{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:56:47Z","timestamp":1777402607997,"version":"3.51.4"},"reference-count":78,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["01\/2310"],"award-info":[{"award-number":["01\/2310"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.expneurol.2006.08.009","type":"journal-article","created":{"date-parts":[[2006,10,26]],"date-time":"2006-10-26T07:16:59Z","timestamp":1161847019000},"page":"302-308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Differential nigral expression of Bcl-2 protein family in chronically haloperidol and clozapine-treated rats: Role in neurotoxicity and stereotyped behavior"],"prefix":"10.1016","volume":"203","author":[{"given":"M.","family":"Salda\u00f1a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bonastre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Marin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2006.08.009_bib1","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","article-title":"The bcl-2 family: arbiters of cell survival","volume":"28","author":"Adams","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2006.08.009_bib2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0301-0082(99)00064-7","article-title":"Neurotoxicity associated with neuroleptic-induced oral dyskinesias in rat. Implications for tardive dyskinesia?","volume":"61","author":"Andreassen","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2006.08.009_bib3","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.neuroscience.2003.08.058","article-title":"Oral dyskinesias and histopathological alterations in substantia nigra after long-term haloperidol treatment of old rats","volume":"122","author":"Andreassen","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2006.08.009_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainres.2004.02.064","article-title":"Antipsychotic drugs clozapine and olanzapine upregulated bcl2 mRNA and protein in rat frontal cortex and hippocampus","volume":"1010","author":"Bai","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2006.08.009_bib5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0893-133X(00)00086-5","article-title":"Further evidence that behavioral tests and neuropeptide mRNA and tissue level alterations can differentiate between typical and atypical antipsychotic drugs","volume":"23","author":"Bauer","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.expneurol.2006.08.009_bib6","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/00001756-199512000-00085","article-title":"Haloperidol-induced cell death-mechanism and protection with vitamin E in vitro","volume":"7","author":"Behl","year":"1995","journal-title":"NeuroReport"},{"key":"10.1016\/j.expneurol.2006.08.009_bib7","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0022-3565(25)22440-5","article-title":"1-Methyl-4-phenylpyridinium-like neurotoxicity of a pyridinium metabolite derived from haloperidol: cell culture and neurotransmitter uptake studies","volume":"270","author":"Bloomquist","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.expneurol.2006.08.009_bib8","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1046\/j.1460-9568.2002.01903.x","article-title":"Differential effects of typical and atypical antipsychotic drugs on striosome and matrix compartments of the striatum","volume":"15","author":"Bubser","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2006.08.009_bib9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.brainres.2004.10.038","article-title":"Acute reserpine and subchronic haloperidol treatments change synaptosomal brain uptake and elicit orofacial dyskinesia in rats","volume":"1031","author":"Burger","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2006.08.009_bib10","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1126\/science.847477","article-title":"Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain","volume":"196","author":"Burt","year":"1977","journal-title":"Science"},{"key":"10.1016\/j.expneurol.2006.08.009_bib11","series-title":"Psychopharmacology: The Four Generation of Progress","first-page":"1497","article-title":"Tardive dyskinesia\u2014Pathophysiology","author":"Casey","year":"1995"},{"key":"10.1016\/j.expneurol.2006.08.009_bib12","first-page":"5","article-title":"Tardive dyskinesia: pathophysiology and animal models","volume":"61","author":"Casey","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.expneurol.2006.08.009_bib13","first-page":"272","article-title":"Basal ganglia abnormalities in tardive dyskinesia. Possible relationship with duration on neuroleptic treatment","volume":"244","author":"Dalgalarrondo","year":"1994","journal-title":"Neur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.expneurol.2006.08.009_bib14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0166-2236(95)93928-Q","article-title":"The bcl-2 family of proteins, and the regulation of cell survival","volume":"18","author":"Davies","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2006.08.009_bib15","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.pnpbp.2005.08.019","article-title":"Antipsychotic-associated neuronal changes in the brain: toxic, therapeutic, or irrelevant to the long-term outcome of schizophrenia?","volume":"30","author":"Dean","year":"2006","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.expneurol.2006.08.009_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0733-8619(05)70370-4","article-title":"Drug-induced movement disorders","volume":"16","author":"Diederich","year":"1998","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.expneurol.2006.08.009_bib17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/BF00403900","article-title":"Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats","volume":"10","author":"Ernst","year":"1967","journal-title":"Psychopharmacologia"},{"key":"10.1016\/j.expneurol.2006.08.009_bib18","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0024-3205(96)00656-X","article-title":"Two pyridinium metabolites of haloperidol are present in the brain of patients at postmortem","volume":"60","author":"Eyles","year":"1997","journal-title":"Life Sci."},{"key":"10.1016\/j.expneurol.2006.08.009_bib19","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0166-2236(84)80254-4","article-title":"Neurobiological susbtrates of tardive dyskinesias: the GABA hypothesis","volume":"7","author":"Fibiger","year":"1984","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2006.08.009_bib20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF00433091","article-title":"An observational method for quantifying the behavioural effects of dopamine agonists: contrasting effects of d-amphetamine and apomorphine","volume":"69","author":"Fray","year":"1980","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.expneurol.2006.08.009_bib21","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/283569a0","article-title":"Chronic blockade of dopamine receptors by antischizophrenic drugs enhances GABA binding in substantia nigra","volume":"283","author":"Gale","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2006.08.009_bib22","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s007020070089","article-title":"Haloperidol-induced neurotoxicity\u2014Possible implications for tardive dyskinesia","volume":"107","author":"Galili-Mosberg","year":"2000","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.expneurol.2006.08.009_bib23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1471-4159.2000.0750101.x","article-title":"NF-\u03baB mediates the cell survival-promoting action of an activity-dependent neurotrophic factor peptide","volume":"75","author":"Glazer","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2006.08.009_bib24","first-page":"347","article-title":"Association with persistent neuroleptic-induced dyskinesia of regional changes in brain GABA synthesis","volume":"30","author":"Gunne","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2006.08.009_bib25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/nbdi.2002.0494","article-title":"Increased expression and redistribution of the antiapoptotic molecule Bcl-xL in Parkinson's disease","volume":"10","author":"Hartmann","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2006.08.009_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainresbull.2003.08.005","article-title":"Bax-protein-immunoreactivity in midbrain neurons of Parkinsons' disease patients","volume":"62","author":"Horowitz","year":"2003","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.expneurol.2006.08.009_bib27","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s007020050234","article-title":"Effects of chronic haloperidol and clozapine on vacuous chewing and dopamine-mediated jaw movements in rats: evaluation of a revised animal model of tardive dyskinesia","volume":"106","author":"Ikeda","year":"1999","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.expneurol.2006.08.009_bib28","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1176\/appi.ajp.161.1.109","article-title":"Apoptotic proteins in the temporal cortex in schizophrenia: high bax\/bcl-2 ratio without caspase-3 activation","volume":"161","author":"Jarskog","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.expneurol.2006.08.009_bib29","unstructured":"Jarskog, L.F., Gilmore, J.H., Glantz, L.A., Gable, K.L., German, T.T., Tong, R.I., Lieberman, J.A., in press. Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics, Neuropsychopharmacology."},{"key":"10.1016\/j.expneurol.2006.08.009_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s007020050001","article-title":"Cell death mechanisms in Parkinson's disease","volume":"107","author":"Jellinger","year":"2000","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.expneurol.2006.08.009_bib32","first-page":"1485","article-title":"Tardive dyskinesia: epidemiology and clinical presentation","volume":"vol. 39","author":"Kane","year":"1995"},{"key":"10.1016\/j.expneurol.2006.08.009_bib33","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0006-8993(97)01202-X","article-title":"Alteration of protein regulating apoptosis, bcl-2, bclx, bax, bak, bad, ICH-1 and CPP32 in Alzheimer's disease","volume":"780","author":"Kitamura","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2006.08.009_bib34","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF01245320","article-title":"An experimental model of tardive dyskinesia","volume":"3","author":"Klawans","year":"1972","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.expneurol.2006.08.009_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1023\/B:NEUR.0000030696.62829.ec","article-title":"Alterations in the cellular distribution of bcl-2, bcl-x and bax in the adult rat substantia nigra following striatal 6-hydroxydopamine lesions","volume":"33","author":"Kramer","year":"2004","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.expneurol.2006.08.009_bib36","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0306-4522(97)00447-8","article-title":"Haloperidol induces persistent down-regulation of tyrosine hydroxylase immunoreactivity in substantia nigra but not ventral tegmental area in the rat","volume":"84","author":"Levinson","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2006.08.009_bib37","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.tox.2005.08.018","article-title":"Effect of subchronic exposure to acrylamide induced on the expression of bcl-2, bax and caspase-3 in the rat nervous system","volume":"217","author":"Li","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.expneurol.2006.08.009_bib38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/1073858404269267","article-title":"Defining the role of the Bcl-2 family of proteins in the nervous system","volume":"11","author":"Lindsten","year":"2005","journal-title":"Neuroscientist"},{"key":"10.1016\/j.expneurol.2006.08.009_bib39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.expneurol.2006.08.009_bib40","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1046\/j.1460-9568.2002.01944.x","article-title":"Sub-chronic treatment with classical but not atypical antipsychotics produces morphological changes in rat nigrostriatal dopaminergic neurons directly related to \u201cearly onset\u201d vacuous chewing","volume":"15","author":"Marchese","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2006.08.009_bib41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2003.10.005","article-title":"Ritanserin counteracts both rat vacuous chewing movements and nigro-striatal tyrosine hydroxylase-immunostaining alterations induced by haloperidol","volume":"483","author":"Marchese","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2006.08.009_bib42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0014-2999(93)90448-Q","article-title":"D-1 but not D-2 dopamine stimulation attenuates haloperidol-induced behavioral supersensitivity and receptor upregulation","volume":"231","author":"Marin","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2006.08.009_bib43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0006-8993(96)00461-1","article-title":"Effect of long-term haloperidol treatment on striatal neuropeptides: relation to stereotyped behavior","volume":"731","author":"Marin","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2006.08.009_bib44","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/(SICI)1098-2396(199606)23:2<89::AID-SYN4>3.0.CO;2-C","article-title":"Striatal c-fos levels do not correlate with haloperidol-induced behavioral supersensitivity","volume":"23","author":"Marin","year":"1996","journal-title":"Synapse"},{"key":"10.1016\/j.expneurol.2006.08.009_bib45","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/bbrc.1997.7604","article-title":"Upregulation of the antiapoptotic protein bcl-2 may be an early event in the neurodegeneration: studies on Parkinson's and incidental Lewy body disease","volume":"240","author":"Marshall","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.expneurol.2006.08.009_bib46","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1136\/jnnp.64.6.799","article-title":"Persistent loss of tyrosine hydroxylase immunoreactivity in the substantia nigra after neuroleptic withdrawal","volume":"64","author":"Mazurek","year":"1998","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.expneurol.2006.08.009_bib47","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev.neuro.20.1.245","article-title":"Bcl-2 gene family in the nervous system","volume":"20","author":"Merry","year":"1997","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.expneurol.2006.08.009_bib48","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF02253587","article-title":"Effect of haloperidol and clozapine on the density of \u201cperforated\u201d synapses in caudate, nucleus accumbens and medial prefrontal cortex","volume":"106","author":"Meshul","year":"1992","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.expneurol.2006.08.009_bib49","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-8993(94)91117-7","article-title":"Haloperidol-induced morphological changes in striatum are associated with glutamate synapses","volume":"648","author":"Meshul","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2006.08.009_bib50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0925-4927(91)90007-D","article-title":"MRI abnormalities in tardive dyskinesia","volume":"40","author":"Minon","year":"1991","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.expneurol.2006.08.009_bib51","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0306-4522(01)00455-9","article-title":"Acute administration of haloperidol induces apoptosis of neurons in the striatum and substantia nigra in the rat","volume":"109","author":"Mitchell","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2006.08.009_bib52","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.brainres.2003.10.035","article-title":"6-Hydorxydopamine increases the level of TNF-\u03b1 and bax mRNA in the striatum and induces apoptosis of dopaminergic neurons in hemiparkinsonian rats","volume":"996","author":"Mladenovic","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2006.08.009_bib53","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0304-3940(96)12961-X","article-title":"Bcl-2 protein is increased in the brain from parkinsonian patients","volume":"215","author":"Mogi","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2006.08.009_bib54","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0014-2999(01)01385-1","article-title":"Possible involvement of prostaglandins in haloperidol-induced orofacial dyskinesia in rats","volume":"430","author":"Naidu","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2006.08.009_bib55","first-page":"1046","article-title":"Haloperidol-induced neuronal apoptosis: blockade by neurotrophins and IGFs","volume":"24","author":"Noh","year":"1997","journal-title":"Abstr.-Soc. Neurosci."},{"key":"10.1016\/j.expneurol.2006.08.009_bib56","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1046\/j.1471-4159.2000.0752327.x","article-title":"Haloperidol-induced neuronal apoptosis: role of p38 and c-Jun-NH2-terminal protein kinase","volume":"75","author":"Noh","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2006.08.009_bib57","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1046\/j.1471-4159.1995.65052057.x","article-title":"Neuroleptics up-regulate adenosine A2A receptors in rat striatum: implications for the mechanism and the treatment of tardive dyskinesia","volume":"65","author":"Parsons","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2006.08.009_bib58","series-title":"Neuroleptic-Induced Movement Disorders","first-page":"141","article-title":"Reanalysis of the dopamine theory of tardive dyskinesia the hypothesis of dopamine D1\/D2 imbalance","author":"Peacock","year":"1997"},{"key":"10.1016\/j.expneurol.2006.08.009_bib59","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.1471-4159.2004.02904.x","article-title":"Brain-derived neurotrophic factor prevent changes in bcl-2 family members and caspase activation induced by excitotoxicity in the striatum","volume":"92","author":"P\u00e9rez-Navarro","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2006.08.009_bib60","doi-asserted-by":"crossref","first-page":"19126","DOI":"10.1073\/pnas.0508215102","article-title":"Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage","volume":"102","author":"Perier","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.expneurol.2006.08.009_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.124.1.1","article-title":"Bcl-2 and the regulation of programmed cell death","volume":"124","author":"Reed","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.expneurol.2006.08.009_bib62","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0022-3565(25)38487-9","article-title":"MPP(+)-like neurotoxicity of a pyridinium metabolite derived from haloperidol: in vivo microdialysis and in vitro mitochondrial studies","volume":"268","author":"Rollema","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.expneurol.2006.08.009_bib63","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1046\/j.1471-4159.1998.71031002.x","article-title":"Induction of reactive oxygen species in neurons by haloperidol","volume":"71","author":"Sagarab","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2006.08.009_bib64","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.euroneuro.2006.01.001","article-title":"Role of nigral NFkB p50 and p65 subunits expression in haloperidol-induced neurotoxicity and stereotyped behavior in rats","volume":"16","author":"Salda\u00f1a","year":"2006","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.expneurol.2006.08.009_bib65","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0006-8993(95)00748-F","article-title":"Immunoreactivity for bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity","volume":"697","author":"Satou","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2006.08.009_bib66","first-page":"25","article-title":"Regulation of neuronal cell death and neurodegeneration by members of the bcl-2 family: therapeutic implications. Current drug targets","volume":"4","author":"Shacka","year":"2005","journal-title":"CNS Neurol. Dis."},{"key":"10.1016\/j.expneurol.2006.08.009_bib67","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s10495-006-5698-6","article-title":"Translocation of AIF in the human and rat striatum following protracted haloperidol, but not clozapine, treatment","volume":"11","author":"Skoblenick","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.expneurol.2006.08.009_bib68","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0028-3908(74)90084-7","article-title":"Behavioral hypersensitivity to apomorphine following chronic treatment with drugs which interfere with synaptic function of catecholamines","volume":"13","author":"Tarsy","year":"1974","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.expneurol.2006.08.009_bib70","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0304-3940(97)00837-9","article-title":"Bcl-2 and bax expression in Lewy bodies from patients with Parkinson's disease and diffuse Lewy body disease","volume":"238","author":"Tortosa","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2006.08.009_bib71","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1176\/ajp.155.9.1207","article-title":"Markers of glutamatergic neurotransmission and oxidatives stress associated with tardive dyskinesia","volume":"155","author":"Tsai","year":"1998","journal-title":"Am. J. Psych."},{"key":"10.1016\/j.expneurol.2006.08.009_bib72","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00702-004-0109-z","article-title":"Neurotoxic potential of haloperidol in comparison with risperidone. Implication of Akt-mediated signal changes by haloperidol","volume":"111","author":"Ukai","year":"2004","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.expneurol.2006.08.009_bib73","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1021\/tx960001y","article-title":"Studies on the conversion of haloperidol and its tetrahydropyridine dehydration product to potentially neurons pyridinium metabolites by human liver microsomes","volume":"9","author":"Usuki","year":"1996","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.expneurol.2006.08.009_bib74","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1073\/pnas.051633998","article-title":"Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease","volume":"98","author":"Vila","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2006.08.009_bib75","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1046\/j.1471-4159.1997.69010223.x","article-title":"Expression of bcl-2 in adult human brain regions with special reference to neurodegenerative disorders","volume":"69","author":"Vyas","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2006.08.009_bib78","series-title":"Neuroleptic-Induced Movements Disorders","first-page":"225","article-title":"Rodent and other animal models of tardive dyskinesia during long-term neuroleptic drug administration. Controversies and implications for the clinical syndrome","author":"Waddington","year":"1997"},{"key":"10.1016\/j.expneurol.2006.08.009_bib79","first-page":"1","article-title":"Haloperidol induces apoptosis via the sigma-2 receptor system and Bcl-Xs","author":"Wei","year":"2006","journal-title":"The Pharmacogenesis"},{"key":"10.1016\/j.expneurol.2006.08.009_bib80","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0006-8993(97)01551-5","article-title":"Effects of haloperidol metabolites on neurotransmitter uptake and release: possible role in neurotoxicity and tardive dyskinesia","volume":"788","author":"Wright","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2006.08.009_bib76","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/369321a0","article-title":"BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerisation with Bax","volume":"369","author":"Yin","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2006.08.009_bib77","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S0891-5849(97)00435-8","article-title":"In vivo analysis of hydrogen peroxide and lipid radicals in the striatum of rats under long-term administration of a neuroleptic","volume":"26","author":"Yokoyama","year":"1998","journal-title":"Free Radical Biol. Mol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488606004791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488606004791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T05:33:54Z","timestamp":1758000834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488606004791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0014488606004791"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2006.08.009","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential nigral expression of Bcl-2 protein family in chronically haloperidol and clozapine-treated rats: Role in neurotoxicity and stereotyped behavior","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2006.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}