{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:59:56Z","timestamp":1793735996591,"version":"4.6.1"},"reference-count":72,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.expneurol.2007.06.025","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T07:18:37Z","timestamp":1184829517000},"page":"227-237","source":"Crossref","is-referenced-by-count":133,"title":["Minocycline protects the blood\u2013brain barrier and reduces edema following intracerebral hemorrhage in the rat"],"prefix":"10.1016","volume":"207","author":[{"given":"Jason K.","family":"Wasserman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyanne C.","family":"Schlichter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2007.06.025_bib72","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3171\/jns.2003.99.1.0065","article-title":"Matrix metalloproteinase-9 concentration after spontaneous intracerebral hemorrhage","volume":"99","author":"Abilleira","year":"2003","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.expneurol.2007.06.025_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1615\/CritRevEukarGeneExpr.v7.i1-2.90","article-title":"Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases","volume":"7","author":"Borden","year":"1997","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.expneurol.2007.06.025_bib1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1097\/00004647-199908000-00001","article-title":"Inflammatory mediators and stroke: new opportunities for novel therapeutics","volume":"19","author":"Barone","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2007.06.025_bib3","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/BF03401714","article-title":"Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia","volume":"3","author":"Botchkina","year":"1997","journal-title":"Mol. Med."},{"key":"10.1016\/j.expneurol.2007.06.025_bib4","first-page":"155","article-title":"Pitfalls of quantitative real-time reverse-transcription polymerase chain reaction","volume":"15","author":"Bustin","year":"2004","journal-title":"J. Biomol. Tech."},{"key":"10.1016\/j.expneurol.2007.06.025_bib5","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1212\/WNL.58.4.624","article-title":"Molecular signatures of brain injury after intracerebral hemorrhage","volume":"58","author":"Castillo","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2007.06.025_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0165-5728(95)00148-4","article-title":"The influence of cytokines on the integrity of the blood\u2013brain barrier in vitro","volume":"64","author":"de Vries","year":"1996","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1046\/j.1471-4159.2003.01829.x","article-title":"Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability","volume":"86","author":"Didier","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2007.06.025_bib8","first-page":"35","article-title":"Cellular expression of tumor necrosis factor a and its receptors in human ischemic stroke","volume":"22","author":"Dziewulska","year":"2003","journal-title":"Clin. Neuropathol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1592\/phco.26.4.515","article-title":"Minocycline for short-term neuroprotection","volume":"26","author":"Elewa","year":"2006","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.expneurol.2007.06.025_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000026331","article-title":"The role of cytokines in the neuropathology of stroke and neurotrauma","volume":"5","author":"Feuerstein","year":"1998","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.expneurol.2007.06.025_bib11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0006-8993(99)01843-0","article-title":"Early appearance of activated matrix metalloproteinase-9 and blood\u2013brain barrier disruption in mice after focal cerebral ischemia and reperfusion","volume":"842","author":"Fujimura","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2007.06.025_bib12","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1097\/00004647-199909000-00010","article-title":"Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: a possible role in blood\u2013brain barrier dysfunction","volume":"19","author":"Gasche","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2007.06.025_bib13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00004647-200001000-00009","article-title":"Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice","volume":"20","author":"Gregersen","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2007.06.025_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.nbd.2006.02.006","article-title":"Blood\u2013brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation","volume":"23","author":"Gurney","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.expneurol.2007.06.025_bib16","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/00004647-200205000-00004","article-title":"Microvascular basal lamina injury after experimental focal cerebral ischemia and reperfusion in the rat","volume":"22","author":"Hamann","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2007.06.025_bib15","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1161\/01.STR.0000116866.60794.21","article-title":"Mild to moderate hypothermia prevents microvascular basal lamina antigen loss in experimental focal cerebral ischemia","volume":"35","author":"Hamann","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2007.06.025_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuroscience.2006.03.071","article-title":"Delayed minocycline treatment reduces long-term functional deficits and histological injury in a rodent model of focal ischemia","volume":"141","author":"Hewlett","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2007.06.025_bib18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3171\/jns.2000.92.1.0108","article-title":"Intracerebral administration of interleukin-1beta and induction of inflammation, apoptosis, and vasogenic edema","volume":"92","author":"Holmin","year":"2000","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.expneurol.2007.06.025_bib19","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1227\/01.NEU.0000197333.55473.AD","article-title":"Tumor necrosis factor-alpha increases in the brain after intracerebral hemorrhage and thrombin stimulation","volume":"58","author":"Hua","year":"2006","journal-title":"Neurosurgery"},{"key":"10.1016\/j.expneurol.2007.06.025_bib20","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/jnen\/60.4.320","article-title":"Production of MMPs in human cerebral endothelial cells and their role in shedding adhesion molecules","volume":"60","author":"Hummel","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib21","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1523\/JNEUROSCI.3593-06.2007","article-title":"The Ca2+-activated K+ channel KCNN4\/KCa3.1 contributes to microglia activation and nitric oxide-dependent neurodegeneration","volume":"27","author":"Kaushal","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.06.025_bib22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/BF00691095","article-title":"Pathophysiological aspects of brain edema","volume":"72","author":"Klatzo","year":"1987","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.expneurol.2007.06.025_bib23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00044067-200504000-00011","article-title":"Hyperosmolar therapy in the treatment of severe head injury in children: mannitol and hypertonic saline","volume":"16","author":"Knapp","year":"2005","journal-title":"AACN Clin. Issues"},{"key":"10.1016\/j.expneurol.2007.06.025_bib24","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/glia.20335","article-title":"Hypoxia-activated microglial mediators of neuronal survival are differentially regulated by tetracyclines","volume":"53","author":"Lai","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2007.06.025_bib25","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1159\/000088981","article-title":"Prognostic significance of blood brain barrier permeability in acute hemorrhagic stroke","volume":"20","author":"Lampl","year":"2005","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.expneurol.2007.06.025_bib26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pain.2005.02.009","article-title":"Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation","volume":"115","author":"Ledeboer","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2007.06.025_bib27","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1212\/01.WNL.0000133204.81153.AC","article-title":"Early neurologic deterioration in intracerebral hemorrhage: predictors and associated factors","volume":"63","author":"Leira","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2007.06.025_bib28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1471-2202-7-56","article-title":"Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke","volume":"17","author":"Machado","year":"2006","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.expneurol.2007.06.025_bib30","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/00004647-200404000-00008","article-title":"Delayed onset of prolonged hypothermia improves outcome after intracerebral hemorrhage in rats","volume":"24","author":"MacLellan","year":"2004","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2007.06.025_bib29","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1161\/01.STR.0000217268.81963.78","article-title":"The influence of hypothermia on outcome after intracerebral hemorrhage in rats","volume":"37","author":"MacLellan","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2007.06.025_bib31","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/ana.20850","article-title":"Evaluating therapeutic targets for reperfusion-related brain hemorrhage","volume":"59","author":"Maier","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib32","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3171\/jns.2001.95.4.0680","article-title":"Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist","volume":"95","author":"Masada","year":"2001","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.expneurol.2007.06.025_bib33","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S1474-4422(05)70195-2","article-title":"Treatment of intracerebral haemorrhage","volume":"4","author":"Mayer","year":"2005","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib34","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/ana.1010","article-title":"Adenosine A2A receptor activation reduces proinflammatory events and decreases cell death following intracerebral hemorrhage","volume":"49","author":"Mayne","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1161\/01.STR.32.1.240","article-title":"Antisense oligodeoxynucleotide inhibition of tumor necrosis factor-alpha expression is neuroprotective after intracerebral hemorrhage","volume":"32","author":"Mayne","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2007.06.025_bib36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0304-3940(92)90823-P","article-title":"Recombinant human tumor necrosis factor alpha constricts pial arterioles and increases blood\u2013brain barrier permeability in newborn piglets","volume":"148","author":"Megyeri","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2007.06.025_bib37","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1182\/blood.V100.12.3853","article-title":"Leukocyte extravasation: chemokine transport and presentation by the endothelium","volume":"100","author":"Middleton","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.expneurol.2007.06.025_bib38","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1089\/089771503767869971","article-title":"Microvascular basal lamina antigen loss after traumatic brain injury in the rat","volume":"20","author":"Muellner","year":"2003","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2007.06.025_bib39","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/ana.10553","article-title":"Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases","volume":"53","author":"Power","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib40","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJM200105103441907","article-title":"Spontaneous intracerebral hemorrhage","volume":"344","author":"Qureshi","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2007.06.025_bib41","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/00075198-200404000-00003","article-title":"Novel therapies for intracerebral hemorrhage","volume":"10","author":"Rincon","year":"2004","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.expneurol.2007.06.025_bib42","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/glia.10108","article-title":"Matrix metalloproteinases in neuroinflammation","volume":"39","author":"Rosenberg","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.expneurol.2007.06.025_bib44","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1212\/WNL.48.4.921","article-title":"Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat","volume":"48","author":"Rosenberg","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.expneurol.2007.06.025_bib43","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1161\/01.STR.21.5.801","article-title":"Collagenase-induced intracerebral hemorrhage in rats","volume":"21","author":"Rosenberg","year":"1990","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2007.06.025_bib45","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1161\/01.STR.32.8.1750","article-title":"Evolution of cerebral tumor necrosis factor-alpha production during human ischemic stroke","volume":"32","author":"Sairanen","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2007.06.025_bib46","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0022-510X(01)00508-1","article-title":"Differential cellular expression of tumor necrosis factor-alpha and Type I tumor necrosis factor receptor after transient global forebrain ischemia","volume":"186","author":"Sairanen","year":"2001","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.expneurol.2007.06.025_bib47","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1227\/00006123-200106000-00051","article-title":"Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction","volume":"48","author":"Sanchez Mejia","year":"2001","journal-title":"Neurosurgery"},{"key":"10.1016\/j.expneurol.2007.06.025_bib48","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/med.20064","article-title":"Neutrophils and the blood\u2013brain barrier dysfunction after trauma","volume":"27","author":"Scholz","year":"2007","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.expneurol.2007.06.025_bib49","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S1474-4422(07)70055-8","article-title":"Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications","volume":"6","author":"Simard","year":"2007","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib50","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/1073858405275175","article-title":"Minocycline as a neuroprotective agent","volume":"11","author":"Stirling","year":"2005","journal-title":"Neuroscientist"},{"key":"10.1016\/j.expneurol.2007.06.025_bib51","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1179\/joc.1995.7.2.118","article-title":"Effect of antimicrobial agents on chemotaxis of polymorphonuclear leukocytes","volume":"7","author":"Sugita","year":"1995","journal-title":"J. Chemother."},{"key":"10.1016\/j.expneurol.2007.06.025_bib52","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1161\/hs0302.104542","article-title":"Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats","volume":"33","author":"Sumii","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2007.06.025_bib53","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.expneurol.2005.09.011","article-title":"Minocycline and intracerebral hemorrhage: influence of injury severity and delay to treatment","volume":"197","author":"Szymanska","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1089\/neu.1992.9.21","article-title":"Breakdown of the blood\u2013brain barrier after fluid percussive brain injury in the rat. Part 1: Distribution and time course of protein extravasation","volume":"9","author":"Tanno","year":"1992","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.expneurol.2007.06.025_bib55","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0165-5728(03)00036-5","article-title":"Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions","volume":"138","author":"Vos","year":"2003","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib57","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1093\/brain\/awh489","article-title":"Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage","volume":"128","author":"Wang","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2007.06.025_bib56","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/sj.jcbfm.9600403","article-title":"Inflammation after intracerebral hemorrhage","volume":"27","author":"Wang","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2007.06.025_bib58","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.brainres.2006.12.035","article-title":"Neuron death and inflammation in a rat model of intracerebral hemorrhage: Effects of delayed minocycline treatment","volume":"1136","author":"Wasserman","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2007.06.025_bib60","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/brain\/awg178","article-title":"Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice","volume":"126","author":"Wells","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2007.06.025_bib59","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1460-9568.2004.03829.x","article-title":"Matrix metalloproteinase (MMP)-12 expression has a negative impact on sensorimotor function following intracerebral haemorrhage in mice","volume":"21","author":"Wells","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.06.025_bib61","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.expneurol.2004.08.008","article-title":"Cytokines, nitric oxide, and cGMP modulate the permeability of an in vitro model of the human blood\u2013brain barrier","volume":"190","author":"Wong","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib62","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF01057957","article-title":"Blood\u2013brain barrier changes following intracerebral injection of human recombinant tumor necrosis factor-alpha in the rat","volume":"20","author":"Wright","year":"1994","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib63","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/01.STR.32.1.162","article-title":"Systemic complement depletion diminishes perihematomal brain edema in rats","volume":"32","author":"Xi","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2007.06.025_bib64","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1474-4422(05)70283-0","article-title":"Mechanisms of brain injury after intracerebral haemorrhage","volume":"5","author":"Xi","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib65","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/01.STR.0000206281.77178.ac","article-title":"Microglia potentiate damage to blood\u2013brain barrier constituents: improvement by minocycline in vivo and in vitro","volume":"37","author":"Yenari","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2007.06.025_bib66","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/35081571","article-title":"Metalloproteinases in biology and pathology of the nervous system","volume":"2","author":"Yong","year":"2001","journal-title":"Nat. Rev., Neurosci."},{"key":"10.1016\/j.expneurol.2007.06.025_bib67","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S1474-4422(04)00937-8","article-title":"The promise of minocycline in neurology","volume":"3","author":"Yong","year":"2004","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.expneurol.2007.06.025_bib68","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.1073\/pnas.95.26.15769","article-title":"Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia","volume":"95","author":"Yrjanheikki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2007.06.025_bib69","doi-asserted-by":"crossref","first-page":"13496","DOI":"10.1073\/pnas.96.23.13496","article-title":"A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window","volume":"96","author":"Yrjanheikki","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2007.06.025_bib70","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1097\/00004647-200006000-00009","article-title":"Inflammatory activation of human brain endothelial cells by hypoxic astrocytes in vitro is mediated by IL-1beta","volume":"20","author":"Zhang","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2007.06.025_bib71","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nm1387","article-title":"Role of matrix metalloproteinases in delayed cortical responses after stroke","volume":"12","author":"Zhao","year":"2006","journal-title":"Nat. Med."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448860700252X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448860700252X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T05:18:18Z","timestamp":1556687898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448860700252X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S001448860700252X"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2007.06.025","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}