{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:34:29Z","timestamp":1793921669731,"version":"4.8.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.expneurol.2007.07.022","type":"journal-article","created":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T07:15:09Z","timestamp":1187853309000},"page":"120-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats"],"prefix":"10.1016","volume":"208","author":[{"given":"Ana I.","family":"Rojo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Cavada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Rosa","family":"de Sagarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cuadrado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2007.07.022_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1034\/j.1600-0404.2003.00128.x","article-title":"Lifestyle-related risk factors for Parkinson's disease: a population-based study","volume":"108","author":"Baldereschi","year":"2003","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.expneurol.2007.07.022_bib2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/aje\/kwf216","article-title":"Neurodegenerative diseases and exposure to pesticides in the elderly","volume":"157","author":"Baldi","year":"2003","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.expneurol.2007.07.022_bib3","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0140-6736(85)91278-4","article-title":"Neurological consequence of industrial exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"1","author":"Barbeau","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.expneurol.2007.07.022_bib4","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/81834","article-title":"Chronic systemic pesticide exposure reproduces features of Parkinson's disease","volume":"3","author":"Betarbet","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.022_bib5","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.ntt.2004.06.014","article-title":"Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease","volume":"26","author":"Bretaud","year":"2004","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.expneurol.2007.07.022_bib6","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.neuro.2004.12.007","article-title":"Studying toxicants as single chemicals: does this strategy adequately identify neurotoxic risk?","volume":"26","author":"Cory-Slechta","year":"2005","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.expneurol.2007.07.022_bib7","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/brain\/122.8.1437","article-title":"The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease","volume":"122","author":"Damier","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2007.07.022_bib8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.brainres.2004.02.016","article-title":"Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence","volume":"1007","author":"de Lago","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2007.07.022_bib9","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S1474-4422(03)00501-5","article-title":"The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?","volume":"2","author":"Di Monte","year":"2003","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.expneurol.2007.07.022_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/1531-8257(199901)14:1<28::AID-MDS1007>3.0.CO;2-O","article-title":"Nutritional and occupational factors influencing the risk of Parkinson's disease: a case-control study in southeastern Sweden","volume":"14","author":"Fall","year":"1999","journal-title":"Mov. Disord."},{"key":"10.1016\/j.expneurol.2007.07.022_bib11","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1002\/jps.20318","article-title":"Nasal drug administration: potential for targeted central nervous system delivery","volume":"94","author":"Graff","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.expneurol.2007.07.022_bib12","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1017\/S0317167100052835","article-title":"A case-control study of Parkinson's disease in urban population of southern Israel","volume":"28","author":"Herishanu","year":"2001","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.expneurol.2007.07.022_bib13","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1523\/JNEUROSCI.16-12-03807.1996","article-title":"[3H]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study","volume":"16","author":"Higgins","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.022_bib14","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1111\/j.1471-4159.2006.04440.x","article-title":"Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone","volume":"101","author":"Inden","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2007.07.022_bib15","series-title":"Handbook of Acute Toxicity of Chemicals to Fish and Aquatic Invertebrates","first-page":"2","volume":"vol. 137","author":"Johnson","year":"1980"},{"key":"10.1016\/j.expneurol.2007.07.022_bib16","series-title":"The Agrochemicals Handbook","first-page":"2","year":"1991"},{"key":"10.1016\/j.expneurol.2007.07.022_bib17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1056\/NEJM198308043090511","article-title":"Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine","volume":"309","author":"Langston","year":"1983","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.expneurol.2007.07.022_bib18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1191\/0748233702th141oa","article-title":"Predictors of survival after acute paraquat poisoning","volume":"18","author":"Lee","year":"2002","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.expneurol.2007.07.022_bib19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/taap.1996.0054","article-title":"Effects of paraquat on the substantia nigra of the Wistar rats: neurochemical, histological, and behavioral studies","volume":"137","author":"Liou","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.07.022_bib20","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1001\/archneur.59.11.1787","article-title":"Plantation work and risk of Parkinson disease in a population-based longitudinal study","volume":"59","author":"Petrovitch","year":"2002","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.expneurol.2007.07.022_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1749-6632.2003.tb07476.x","article-title":"The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease","volume":"991","author":"Przedborski","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.expneurol.2007.07.022_bib22","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1046\/j.1471-4159.2001.00183.x","article-title":"The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety","volume":"76","author":"Przedborski","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.expneurol.2007.07.022_bib23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/toxsci\/kfi304","article-title":"Paraquat neurotoxicity is distinct from that of MPTP and rotenone","volume":"88","author":"Richardson","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.expneurol.2007.07.022_bib24","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1111\/j.1460-9568.2006.05060.x","article-title":"Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice","volume":"24","author":"Rojo","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.022_bib25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.brainres.2005.04.051","article-title":"Acute intranigral infusion of rotenone in rats causes progressive biochemical lesions in the striatum similar to Parkinson's disease","volume":"1049","author":"Saravanan","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2007.07.022_bib26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1100\/tsw.2001.35","article-title":"Pesticides and Parkinson's disease","volume":"1","author":"Sherer","year":"2001","journal-title":"Sci. World J."},{"key":"10.1016\/j.expneurol.2007.07.022_bib27","doi-asserted-by":"crossref","first-page":"10756","DOI":"10.1523\/JNEUROSCI.23-34-10756.2003","article-title":"Mechanism of toxicity in rotenone models of Parkinson's disease","volume":"23","author":"Sherer","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.022_bib28","doi-asserted-by":"crossref","first-page":"9207","DOI":"10.1523\/JNEUROSCI.20-24-09207.2000","article-title":"The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease","volume":"20","author":"Thiruchelvam","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.07.022_bib29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.neuroscience.2004.05.029","article-title":"Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration","volume":"127","author":"Thorne","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2007.07.022_bib30","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1056\/NEJM198402023100519","article-title":"Chronic parkinsonism secondary to intranasal administration of a product of meperidine-analogue synthesis","volume":"310","author":"Wright","year":"1984","journal-title":"N. Engl. J. Med."}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488607003007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488607003007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T05:41:41Z","timestamp":1762148501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488607003007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0014488607003007"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2007.07.022","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats","name":"articletitle","label":"Article Title"},{"value":"Experimental Neurology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.expneurol.2007.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}