{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:36:09Z","timestamp":1789803369143,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.expneurol.2007.07.010","type":"journal-article","created":{"date-parts":[[2007,7,20]],"date-time":"2007-07-20T09:38:09Z","timestamp":1184924289000},"page":"63-72","source":"Crossref","is-referenced-by-count":27,"title":["Effects of ralfinamide, a Na+ channel blocker, on firing properties of nociceptive dorsal root ganglion neurons of adult rats"],"prefix":"10.1016","volume":"208","author":[{"given":"Hana","family":"Yamane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"de Groat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Sculptoreanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2007.07.010_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jpain.2006.01.444","article-title":"The role of sodium channels in chronic inflammatory and neuropathic pain","volume":"7","author":"Amir","year":"2006","journal-title":"J. Pain"},{"key":"10.1016\/j.expneurol.2007.07.010_bib2","article-title":"Effects of NW-1029, a Na+ channel blocker, in anesthetized rat models of bladder pain","author":"Artim","year":"2005","journal-title":"Soc. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.010_bib3","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.jpain.2005.09.005","article-title":"Translating basic research on sodium channels in human neuropathic pain","volume":"7","author":"Attal","year":"2006","journal-title":"J. Pain"},{"key":"10.1016\/j.expneurol.2007.07.010_bib4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0006-8993(02)03957-4","article-title":"Tetrodotoxin-resistant sodium channels Nav1.8\/SNS and Nav1.9\/NaN in afferent neurons innervating urinary bladder in control and spinal cord injury rats","volume":"963","author":"Black","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2007.07.010_bib5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/00000542-200101000-00024","article-title":"Effect of drugs used for neuropathic pain management on tetrodotoxin-resistant Na+ currents in rat sensory neurons","volume":"94","author":"Brau","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.expneurol.2007.07.010_bib6","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/sj.bjp.0705796","article-title":"Differential modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by the local anesthetic lidocaine","volume":"142","author":"Chevrier","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.07.010_bib7","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1152\/jn.01033.2006","article-title":"Differential slow inactivation and use-dependent inhibition of Nav1.8 channels contribute to distinct firing properties in IB4+ and IB4-","volume":"97","author":"Choi","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2007.07.010_bib8","article-title":"Effects of NW-1029, a Na+ channel blocker, on voluntary voiding in the rat","author":"Giesselman","year":"2005","journal-title":"Soc. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.010_bib9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1085\/jgp.69.4.497","article-title":"Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction","volume":"69","author":"Hille","year":"1977","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.expneurol.2007.07.010_bib10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1113\/jphysiol.2006.113597","article-title":"Dissecting the role of sodium currents in visceral sensory neurons in a model of chronic hyperexcitability using Nav1.8 and Nav1.9 null mice","volume":"576","author":"Hillsley","year":"2006","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.expneurol.2007.07.010_bib11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0304-4157(77)90003-X","article-title":"Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels","volume":"472","author":"Hondeghem","year":"1977","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.expneurol.2007.07.010_bib12","first-page":"716","article-title":"Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons","volume":"46","author":"Kuo","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.07.010_bib13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev.pharmtox.44.101802.121627","article-title":"Voltage-gated sodium channels and hyperalgesia","volume":"44","author":"Lai","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.expneurol.2007.07.010_bib37","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1124\/mol.106.026419","article-title":"The mechanism of activity-dependent sodium channel inhibition by the antidepressants fluoxetine and desipramine","volume":"70","author":"Lenkey","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.07.010_bib14","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0165-1838(92)90031-B","article-title":"Cyclophosphamide cystitis in rats: involvement of capsaicin-sensitive primary afferents","volume":"38","author":"Maggi","year":"1992","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.expneurol.2007.07.010_bib15","first-page":"G1045","article-title":"TNBS ileitis evokes hyperexcitability and changes in ionic membrane properties of nociceptive DRG neurons","volume":"282","author":"Moore","year":"2002","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.expneurol.2007.07.010_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/003655999750016348","article-title":"Activation of pelvic afferent nerves from the rat bladder during filling","volume":"201","author":"Morrison","year":"1999","journal-title":"Scand. J. Urol. Nephrol. Suppl."},{"key":"10.1016\/j.expneurol.2007.07.010_bib17","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S1016-8478(23)13797-6","article-title":"Downregulation of voltage-gated potassium channel a gene expression by axotomy and neurotrophins in rat dorsal root ganglia","volume":"12","author":"Park","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.expneurol.2007.07.010_bib18","doi-asserted-by":"crossref","first-page":"9382","DOI":"10.1073\/pnas.0501549102","article-title":"Contribution of the tetrodotoxin-resistant voltage-gated sodium channel Nav1.9 to sensory transmission and nociceptive behavior","volume":"102","author":"Priest","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2007.07.010_bib19","doi-asserted-by":"crossref","first-page":"9270","DOI":"10.1073\/pnas.93.17.9270","article-title":"Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels","volume":"93","author":"Ragsdale","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2007.07.010_bib20","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/jn.2001.86.2.629","article-title":"Contribution of Nav1.8 sodium channels to action potential electrogenesis in DRG neurons","volume":"86","author":"Renganathan","year":"2001","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.expneurol.2007.07.010_bib22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0304-3959(00)00345-6","article-title":"Tetrodotoxin-resistant action potentials in dorsal root ganglion neurons are blocked by local anesthetics","volume":"89","author":"Scholz","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2007.07.010_bib21","first-page":"746","article-title":"Complex blockage of TTX-resistant Na+ currents by lidocaine and bupivacaine reduce firing frequency in DRG Neurons","volume":"79l","author":"Scholz","year":"1998","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.expneurol.2007.07.010_bib23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.expneurol.2007.01.038","article-title":"Neurokinins enhance excitability in capsaicin responsive DRG neurons","volume":"205","author":"Sculptoreanu","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2007.07.010_bib25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1124\/jpet.104.065409","article-title":"KW-7158 ((2S)-(+)-3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno (3,2-c) (1) benzothiepin-9-yl)propanamide) enhances A-type K+ currents in neurons of the dorsal root ganglion of the adult rat","volume":"310","author":"Sculptoreanu","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.expneurol.2007.07.010_bib26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejphar.2005.01.030","article-title":"The anti-nociceptive agent ralfinamide inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive Na+ currents in dorsal root ganglion neurons","volume":"510","author":"Stummann","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.07.010_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/s0304-3959(02)00183-5","article-title":"Anti-allodynic effect of NW-1029, a novel Na+ channel blocker, in experimental animal models of inflammatory and neuropathic pain","volume":"102","author":"Veneroni","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.expneurol.2007.07.010_bib28","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/exnr.1999.7254","article-title":"Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction","volume":"161","author":"Vizzard","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2007.07.010_bib29","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.neuroscience.2003.11.014","article-title":"Altered expression of potassium channel subunit mRNA and alpha-dendrotoxin sensitivity of potassium currents in rat dorsal root ganglion neurons after axotomy","volume":"123","author":"Yang","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2007.07.010_bib32","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1523\/JNEUROSCI.19-11-04644.1999","article-title":"Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation","volume":"19","author":"Yoshimura","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.010_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1996.sp021471","article-title":"Different types of Na+ and A-type K+ currents in dorsal root ganglion neurons innervating the rat urinary bladder","volume":"494","author":"Yoshimura","year":"1996","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.expneurol.2007.07.010_bib33","doi-asserted-by":"crossref","first-page":"8690","DOI":"10.1523\/JNEUROSCI.21-21-08690.2001","article-title":"The involvement of the tetrodotoxin-resistant sodium channel Nav1.8 (PN3\/SNS) in a rat model of visceral pain","volume":"21","author":"Yoshimura","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.010_bib34","doi-asserted-by":"crossref","first-page":"10847","DOI":"10.1523\/JNEUROSCI.3023-06.2006","article-title":"Bladder overactivity and hyperexcitability of bladder afferent neurons after intrathecal delivery of Nerve Growth Factor in rats","volume":"26","author":"Yoshimura","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.010_bib35","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.toxicon.2004.11.015","article-title":"Heteropoda toxin 2 is a gating modifier toxin specific for voltage-gated K+ channels of the KV4 family","volume":"45","author":"Zarayskiy","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.expneurol.2007.07.010_bib36","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0014-2999(89)90452-4","article-title":"Evidence for a common site of action of lidocaine and carbamazepine in voltage-dependent sodium channels","volume":"167","author":"Zim\u00e1nyi","year":"1989","journal-title":"Eur. J. Pharmacol."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488607002877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488607002877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T18:40:49Z","timestamp":1708108849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488607002877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0014488607002877"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2007.07.010","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}