{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:53:49Z","timestamp":1789952029582,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Neurology"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.expneurol.2007.12.004","type":"journal-article","created":{"date-parts":[[2008,1,15]],"date-time":"2008-01-15T12:18:57Z","timestamp":1200399537000},"page":"577-584","source":"Crossref","is-referenced-by-count":12,"title":["Effects of urotensin-II on cerebral blood flow and ischemia in anesthetized rats"],"prefix":"10.1016","volume":"210","author":[{"given":"Julien","family":"Chuquet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clotilde","family":"Lecrux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chatenet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Leprince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Chazalviel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Roussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric T.","family":"MacKenzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Vaudry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Touzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.expneurol.2007.12.004_bib1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0024-3205(02)01743-5","article-title":"Involvement of the nitric oxide\/l-arginine and sympathetic nervous systems on the vasodepressor action of human urotensin II in anesthetized rats","volume":"71","author":"Abdelrahman","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.expneurol.2007.12.004_bib2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1046\/j.1365-2125.2002.t01-1-01704.x","article-title":"No effect on central or peripheral blood pressure of systemic urotensin II infusion in humans","volume":"54","author":"Affolter","year":"2002","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/45809","article-title":"Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14","volume":"401","author":"Ames","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.expneurol.2007.12.004_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/sj.bjp.0704448","article-title":"Urotensin II evokes potent vasoconstriction in humans in vivo","volume":"135","author":"Bohm","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib5","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1038\/sj.bjp.0703513","article-title":"Human urotensin-II is an endothelium-dependent vasodilator in rat small arteries","volume":"130","author":"Bottrill","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00210-001-0503-0","article-title":"Effects of human urotensin II in isolated vessels of various species; comparison with other vasoactive agents","volume":"365","author":"Camarda","year":"2002","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib7","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1161\/01.STR.0000039401.48915.9F","article-title":"Selective blockade of endothelin-B receptors exacerbates ischemic brain damage in the rat","volume":"33","author":"Chuquet","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.expneurol.2007.12.004_bib8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0006-8993(01)03208-5","article-title":"The urotensin II receptor is expressed in the cholinergic mesopontine tegmentum of the rat","volume":"923","author":"Clark","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.expneurol.2007.12.004_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0167-0115(97)02135-6","article-title":"Somatostatin- and urotensin II-related peptides: molecular diversity and evolutionary perspectives","volume":"69","author":"Conlon","year":"1997","journal-title":"Regul. Pept."},{"key":"10.1016\/j.expneurol.2007.12.004_bib10","doi-asserted-by":"crossref","first-page":"15803","DOI":"10.1073\/pnas.95.26.15803","article-title":"Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord","volume":"95","author":"Coulouarn","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2007.12.004_bib11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0014-5793(99)01003-0","article-title":"Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors","volume":"457","author":"Coulouarn","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.expneurol.2007.12.004_bib12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0163-7258(95)00022-4","article-title":"Cholinergic and vasoactive intestinal polypeptidergic innervation of the cerebral arteries","volume":"67","author":"Dauphin","year":"1995","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.expneurol.2007.12.004_bib13","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/sj.bjp.0703690","article-title":"Differential vasoconstrictor activity of human urotensin-II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey","volume":"131","author":"Douglas","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1471-4892(03)00012-2","article-title":"Human urotensin-II as a novel cardiovascular target: \u2018heart\u2019 of the matter or simply a fishy \u2018tail\u2019?","volume":"3","author":"Douglas","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0304-3940(01)01804-3","article-title":"Urotensin II-immunoreactivity in the brainstem and spinal cord of the rat","volume":"305","author":"Dun","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.expneurol.2007.12.004_bib16","series-title":"Cerebral Blood Flow and Metabolism","first-page":"256","article-title":"Neuropeptides","author":"Edvinsson","year":"2002"},{"key":"10.1016\/j.expneurol.2007.12.004_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.bjp.0704671","article-title":"Molecular and pharmacological characterization of genes encoding urotensin-II peptides and their cognate G-protein-coupled receptors from the mouse and monkey","volume":"136","author":"Elshourbagy","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib18","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/00004647-199601000-00018","article-title":"Laser-Doppler evaluation of rat brain microcirculation: comparison with the [14C]-iodoantipyrine method suggests discordance during cerebral blood flow increases","volume":"16","author":"Fabricius","year":"1996","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2007.12.004_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1152\/physrev.1998.78.1.53","article-title":"Regulation of the cerebral circulation: role of endothelium and potassium channels","volume":"78","author":"Faraci","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.expneurol.2007.12.004_bib20","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1038\/sj.bjp.0704051","article-title":"Depressor and regionally-selective vasodilator effects of human and rat urotensin II in conscious rats","volume":"132","author":"Gardiner","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib21","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s002130100715","article-title":"Central effects of urotensin-II following ICV administration in rats","volume":"155","author":"Gartlon","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.expneurol.2007.12.004_bib22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1476-5381.1987.tb09000.x","article-title":"Complex effects of Gillichthys urotensin II on rat aortic strips","volume":"91","author":"Gibson","year":"1987","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib23","first-page":"H1247","article-title":"Laser-Doppler assessment of brain microcirculation: effect of systemic alterations","volume":"256","author":"Haberl","year":"1989","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib24","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/00004647-199704000-00004","article-title":"Repeat positron emission tomographic studies in transient middle cerebral artery occlusion in cats: residual perfusion and efficacy of postischemic reperfusion","volume":"17","author":"Heiss","year":"1997","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2007.12.004_bib25","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1161\/01.CIR.103.10.1378","article-title":"Effects of urotensin II in human arteries and veins of varying caliber","volume":"103","author":"Hillier","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.expneurol.2007.12.004_bib26","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.1523\/JNEUROSCI.4501-04.2005","article-title":"Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons","volume":"25","author":"Huitron-Resendiz","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.expneurol.2007.12.004_bib27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.surneu.2005.12.028","article-title":"Inflammation in stroke and focal cerebral ischemia","volume":"66","author":"Huang","year":"2006","journal-title":"Surg. Neurol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib28","first-page":"R361","article-title":"Contraction of major artery segments of rat by fish neuropeptide urotensin II","volume":"252","author":"Itoh","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/cne.20845","article-title":"Localization of the urotensin II receptor in the rat central nervous system","volume":"495","author":"J\u00e9gou","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/1475636031000093507","article-title":"Structure-activity relationships of human urotensin II and related analogues on rat aorta ring contraction","volume":"18","author":"Labarr\u00e8re","year":"2003","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.expneurol.2007.12.004_bib31","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1016\/j.lfs.2005.11.002","article-title":"Urotensin-II is a nitric oxide-dependent vasodilator in the pial arteries of the newborn pig","volume":"78","author":"Lacza","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.expneurol.2007.12.004_bib32","first-page":"R1335","article-title":"Cardiovascular actions of trout urotensin II in the conscious trout, Oncorhyncus mykiss","volume":"271","author":"Le Mevel","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00004872-200301000-00026","article-title":"Central cardiovascular action of urotensin II in conscious rats","volume":"21","author":"Lin","year":"2003","journal-title":"J. Hypertens."},{"key":"10.1016\/j.expneurol.2007.12.004_bib34","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1006\/bbrc.1999.1796","article-title":"Identification of urotensin II as the endogenous ligand for the orphan G-protein coupled receptor GPR14","volume":"266","author":"Liu","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.expneurol.2007.12.004_bib35","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1152\/ajplegacy.1976.231.2.489","article-title":"Influence of endogenous norepinephrine on cerebral blood flow and metabolism","volume":"231","author":"MacKenzie","year":"1976","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib36","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/sj.bjp.0703601","article-title":"Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1","volume":"131","author":"Maguire","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib37","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/sj.bjp.0704924","article-title":"Is urotensin-II the new endothelin?","volume":"137","author":"Maguire","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib38","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/brain\/119.2.409","article-title":"Early spontaneous hyperperfusion after stroke. A marker of favourable tissue outcome?","volume":"119","author":"Marchal","year":"1996","journal-title":"Brain"},{"key":"10.1016\/j.expneurol.2007.12.004_bib39","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/00004647-199905000-00001","article-title":"Early postischemic hyperperfusion: pathophysiologic insights from positron emission tomography","volume":"19","author":"Marchal","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2007.12.004_bib40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/bbrc.1999.1640","article-title":"Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor, SENR (GPR14)","volume":"265","author":"Mori","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.expneurol.2007.12.004_bib41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/14081","article-title":"Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction","volume":"1","author":"Nothacker","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tem.2004.03.007","article-title":"Urotensin II: the old kid in town","volume":"15","author":"Onan","year":"2004","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.expneurol.2007.12.004_bib43","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1073\/pnas.77.8.5021","article-title":"Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes","volume":"77","author":"Pearson","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2007.12.004_bib44","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.neuroscience.2004.12.045","article-title":"Androgenic down-regulation of urotensin II precursor, urotensin II-related peptide precursor and androgen receptor mRNA in the mouse spinal cord","volume":"132","author":"Pelletier","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.expneurol.2007.12.004_bib45","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/00004647-200404000-00001","article-title":"Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy","volume":"24","author":"Schaller","year":"2004","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.expneurol.2007.12.004_bib46","first-page":"1107","article-title":"Urotensin-II and its receptor (UT-R) are expressed in rat brain endothelial cells, and urotensin-II via UT-R stimulates angiogenesis in vivo and in vitro","volume":"18","author":"Spinazzi","year":"2006","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.expneurol.2007.12.004_bib47","first-page":"1409","article-title":"Detection of reperfusion injury using PET in a monkey model of cerebral ischemia","volume":"41","author":"Takamatsu","year":"2000","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.expneurol.2007.12.004_bib48","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1113\/expphysiol.2004.029512","article-title":"Laser Doppler flowmetry is valid for measurement of cerebral blood flow autoregulation lower limit in rats","volume":"90","author":"Tonnesen","year":"2005","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.expneurol.2007.12.004_bib49","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1073\/pnas.0510700103","article-title":"Comparative genomics provides evidence for close evolutionary relationships between the urotensin II and somatostatin gene families","volume":"103","author":"Tostivint","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.expneurol.2007.12.004_bib50","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1161\/01.HYP.0000084633.85427.E6","article-title":"Urotensin II acts centrally to increase epinephrine and ACTH release and cause potent inotropic and chronotropic actions","volume":"42","author":"Watson","year":"2003","journal-title":"Hypertension"}],"container-title":["Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488607004505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014488607004505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T22:38:54Z","timestamp":1557182334000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014488607004505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0014488607004505"],"URL":"https:\/\/doi.org\/10.1016\/j.expneurol.2007.12.004","relation":{},"ISSN":["0014-4886"],"issn-type":[{"value":"0014-4886","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}