{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:13:40Z","timestamp":1760170420406},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.expneurol.2007.07.014","type":"journal-article","created":{"date-parts":[[2007,8,2]],"date-time":"2007-08-02T11:27:04Z","timestamp":1186054024000},"page":"92-99","source":"Crossref","is-referenced-by-count":8,"title":["Immunodeficiency impairs re-injury induced reversal of neuronal atrophy: Relation to T cell subsets and microglia"],"prefix":"10.1016","volume":"208","author":[{"given":"Grace K.","family":"Ha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlon","family":"Pastrana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Petitto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2007.07.014_bib1","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1111\/j.1460-9568.2007.05458.x","article-title":"Central nervous system and non-central nervous system antigen vaccines exacerbate neuropathology caused by nerve injury","volume":"25","author":"Ankeny","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.014_bib2","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1097\/00001756-200412030-00018","article-title":"Restoration of axotomy-induced PACAP gene induction in SCID mice with CD4+ T-lymphocytes","volume":"15","author":"Armstrong","year":"2004","journal-title":"NeuroReport"},{"key":"10.1016\/j.expneurol.2007.07.014_bib3","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1523\/JNEUROSCI.19-05-01708.1999","article-title":"Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor","volume":"19","author":"Batchelor","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.014_bib4","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/cne.20017","article-title":"Microglial major histocompatibility complex glycoprotein-1 in the axotomized facial motor nucleus: regulation and role of tumor necrosis factor receptors 1 and 2","volume":"470","author":"Bohatschek","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib5","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1523\/JNEUROSCI.5276-03.2004","article-title":"CD4-positive T cell-mediated neuroprotection requires dual compartment antigen presentation","volume":"24","author":"Byram","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.014_bib6","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/eji.200535539","article-title":"Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway","volume":"36","author":"Cose","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib7","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.expneurol.2006.04.028","article-title":"Immune-mediated neuroprotection of axotomized mouse facial motoneurons is dependent on the IL-4\/STAT6 signaling pathway in CD4(+) T cells","volume":"201","author":"Deboy","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2005.10.012","article-title":"Endogenous T lymphocytes and microglial reactivity in the axotomized facial motor nucleus of mice: effect of genetic background and the RAG2 gene","volume":"172","author":"Ha","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jneuroim.2006.11.029","article-title":"Prior facial motor neuron injury elicits endogenous T cell memory: relation to neuroregeneration","volume":"183","author":"Ha","year":"2007","journal-title":"J Neuroimmunol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0006-8993(89)90112-1","article-title":"Nerve growth factor (NGF) reverses axotomy-induced decreases in choline acetyltransferase, NGF receptor and size of medial septum cholinergic neurons","volume":"505","author":"Hagg","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2007.07.014_bib11","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/jnr.490280213","article-title":"T-lymphocyte entry into the central nervous system","volume":"28","author":"Hickey","year":"1991","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2007.07.014_bib12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2249.2006.03056.x","article-title":"Cerebral leucocyte infiltration in lupus-prone MRL\/MpJ-fas lpr mice-roles of intercellular adhesion molecule-1 and P-selectin","volume":"144","author":"James","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bbi.2004.05.004","article-title":"Role of the immune system in the maintenance of mouse facial motoneuron viability after nerve injury","volume":"19","author":"Jones","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.expneurol.2007.07.014_bib14","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.expneurol.2006.03.014","article-title":"T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression","volume":"200","author":"Kleinschnitz","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib15","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1073\/pnas.052308899","article-title":"Survival and regeneration of rubrospinal neurons 1\u00a0year after spinal cord injury","volume":"99","author":"Kwon","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2007.07.014_bib16","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.4049\/jimmunol.147.4.1208","article-title":"Nonencephalitogenic CD4\u2212CD8\u2212 V alpha 2V beta 8.2+ anti-myelin basic protein rat T lymphocytes inhibit disease induction","volume":"147","author":"Lider","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib17","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.neuroscience.2004.10.043","article-title":"Major histocompatibility complex (MHC2+) perivascular macrophages in the axotomized facial motor nucleus are regulated by receptors for interferon-gamma (IFNgamma) and tumor necrosis factor (TNF)","volume":"131","author":"Liu","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2007.07.014_bib18","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1046\/j.0953-816x.2001.01507.x","article-title":"Retrograde response of the rat facial motor nucleus to muscle inflammation elicited by phytohaemagglutinin","volume":"13","author":"Mariotti","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.014_bib19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00019052-199906000-00010","article-title":"Immunopathogenesis of multiple sclerosis: the role of T cells","volume":"12","author":"Martino","year":"1999","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib20","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/eji.1830260623","article-title":"Characterization of CD4\u2212CD8\u2212 T cell receptor alpha beta+ T cells appearing in the subarachnoid space of rats with autoimmune encephalomyelitis","volume":"26","author":"Matsumoto","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.expneurol.2004.04.010","article-title":"Axonal reinjury reveals the survival and re-expression of regeneration-associated genes in chronically axotomized adult mouse motoneurons","volume":"188","author":"McPhail","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.expneurol.2005.04.013","article-title":"Both positive and negative factors regulate gene expression following chronic facial nerve resection","volume":"195","author":"McPhail","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib23","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.neuroscience.2004.08.035","article-title":"T lymphocytes play a role in neuropathic pain following peripheral nerve injury in rats","volume":"129","author":"Moalem","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2007.07.014_bib24","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.brainresrev.2003.11.004","article-title":"The facial nerve axotomy model","volume":"44","author":"Moran","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.expneurol.2007.07.014_bib25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0166-2236(00)02024-5","article-title":"Neuronal injury in bacterial meningitis: mechanisms and implications for therapy","volume":"25","author":"Nau","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.014_bib26","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.4049\/jimmunol.173.6.3916","article-title":"Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs","volume":"173","author":"Olson","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib27","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1523\/JNEUROSCI.18-15-05804.1998","article-title":"Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration","volume":"18","author":"Raivich","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.014_bib28","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.4049\/jimmunol.164.5.2338","article-title":"Qualitative changes accompany memory T cell generation: faster, more effective responses at lower doses of antigen","volume":"164","author":"Rogers","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0165-5728(00)00447-1","article-title":"Beneficial immune activity after CNS injury: prospects for vaccination","volume":"113","author":"Schwartz","year":"2001","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib29","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/00004647-200304000-00001","article-title":"Macrophages and microglia in central nervous system injury: are they helpful or harmful?","volume":"23","author":"Schwartz","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2007.07.014_bib31","doi-asserted-by":"crossref","first-page":"RC7","DOI":"10.1523\/JNEUROSCI.19-11-j0004.1999","article-title":"Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice","volume":"19","author":"Serpe","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.014_bib33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/1097-4547(20001015)62:2<273::AID-JNR11>3.0.CO;2-C","article-title":"Kinetics of facial motoneuron loss following facial nerve transection in severe combined immunodeficient mice","volume":"62","author":"Serpe","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.expneurol.2007.07.014_bib32","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0889-1591(03)00028-X","article-title":"CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection","volume":"17","author":"Serpe","year":"2003","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.expneurol.2007.07.014_bib34","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0301-0082(98)00069-0","article-title":"Reactive microgliosis","volume":"57","author":"Streit","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib35","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/neu.480241202","article-title":"Influences of neurotrophins on mammalian motoneurons in vivo","volume":"24","author":"Yan","year":"1993","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.expneurol.2007.07.014_bib36","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1523\/JNEUROSCI.14-09-05281.1994","article-title":"The biological responses of axotomized adult motoneurons to brain-derived neurotrophic factor","volume":"14","author":"Yan","year":"1994","journal-title":"J. Neurosci."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488607002919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488607002919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T17:11:51Z","timestamp":1683997911000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488607002919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0014488607002919"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2007.07.014","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}