. Neurobiol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1515\/REVNEURO.1996.7.3.165","article-title":"Therapeutic potentials for glial cell line-derived neurotrophic factor (GDNF) based upon pharmacological activities in the CNS","volume":"7","author":"Lapchak","year":"1996","journal-title":"Rev. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0205","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/(SICI)1098-1136(199912)28:3<215::AID-GLIA5>3.0.CO;2-C","article-title":"Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS)","volume":"28","author":"Levine","year":"1999","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0210","doi-asserted-by":"crossref","first-page":"9771","DOI":"10.1073\/pnas.92.21.9771","article-title":"Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor","volume":"92","author":"Li","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0215","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1126\/science.8493557","article-title":"GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons","volume":"260","author":"Lin","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0220","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0092-8674(00)81770-5","article-title":"Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression","volume":"95","author":"Lin","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0225","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1523\/JNEUROSCI.23-13-05416.2003","article-title":"Glial reactivity in ciliary neurotrophic factor-deficient mice after optic nerve lesion","volume":"23","author":"Martin","year":"2003","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0230","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1097\/00001756-199705060-00034","article-title":"Long-term survival effects of GDNF on neonatal rat facial motoneurons after axotomy","volume":"8","author":"Matheson","year":"1997","journal-title":"NeuroReport"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0235","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1046\/j.1460-9568.2000.00924.x","article-title":"A dynamic regulation of GDNF-family receptors correlates with a specific trophic dependency of cranial motor neuron subpopulations during development","volume":"12","author":"Mikaels","year":"2000","journal-title":"Eur. J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0240","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1089\/10430349950017536","article-title":"Intramuscular grafts of myoblasts genetically modified to secrete glial cell line-derived neurotrophic factor prevent motoneuron loss and disease progression in a mouse model of familial amyotrophic lateral sclerosis","volume":"10","author":"Mohajeri","year":"1999","journal-title":"Hum. Gene Ther"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0245","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/382076a0","article-title":"Renal and neuronal abnormalities in mice lacking GDNF","volume":"382","author":"Moore","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0250","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1111\/j.1460-9568.1997.tb01499.x","article-title":"Differential regulation of mRNAs for GDNF and its receptors Ret and GDNFR alpha after sciatic nerve lesion in the mouse","volume":"9","author":"Naveilhan","year":"1997","journal-title":"Eur. J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0255","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1126\/science.279.5357.1725","article-title":"Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle","volume":"279","author":"Nguyen","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0260","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1523\/JNEUROSCI.21-09-03024.2001","article-title":"Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway","volume":"21","author":"Nicole","year":"2001","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0265","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1523\/JNEUROSCI.20-01-00326.2000","article-title":"Hepatocyte growth factor\/scatter factor is a neurotrophic survival factor for lumbar but not for other somatic motoneurons in the chick embryo","volume":"20","author":"Novak","year":"2000","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0270","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0896-6273(00)80151-8","article-title":"Neurotrophic survival molecules for motoneurons: an embarrassment of riches","volume":"17","author":"Oppenheim","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0275","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/373344a0","article-title":"Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF","volume":"373","author":"Oppenheim","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0280","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1523\/JNEUROSCI.20-13-05001.2000","article-title":"Glial cell line-derived neurotrophic factor and developing mammalian motoneurons: regulation of programmed cell death among motoneuron subtypes","volume":"20","author":"Oppenheim","year":"2000","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0285","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1523\/JNEUROSCI.21-04-01283.2001","article-title":"Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons","volume":"21","author":"Oppenheim","year":"2001","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0290","first-page":"428.16","article-title":"Neuronal development and survival in mice deficient in the GDNF co-receptor","volume":"28","author":"Oppenheim","year":"2002","journal-title":"Ret. Soc. Neurosci. Abs"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0295","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1523\/JNEUROSCI.18-03-01009.1998","article-title":"Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons","volume":"18","author":"Parsadanian","year":"1998","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0300","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1523\/JNEUROSCI.18-03-01132.1998","article-title":"Differential effects of neurotrophic factors on motoneuron retrograde labeling in a murine model of motoneuron disease","volume":"18","author":"Sagot","year":"1998","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0305","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/jnr.10558","article-title":"Adenoviral gene transfer of GDNF, BDNF and TGF beta 2, but not CNTF, cardiotrophin-1 or IGF1, protects injured adult motoneurons after facial nerve avulsion","volume":"72","author":"Sakamoto","year":"2003","journal-title":"J. Neurosci. Res"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0310","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/382070a0","article-title":"Renal agenesis and the absence of enteric neurons in mice lacking GDNF","volume":"382","author":"Sanchez","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0315","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1212\/WNL.47.2.535","article-title":"Impairment of fast axonal transport in the proximal axons of anterior horn neurons in amyotrophic lateral sclerosis","volume":"47","author":"Sasaki","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0320","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1006\/exnr.1993.1207","article-title":"Regional and cell-specific expression of GDNF in rat brain","volume":"124","author":"Schaar","year":"1993","journal-title":"Exp. Neurol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0325","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/neu.480230913","article-title":"Axotomy-induced neuronal death during development","volume":"23","author":"Snider","year":"1992","journal-title":"J. Neurobiol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0330","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/(SICI)1098-1136(199906)26:4<291::AID-GLIA3>3.0.CO;2-P","article-title":"GDNF family members and their receptors: expression and functions in two oligodendroglial cell lines representing distinct stages of oligodendroglial development","volume":"26","author":"Strelau","year":"1999","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0335","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S1044-7431(03)00219-7","article-title":"Response of motoneurons to neonatal sciatic nerve axotomy in Bax-knockout mice","volume":"24","author":"Sun","year":"2003","journal-title":"Mol. Cell. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0340","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1023\/A:1007067305837","article-title":"Glial cell responses, complement and apolipoprotein J expression following axon injury in the neonatal rat","volume":"28","author":"Tao","year":"1999","journal-title":"J. Neurocytol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0345","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1083\/jcb.130.1.137","article-title":"Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons","volume":"130","author":"Trupp","year":"1995","journal-title":"J. Cell Biol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0350","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1523\/JNEUROSCI.17-10-03554.1997","article-title":"Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS","volume":"17","author":"Trupp","year":"1997","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0355","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0092-8674(94)90027-2","article-title":"Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes","volume":"79","author":"Tsuchida","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0360","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1046\/j.1460-9568.2000.00241.x","article-title":"Caspase-3 is activated following axotomy of neonatal facial motoneurons and caspase-3 gene deletion delays axotomy-induced cell death in rodents","volume":"12","author":"Vanderluit","year":"2000","journal-title":"Eur. J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0365","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1460-9568.1995.tb01025.x","article-title":"Quantitative comparison of the transient rescue effects of neurotrophic factors on axotomized motoneurons in vivo","volume":"7","author":"Vejsada","year":"1995","journal-title":"Eur. J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0370","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0306-4522(97)00497-1","article-title":"Synergistic but transient rescue effects of BDNF and GDNF on axotomized neonatal motoneurons","volume":"84","author":"Vejsada","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0375","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/(SICI)1097-4547(20000515)60:4<511::AID-JNR10>3.0.CO;2-I","article-title":"Rescue of lesioned adult rat spinal motoneurons by adenoviral gene transfer of glial cell line-derived neurotrophic factor","volume":"60","author":"Watabe","year":"2000","journal-title":"J. Neurosci. Res"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0380","first-page":"7","article-title":"Adenoviral gene transfer of glial cell line-derived neurotrophic factor to injured adult motoneurons","volume":"14","author":"Watabe","year":"2001","journal-title":"Hum. Cell"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0385","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1523\/JNEUROSCI.23-12-04967.2003","article-title":"Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor","volume":"23","author":"Wilkins","year":"2003","journal-title":"J. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0390","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/4553","article-title":"Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons","volume":"2","author":"Williamson","year":"1999","journal-title":"Nat. Neurosci"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0395","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s004410050689","article-title":"Focal expression of glial cell line-derived neurotrophic factor in developing mouse limb bud","volume":"286","author":"Wright","year":"1996","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0400","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1089\/089771503767168528","article-title":"GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats","volume":"20","author":"Wu","year":"2003","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0405","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1242\/dev.124.15.2903","article-title":"Hepatocyte growth factor (HGF\/SF) is a muscle-derived survival factor for a subpopulation of embryonic motoneurons","volume":"124","author":"Yamamoto","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0410","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/373341a0","article-title":"In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons","volume":"373","author":"Yan","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0415","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1006\/dbio.1997.8601","article-title":"Live astrocytes visualized by green fluorescent protein in transgenic mice","volume":"187","author":"Zhuo","year":"1997","journal-title":"Dev. Biol"},{"key":"10.1016\/j.expneurol.2004.06.015_bb0420","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/gene.10008","article-title":"hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo","volume":"31","author":"Zhuo","year":"2001","journal-title":"Genesis"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488604002353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488604002353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:31:03Z","timestamp":1758000663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488604002353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":84,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S0014488604002353"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2004.06.015","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overexpression of glial cell line-derived neurotrophic factor in the CNS rescues motoneurons from programmed cell death and promotes their long-term survival following axotomy","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2004.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}