{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T05:50:36Z","timestamp":1769233836050,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.expneurol.2006.03.012","type":"journal-article","created":{"date-parts":[[2006,5,20]],"date-time":"2006-05-20T11:22:17Z","timestamp":1148124137000},"page":"92-102","source":"Crossref","is-referenced-by-count":52,"title":["Increased number of new neurons in the olfactory bulb and hippocampus of adult non-human primates after focal ischemia"],"prefix":"10.1016","volume":"199","author":[{"given":"Daisuke","family":"Koketsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Furuichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuya","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusei","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuhiro","family":"Hisatsune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2006.03.012_bib1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/cne.901370404","article-title":"Autoradiographic and histological studies of postnatal neurogenesis: IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb","volume":"137","author":"Altman","year":"1969","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2006.03.012_bib2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/cne.901240303","article-title":"Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats","volume":"124","author":"Altman","year":"1965","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2006.03.012_bib3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/cne.901260302","article-title":"Autoradiographic and histological studies of postnatal neurogenesis: I. A longitudinal investigation of the kinetics, migration and transformation of cells incorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions","volume":"126","author":"Altman","year":"1966","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2006.03.012_bib4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1046\/j.0953-816x.2001.01611.x","article-title":"N-methyl-d-aspartate receptor-mediated increase of neurogenesis in adult rat dentate gyrus following stroke","volume":"14","author":"Arvidsson","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2006.03.012_bib5","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm747","article-title":"Neuronal replacement from endogenous precursors in the adult brain after stroke","volume":"8","author":"Arvidsson","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2006.03.012_bib6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0306-4522(93)90335-D","article-title":"Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat","volume":"56","author":"Cameron","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2006.03.012_bib7","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ana.10555","article-title":"Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke","volume":"53","author":"Chen","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2006.03.012_bib8","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/cne.10675","article-title":"Short-term and long-term survival of new neurons in the rat dentate gyrus","volume":"460","author":"Dayer","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2006.03.012_bib9","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1046\/j.1471-4159.2003.02022.x","article-title":"Stroke-induced progenitor cell proliferation in adult spontaneously hypertensive rat brain: effect of exogenous IGF-1 and GDNF","volume":"87","author":"Dempsey","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2006.03.012_bib10","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/3305","article-title":"Neurogenesis in the adult human hippocampus","volume":"4","author":"Eriksson","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.expneurol.2006.03.012_bib11","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1097\/01.WCB.0000088761.02615.EB","article-title":"Tacrolimus, a potential neuroprotective agent, ameliorates ischemic brain damage and neurologic deficits after focal cerebral ischemia in nonhuman primates","volume":"23","author":"Furuichi","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2006.03.012_bib12","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1073\/pnas.96.9.5263","article-title":"Hippocampal neurogenesis in adult Old World primates","volume":"96","author":"Gould","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2006.03.012_bib13","doi-asserted-by":"crossref","first-page":"10910","DOI":"10.1073\/pnas.181354698","article-title":"Adult-generated hippocampal and neocortical neurons in macaques have a transient existence","volume":"98","author":"Gould","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2006.03.012_bib14","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/jcbfm.1988.131","article-title":"Focal cerebral infarction","volume":"8","author":"Graham","year":"1988","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2006.03.012_bib41","doi-asserted-by":"crossref","first-page":"18117","DOI":"10.1073\/pnas.0408258102","article-title":"Directed migration of human and mouse neural stem cells to site of CNS injury by the SDF1\u03b1\/CXCR4-dependent pathway","volume":"101","author":"Imitola","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2006.03.012_bib15","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/00004647-200204000-00005","article-title":"Three steps of neural stem cells development in gerbil dentate gyrus after transient ischemia","volume":"22","author":"Iwai","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2006.03.012_bib16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00004647-200303000-00008","article-title":"Temporal profile of stem cell division, migration, and differentiation from subventricular zone to olfactory bulb after transient forebrain ischemia in gerbils","volume":"23","author":"Iwai","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2006.03.012_bib17","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1073\/pnas.081011098","article-title":"Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat","volume":"98","author":"Jin","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2006.03.012_bib18","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1523\/JNEUROSCI.04-06-01429.1984","article-title":"Mitotic neuroblasts in the 9-day-old and 11-month-old rodent hippocampus","volume":"4","author":"Kaplan","year":"1984","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2006.03.012_bib19","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/00004647-200405000-00009","article-title":"Characterization of BrdU-positive neurons induced by transient global ischemia in adult hippocampus","volume":"24","author":"Kawai","year":"2004","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2006.03.012_bib20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-0270(00)00351-4","article-title":"Experimental thromboembolic stroke in cynomolgus monkey","volume":"105","author":"Kito","year":"2001","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.expneurol.2006.03.012_bib21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/exnr.1995.1085","article-title":"Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage","volume":"136","author":"Kokaia","year":"1995","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2006.03.012_bib22","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1523\/JNEUROSCI.23-03-00937.2003","article-title":"Nonrenewal of neurons in the cerebral neocortex of adult macaque monkeys","volume":"23","author":"Koketsu","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2006.03.012_bib23","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1073\/pnas.96.10.5768","article-title":"Continuation of neurogenesis in the hippocampus of the adult macaque monkey","volume":"96","author":"Kornack","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2006.03.012_bib24","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1073\/pnas.081074998","article-title":"The generation, migration, and differentiation of olfactory neurons in the adult primate brain","volume":"98","author":"Kornack","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2006.03.012_bib25","doi-asserted-by":"crossref","first-page":"10763","DOI":"10.1523\/JNEUROSCI.3883-04.2004","article-title":"Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain","volume":"24","author":"Kuan","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2006.03.012_bib26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0169-328X(97)00152-6","article-title":"Induction of basic fibroblast growth factor (bFGF) expression following focal cerebral ischemia","volume":"49","author":"Lin","year":"1997","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.expneurol.2006.03.012_bib27","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.1523\/JNEUROSCI.18-19-07768.1998","article-title":"Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils","volume":"18","author":"Liu","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2006.03.012_bib28","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1073\/pnas.90.5.2074","article-title":"Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia","volume":"90","author":"Lois","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2006.03.012_bib29","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1126\/science.271.5251.978","article-title":"Chain migration of neuronal precursors","volume":"271","author":"Lois","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2006.03.012_bib30","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.mcn.2004.04.002","article-title":"DNA repair in the degenerating mouse retina","volume":"26","author":"Menu dit Huart","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2006.03.012_bib31","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/ana.10393","article-title":"Rat forebrain neurogenesis and striatal neuron replacement after focal stroke","volume":"52","author":"Parent","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2006.03.012_bib42","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nbt751","article-title":"The injured brain interacts reciprocally with neural stem cells supported on scaffolds to reconstitute lost tissue","volume":"20","author":"Park","year":"2002","journal-title":"Nature Biotech."},{"issue":"1","key":"10.1016\/j.expneurol.2006.03.012_bib43","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.expneurol.2006.04.002","article-title":"Acute injury directs the migration, proliferation, and the differentiation of solid organ stem cells: Evidence from the effects of hypoxia -- ischemia in the CNS on clonal \u201creporter\u201d neural stem cells","volume":"199","author":"Park","year":"2006","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.expneurol.2006.03.012_bib44","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.expneurol.2006.03.016","article-title":"Neural stem cells may be uniquely suited for combined gene therapy & cell replacement: evidence from engraftment of NT-3-expressing cells in asphyxial brain injury","volume":"199","author":"Park","year":"2006","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.expneurol.2006.03.012_bib45","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.expneurol.2005.12.011","article-title":"A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke","volume":"199","author":"Pollock","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2006.03.012_bib32","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1750-3639.2004.tb00060.x","article-title":"Direct stimulation of adult neural stem cells in vitro and neurogenesis in vivo by vascular endothelial growth factor","volume":"14","author":"Schanzer","year":"2004","journal-title":"Brain Pathol."},{"key":"10.1016\/j.expneurol.2006.03.012_bib33","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1161\/01.STR.0000126480.40967.b3","article-title":"Neurogenesis after transient global ischemia in the adult hippocampus visualized by improved retroviral vector","volume":"35","author":"Tanaka","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2006.03.012_bib34","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1044-7431(03)00058-7","article-title":"Proliferation of neural and neuronal progenitors after global brain ischemia in young adult macaque monkeys","volume":"23","author":"Tonchev","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.expneurol.2006.03.012_bib35","unstructured":"Van Praag, H., Schinder, A.F., Christie, B.R., Toni, N., Palmer, T.D., Gage, F.H. 2002. Functional neurogenesis in the adult hippocampus. Nature 415, 1030--1034."},{"key":"10.1016\/j.expneurol.2006.03.012_bib36","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1161\/01.STR.0000132196.49028.a4","article-title":"Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats","volume":"35","author":"Wang","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2006.03.012_bib37","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0166-2236(98)01362-9","article-title":"Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias","volume":"22","author":"West","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2006.03.012_bib38","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.1073\/pnas.101034998","article-title":"FGF-2 regulation of neurogenesis in adult hippocampus after brain injury","volume":"98","author":"Yoshimura","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2006.03.012_bib39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0306-4522(01)00117-8","article-title":"Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia","volume":"105","author":"Zhang","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2006.03.012_bib40","doi-asserted-by":"crossref","first-page":"9453","DOI":"10.1073\/pnas.0401063101","article-title":"Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus","volume":"101","author":"Zhu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488606001968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488606001968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T23:19:56Z","timestamp":1555629596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488606001968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0014488606001968"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2006.03.012","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}